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Xintao Qiu

As seen in: Nature, Cell Press, Cell Reports
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Articles

Whole-genome doubling drives immune evasion by silencing antigen presentation

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By Pierre Foidart, Zheqi Li, Xinran Cai, Marco Seehawer, Daniel Brown Verified, Pilar Baldominos, Salma Parvin, Jun Nishida, Triet M. Bui, Benedetto DiCiaccio, Rahul Kumar, Brent T. Schlegel, Marie-Anne Goyette, TashJaé Q. Scales, Pengze Yan, Xintao Qiu, Rong Li, Yijia Jiang, Yingtian Xie, Mahmoud Aarabi, Xiao-yun Huang, Laura Stevens Verified, Paloma Cejas, Lise Mangiante, Kathleen E. Houlahan, Christina Curtis, Steffi Oesterreich, Isaac Harris, Anthony Letai, Adrian Lee Verified, Henry Long, Judith Agudo, Kornelia Polyak, Amatullah Tawawalla, Ernesto Rojas-Jimenez
| Cell Press Verified
ArticleOnline nowOpen access Affiliations & Notes 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA 3Department of Medicine, Harvard Medical School, Boston, MA 02115, USA 4Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA 5Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 6Department of Immunology,...
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Whole-genome doubling drives immune evasion by silencing antigen presentation

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By Pierre Foidart, Zheqi Li, Xinran Cai, Marco Seehawer, Daniel Brown Verified, Amatullah Tawawalla, Pilar Baldominos, Salma Parvin, Jun Nishida, Ernesto Rojas-Jimenez, Triet M. Bui, Benedetto DiCiaccio, Rahul Kumar, Brent T. Schlegel, Marie-Anne Goyette, TashJaé Q. Scales, Pengze Yan, Xintao Qiu, Rong Li, Yijia Jiang, Yingtian Xie, Mahmoud Aarabi, Xiao-yun Huang, Laura Stevens Verified, Paloma Cejas, Lise Mangiante, Kathleen E. Houlahan, Christina Curtis, Steffi Oesterreich, Isaac Harris, Anthony Letai, Adrian Lee Verified, Henry Long, Judith Agudo, Kornelia Polyak
| Cell Press Verified
ArticleVolume 44, Issue 7p1418-1436.e12Open access Affiliations & Notes 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA, 02115, United States of America 3Department of Medicine, Harvard Medical School, Boston, MA, 02115, United States of America 4Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America 5Department of...
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KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage - Nature Genetics

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By Zheqi Li, Xintao Qiu, Marco Seehawer, Maeve McFadden Verified, Eva Papachristou, Natalie Kingston, Jun Nishida, Kendell Clement, Daniel Temko, Muhammad B. Ekram, Rong Li, Matthew Rees, Melissa Ronan, Jennifer Roth, Anton Simeonov, Stephen C. Kales, Ajit Jadhav, Franziska Michor, Alex Meissner, Justin M. Balko, Jason Carroll, Malvina Papanastasiou, Henry Long
| Nature Verified
Abstract Basal breast cancer is a subtype with a poor prognosis in need of more effective therapeutic approaches. Here we describe a unique role for the KDM4C histone lysine demethylase in KDM4C-amplified basal breast cancers, where KDM4C inhibition reshapes chromatin and transcriptomic landscapes without substantial alterations of its canonical substrates, trimethylated histone H3 lysine 9 (H3K9me3) and lysine 36 (H3K36me3).
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