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Articles by Kan Wang
Effects of intensive blood pressure control on cardio-kidney outcomes by KDIGO risk categories: a Post Hoc analysis of ACCORD-BP and SPRINT trials
Abstract The effects of intensive systolic blood pressure (SBP) control on cardiovascular (CV) and kidney outcomes across different Kidney Disease Improving Global Outcomes (KDIGO) risk categories remain unclear. We performed a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) and the SPRINT-eligible Action to Control Cardiovascular Risk in Diabetes Blood Pressure (ACCORD-BP) trial. Participants were categorized into low, moderate, and high/very-high KDIGO risk groups.
Single-cell transcriptomic profile unveils distinct immune ecosystems in alcohol- and nonalcohol-associated hepatocellular carcinoma
Abstract Alcohol-associated hepatocellular carcinoma (A-HCC) shows more aggressive progression and has a poorer prognosis than nonalcohol-associated HCC (NA-HCC), but the underlying tumor microenvironment (TME) heterogeneity remains poorly characterized. Here, we performed single-cell RNA sequencing (scRNA-seq) on tumor and adjacent normal tissues from two A-HCC patients, constructing the first single-cell transcriptomic profile of human A-HCC.
Inventory Replenishment and Transshipment for Distributed Autologous Cell Therapy Manufacturing Networks
1 Introduction Autologous cell therapy (AuCT) has emerged as a promising treatment platform for several severe diseases and has attracted growing attention as cell and gene therapy (CGT) programs move from clinical development toward commercialization (Rosenberg and Restifo 2015; June et al. 2018).
Combined Double-Filtration Plasmapheresis and Corticosteroids are Associated with Improved Outcomes in Acute Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: An Ambispective Multicenter Cohort Study
Back to Journals » Drug Design, Development and Therapy » Volume 20 Authors Xue C, Wang K , Zhang L, Peng J, Xie C, Zhu D , Hao K, Li X , Li Q, Hao Y, Guan Y Received 1 July 2026 Accepted for publication 12 September 2026 Published 24 September 2026 Volume 2026:20 637003 DOI https://doi.org/10.2147/DDDT.S637003 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Tuo Deng Chunran Xue,1,* Kan Wang,1,* Lu...
Towards intelligent supply networks: AI‑enabled simulation in the evolution of digital twins for autologous cell therapy manufacturing
What you will learn 01 Why AuCT supply chains are uniquely complex – and why conventional simulation approaches cannot scale to meet this challenge 02 How an agentic orchestration layer structures simulation-based experimentation as a coordinated, hypothesis-driven reasoning process 03 How this framework supports resilience prioritisation, reproducibility, and transparency – and what it means for decentralised AuCT manufacturing The four cooperative agents 1 Monitor Agent – detects...
YK-4–250 mitigates gastrointestinal radiation syndrome and promotes overall survival following partial body radiation injury
Abstract Acute gastrointestinal radiation syndrome (GI-ARS) is a significant health threat following high-dose ionizing radiation (IR) exposure, leading to severe morbidity and mortality. The syndrome is characterized by gastrointestinal tissue damage caused by angiotensin II (Ang II) and reactive oxygen species (ROS), resulting in impaired GI function, systemic bacteremia, multi-organ failure, and eventual death.
Human umbilical cord mesenchymal stromal cells therapy for neuromyelitis optica spectrum disorder: a phase 1/2a trial
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Abstract Current treatments for neuromyelitis optica spectrum disorder (NMOSD) highlight recurrence management, while little attention is paid to the relief of residual neurological dysfunction. Here we aimed to evaluate the safety and efficacy of human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) in reducing relapses and mitigating neurological impairments.
By Xiao-Ying Yao, Zhong-jiao Lu, Nan Zhao, Li Xie, Yi-Shu Wang, Ying Zhang, Yan Lin, Ye Deng, Xi-Ying Wang, Yi Chen, He Zhu, Lin-Feng Li, Hui-Ming Xu, Jie Ding, Yi-Fan Wu, Ze Wang, Ya-Ying Song, Kan Wang, Yan Zhou, Quan Guo, Bi-yun Qian, Yang-Tai Guan, Chun-Ran Xue, Xu-Zhong Pei, Meng-Ze Zhang, Wen-Bin Wan, Hui-Ying Qiu, Yu-Yan Jin, Li-Ping Ni, Jia-Li Yan, Jia-Hui Xue, Yu-Fang Mei, Hao-Jun Yu
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Nature
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Double-Filtration Plasmapheresis Versus Efgartigimod for Generalized Myasthenia Gravis: Severity-Stratified Benefits in a Prospective Observational Multicenter Study
1 Introduction Myasthenia gravis (MG) is an autoimmune disorder mediated by pathogenic antibodies targeting the neuromuscular junction (NMJ). Central to its pathology is the impairment of synaptic transmission by IgG autoantibodies, such as those against the acetylcholine receptor (AChR), leading to recurrent episodes of fluctuating muscle weakness [1]. Globally, MG has a prevalence of approximately 150–250 cases per million people [2, 3].
