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ArticleOnline nowOpen access Affiliations & Notes 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, United States of America 3Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 4Department of Immunology, Harvard Medical School, Boston, MA, 02115, United States of America 5Systems,...
Abstract Even when presenting in the clinic with localized disease, patients with pancreatic ductal adenocarcinoma (PDAC) experience extremely poor survival, owing to local recurrence and/or distant progression driven by micrometastatic lesions despite aggressive systemic chemotherapy.
Abstract Triple-negative breast cancer (TNBC) has poor outcomes and few effective treatments, partly because of epigenetic heterogeneity. We show that the heterochromatin mark H4K20me3 is more variable than H3K9me3 across normal and malignant breast tissues, and that H4K20me3-enriched regions are linked to more open chromatin and active transcription.
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