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Articles by Ji Lin
SH3GLB1 mediates tumor cell resistance to tyrosine kinase inhibitors by regulating mitophagy
Abstract Tyrosine kinase inhibitors (TKIs) have been widely utilized in cancer treatment, but their effectiveness was often hampered by the development of drug resistance. A better understanding of the TKIs resistance mechanism is beneficial to improving therapeutic strategies. Our study found that SH3GLB1 expression was elevated in drug-resistant cells by transcriptome sequencing and correlated with poor prognosis. Silencing SH3GLB1 substantially abrogated TKIs resistance in tumor cells.
A Zero-Waste City, a healthy community: impacts of Zero-Waste City policy on urban residents’ health
Abstract This paper treats the first group of Zero-Waste City pilots launched in 2019 as a natural policy experiment. Drawing on a panel of 252 prefecture-level cities over 2012 to 2023, it applies a double machine learning model to identify the causal effect of comprehensive solid-waste governance on urban residents’ health. The results indicate that Zero-Waste City construction brings a significant gain in the health of residents in pilot cities.
The Reversed Multi-Arm Two-Stage (RevMATS) Design in Oncology Dose Optimization
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description bimj70195-sup-0001-SuppMat.zip475.6 KB Additional Tables may be found in the online version of this article at the publisher's website.Supporting File: bimj70195-sup-0001-SuppMat.zip. References , , , et al. 2023.
The impact of the zero-waste city pilot policy on the synergistic reduction of CO₂ and air pollutant emissions: evidence from China
Abstract Against the backdrop of China’s carbon peaking and carbon neutrality agenda and intensified pollution control efforts, advancing the synergistic control of CO₂ and air pollutant emissions has become an important pathway toward green transformation and the reduction of environmental health risks.
NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer
eLife Assessment This fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. After major revisions, the evidence supporting the conclusions is solid. However, some new experiments are needed to draw more robust conclusions regarding the ferroptosis-associated studies.
Utilizing statistical analysis for motion imagination classification in brain-computer interface systems
Loading metrics Open Access Peer-reviewed Research Article Citation: Li Y, Zhang J (2025) Utilizing statistical analysis for motion imagination classification in brain-computer interface systems. PLoS One 20(7): e0327121. https://doi.org/10.1371/journal.pone.0327121 Editor: Miguel Angel Sánchez Granero, Universidad de Almeria, SPAIN Received: October 12, 2024; Accepted: June 10, 2025; Published: July 8, 2025 Copyright: © 2025 Li, Zhang.
Wearable and stretchable electronics enabled by MXene-PVA films via layer-by-layer assembly with integrated UV, thermal, and mechanical sensing
Wearable and stretchable electronics enabled by MXene–PVA films via layer-by-layer assembly with integrated UV, thermal, and mechanical sensing† We integrate MXene with polyvinyl alcohol (PVA) through a meticulous layer-by-layer assembly process, not only enhancing the mechanical flexibility and robustness of MXene but also significantly improving its environmental stability.
Simulation of Antiplane Piezoelectricity Problems with Multiple Inclusions by the Meshless Method of Fundamental Solution with the LOOCV Algorithm for Determining Sources
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
WTAP-mediated m6A methylation of PHF19 facilitates cell cycle progression by remodeling the accessible chromatin landscape in t(8;21) AML - Oncogene
Abstract Wilms’ tumor 1-associated protein (WTAP) is a key N6-methyladenosine (m6A) methyltransferase that is upregulated in t(8;21) acute myeloid leukemia (AML) under hypoxia inducible factor 1α-mediated transcriptional activation, promoting leukemogenesis through transcriptome-wide m6A modifications. However, the specific substrates and intrinsic regulatory mechanisms of WTAP are not well understood.
A Hybrid Collocation Method for Long‐Time Simulation of Heat Conduction in Anisotropic Functionally Graded Materials
Conflicts of Interest The authors declare no conflicts of interest. References 1 and , “Metallic Functionally Graded Materials: A Specific Class of Advanced Composites,” Journal of Materials Science and Technology 29 (2013): 297–316. 2, , , and , “Design Methodology for Functionally Graded Materials: Framework for Considering Cracking,” Additive Manufacturing 73 (2023): 103672. 3, , and , “A Review on Functionally Graded Materials,” International Journal of Engineering Science 3 (2014): 90–101.
