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Chen Weller

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Articles by Chen Weller

Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome

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By Roberto Vendramin, Hongchang Fu, Shanila Fernandez Patel, Yue Zhao, Danwen Qian, Lorena Ligammari, Osnat Bartok, Polina Greenberg, Ronen Levy, Andrea Castro, Krupa Thakkar, Jun Murai, Wei-Ting Lu, Christopher C.T. Sng, Chen Weller, Gordon Beattie, Amandeep Bhamra, Roc Farriol-Duran, Despoina Karagianni, Krijn K. Dijkstra, Christopher L. Pinder, Benjamin Simpson, Gordon Cheung, Felipe Galvez-Cancino, Petra Vlckova, Silvia Surinova, Manuel Rodriguez-Justo, Mansi Shah, Nicholas McGranahan, Jeremy G. Carlton, Eva Grönroos, James L. Reading, Yardena Samuels, Charles Swanton, Sergio A Quezada, Kevin Litchfield, Marcellus Augustine
| Cell Press Verified
Keywords nonsense-mediated mRNA decay non-canonical neoantigens cryptic peptides cancer immunopeptidome SMG1 tumor immunogenicity cancer immunotherapy patient-derived fragments Introduction Effective anti-tumor immunity relies on the ability of T cells to detect cancer-associated peptides presented by the major histocompatibility complex (MHC) molecules and is shaped by both the quantity and quality of neoantigens.1,2 Among these, mutation-derived neoantigens (peptides derived from...
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Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome

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By Roberto Vendramin, Hongchang Fu, Shanila Fernandez Patel, Yue Zhao, Danwen Qian, Lorena Ligammari, Osnat Bartok, Polina Greenberg, Ronen Levy, Andrea Castro, Krupa Thakkar, Jun Murai, Wei-Ting Lu, Christopher C.T. Sng, Chen Weller, Gordon Beattie, Amandeep Bhamra, Roc Farriol-Duran, Despoina Karagianni, Marcellus Augustine, Krijn K. Dijkstra, Christopher L. Pinder, Benjamin Simpson, Gordon Cheung, Felipe Galvez-Cancino, Petra Vlckova, Silvia Surinova, Manuel Rodriguez-Justo, Mansi Shah, Nicholas McGranahan, Jeremy G. Carlton, Eva Grönroos, James L. Reading, Yardena Samuels, Charles Swanton, Sergio A Quezada, Kevin Litchfield
| Cell Press Verified
Keywords nonsense-mediated mRNA decay non-canonical neoantigens cryptic peptides cancer immunopeptidome SMG1 tumor immunogenicity cancer immunotherapy patient-derived fragments Introduction Effective anti-tumor immunity relies on the ability of T cells to detect cancer-associated peptides presented by the major histocompatibility complex (MHC) molecules and is shaped by both the quantity and quality of neoantigens.1,2 Among these, mutation-derived neoantigens (peptides derived from...
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Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation

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By Shira Sagie, Tomer Babu, Chen Weller, Ido Livneh, Nele P Quast, Nofar Gumpert, Alina S. Shomuradova, Ronen Levy, Dmitry Malko, Michal Alon, Franco Hessling Herrera, Mikhail Kutuzov, Mirie Zerbib, Polina Greenberg, Gil Benedek, Yishai Levin, Chani Stossel, Iris Kamer, Talia Golan, Roni Oren, Merav D. Shmueli, Osnat Bartok, Jair Bar, Jonathan Cohen, Omer Dushek, Charlotte M. Deane, Yardena Samuels, Claire Tabachnik, Matthew I. Raybould, Adi Alfia, Talal Ben Lulu, Talya Wasserman-Bartov
| Cell Reports Medicine Verified
Results Utilizing our previously developed data-driven pipeline,26 we prioritized candidate neoantigens from The Cancer Genome Atlas (TCGA) lung cancer dataset and identified the KRAS.G12V-HLA-A∗03:01 combination as a leading candidate. This HLA-mutation combination is found in approximately 94,000 patients worldwide (Figure 1A; Table S1).
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HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion

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By Yoav Chemla, Orit Itzhaki, Stav Melamed, Chen Weller, Yuval Sade, Paulee Manich, Keren Reshef, Nicolas Xenidis, Avishai Maliah, Gilad Levy, Roma Parikh, Osnat Bartok, Itay Tal, Gal Aziel, Abraham Nissani, Sharon Yunger, Daniela Likonen, Tamar Golan, Coralie Capron, Ronen Levy, Diana Rasoulouniriana, Zohar Eyal, Yuval Barzilay, Aseel Khateeb, Tamar Ziv, Polina Greenberg, Xunwei Wu, Yael Amitay, Dov Hershkovitz, Tal Yardeni, Valentina Zemser-Werner, Oren Kobiler, David Bassan, Ron Shamir, Nadine Santana-Magal, Michael Milyavsky, Galit Eisenberg, Leeat Keren, Merav Cohen, Dvir Gur, Boaz Barak, Michal Lotem, David Sprinzak, Shoshana Greenberger, David Fisher, Michal J. Besser, Mehdi Khaled, Pierre Close, Ronnie Shapira, Sebastien Apcher, Asaf Madi, Mitchell Levesque, Yaron Carmi, Shivang Parikh, Yardena Samuels, Carmit Levy, Vitaly Kliminsky, Valentina Ace, Roi Balaban, Rami Khosravi, Amir Grau, Dvir Netanely, Hananya Vaknin, Ronen Brenner, Yael Friedmann, Lea Eisenbach, Francessca Rapino
| Cell Press Verified
STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies 112Cd Rat Anti mouse CD45 BioLegend Clone:30-F11; Cat#103120; RRID: AB_312985 113In anti-mouse/human CD44 BioLegend Clone:IM7; Cat#103014; RRID: AB_312965 115In Rat anti-mouse CD3 BioLegend Clone: 145-2C11; Cat#100340; RRID: AB_11149115 141Pr Rat anti-mouse CD274 BioLegend Clone:10F.9G2; Cat#124302; RRID: AB_961228 142Nd Ratr anti-mouse Ly-6G/Ly-6C (Gr-1) BioLegend Clone: RB6-8C5; Cat#108449; RRID: AB_2563785 143Nd Ratr anti-mouse...
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Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion

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By Yun Yang, Hai-bo Li, Chen Weller, Yardena Samuels
| ScienceDirect Verified
The tumor microenvironment (TME) represents a complex ecosystem harboring cancer cells, stromal cells, immune cells, and a diverse array of signaling molecules.1 This complicated network orchestrates crucial aspects of tumor biology, including progression, metastasis, immune evasion, and response to therapy.2,3,4 Central to TME dynamics is its immunosuppressive milieu, often driven by metabolic reprogramming of resident cells.3,5 Cancer cells undergo distinct metabolic alterations,...
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