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Articles by Jing Qu
Wind-constrained Pareto multi-objective reinforcement learning for low-carbon vessel traffic organization in port approach channels
Abstract Port approach channels concentrate vessel conflicts, waiting, and speed adjustments that can increase fuel use and CO2 emissions, yet real-time wind is rarely represented as both an emission driver and a scheduling constraint. This study develops a wind-constrained vessel traffic organization framework and a Pareto-based multi-objective proximal policy optimization algorithm (Pareto MO-PPO).
Ovarian aging and systemic health: Mechanisms and emerging intervention strategies
Keywords ovarian aging ovarian-systemic axis inflammaging interventions healthspan extension Get full text access Log in, subscribe or purchase for full access. References 1. Wang, S. ∙ Ren, J. ∙ Jing, Y. ... Perspectives on biomarkers of reproductive aging for fertility and beyond Nat Aging. 2024; 4:1697-1710 2. Liu, X. ∙ Zhao, Y. ∙ Feng, Y. ... Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body Aging Dis. 2025; 17:132-158 3. Wu, J. ∙ Wu, P. ∙ Wang, S. ...
Admission FDP and D-Dimer Predict Functional Outcomes in Closed TBI: A Single-Center Retrospective Cohort Study
You are already at the latest version Coagulopathy is a frequent complication after traumatic brain injury (TBI), yet few studies directly compare fibrin degradation products (FDP) and D-dimer as independent predictors of discharge functional impairment evaluated by modified Rankin Scale (mRS) in mild-to-moderate closed TBI.
SenSpots: when B cells age in place
Get full text access Log in, subscribe or purchase for full access. References 1. Walford, R.L. The immunologic theory of aging Gerontologist. 1964; 4:195-197 2. Liu, Z. ... Immunosenescence: molecular mechanisms and diseases Signal Transduct. Target. Ther. 2023; 8:200 3. Terekhova, M. ... Human immune aging Immunity. 2025; 58:2646-2669 4. Li, J. ... Multimodal clocks of human aging Cell. 2026; 189:4489-4511.e31 5. Cruz de Casas, P. ... Same yet different – how lymph node heterogeneity affects immune responses Nat.
Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level
Get full text access Log in, subscribe or purchase for full access. References 1. Fliedner, T.M. ∙ Graessle, D. ∙ Paulsen, C. ... Structure and function of bone marrow hemopoiesis: Mechanisms of response to ionizing radiation exposure Cancer Biother. Radiopharm. 2002; 17:405-426 2. Iwasaki, H. ∙ Akashi, K. Myeloid lineage commitment from the hematopoietic stem cell Immunity. 2007; 26:726-740 3. Liggett, L.A. ∙ Sankaran, V.G. Unraveling Hematopoiesis through the Lens of Genomics Cell. 2020; 182:1384-1400 4.
Mechanisms and interventions of epigenetic aging
Keywords aging age-related diseases senescence epigenetic mechanisms interventions Introduction Aging is defined by a progressive loss of physiological integrity that erodes functional capacity, thus shortening healthspan and raising mortality risk.1 Advancing age is accompanied by an increased risk of age-related disorders, including neurodegenerative, metabolic, cardiovascular, and neoplastic diseases.2 To systematically dissect the biological aging process, Kroemer et al.
Author Correction: CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord
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Correction to: Nature https://doi.org/10.1038/s41586-023-06783-1 Published online 31 October 2023 In the version of this article initially published, data from another experimental group were inadvertently entered into the corresponding Source Data table for Extended Data Fig. 9d. The Source Data and figure are now updated in the HTML and PDF versions of the article. The corrected data do not affect the results or conclusions of the paper. About this article Sun, S., Li, J., Wang, S. et al.
By Shuhui Sun, Jiaming Li, Si Ran Wang, Jingyi Li, Jie Ren, Zhaoshi Bao, Le Chang Sun, Xibo Ma, Fangshuo Zheng, Shuai Ma, Liang Sun, Min Wang, Yan Yu, Miyang Ma, Qiaoran Wang, Zhiyuan Chen, He Ma, Xuebao Wang, Zeming Wu, Kaowen Yan, Yuanhan Yang, Yixin Zhang, Sheng Zhang, Jinghui Lei, Zhao-Qian Teng, Chang-Mei Liu, Ge Bai, Yan-Jiang Wang, Jian Li, Xiaoqun Wang, Guoguang Zhao, Tao Jiang, Jing Qu, Weiqi Zhang, Guang-Hui Liu
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Nature
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Mesenchymal drift: A convergent framework for the hallmarks of aging
Keywords aging epithelial-to-mesenchymal transition endothelial-to-mesenchymal transition rejuvenation biomarkers partial reprogramming Yamanaka factors fibrosis cellular identity and plasticity geroscience Introduction Aging biology is commonly framed through a set of canonical “hallmarks.” Since their original formulation,1 these hallmarks have expanded from nine to twelve2 and more recently to fourteen,3 reflecting both the growing complexity of aging biology and the field’s effort to...
Veterinary macrolides against Streptococcus agalactiae : antibacterial basis, resistance determinants, and PK/PD implications
Abstract Streptococcus agalactiae remains an important pathogen causing bovine mastitis, with measurable impacts on herd productivity and milk quality. Veterinary macrolides retain antibacterial activity against a substantial proportion of S. agalactiae isolates, as evidenced by in vitro susceptibility data across multiple geographic regions, although resistance determinants such as erm(B) are prevalent.
Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence
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Keywords immunosenescence immune aging clock T cell senescence RUNX1 T cell receptor inflammaging rejuvenation Get full text access Log in, subscribe or purchase for full access. References 1. Iwasaki, A. ∙ Medzhitov, R. Control of adaptive immunity by the innate immune system Nat. Immunol. 2015; 16:343-353 2. Carroll, S.L. ∙ Pasare, C. ∙ Barton, G.M. Control of adaptive immunity by pattern recognition receptors Immunity. 2024; 57:632-648 3. Bolla, A.S. ∙ Priefer, R.
By Jiale Ping, Qin Qiao, Yun Li Verified, Yanling Fan, Yutong Tian, Muzhao Xiong, Quan Zheng, Beier Jiang, Jiaming Li, Zheng Huang, Zikai Zheng, Xiaoyong Lu, Yiwen Hu, Yangqing Xu, Xiaoyan Sun, Qiaoran Wang, Si-jia Chen, Qi Wu, Lixiao Liu, Yuesheng Zuo, Shuhui Song, Si Qi Wang, Shuai Ma, Jing Qu, Yun-Gui Yang, Lan Jiang, Feng Zhang, Guang-Hui Liu, Weiqi Zhang, Dan-Dan Gao, Qinxin Tu, Liu-Jun Xu, Jin-Lin Ye, Cheng-Shui Chen
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Cell Press
Verified
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates
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ArticleVolume 38, Issue 4p673-693.e17 Affiliations & Notes 1China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China 2State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 3University of Chinese Academy of Sciences, Beijing 100049, China 4State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of...
By Lixiao Liu, Zikai Zheng, Wanbang You, Peng Yang, Yifan Wen Verified, Yicheng Qiao, Shuai Ma, Shuo Zhang, Gang Xu, Chencan Ma, Ao Tian, Mengmeng Jiang, Tongtong Zhang, Lingling Geng, Jingyi Li, Xiaoyan Sun, Feibo Wang, Muzhao Xiong, Yuanhan Yang, Xiaoyong Lu, Xiaoyu Jiang, Xueda Dong, Zhiyi Zhang, Ying Huang, Baohu Zhang, Qin Qiao, Shuhui Sun, Yanling Fan, Yusheng Cai, Kaowen Yan, Yiyuan Zhang, Ying Jing, Yaobin Jing, Qiaoran Wang, Jinghui Lei, Ansheng Tan, Zichu Han, Pradeep Reddy, Amin Haghani, Concepcion Rodriguez Esteban, Feng Zhang, Zhili Liu, Ning Liu, Si Qi Wang, Steve Horvath, Jiayin Yang, Weiqi Zhang, Jing Qu, Guang-Hui Liu
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Cell Metabolism
Verified
Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases:
JACC Journals › JACC: Asia › Archives › Vol. 6 No. 2 State-of-the-Art Review : JACC: Asia Volume 6, Number 2 The heart and vasculature collectively constitute the human cardiovascular system, functioning primarily to deliver oxygen and nutrients throughout the body.