Vaccines | Free Full-Text | Exploring Perceptions and Barriers: A Health Belief Model-Based Analysis of Seasonal Influenza Vaccination among High-Risk Healthcare Workers in China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Soliton in Bose-Einstein condensates with helicoidal spin-orbit coupling under a Zeeman lattice
We investigate the existence and stability of higher-order bright solitons, stripe solitons, and bright-dark solitons in a Bose-Einstein condensate with helicoidal spin-orbit coupling under a Zeeman lattice using numerical methods. The higher-order bright solitons that exist in the first-finite energy gap are stable except near the edge.
A seamless phase II/III design with dose optimization for oncology drug development
REFERENCES 1, , . Estimation of clinical trial success rates and related parameters. Biostatistics. 2019; 20(2): 273-286. 2European Medicines Agency. Reflection Paper on Methodological Issues in Confirmatory Clinical Trials Planned with an Adaptive Design. London: EMEA; 2007. 3, , , et al. The future of drug development: advancing clinical trial design. Nat Rev Drug Discov. 2009; 8(12): 949-957. 4, , .
Visual Language Models on NVIDIA Hardware with VILA
Visual language models have evolved significantly recently. However, the existing technology typically only supports one single image. They cannot reason among multiple images, support in context learning or understand videos. Also, they don’t optimize for inference speed. We developed VILA, a visual language model with a holistic pretraining, instruction tuning, and deployment pipeline that helps our NVIDIA clients succeed in their multi-modal products.
Visual Language Intelligence and Edge AI 2.0
VILA is a family of high-performance vision language models developed by NVIDIA Research and MIT. The largest model comes with ~40B parameters and the smallest model comes with ~3B parameters. It is fully open source (including model checkpoints and even training code and training data). In this post, we describe how VILA performs against other models to deliver edge AI 2.0. Initial versions of edge AI involved deploying compressed AI models onto edge devices.
Dynamics and Stability via Thin‐Shell of Approximated Black Holes in f(Q)$f(\mathbb {Q})$ Gravity
The current study is devoted to exploring the geometrical configuration of a thin-shell in the background of symmetric teleparallel gravity.
Insights into dynamical evolution and stability of thin-shell configurations through acoustic black holes
Eur. Phys. J.
Mode conversion of various solitons in parabolic and cross-phase potential wells
We numerically establish the controllable conversion between Laguerre–Gaussian and Hermite–Gaussian solitons in nonlinear media featuring parabolic and cross-phase potential wells. The parabolic potential maintains the stability of Laguerre–Gaussian and Hermite–Gaussian beams, while the actual conversion between the two modes is facilitated by the cross-phase potential, which induces an additional phase shift.
Magnetic resonance imaging of femoral nerve injury in the setting of anterior approach total hip arthroplasty
To illustrate MRI findings in patients with femoral neuropathy following anterior approach total hip arthroplasty (THA). This was a retrospective review of patients who underwent MRI for femoral neuropathy following anterior approach THA between January 1, 2010, and July 1, 2022. Included patients had no preexisting neurologic condition. Clinical and diagnostic data were collected. MRIs were reviewed in consensus by 2 musculoskeletal radiologists.
Risk factors for social isolation in older adults: A systematic review and meta‐analysis
DATA AVAILABILITY STATEMENT The data that supported the findings of this study are available from the corresponding author upon reasonable request.
Spiraling Laguerre-Gaussian solitons and arrays in parabolic potential wells
Abstract Controllable trajectories of beams are one of the main themes in optical science. Here, we investigate the propagation dynamics of Laguerre–Gaussian (LG) solitons in parabolic potential wells and introduce off-axis and chirp parameters (which represent the displacement and the initial angle of beams) to make solitons sinusoidally oscillate in the x and y directions and undergo elliptically or circularly spiraling trajectories during propagation.
Antibiotics | Free Full-Text | Multi-Model Strategies for Prevention of Infection Caused by Certain Multi-Drug Resistant Organisms in A Rehabilitation Unit: A Semi-Experimental Study
1. Introduction In recent years, healthcare-associated infections (HAIs) caused by multi-drug resistant organisms (MDROs) have become severe challenges to clinical treatment, often prolonging the length of stay (LOS), increasing mortality, and increasing medical costs [1,2,3]. The prevalence of MDROs poses a threat to public health worldwide.
Enhancing Intermolecular Packing and Light Harvesting through Asymmetric Non-Fullerene Acceptors for Achieving 18.7% Efficiency Ternary Organic Solar Cells
Enhancing Intermolecular Packing and Light Harvesting through Asymmetric Non-Fullerene Acceptors for Achieving 18.7% Efficiency Ternary Organic Solar Cells Zhiliang Zhang, Jingnan Wu, Ji Lin, Rui Zhang, Junfang Lv, LinFeng Yu, Xia Guo and Maojie Zhang Abstract In recent years, the ternary strategy has been proven to be an effective way to improve the performance of organic solar cells (OSCs).
HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m6A-dependent stabilization of KDM4B mRNA - Leukemia
Author notes These authors contributed equally: Yang-Liu Shao, Yu-Qing Li, Meng-Yue Li, Li-Li Wang. These authors jointly supervised this work: Ji Lin, Xiao-Ning Gao.
Omni-Dimensional Dynamic Convolution Meets Bottleneck Transformer: A Novel Improved High Accuracy Forest Fire Smoke Detection Model
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Generation and Controllability of High-Dimensional Rogue Waves in an Electromagnetically Induced Transparent Medium
Abstract : We propose a scheme to generate and control high-dimensional rogue waves in a coherent three-level Λ -type atomic system via electromagnetically induced transparency (EIT). Under EIT conditions, the probe field envelopes obey the non-integrable nonlinear Schrödinger equations (NLSE) with or without the external potential, which result from the stark (Zeeman) effect contributed by an electric (magnetic) field.
TSBA-YOLO: An Improved Tea Diseases Detection Model Based on Attention Mechanisms and Feature Fusion
Abstract : Tea diseases have a significant impact on the yield and quality of tea during the growth of tea trees. The shape and scale of tea diseases are variable, and the tea disease targets are usually small, with the intelligent detection processes of tea diseases also easily disturbed by the complex background of the growing region. In addition, some tea diseases are concentrated in the entire area of the leaves, needing to be inferred from global information.
The Novel Analytical–Numerical Method for Multi-Dimensional Multi-Term Time-Fractional Equations with General Boundary Conditions
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Ji Lin 1,†, Sergiy Reutskiy 2,†, Yuhui Zhang 1,†, Yu Sun 3,† and Jun Lu 3,*,† 1 College of Mechanics and Materials, Hohai University, Nanjing 210098, China 2 A.
A Semi-Supervised Method for Real-time Forest Fire Detection Algorithm Based on Adaptively Spatial Feature Fusion
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Ji Lin 1, Haifeng Lin 1,* and Fang Wang 2,* 1 College of Information Science and Technology, Nanjing Forestry University, Nanjing 210037, China 2 College of Electronic Engineering, Nanjing XiaoZhuang University, Nanjing 211171, China * Authors to whom correspondence should be addressed.
Soliton transformation between different potential wells
Abstract This paper presents a novel, to the best of our knowledge, method for realizing soliton transformation between different potential wells by gradually manipulating their depths in the propagation direction. The only requirements for such a transformation are that the gradient of the manipulated depth is smooth enough and the solitons in different potential wells are both in the regions of stability.
An asymmetric wide-bandgap acceptor simultaneously enabling highly efficient single-junction and tandem organic solar cells
An asymmetric wide-bandgap acceptor simultaneously enabling highly efficient single-junction and tandem organic solar cells Jianqiu Wang, Maojie Zhang, Ji Lin, Zhong Zheng, Lei Zhu, Pengqing Bi, Haiyan Liang, Xia Guo, Jingnan Wu, Yafei Wang, LinFeng Yu, Jiayao Li, Junfang Lv, Xiaoyu Liu, Feng Liu, Jianhui Hou and Yongfang Li Abstract The ternary and tandem strategies are effective methods for improving the photovoltaic performance of organic solar cells (OSCs).
Asymptomatic COVID-19 Patients Can Contaminate Their Surroundings: an Environment Sampling Study
Observation | Applied and Environmental Science Li Wei, Ji Lin, Xiaofei Duan, Wenzhi Huang, Xiaojun Lu, Juan Zhou, Zhiyong Zong Katherine McMahon, Editor DOI: 10.1128/mSphere.00442-20 ABSTRACT The contamination of patients’ surroundings by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains understudied.
Integrated Multifunctional Flexible Electronics Based on Tough Supramolecular Hydrogels with Patterned Silver Nanowires
Integrated Multifunctional Flexible Electronics Based on Tough Supramolecular Hydrogels with Patterned Silver Nanowires Conductive hydrogels based soft electronics with superior mechanical/electrical properties and biocompatibility have great potentials for sensing and stimulation at device-human interfaces, in which one piece of functional gel is usually used as a multi-sensor to chemicals, mechanical deformations, etc.
