Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Chen Chu
Co-targeting CDK2 and CDK9 inhibits MYC oncogenic programs and has anti-tumor effects in CIC -rearranged sarcoma
Abstract CIC-rearranged sarcoma is a rare and highly aggressive cancer that primarily affects children and young adults and has few effective treatment options. Previous studies have identified molecular dependence on cyclin-dependent kinase 2 (CDK2), but additional therapeutic vulnerabilities remain poorly defined. Here, we investigate the activity of CDK2-targeted therapies and evaluate combination strategies using new patient-derived models of CIC-rearranged sarcoma.
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4
|
ArticleOnline nowOpen access Affiliations & Notes 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, United States of America 3Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 4Department of Immunology, Harvard Medical School, Boston, MA, 02115, United States of America 5Systems,...
By Chen Chu, Shanshan Zheng, Ning Mitchell, Zheqi Li, Xixi Zhang, Xiaowei Wu, Tian Zhang, Fabin Dang, Wojciech Michowski, Aleksandra A. Kolodziejczyk, Miranda Xu, Krzysztof Kotowski, Zhe Yang, Diego Martínez-Alonso, João Paulo, Jindan Sheng, Jane Kirby Verified, Finn Groezinger, Yubin Zhou, Miao He, Yoshinaga Ito, Anushree Gulvady, Michael Cole, Pierre Foidart, Jun Nishida, Xiaohan Ning, Samanta Sharma, Jan M. Suski, Anne Fassl, Yu Zhou, Yan Geng, Wenyi Wei, Steven Gygi, Kornelia Polyak, Kai W. Wucherpfennig, Piotr Sicinski
|
Cell Press
Verified
Targeting EZH2-driven cholesterol metabolic vulnerability through Napabucasin suppresses ovarian cancer metastasis
Abstract Ovarian cancer represents the most lethal gynecologic malignancy, with tumor metastasis being the primary contributor to patient mortality. EZH2, frequently overexpressed in various cancers, has been implicated in promoting metastatic progression through metabolic dysregulation. However, the mechanistic basis by which EZH2 reprograms cholesterol metabolism to facilitate ovarian cancer metastasis remains poorly defined.
Unveiling EMC6 as a novel pathogenic determinant in hepatocellular carcinoma: orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13 | Oncogene
Abstract The endoplasmic reticulum (ER) membrane protein complex (EMC) is an ER multiprotein complex that affects a wide range of pathophysiological processes. Recently, the function of EMC6, a subunit of EMC, has been attracting attention for its role in cancers. However, research on EMC6 in the context of hepatocellular carcinoma (HCC) remains unknown.
The Role of Nitric Oxide in the Growth and Development of Schizophyllum commune Under Anaerobic Conditions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Evidence for the Existence of Mating Subtypes Within the Schizophyllum commune: Mating Behavior and Genetic Divergence
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Interaction Lubrication Mechanism Between Nano-Biochar and Traditional Oil Additives Under Various Sliding Conditions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Nitric Oxide-Mediated Regulation of Chitinase Activity and Cadmium Sequestration in the Response of Schizophyllum commune to Cadmium Stress
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Changes in the correlation between substantia nigra hyperechogenicity area and Parkinson’s disease severity at different Hoehn and Yahr stages - Neurological Sciences
Abstract It is debatable whether the area of substantia nigra hyperechogenicity (SN+) in transcranial sonography (TCS) is related to Parkinson’s disease (PD) severity. Iron deposition, which is associated with the formation of SN+, may have different effects on dopamine nerve function as PD progresses. However, little research has explored the association between the SN + area and disease severity of PD in stages.
Impact of the Russia-Ukraine Conflict on Global Marine Network Based on Massive Vessel Trajectories
1. Introduction Transportation networks are highly vulnerable to various disruptions, including warfare conflicts, extreme climate change, COVID-19 [1], black swan events, and political regime changes. The global maritime transportation network serves as an indicator of global economic functioning and is also a crucial safeguard for global trade and energy transportation security.
DeepIndoorCrowd: Predicting crowd flow in indoor shopping malls with an interpretable transformer network
CONFLICT OF INTEREST STATEMENT The authors declare that there is no conflict of interest that could have appeared to influence the work reported in this article. REFERENCES , & (1979). Analysis of freeway traffic time-series data by using box-Jenkins techniques. Transportation Research Record, 722, 1–9. http://onlinepubs.trb.org/Onlinepubs/trr/1979/722/722-001.pdf , , & (2016). Layer normalization. arXiv:1607.06450. , , , , & (2020).
PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity - Nature Communications
Abstract Activation of the cGAS/STING innate immunity pathway is essential and effective for anti-tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS signaling is suppressed to facilitate tumorigenesis by escaping immune surveillance. Here, we report that the protein arginine methyltransferase, PRMT1, methylates cGAS at the conserved Arg133 residue, which prevents cGAS dimerization and suppresses the cGAS/STING signaling in cancer cells.