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging
Keywords vascular aging Hutchinson-Gilford progeria syndrome blood vessel aging senescence organoid endothelial cell SRF premature aging angiogenesis Get full text access Log in, subscribe or purchase for full access. References 1. Augustin, H.G. ∙ Koh, G.Y. Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology Science. 2017; 357, eaal2379 2. Oostendorp, M. ∙ Post, M.J. ∙ Backes, W.H. Vessel growth and function: depiction with contrast-enhanced MR imaging Radiology.
WRKY27‐RAP2.7 Regulatory Module Promotes Cold Tolerance via Modulation of Lignin Biosynthesis and Redox Homeostasis by Regulating Cinnamyl Alcohol Dehydrogenase 7 and Glutathione S‐Transferase F6
1 Introduction Citrus is one of the most economically important fruit crops, serving as a key nutritional source while contributing significantly to global agriculture. However, as a fruit tree of tropical origin, most commercial citrus cultivars are vulnerable to cold stress, which has been frequently reported to cause immense restrictions on plant growth and development, fruit yield, and quality of citrus (Dahro et al. 2023; Ding et al. 2024).
Relative Humidity Modulates Photochemical Aging of Light-Absorbing Carbonaceous Aerosols: Insights from Ambient Oxidation Flow Reactor
Occurrence, Fate, and Transport of Contaminants in Indoor Air and AtmosphereNovember 4, 2025 Jing Duan State Key Laboratory of Loess Science, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710061, China * Ru-Jin Huang State Key Laboratory of Loess Science, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710061, China Institute of Global Environmental Change, Xi’an Jiaotong University, Xi’an 710049, China University of Chinese Academy of Sciences, Beijing...
Vitamin C conveys geroprotection on primate ovaries
Keywords ovary aging vitamin C antioxidant oxidative stress senescence inflammation aging clock primate NRF2 Introduction Ovaries are among the earliest aging organs in women, typically beginning their decline in the third decade of life, profoundly impacting fertility.1,2,3,4,5,6 This degenerative process is marked by the depletion of ovarian follicle reserves and a decline in oocyte quality, which compromises ovarian regenerative potential and reproductive capacity maintenance.1,2,7,8,9,10...
Biomarkers of ageing of humans and non-human primates
Abstract Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice.
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
1China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China 2State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 3Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China 4Liver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu 610000, China 5Laboratory of Liver...
A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung - Nature Microbiology
Abstract Patients with a history of Mycobacterium tuberculosis infection often suffer from irreversible and progressive pulmonary damage, yet the underlying mechanisms are not fully understood. Here we conducted single-cell transcriptomic analysis of human lung tissues including 19 post-tuberculosis lung tissues and 13 matched normal lung samples as controls, focusing on areas within and surrounding tuberculosis lesions.
Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging - Nature Aging
Abstract Cochlear aging causes substantial hearing impairment in older adults, yet primate-specific mechanisms remain poorly characterized. Our comprehensive analysis combining single-cell and histopathological profiling in aging Macaca fascicularis demonstrates progressive cochlear degeneration featuring accelerated sensory hair cell loss, senescent spiral ganglion neurons with elevated neuroinflammation, and marked stria vascularis atrophy.
Senescence-resistant human mesenchymal progenitor cells counter aging in primates
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Keywords aging senescence biomarker stem cell intervention rejuvenation gene editing FOXO3 brain reproductive system Introduction Aging, an unavoidable trajectory, precipitates tissue and physiological deterioration, leading to conditions such as neurodegenerative diseases, reduced fertility, and cardiovascular problems.1,2,3,4,5,6,7,8,9,10,11 Emerging research implicates the decline of stem cell populations and a diminishing regenerative potential as pivotal to the aging...