Blood Pressure Levels and Outcomes in Type 2 Diabetes: Dose-Response Meta-Analysis of 5.87 Million Cohort Participants
Get full access to this article View all available purchase options and get full access to this article. Supplementary Material Supplemental Material (mmc1.pdf) References 1. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398:957-980. 2. McEvoy J.W., McCarthy C.P., Bruno R.M., et al.
Intraventricular hemorrhage, suspected EBV reactivation, and TBA-positive epilepsy after deep cervical lymphovenous anastomosis in Alzheimer’s disease: a case report
Abstract Lymphovenous anastomosis (LVA) is emerging as a potential surgical intervention to ameliorate cervical lymphatic outflow and enhance glymphatic clearance in Alzheimer’s disease (AD). However, the spectrum of neurological sequelae associated with this procedure remains poorly characterized. We report the case of a 67-years-old male with amyloid PET–confirmed AD who underwent bilateral deep cervical LVA.
Magnetic field-assisted ECDM of SiCp/Al composites: process optimization and validation
ABSTRACT Silicon carbide-reinforced aluminum matrix composites (SiCp/Al) are widely applied in aerospace and electronics for their excellent mechanical performance. However, conventional electrical discharge machining (EDM) of SiCp/Al suffers from severe electrode wear, poor surface integrity, and recast layer formation.
Optimisation of Agrobacterium‐Mediated Seedling Leaf Transformation Across Multiple Sorghum Genotypes
To Editor, Genetic transformation in sorghum faces major challenges, including limited explant availability, phenolic compound accumulation, and strong genotype dependence. Morphogenic transcription factors (MTFs), such as Baby boom (Bbm) and Wushel2 (Wus2), markedly improve transformation efficiency using seedling leaf whorls. The Cre/loxP system subsequently removes MTF genes after somatic embryogenesis, enabling fertile plant regeneration (Wang et al. 2023).
IMAGE: INTEGRATE-Mediated Agrobacterium Genome Engineering
1 Introduction Agrobacterium tumefaciens is a fundamental tool in plant biotechnology, widely utilized for genetic transformation thanks to its natural ability to transfer DNA (T-DNA) into plant genomes. This soil-borne, gram-negative bacterium exists as a free-living organism but can adopt a pathogenic lifestyle upon acquiring a tumor-inducing (Ti) plasmid (Goodner et al., 2001; Wood et al., 2001; Gelvin, 2003).
Relationship between sleep disorders and the efficacy of immune checkpoint inhibitors in older patients with non-small cell lung cancer
Department of Thoracic Surgery, The First People’s Hospital of Shangqiu, Shangqiu, Henan, China Background: Immune checkpoint inhibitors (ICIs) represent a critical treatment modality for older adults with advanced non-small cell lung cancer (NSCLC). The objective of this study was to investigate the potential relationship between sleep disorders, a condition commonly observed in this older population, and the efficacy of ICIs in treating advanced NSCLC.
Hypoglycemic Agents
Back to Journals » Journal of Inflammation Research » Volume 18 Review Respiratory Inflammation Authors Yang Y , Wang K, Chen S Received 28 July 2025 Accepted for publication 16 December 2025 Published 24 December 2025 Volume 2025:18 Pages 18053—18078 DOI https://doi.org/10.2147/JIR.S556790 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Tara Strutt Yu Yang,1 Kan Wang,2 Shuchun Chen3– 5 1Department of Pharmacy, The...
Causal Effects of Type 2 Diabetes and Glycemic Traits on Dementia and Stroke: A Mendelian Randomization Study including Imaging Endpoints
The authors have declared no competing interest. S.H. is supported by a scholarship from the China Scholarship Council (CSC) under Grant No. 202208330062. by the China Scholarship Council Program (No. 202208330062). The study funder was not involved in the study design, the collection, analysis, and interpretation of data, or writing of the report, and did not impose any restrictions regarding the publication of the report.
A Critical Review of Life Cycle Assessments on Bioenergy Technologies: Methodological Choices, Limitations, and Suggestions for Future Studies
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Influences of Discontinuous Attitudes on GNSS/LEO Integrated Precise Orbit Determination Based on Sparse or Regional Networks
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A Combination of Classification Robust Adaptive Kalman Filter with PPP-RTK to Improve Fault Detection for Integrity Monitoring of Autonomous Vehicles
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Unlocking regeneration potential: harnessing morphogenic regulators and small peptides for enhanced plant engineering
Utilizing axillary shoot meristem genes In addition to genes involved in shoot and root development, MRs capable of initiating axillary meristems (AMs) have been investigated for their transformation-enhancing potential. Both SAMs and AMs are regulated in a WUS-dependent manner, but AM initiation occurs independently of WUS (Cao & Jiao, 2020; Wang & Jiao, 2018).
Impact of Latency and Continuity of GNSS Products on Filter-Based Real-Time LEO Satellite Clock Determination
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Ot
Kan Wang,1,* Jinxin Wan,2,* Ruipeng Zheng,1,* Yifei Xiao,1 Fengjun Lv,1 Haitao Ge,1 Guang Yang,3 Yu Cheng1 1Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, 150007, People’s Republic of China; 2Department of Neurosurgery, Guangdong Provincial People’s Hospital, Zhuhai Hospital (Jinwan Central Hospital of Zhuhai), Zhuhai City, Guangdong Province, 519090, People’s Republic of China; 3Department of...
A Multi-Scale Evaluation Model of Sustainable Development Goal 11.7 for Problem-Solving at Different Levels
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Subclassification of obesity for precision prediction of cardiometabolic diseases - Nature Medicine
Abstract Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (N ≈ 173,000).
Enhancing Federated Learning in Heterogeneous Internet of Vehicles: A Collaborative Training Approach
1. Introduction In recent years, the rapid technological advancements in the information age have led to a significant increase in the number of Internet of Things (IoT) devices, resulting in the generation of massive amounts of data [1]. Leveraging these data to offer more intelligent and convenient application services has become a major research focus [2]. As a pivotal IoT scenario, the Internet of Vehicles (IoV) has garnered substantial interest from researchers.
Characteristics of Transient Flow in Rapidly Filled Closed Pipeline
1. Introduction When a pipeline water transmission system is newly constructed or undergoing overhaul, its pipes initially contain no water. The first operational step involves opening gates, valves, and activating pumps along the pipeline to inject water. This procedure is essential for expelling air from the pipeline and ensuring it meets design requirements. Only after the pipeline is adequately purged of air can the system transition into its normal operational phase.
A Highly Integrated Millimeter-Wave Circularly Polarized Wide-Angle Scanning Antenna Unit
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Co-Deposition of Bimetallic Au-Pt with L-Cysteine on Electrodes and Removal of Copper by Iron Powder for Trace Aqueous Arsenic Detection
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Toto: Time Series Optimized Transformer for Observability
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Pattern reconfigurable mm‐Wave leaky‐wave antenna array using contactless excitation
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , , et al. Single-shot frequency-diverse near-field imaging using high-scanning-rate leaky-wave antenna. IEEE Trans Microw Theory Tech. 2021; 69(7): 3399-3412. doi:10.1109/TMTT.2021.3065713 2, , , . Channel estimation and hybrid precoding for millimeter wave cellular systems. IEEE J Sel Top Signal Process. 2014; 8(5): 831-846.
CD22 blockade aggravates EAE and its role in microglia polarization
1 INTRODUCTION Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS),1, 2 and experimental autoimmune encephalomyelitis (EAE) mimics the typical pathologies of MS including inflammation and demyelinating and glial hyperplasia, and induces typical behavioral manifestations.3, 4 Microglia are a group of glial cells with multiple functions that are widely distributed in the CNS.5 The pathogenesis of EAE and MS involves microglia.6-11 The effector functions of...
Experimental Study on the Hot Surface Ignition Characteristics and a Predictive Model of Marine Diesel in a Ship Engine Room
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Real-Time Estimation of BDS-3 Satellite Clock Offset with Ambiguity Resolution Using B1C/B2a Signals
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Hierarchical joint analysis of marginal summary statistics—Part I: Multipopulation fine mapping and credible set construction
1 INTRODUCTION The development of high-throughput genotyping and genotype imputation has boosted the application of genome-wide association studies (GWAS) which is now a standard approach to identify susceptibility loci or genomic regions for many complex diseases and traits (Buniello et al., 2019; Schaid et al., 2018).
Real-Time LEO Satellite Clocks Based on Near-Real-Time Clock Determination with Ultra-Short-Term Prediction
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio in Complex Coronary Lesions
CLINICAL PERSPECTIVE Functional evaluation of complex coronary lesions is crucial for decision-making regarding invasive interventions; however, it remains a significant challenge in clinical practice. Specific anatomic features of these lesions, including tandem, bifurcation, and extensive calcification, have been shown to lead to visual-functional mismatches in coronary stenosis assessment.
Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis
1 Introduction Calcific aortic valve disease (CAVD) is increasingly prevalent among the elderly, with its incidence increasing in tandem with the growing number of older individuals.[1] Currently, none of the currently available medical interventions effectively halt CAVD progression, leaving surgical or transcatheter aortic valve replacement as the only option for patients experiencing severe symptomatic CAVD.[2] A correlation exists between valvular calcification and chronic inflammation as...
Pollution Load Coordination and Eco-Compensation for Trans-Boundary Water Pollution Control: The Case of the Tri-Border Region of the Yangtze Delta
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Influence of Edge-Limited Hot Surfaces on Accidental Ignition and Combustion in Ship Engine Rooms: A Case Study of Marine Diesel Leakage
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Enhanced Chalcopyrite Dissolution in Acidic Culture Medium: The Impact of Arsenopyrite Presence
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Spatio-Temporal-Attention-Based Vehicle Trajectory Prediction Considering Multi-Vehicle Interaction in Mixed Traffic Flow
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Sub-Nanosecond UTC Dissemination Based on BDS-3 PPP-B2b Service
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Application of CRISPR/Cas9 for targeted mutagenesis in teosinte Zea mays ssp. parviglumis
To Editor, Maize (Zea mays ssp. mays L.) is one of the major cereal crops grown for food, fibre and bioenergy production. Modern maize was domesticated ~9000 years ago from teosinte with the closest progenitor being Zea mays ssp. parviglumis. Teosinte contains a greater amount of genetic diversity compared to modern maize (Hufford et al., 2012) and may serve as a model system to understand maize evolution and provide genetic resources to further improve maize (Barnes et al., 2022).
Experimental Research and Numerical Analysis of Marine Oil Leakage and Accidental Ignition in Fishing Vessels
2.1. Experimental Set-Up 2.1.1. Experimental Site The object of this research is a distant-water double-deck trawler, which is mainly used for single bottom trawling in waters of West African countries such as Morocco.
Exploring Metabolomic Patterns in Type 2 Diabetes Mellitus and Response to Glucose-Lowering Medications-Review
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by 1,†, 1,†, 1 and 2,* 1 Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands 2 Department of Data Science & Biostatistics, Julius Global Health, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands * Author to whom correspondence should be addressed. † These authors contributed equally to this work.
LEO Satellite Clock Modeling and Its Benefits for LEO Kinematic POD
Abstract : High-accuracy Low Earth Orbit (LEO) satellite clock and orbital products are preconditions to realize LEO augmentation for high-accuracy GNSS-based positioning on the ground. There is a high correlation between the orbit and clock parameters in the kinematic Precise Orbit Determination (POD) process.
Dynamic Process and Damage Evaluation Subject to Explosion Consequences Resulting from a LPG Tank Trailer Accident
Abstract : The involvement of liquefied petroleum gas (LPG), which is highly combustible and explosive, greatly increases risk in road transport. A 3D numerical model was conducted in FLACS, which depicts the dynamic process and variation of combined effects along the multi-directions of LPG explosion under an actual case.
Salicylhydroxamic Acid as a Novel Switchable Adhesive Molecule
The feasibility of salicylhydroxamic acid (SHAM) to function as a pH-responsive, switchable adhesive molecule is explored here. Using a custom-built Johnson–Kendall–Roberts contact mechanics test setup, SHAM-containing adhesive demonstrated strong, wet adhesion to various surfaces (glass, titanium, polystyrene and amine-functionalized glass) at pH 5 with adhesive properties that were comparable to those of catechol.
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