Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Jonathan Casey
Effect of Vasopressin Initiation Threshold on Septic Shock Mortality : The VASSPR Cluster Crossover Randomized Strategy Trial
Effect of Vasopressin Initiation Threshold on Septic Shock Mortality: The VASSPR Cluster Crossover Randomized Strategy Trial Supplement 1. Supplement 2. Statistical analysis plan Supplement 3. eTable 3. Sensitivity analyses and cohorts eTable 4. Patient comorbidities based on historic diagnosis codes eTable 5. Enrollment and experimental separation by trial site eTable 6. Demographics and patient characteristics for all eligible encounters eTable 7.
Introduction to Fault-Managed Power
Editor’s Note: The paper on which this article is based was originally presented at the 2025 IEEE Product International Symposium on Product Compliance Engineering (ISPCE), held in San Francisco, CA in May 2025, where it received the 2025 Best Paper Award. It is reprinted here with the gracious permission of the IEEE. Copyright 2026, IEEE.
Airway management of adults in the acute care setting
Box 2 Prepare patient Preoxygenate—for at least 3-5 min with a fraction of inspired oxygen of 100% using NIPPV. If contraindicated, use high flow nasal cannula or a facemask with nasal cannula at the maximum available flow rate Resuscitate—for patients at risk of hypotension during intubation, consider administering a vasopressor before induction.
Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults
Notes The views and statements presented in this article are solely the responsibility of the authors and do not necessarily represent the views of the Patient-Centered Outcomes Research Institute or the National Institutes of Health. This article was published on December 9, 2025, at NEJM.org. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org.
Preoxygenation with noninvasive ventilation reduces hypoxemia during intubation
You've successfully added to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Key takeaways: Across several subgroups, preoxygenation with noninvasive ventilation lowered hypoxemia more than an oxygen mask during intubation. Fewer patients receiving noninvasive ventilation experienced cardiac arrest.
Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults
Key Points Question Among critically ill adults, do the effects of peripheral oxygen-saturation (Spo2) targets on outcomes differ based on an individual’s characteristics? Findings A machine learning model derived in one randomized trial and validated in another found that the predicted effect of lower vs higher Spo2 targets ranged from a 27% absolute reduction to a 34% absolute increase in 28-day mortality and differed significantly based on an individual’s characteristics.
Cefepime vs Piperacillin-Tazobactam for Acute Infection in Hospitalized Adults-Reply
Cefepime vs Piperacillin-Tazobactam for Acute Infection in Hospitalized Adults—Reply Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection Edward T. Qian, MD, MSc; Jonathan D. Casey, MD, MSc; Adam Wright, PhD; Li Wang, MS; Matthew S. Shotwell, PhD; Justin K. Siemann, PhD; Mary Lynn Dear, PhD; Joanna L. Stollings, PharmD; Brad D. Lloyd, RRT-ACCS; Tanya K. Marvi, MD; Kevin P. Seitz, MD, MSc; George E. Nelson, MD; Patty W. Wright, MD; Edward D. Siew, MD, MSc; Bradley M.
Legal Issues In Parenting
What if two parents cannot agree on their holiday arrangements? Many parents can strike a balance in terms of agreeing where, when and with whom a child will spend their holidays. However, sometimes separated parents seek assistance from lawyers and the family court to address holiday disputes.
Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection
Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial Key Points Question Does the choice between cefepime and piperacillin-tazobactam affect the risks of acute kidney injury or neurological dysfunction in adults hospitalized with acute infection?
Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection
Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial Key Points Question Does the choice between cefepime and piperacillin-tazobactam affect the risks of acute kidney injury or neurological dysfunction in adults hospitalized with acute infection?
Maintaining Your Lifestyle After Divorce
The end of a marriage can cause anxiety for everyone involved. A common concern is about maintaining a certain lifestyle that may have been enjoyed during the marriage. The recent celebrity divorce of Kevin Costner and Christine Baumgartner — the subject of numerous news reports — highlights some of what a court may need to consider when assessing needs.
Maintaining your lifestyle after divorce
The end of a marriage can cause anxiety for everyone involved. A common concern is about maintaining a certain lifestyle that may have been enjoyed during the marriage. The recent celebrity divorce of Kevin Costner and Christine Baumgartner - the subject of numerous news reports - highlights some of what a court may need to consider when assessing needs.
Legal issues in parenting
With summer vacation fast approaching, dividing children's holidays between separated parents can often be difficult. Open lines of communication and planning between the parents is essential. What if two parents cannot agree on their holiday arrangements? Many parents can strike a balance in terms of agreeing where, when and with whom a child will spend their holidays. However, sometimes separated parents seek assistance from lawyers and the family court to address holiday disputes.
Association Between Endotracheal Tube Size and Outcomes in Critically Ill Patients-Reply
Association Between Endotracheal Tube Size and Outcomes in Critically Ill Patients—Reply In Reply We thank Schober et al for their expert review of our recent study.3 Viewing recovery from critical illness via the lens of long-term functional outcomes is difficult, particularly for clinicians (or specialists) focused on patients’ short-term survival. Given the increasingly complex nature of modern medicine, we believe improved care arises at the intersection of collaborating specialties.
Association of Educational Intervention With Knowledge of Airway Injury After Endotracheal Intubation and Tube Size Selection
Association of Educational Intervention With Knowledge of Airway Injury After Endotracheal Intubation and Tube Size Selection Intubation is a common, lifesaving procedure for critically ill patients.
Protocol and statistical analysis plan for the Antibiotic Choice On ReNal outcomes (ACORN) randomised clinical trial
Methods and analysis This manuscript was written in accordance with Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines (table 1, online supplemental file 1).28 The Learning Healthcare System (LHS) Platform at Vanderbilt University Medical Center conducts research studies using a unique model that leverages pragmatic, randomised, controlled clinical trials embedded within usual care.29 The LHS Platform is composed of stakeholders from across the enterprise...
Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation-Reply
[Skip to Navigation] November 22/29, 2022 JAMA. 2022;328(20):2071-2072. doi:10.1001/jama.2022.17508 Full Text In Reply In their respective letters, Dr Tejpal and colleagues, Dr van der Ven and colleagues, and Dr Pal and colleagues ask several important questions related to the PREPARE II trial,1 which found that administration of a 500-mL fluid bolus did not reduce the incidence of cardiovascular collapse among 1065 critically ill adults undergoing tracheal intubation. Full Text
The approach to informed consent in acute care research - Authors' reply
TableApproach to consent and enrolment in the RECOVERY trial in the UK and in explanatory trials in the USA ORCHID=Outcomes Related to COVID-19 Treated with Hydroxychloroquine Among Inpatients with Symptomatic Disease. RECOVERY=Randomised Evaluation of COVID-19 Therapy.
Cognitive Outcomes in the Pragmatic Investigation of optimaL Oxygen Targets (CO-PILOT) trial: protocol and statistical analysis plan
Outcomes The primary outcome for the CO-PILOT ancillary study is the telephone version of the Montreal Cognitive Assessment (T-MoCA), which is identical in form to the MoCA-Blind.28–33 The T-MoCA consists of a wide array of questions that sample a variety of cognitive domains (attention, language, abstraction, delayed memory and orientation) without containing the questions requiring visual assessment or pen and paper that are present in the original MoCA.
Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation
This article is available to subscribers. Subscribe now. Already have an account? Sign in Original ArticleFree Preview List of authors. Matthew W. Semler, M.D., Jonathan D. Casey, M.D., Bradley D. Lloyd, R.R.T.-A.C.C.S., Pamela G. Hastings, R.R.T.-A.C.C.S., Margaret A. Hays, R.N., Joanna L. Stollings, Pharm.D., Kevin G. Buell, M.B., B.S., John H. Brems, M.D., Edward T. Qian, M.D., Kevin P. Seitz, M.D., Li Wang, M.S., Christopher J. Lindsell, Ph.D., Robert E. Freundlich, M.D., Jonathan P. Wanderer, M.D., Jin H.
CABI’s 100 years in identifying and combating emerging fungal diseases in response to climate change
David Smith A * , Jonathan Casey B , Matthew J. Ryan A , Lisa Offord A , Alexis Rendell-Dunn B and Rob Reeder A + Author Affiliations - Author Affiliations A CAB International, Bakeham Lane, Egham, Surrey TW20 9TY, UK. B CAB International, Noseworthy Road, Wallingford, Oxfordshire OX10 8DE, UK. David Smith is Director Biological Resources at CAB International. His research interests are in the conservation and sustainable use of microorganisms in agriculture and the environment.