Influence of Diabetes Complications on HbA1c Treatment Goals Among Older U.S. Adults: A Cost-effectiveness Analysis
Cardiovascular and Metabolic Risk Abstract OBJECTIVE Guidelines on the standard care of diabetes recommend that glycemic treatment goals for older adults consider the patient’s complications and life expectancy. In this study, we examined the influence of diabetes complications and associated life expectancies on the cost-effectiveness (CE) of HbA1c treatment goals.
Influence of Diabetes Complications on HbA1c Treatment Goals Among Older U.S. Adults: A Cost-Effectiveness Analysis
Original Research Influence of Diabetes Complications on HbA1c Treatment Goals Among Older U.S. Adults: A Cost-Effectiveness Analysis Hui Shao, Ji Lin, Xiaohui Zhuo, Deborah B. Rolka, Edward W. Gregg, Ping Zhang Abstract OBJECTIVE Guidelines on the standard care of diabetes recommend that glycemic treatment goals for older adults consider the patient’s complications and life expectancy.
Slide-Ring Cross-Links Mediated Tough Metallosupramolecular Hydrogels with Superior Self-Recoverability
Stiff yet recoverable water-containing materials can be found in many biological tissues including tendons, cartilages, and skins. However, it remains a challenge to develop hydrogels as load-bearing materials where high stiffness and toughness, as well as fast recoverability, are required. Making framework more compact with more rigid chains could make a gel stiffer but also restrict its recovery for lower chain mobility.
Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study
Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study Edward W. Gregg, Ji Lin, Barbara Bardenheier, Haiying Chen, W. Jack Rejeski, Xiaohui Zhuo, Andrea L. Hergenroeder, Stephen B. Kritchevsky, Anne L. Peters, Lynne E. Wagenknecht, Edward H. Ip, Mark A. Espeland Diabetes Care May 2018, 41 (5) 1040-1048; DOI: 10.2337/dc17-2110
Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study
Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study Edward W. Gregg, Ji Lin, Barbara Bardenheier, Haiying Chen, W. Jack Rejeski, Xiaohui Zhuo, Andrea L. Hergenroeder, Stephen B. Kritchevsky, Anne L. Peters, Lynne E. Wagenknecht, Edward H. Ip, Mark A. Espeland, for the Look AHEAD Study Group Diabetes Care Mar 2018, dc172110; DOI: 10.2337/dc17-2110
Cost-effectiveness of the 2014 U.S. Preventive Services Task Force (USPSTF) Recommendations for Intensive Behavioral Counseling Interventions for Adults With Cardiovascular Risk Factors
AbstractOBJECTIVE In 2014, the U.S. Preventive Services Task Force (USPSTF) recommended behavioral counseling interventions for overweight or obese adults with the following known cardiovascular disease risk factors: impaired fasting glucose (IFG), hypertension, dyslipidemia, or metabolic syndrome.
Changes in diagnosed diabetes, obesity, and physical inactivity prevalence in US counties, 2004-2012
Recent studies suggest that prevalence of diagnosed diabetes in the United States reached a plateau or slowed around 2008, and that this change coincided with obesity plateaus and increases in physical activity. However, national estimates can obscure important variations in geographic subgroups. We examine whether a slowing or leveling off in diagnosed diabetes, obesity, and leisure time physical inactivity prevalence is also evident across the 3143 counties of the United States.
Disability-Free Life-Years Lost Among Adults Aged ≥50 Years With and Without Diabetes
Disability-Free Life-Years Lost Among Adults Aged ≥50 Years With and Without Diabetes Barbara H. Bardenheier, Ji Lin, Xiaohui Zhuo, Mohammed K. Ali, Theodore J. Thompson, Yiling J. Cheng, Edward W. Gregg Diabetes Care Jul 2016, 39 (7) 1222-1229; DOI: 10.2337/dc15-1095
Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer
Patients and Methods This phase I, nonrandomized, open-label, dose-escalation trial used a 3 + 3 dose-escalation scheme and included patients with advanced solid tumors. Intravenous LY2606368 was dose escalated from 10 to 50 mg/m 2 on schedule 1 (days 1 to 3 every 14 days) or from 40 to 130 mg/m 2 on schedule 2 (day 1 every 14 days). Safety measures and pharmacokinetics were assessed, and pharmacodynamics were measured in blood, hair follicles, and circulating tumor cells.
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