By Jinghui Lei, Zijuan Xin, Ning Liu, Taixin Ning, Ying Jing, Zan He, Mengmeng Jiang, Yuanhan Yang, Zhiyi Zhang, Liyun Zhao, Jingyi Li, Yupeng Yan, Lingling Xiao, Baohu Zhang, Haoyan Huang, Shuhui Sun, Fangshuo Zheng, Xiaoyu Jiang, Huifen Lu, Feifei Liu, Yanxia Ye, Kaowen Yan, Qinchao Hu, Gang Xu, Qian Zhao, Ruochen Wu, Yusheng Cai, Yanling Fan, Yaobin Jing, Qiaoran Wang, Pradeep Reddy, Xiaoyong Lu, Zikai Zheng, Beibei Liu, Amin Haghani, Shuai Ma, Keiichiro Suzuki, Concepcion Rodriguez Esteban, Jiayin Yang, Moshi Song, Steve Horvath, Weiqi Zhang, Wei Li, Andy Xiang, Lan Zhu, Xiaobing Fu, Guoguang Zhao, Jing Qu, Si Qi Wang, Guang-Hui Liu, Yicheng Qiao, Dongliang Lv, Xueda Dong, Shasha Yue, Chencan Ma, Jichen Shuai, Zhejun Ji
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Cell Press
Verified
SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1 - Nature Metabolism
Abstract Ageing-induced skeletal muscle deterioration contributes to sarcopenia and frailty, adversely impacting the quality of life in the elderly. However, the molecular mechanisms behind primate skeletal muscle ageing remain largely unexplored. Here, we show that SIRT5 expression is reduced in aged primate skeletal muscles from both genders. SIRT5 deficiency in human myotubes hastens cellular senescence and intensifies inflammation.
Author Correction: A single-cell transcriptomic landscape of primate arterial aging - Nature Communications
Correction to: Nature Communications https://doi.org/10.1038/s41467-020-15997-0, published online 5 May 2020 In the version of the article initially published, the “Phospho-H3 (Ser 10), EV” image in Supplementary Fig. 10g was switched with the “Phospho-H3 (Ser 10), si-NC” image in Supplementary Fig. 10k. This error, which does not impact the results or conclusions of the article, has been corrected and the amended Supplementary information can now be found online.
Author Correction: SGF29 nuclear condensates reinforce cellular aging - Cell Discovery
Correction to: Cell Discovery https://doi.org/10.1038/s41421-023-00602-7, published online 07 November 2023 In this article, we identified an oversight in Fig. 5g1, where the red and green channel images were inadvertently reversed. Also, Supplementary Fig. S7d contained an oversight with the selection of an atypical nucleus for EGFP-SGF29-WT group.
Orthographic and phonological processing in the left ventral occipitotemporal cortex during Chinese word reading
CONFLICT OF INTEREST STATEMENT All authors declare that they have no conflict of interest. Supporting Information Filename Description psyp14703-sup-0001-Supinfo.docxWord 2007 document , 968.5 KB Data S1. REFERENCES , , & (2003). General multilevel linear modeling for group analysis in FMRI. NeuroImage, 20(2), 1052–1063. https://doi.org/10.1016/S1053-8119(03)00435-X , , , , , , & (2014). Anatomical connections of the visual word form area. The Journal of Neuroscience, 34(46), 15402–15414.
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases - Nature Reviews Molecular Cell Biology
Abstract Ageing is a complex biological process in which a gradual decline in physiological fitness increases susceptibility to diseases such as neurodegenerative disorders and cancer. Cellular senescence, a state of irreversible cell-growth arrest accompanied by functional deterioration, has emerged as a pivotal driver of ageing.
A Comparative Evaluation of Three Diagnostic Assays for the Detection of Human Monkeypox
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Publisher Correction: SGF29 nuclear condensates reinforce cellular aging - Cell Discovery
Correction to: Cell Discovery (2023) 9:110 During the production, we misupdated Supplementary Fig. S8 in the article1. The original Supplementary Figures have been corrected. We apologize for any inconvenience that it may have caused.
Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland - Nature Aging
Abstract Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses and immune activation, experience age-related decline, impacting systemic health. However, the regulatory mechanisms underlying adrenal aging remain largely uninvestigated. Here we established a single-nucleus transcriptomic atlas of both young and aged primate suprarenal glands, identifying lipid metabolism and steroidogenic pathways as core processes impacted by aging.
Experimental Study on the Wind Erosion Resistance of Aeolian Sand Solidified by Microbially Induced Calcite Precipitation (MICP)
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Endogenous Production and Vibrational Analysis of Heavy‐Isotope‐Labeled Peptides from Cyanobacteria
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Emerging epigenetic insights into aging mechanisms and interventions
Highlights Epigenetics, a mechanism beyond genetics in regulating gene expression, has been updated for its role in indexing and targeting aging and related disorders. DNA methylation-based epigenetic clocks or marker genes are emerging as valuable tools for assessing the progression of aging in cells, tissues, and organisms, as well as for understanding disease development.
Statistical Insight into China’s Indigenous Diagnosis-Related-Group System Evolution
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Stress, epigenetics, and aging: Unraveling the intricate crosstalk
Tian Y.E. Cropley V. Maier A.B. Lautenschlager N.T. Breakspear M. Zalesky A. Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality. Nat. Med. 2023; 29: 1221-1231https://doi.org/10.1038/s41591-023-02296-6 Kennedy B.K. Berger S.L. Brunet A. Campisi J. Cuervo A.M. Epel E.S. Franceschi C. Lithgow G.J. Morimoto R.I. Pessin J.E. et al. Geroscience: linking aging to chronic disease. Cell. 2014; 159: 709-713https://doi.org/10.1016/j.cell.2014.10.039 Sun Y. Li Q.
SGF29 nuclear condensates reinforce cellular aging - Cell Discovery
Abstract Phase separation, a biophysical segregation of subcellular milieus referred as condensates, is known to regulate transcription, but its impacts on physiological processes are less clear. Here, we demonstrate the formation of liquid-like nuclear condensates by SGF29, a component of the SAGA transcriptional coactivator complex, during cellular senescence in human mesenchymal progenitor cells (hMPCs) and fibroblasts.
CHIT1-positive microglia drive motor neuron aging in the primate spinal cord - Nature
Abstract Aging is a critical factor in spinal cord-associated disorders1, yet aging-specific mechanisms underlying this relationship remain poorly understood. To address this knowledge gap, we combined single-nucleus RNA sequencing with behavioral and neurophysiological analysis in non-human primates (NHPs). We identified motor neuron senescence and neuroinflammation with microglial hyperactivation as intertwined hallmarks of spinal cord aging.
SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B - Nature Aging
Abstract Aging is a major risk factor contributing to pathophysiological changes in the heart, yet its intrinsic mechanisms have been largely unexplored in primates. In this study, we investigated the hypertrophic and senescence phenotypes in the hearts of aged cynomolgus monkeys as well as the transcriptomic and proteomic landscapes of young and aged primate hearts.
Decision‐making of powerful CEOs on green innovation: The roles of performance feedback and institutional investors
This study assesses the effects of CEO power on green innovation and, more importantly, explores how different performance feedback affects this relationship by considering the positive and negative aspects of financial and environmental performance feedback. We further discuss how institutional investors respond to the decision-making of powerful CEOs on green innovation.
The Aging Biomarker Consortium represents a new era for aging research in China - Nature Medicine
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‘Aging biomarkers’ refers to scientifically measurable parameters of the aging process; these are age-related changes at cellular, organ and organismal levels that can be applied to predict the transition into a pathological state1. Biomarkers can be classified into six categories: physiological characteristics; imaging traits; histological features; cellular alterations; molecular changes; and secretory factors.
By Moshi Song, Weiqi Zhang, Guobing Chen, Weimin Ci, Qiurong Ding, Feng Gao, Shaorong Gao, Jing-Dong J. Han, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jingyi Li, Baohua Liu, Feng Liu, Jun-Ping Liu, Qiang Liu, Xingguo Liu, Yong Liu, Zhiyong Mao, Jing Qu, Zhou Songyang, Liang Sun, Shusen Wang, Xia Wang, Andy Xiang, Yichuan Xiao, Zhi-Xiong Xiao, Wei Xiong, Daichao Xu, Wei Yu, Rui Yue, Hongbo Zhang, Liang Zhang, Yong Zhang, Yun-wu Zhang, Tongbiao Zhao, Yuzheng Zhao, Zhongjun Zhou, DaHai Zhu, Weiguo Zou, Wengong Wang, Zhuohua Zhang
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Nature
Verified
[Effects of adipokine chemerin on the improvement of islet function in diabetic mice by aerobic exercise and its mechanisms]
Display options Abstract in English, Chinese Objective: To investigate the effects of adipokines chemerin on the improvement of islet function caused by exercise in mice with diabetes, and the possible mechanism of glucagon-like peptide 1 (GLP-1). Methods: Male ICR mice were randomly divided into a control group fed with normal diet (Con, n=6) and a diabetic modeling group fed with 60% kcal high-fat diet (n=44).
Structure and Dynamics of DNA and RNA Double Helices Formed by d(CTG), d(GTC), r(CUG), and r(GUC) Trinucleotide Repeats and Associated DNA-RNA Hybrids | The Journal of Physical Chemistry B
Myotonic dystrophy type 1 is the most frequent form of muscular dystrophy in adults caused by an abnormal expansion of the CTG trinucleotide. Both the expanded DNA and the expanded CUG RNA transcript can fold into hairpins. Co-transcriptional formation of stable RNA·DNA hybrids can also enhance the instability of repeat tracts.
Repurposing CRISPR/Cas to Discover SARS‐CoV‐2 Detecting and Neutralizing Aptamers
CRISmers Screening Lentiviral-CRISmers Random Library Construction: Human codon optimized nucleotide sequences encoding the RBD of Spike protein (S1, RBD amino acids 319 to 541, GISAID accession ID: EPI_ISL_414 631) were synthesized by GenScipt. The RBD was first inserted into the library shuttle vector phU6-gLuc sgRNA-scaffold-1.2 BsmBI- scaffold-polyT-EF1a-NLS-linker-EcoRI-linker-VPH at the EcoRI restriction sites.
Facile access to 2-hydroxy-3-indolinones via copper-catalyzed oxidative cyclization of 2-arylethynylanilines
Facile access to 2-hydroxy-3-indolinones via copper-catalyzed oxidative cyclization of 2-arylethynylanilines Jiaqiang Wu, Weiqiang Sun, Xueli Cui, Jing Qu, Xiaojia Cai, Jinhui Hu, Zhuang Xiong, Suqin Guo, Jun Xu and Wen-Hua Chen Abstract This paper reports a practical and versatile oxidative cyclization of 2-arylethynylanilines towards 2-hydroxy-2-substituted indol-3-ones via a copper-catalyzed radical approach in the presence of O2.
The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials
Introduction Nutritional support is important for critically ill patients in intensive care unit (ICU), adequate nutritional therapy can improve clinical outcomes associated with malnutrition (1, 2). The methods of nutritional support have been widely described, including enteral nutrition (EN) and parenteral nutrition (PN) (3). EN is safer and more cost-effective than PN, and EN has the potential advantage of maintaining gastrointestinal tract integrity to prevent bacterial translocation (4, 5).
Influence of Polycaprolactone Concentration and Solvent Type on the Dimensions and Morphology of Electrosprayed Particles
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Laura Alberto 1, Lohitha Kalluri 1, Jing Qu 2, Yongfeng Zhao 2 and Yuanyuan Duan 1,* 1 Department of Biomedical Materials Science, University of Mississippi Medical Center, Jackson, MS 39216, USA 2 Department of Chemistry, Physics and Atmospheric Sciences, Jackson State University, Jackson, MS 39216, USA * Author to whom correspondence should be addressed.
Rh(III)-catalyzed redox-neutral C-H alkenylation of benzamides with gem-difluorohomoallylic silyl ethers via β-H elimination
Rh(III)-catalyzed redox-neutral C-H alkenylation of benzamides with gem-difluorohomoallylic silyl ethers via β-H elimination Jiaqiang Wu, Xueli Cui, Jing Qu, Jiangfeng Yi, Weiqiang Sun, Jinhui Hu, Suqin Guo, Jingwei Jin, Wen-Hua Chen and Wing-Leung Wong Abstract Fluorinated molecules are widely used in pharmaceutical and agrochemical industries.
The Relative Distance Prediction of Transmembrane Protein Surface Residue Based on Improved Residual Networks
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Author Correction: Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing - Nature Communications
Correction to: Nature Communications https://doi.org/10.1038/s41467-022-31220-8, published online 25 June 2022. The original version of this Article contains an error in the order of authorship of Mo Li and Juan Carlos Izpisua Belmonte. This has been corrected in both the HTML and PDF versions of the Article. Author information Author notes These authors contributed equally: Baolei Yuan, Xuan Zhou.
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing - Nature Communications
Abstract The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome (WAS), remain poorly defined. We generated three isogenic WAS models using patient induced pluripotent stem cells and genome editing. These models recapitulated WAS phenotypes and revealed that WASP deficiency causes an upregulation of numerous RNA splicing factors and widespread altered splicing. Loss of WASP binding to splicing factor gene promoters frequently leads to aberrant epigenetic activation.
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