Structure of a SIN3–HDAC complex from budding yeast - Nature Structural & Molecular Biology
Vidal, M. & Gaber, R. F. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 6317–6327 (1991). CAS PubMed PubMed Central Google Scholar Taunton, J., Hassig, C. A. & Schreiber, S. L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408–411 (1996). Article CAS PubMed Google Scholar Verdin, E. & Ott, M.
Two assembly modes for SIN3 histone deacetylase complexes - Cell Discovery
Abstract The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential roles in regulating chromatin accessibility and gene expression. There are two major types of SIN3/HDAC complexes (named SIN3L and SIN3S) targeting different chromatin regions. Here we present the cryo-electron microscopy structures of the SIN3L and SIN3S complexes from Schizosaccharomyces pombe (S. pombe), revealing two distinct assembly modes.
Molecules | Free Full-Text | Enhancing Heat Transfer Behaviour of Ethylene Glycol by the Introduction of Silicon Carbide Nanoparticles: An Experimental and Molecular Dynamics Simulation Study
Open AccessArticle by Xianjun Hou 1, Chen Chu 1, Hua Jiang 1,2,*, Mohamed Kamal Ahmed Ali 3 and Karl D.
Cyclin E in normal physiology and disease states
Highlights Cyclin E, a cell cycle protein, has a variety of non-canonical, cell cycle-independent physiological roles, such as regulating liver function, neurophysiology, spermatogenesis, and stem cell maintenance. The diversity of the physiological functions of cyclin E is achieved through activation or inhibition of CDKs, and possibly also via kinase-independent mechanisms. Cyclin E is frequently overexpressed in cancer.
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy
Abstract Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours. However, only a subset of patients achieves durable responses, suggesting that the mechanisms of the immune checkpoint pathways are not completely understood.
Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells
Allen J.J. Li M. Brinkworth C.S. Paulson J.L. Wang D. Hübner A. Chou W.H. Davis R.J. Burlingame A.L. Messing R.O. et al. A semisynthetic epitope for kinase substrates. Nat. Methods. 2007; 4: 511-516 Banko M.R. Allen J.J. Schaffer B.E. Wilker E.W. Tsou P. White J.L. Villén J. Wang B. Kim S.R. Sakamoto K. et al. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol. Cell. 2011; 44: 878-892 Bernstein B.E. Mikkelsen T.S. Xie X. Kamal M. Huebert D.J. Cuff J. Fry B.
Systemic Artery Aneurysms and Kawasaki Disease
Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$25.00 Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
环球评论 | 重磅：中国对美商品加征关税清单：税目商品排除申请十问 | Lexology
China, USA June 14 2019 重要提示： 一部分企业对于进口商品的税号并没有严格进行合规性审查，一些进口商品税号错误，企业在判断某进口商品是否加税以及加税幅度及其对于企业所可能造成的不利影响时，不可避免地将出现判断失误。此外，以错误的税号发起排除性申请，即便排除加税申请获准，企业继续申报该进口税号，缉私局将追究企业的违规甚至走私的行政和刑事责任。因此，企业在税号合规和准备排除性申请方面，寻求专业人士协助，显得尤为重要。 2019年6月3日起，对于中国针对原产于美国的商品所公布的加税清单中的一些税目商品，境内企业或者行业协会可以开始在线填报申请，争取将之从中方加税清单上剔除（税委会公告[2019]...
环球评论 | 上海自由贸易试验区新政实施方案解读（二）：贸易便利 化措施 | Lexology
在中美贸易战的背景之下，2019年3月9日，上海市人民政府印发沪府规〔2019〕12号文，推出《本市贯彻〈关于支持自由贸易试验区深化改革创新若干措施〉实施方案》（简称“新政实施方案”）。该新政实施方案，目的是贯彻国发〔2018〕38号文《关于支持自由贸易试验区深化改革创新若干措施》的精神，继续推进中国（上海）自由贸易试验区新政，提升改革和开放水平。该文发出的对象是上海市各区人民政府，市政府各委、办、局。上海新一轮改革开放的新政措施，于2019年3月31日就此展开。...
Cooperation enhanced by the coevolution of teaching activity in evolutionary prisoner's dilemma games with voluntary participation
Voluntary participation, as an additional strategy involved in repeated games, has been proved to be an efficient way to promote the evolution of cooperation theoretically and empirically. Besides, current studies show that the coevolution of teaching activity can promote cooperation.
Exploring Mouse Protein Function via Multiple Approaches
Although the number of available protein sequences is growing exponentially, functional protein annotations lag far behind. Therefore, accurate identification of protein functions remains one of the major challenges in molecular biology. In this study, we presented a novel approach to predict mouse protein functions. The approach was a sequential combination of a similarity-based approach, an interaction-based approach and a pseudo amino acid composition-based approach.
The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life
Citation: Zhang Y-H, Chu C, Wang S, Chen L, Lu J, Kong X, et al. (2016) The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life. PLoS ONE 11(10): e0165496. doi:10.1371/journal.pone.0165496 Copyright: © 2016 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Chen
Contact Chen, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack