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Whole-genome doubling drives immune evasion by silencing antigen presentation
ArticleVolume 44, Issue 7p1418-1436.e12Open access Affiliations & Notes 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA, 02115, United States of America 3Department of Medicine, Harvard Medical School, Boston, MA, 02115, United States of America 4Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America 5Department of...
Whole-genome doubling drives immune evasion by silencing antigen presentation
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ArticleOnline nowOpen access Affiliations & Notes 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA 3Department of Medicine, Harvard Medical School, Boston, MA 02115, USA 4Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA 5Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 6Department of Immunology,...
By Pierre Foidart, Zheqi Li, Xinran Cai, Marco Seehawer, Daniel Brown Verified, Pilar Baldominos, Salma Parvin, Jun Nishida, Triet M. Bui, Benedetto DiCiaccio, Rahul Kumar, Brent T. Schlegel, Marie-Anne Goyette, TashJaé Q. Scales, Pengze Yan, Xintao Qiu, Rong Li, Yijia Jiang, Yingtian Xie, Mahmoud Aarabi, Xiao-yun Huang, Laura Stevens Verified, Paloma Cejas, Lise Mangiante, Kathleen E. Houlahan, Christina Curtis, Steffi Oesterreich, Isaac Harris, Anthony Letai, Adrian Lee Verified, Henry Long, Judith Agudo, Kornelia Polyak, Amatullah Tawawalla, Ernesto Rojas-Jimenez
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Cell Press
Verified
Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer
Abstract Immunotherapies have yet to demonstrate significant efficacy in the treatment of hormone receptor-positive (HR+) breast cancer. Given that endocrine therapy (ET) is the primary approach for treating HR+ breast cancer, we investigated the effects of ET on the tumor immune microenvironment (TME) in HR+ breast cancer.
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