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19
Summary Unique challenges arise when conducting trials to evaluate therapies already in common clinical use, including difficulty enrolling patients owing to widespread open-label use of trial therapies and the need for large sample sizes to detect small but clinically meaningful treatment effects.
Use of a Bougie vs Endotracheal Tube With Stylet and Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation-Reply | JAMA | JAMA Network
April 19, 2022 JAMA. 2022;327(15):1503-1504. doi:10.1001/jama.2022.2716 Original Investigation Bougie vs Stylet During Tracheal Intubation Brian E. Driver, MD; Matthew W. Semler, MD; Wesley H. Self, MD; Adit A. Ginde, MD; Stacy A. Trent, MD; Sheetal Gandotra, MD; Lane M. Smith, MD, PhD; David B. Page, MD; Derek J. Vonderhaar, MD; Jason R. West, MD; Aaron M. Joffe, DO; Steven H. Mitchell, MD; Kevin C. Doerschug, MD; Christopher G. Hughes, MD; Kevin High, RN; Janna S. Landsperger, PA-C; Karen E.
Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19
Key Points Question Does treatment with hydroxychloroquine improve clinical outcomes of adults hospitalized with coronavirus disease 2019 (COVID-19)?
Effect of Early Balanced Crystalloids before ICU Admission on Sepsis Outcomes
This paper is only available as a PDF. To read, Please Download here. ABSTRACT Background Recent studies suggest using balanced crystalloids (lactated Ringer’s solution or Plasma-Lyte A) rather than saline (0.9% sodium chloride) may improve outcomes for patients with sepsis in the emergency department (ED) and intensive care unit (ICU). Research Question What is the relative impact on sepsis outcomes of fluid composition during early resuscitation in the ED versus after ICU admission?
Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial
Summary Background Tracheal intubation is common in the care of critically ill adults and is frequently complicated by hypotension, cardiac arrest, or death. We aimed to evaluate administration of an intravenous fluid bolus to prevent cardiovascular collapse during intubation of critically ill adults. Methods We did a pragmatic, multicentre, unblinded, randomised trial in nine sites (eight ICUs and one emergency department) around the USA.
Ventilation before intubation: how to prevent hypoxaemia?
How can we prevent the millions of critically ill adults who undergo tracheal intubation each year from developing life-threatening hypoxaemia? An answer to that question has begun to emerge from a series of critical care clinical trials comparing various approaches to oxygenation and ventilation during different phases of the intubation procedure.
Manual ventilation to prevent hypoxaemia during endotracheal intubation of critically ill adults: protocol and statistical analysis plan for a multicentre randomised trial
Despite being one of the largest randomised trials to examine endotracheal intubation of critically ill patients, statistical power will be inadequate to detect differences between study groups in uncommon outcomes (eg, operator-reported aspiration). This ongoing pragmatic trial will provide the first comparison of clinical outcomes with prophylactic ventilation versus no prophylactic ventilation during endotracheal intubation of critically ill adults.
LensBaby Velvet 85mm Review
This is my first time using a Lensbaby product and honestly just off first impressions I am blown away by the incredible build quality. It features a good amount of heft to it at 18.7oz. Which is far from the heaviest 85mm out there, but still provides excellent usability. The construction is solid metal down to the lens cap and has held up nicely despite being tossed around in my camera bag or bumped when carrying my 5D IV. Honestly, the only gripe I have about the build is the mount portion.
How To Turn Your Audio Technica M50X’s Into Wireless Headphones
One problem with bluetooth heads is that most of the time their is a decrease in audio quality. East Brooklyn Labs thought of this and integrated a built in amplifier into the adapter which boost the audio signal and improves sound quality. Honestly, it sounds really good especially when considering this is an adapter. The range I found to be good as well. Without any obstructions you can definitely be a good distance away from your paired device.
Dissecting a Case of Abdominal Pain
A 43-year-old man with no notable medical history presented to the emergency department within 1 hour after the abrupt onset of abdominal pain. The patient stated that he had been dressing for work when severe, “crampy” abdominal pain occurred in the left upper quadrant. On a scale of 0 to 10, with 0 indicating no pain and 10 the worst imaginable pain, the patient rated the pain at 10. . . . Play as a guest. Please note that your work will not be saved.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Jonathan
Contact Jonathan, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack