Articles by Ke Li
Rewiring dendritic cell function with CLEC9A and DEC205 CARs
Abstract Dendritic cells (DCs) are central orchestrators of antitumor immunity, yet their therapeutic potential is constrained by dysfunction and inadequate activation within solid tumors. Here we report chimeric antigen receptor-engineered DCs (CAR-DCs) that prime T cells and reprogram the tumor microenvironment.
Neuromelanin-inspired metal-selenomelanin nanonetworks restore neuronal excitability in radiation-induced brain injury
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Radiation-induced brain injury (RIBI) affects up to 30% of patients receiving cranial radiotherapy, representing an irreversible complication lacking effective therapies.
AI-driven discovery and engineering of human-derived protein scaffolds for mRNA delivery
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Abstract Safe and effective gene delivery remains a central challenge for therapeutic applications. While non-viral and viral vectors have enabled substantial progress, their reliance on non-human components often triggers immune responses, limiting their use in chronic treatments. Here, we develop DeepDelivery, an artificial intelligence-driven platform to identify human proteins with scaffold potential for mRNA delivery.
By Dongmin Xun, Lanqing Li, Jie Jenny Zou Verified, Yi Liu, Ziyue Yang, Qianyi Liang, Ke Li, Zhu Zhu, Jicong Zhang, Lijun Lang, Kun Liu, Xinyu Wang, Meilin Tian, Guangyong Chen, Jun Yang, Bolin An, Pheng Ann Heng, Chao Zhong
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Nature
Verified
Towards CRISPR-on-Demand: A Platform Manufacturing Approach for Gene-edited Cell Therapies
For patients with rare genetic diseases, the window to treat is often short. Dr. Ke Li, Scientific Director of the Investigational Cellular Therapy Program at the University of California, San Francisco (UCSF), will share how his team is building a CRISPR-on-Demand platform to bring personalized gene-edited cell therapies to the clinic faster, using primary HLH as a model. He will also cover a non-viral genome engineering approach to ultra-large DNA knock-in for next-generation cell therapies.
Author Correction: HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
Correction to: Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-026-01871-y, published online 28 September 2026. In the version of this article initially published, the representative TUNEL staining image for control-treated Herc4−/− mice in Fig. 6g was incorrect. The figure has been updated in the HTML and PDF versions of the article. For comparison, the original and revised image and raw data are available as Supplementary Information accompanying this amendment.
Water conservancy under the People's Commune: the construction, characteristics and heritage values of the Red Flag Canal, China (1959–1969)
ABSTRACT This article examines the Red Flag Canal, constructed in central China’s Henan Province between 1959 and 1969, as a representative water conservancy project of the People’s Commune period (1958–1983). From a planning-history perspective, it moves beyond interpretations that reduce the canal to either a political symbol or a centrally planned state project.
HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
Abstract TNF can activate both prosurvival and prodeath signaling downstream of tumor necrosis factor receptor 1 (TNFR1). Survival signaling originates from TNFR1-containing membrane-bound complex I, while death signaling is driven by cytosolic complex II. Receptor-interacting protein kinase 1 (RIPK1) is a central component of both complexes but the molecular switch converting RIPK1 from a prosurvival scaffold in complex I to a prodeath kinase in complex II has remained elusive.
Pancreatic and biliary safety signals of GLP-1 receptor agonists and tirzepatide: a disproportionality analysis of FAERS reports
Abstract Background: The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and tirzepatide is increasing rapidly worldwide, and the pancreatic and biliary safety of these drugs has been a concern. This study was based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) to evaluate the pancreatic and biliary adverse event reporting signals of liraglutide, semaglutide, tirzepatide and dulaglutide.
Case Report: breast cancer presenting as dermatomyositis
Abstract Background: Cancer-associated dermatomyositis (CADM) is a rare paraneoplastic syndrome characterized by inflammatory myopathy and distinctive cutaneous manifestations. Early recognition of an underlying malignancy is essential for improving patient outcomes. Case presentation: We report the case of a 48-year-old woman who initially presented with dermatomyositis as the first manifestation of breast cancer.
Dynamic Asymmetry in O/N-Coordinated Zn Single-Atom Catalysts Promotes Sabatier-Favorable Urea and Urea Peroxide Electrosynthesis
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article Supporting Information Filename Description anie74794-sup-0001-SuppMat.doc65.4 MB Supporting File: anie74794-sup-0001-SuppMat.doc.
Value of preoperative peripheral blood inflammation markers in predicting prognosis after radical gastric cancer surgery
Abstract We aimed to systematically investigate the association between ten preoperative peripheral blood inflammatory markers and the clinicopathologic characteristics and outcomes of gastric cancer (GC) and develop a prediction model for overall survival (OS) based on these markers. We conducted retrospective analyses of the clinicopathological data of 921 patients with gastric cancer who underwent radical gastrectomy, adjusting baseline characteristics using propensity score matching (PSM).
Zinc-finger proteins C3H14 and C3H15 maintain meiocyte identity in flowering plants
Abstract In the anthers of flowering plants, the innermost meiocytes and surrounding somatic cells (tapetum) are differentiated from the same precursor archesporial cells, and these cells acquire distinct cell identities after specification. However, the underlying mechanism regulating meiocyte identity is elusive.
Disentangling cation–polyanion coupling reveals which anion motion dominates cation transport in solid electrolytes
Abstract Polyanion dynamics, notably rotation, have long been linked to fast cation transport in solid electrolytes, yet their contribution to ionic conductivity remains unquantified, and even rotation’s role, disputed. Here, we quantify the contributions of polyanion translation, rotation, and vibration to conductivity in plastic crystals by combining a constraint algorithm and machine learning molecular dynamics.
Therapeutic potential of gut microbiota metabolites against Klebsiella pneumoniae pneumonia: a multiomics analysis integrating network pharmacology, molecular docking, and dynamics simulations
Abstract Although gut microbiota metabolites (GMMs) show therapeutic activity against Klebsiella pneumoniae pneumonia (KPP), their underlying mechanisms remain unclear. Therefore, identifying biomarkers associated with the therapeutic effects of GMM on KPP is crucial. Targets associated with gut microbiota (GM), GMM, and KPP were collected from several databases.
Study on occurrence, estimation, and health risks of microplastics in outdoor sports venues in Chongqing
Abstract Outdoor artificial sports venues are emerging yet underestimated hotspots of urban microplastic (MP) pollution, with far-reaching ecological and human health implications, particularly in subtropical mountainous megacities. This study systematically investigated MP occurrence, emission characteristics, spatial patterns, and risks of MPs associated with plastic running tracks and artificial lawns in the main urban area of Chongqing.
Risk of osteoporosis and fracture among patients with breast cancer: a systematic review and meta-analysis of cohort studies
Abstract Background: Breast cancer survivors may be at increased risk of osteoporosis and fractures because of disease-related factors and treatment-induced bone loss. However, the available evidence remains inconsistent. This study aimed to evaluate the associations between breast cancer and the risks of osteoporosis and fracture through a systematic review and meta-analysis.
Brucea javanica Oil Emulsion Promotes Breast Cancer Cell Autophagy and Apoptosis by Regulating PAX6 mRNA Stability Through the hsa_circ_0001589/G3BP1 Axis
Ke Li and MeiXia Li contributed equally to this study. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Peer Review For transparency, the peer review documents associated with this article are available at https://doi.org/10.1111/1440-1681.70150.
Integrative ferroptosis-related bioinformatics identifies PPARγ as a therapeutic target of ursolic acid against inflammation and pathological osteogenesis in ankylosing spondylitis
Abstract Background: Ankylosing spondylitis (AS) is an immune-mediated inflammatory disease characterized by persistent inflammation and aberrant new bone formation. Ferroptosis has increasingly been implicated in immune dysregulation and pathological bone remodeling; however, its molecular involvement in AS and its potential value for natural product discovery remain poorly understood.
A Deadbeat Predictive Sliding-Mode Observer and Finite Position Set-PLL for Sensorless Control of PMSM Drives
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Research data are not shared. References 1, , , , and , “Sliding-Mode-Based Robust Output Regulation and Its Application in PMSM Servo Systems,” IEEE Transactions on Industrial Electronics 70, no. 2 (2023): 1852–1860.
Heteroporous 2D Covalent Organic Frameworks With Functional Differentiated Crown-Amino Pores Constructed by Node Engineering for Gold Recovery
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description adfm78013-sup-0001-SuppMat.docx15.1 MB Supporting File: adfm78013-sup-0001-SuppMat.docx.
Electrochemical coupling of CO 2 and phosphite for foscarnet synthesis
Abstract Foscarnet is a clinically vital antiviral drug with substantial market value, yet its conventional synthesis remains challenging. The coupling of CO2 with phosphite represents an attractive and sustainable alternative route for foscarnet production, although this approach has not been successfully demonstrated so far. Here we show the electrosynthesis of foscarnet via the coupling of CO2 and phosphite, enabled by an ionic liquid-modified bismuth (IL@Bi) catalyst.
Spatiotemporal distribution and evolution mechanisms of land subsidence in areas with combined coal mining and groundwater extraction
Abstract Land subsidence in areas with combined coal mining and groundwater extraction is characterized by multi-source induction, multi-field coupling, and multi-stage transfer, making its formation and evolution mechanisms particularly complex. Taking the Xuchang Coal Mine as the study area, this paper systematically investigates the spatiotemporal distribution patterns of land subsidence.
RNF6 activates the AKT/mTOR signaling pathway by inhibiting PTEN via K27-linked polyubiquitination in myeloma
Abstract As the second most hematological malignancy, multiple myeloma (MM) is closely associated with dysregulated AKT/mTOR signaling. However, the underlying mechanism remains unclear. In the present study, we find the AKT/mTOR signaling pathway is activated by the ring finger protein RNF6. Acting as a ubiquitin ligase, RNF6 binds to and mediates PTEN polyubiquitination, altering its stability. Further investigations reveal that RNF6 specifically induces K27-linked ubiquitination of PTEN.
The efficacy and safety of pembrolizumab in the treatment of HER2-negative advanced gastric or gastroesophageal junction cancer: a systematic review and meta-analysis of emerging clinical data
Abstract Introduction: Pembrolizumab, an immune checkpoint inhibitor (ICI) targeting programmed cell death protein 1 (PD-1), has demonstrated significant clinical value in the treatment of human epidermal growth factor receptor 2 (HER2)-negative advanced gastric cancer (GC) and gastroesophageal junction cancer (GEJC).
HHBayes: A Flexible Bayesian Framework for Simulating and Analyzing Household Transmission Dynamics
DMW has received consulting fees from Pfizer, Merck, and GSK unrelated to this manuscript and has received research funding from Pfizer, Merck, and GSK, unrelated to this manuscript. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
A potassium-based single-atom catalyst enables acute lung injury immunotherapy in mice by inhibiting macrophage pyroptosis
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Abstract Acute lung injury (ALI), which can have a mortality rate approaching 40%, lacks effective therapies. Macrophage pyroptosis represents a pro-inflammatory event and a potential therapeutic target. Here, we report a single-atom immunomodulator, a potassium-based single-atom catalyst (K-SAC) with K–N4 sites, that suppresses macrophage pyroptosis for ALI therapy through antioxidant catalysis.
By Xiangyu Lu, Xuan Shi, Yanmin Jian, Cai Sun, Lijie Mao, Si Chen, Fang Huang, Ji Lu, Zhiyi Song, Xin Li Verified, Yongjun Chen, Ke Li, Xin Lv, Jianlin Shi, Yuanru Zhao, Guanning Liu
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Nature
Verified
Design and evaluation of a tendon-and-linkage hybrid-driven humanoid dexterous hand
Abstract Dexterous hands are essential for robotic grasping and manipulation; however, existing designs remain limited in achieving both structural and functional biomimicry. In this study, a humanoid dexterous hand, termed the REL Hand, was developed and experimentally evaluated. The REL Hand adopts a modular architecture comprising five digits and one palm, with 15 active and 5 passive degrees of freedom.
Extraction of Micra Leadless Pacemaker and Upgrade to Left Bundle Branch Pacing: A Case Report
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All data are available in the paper; the datasets generated during the study are available from the clinical work. References 1, , , et al., “Incidence and Predictors of Pacemaker-Induced Cardiomyopathy With Comparison Between Apical and Non-Apical Right Ventricular Pacing Sites,” Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing 56, no.
OTUD4 stabilizes CYLD and counteracts BCL3 K63-linked polyubiquitination to suppress melanoma progression
Abstract Melanoma is a highly aggressive malignancy in which dysregulated ubiquitin-dependent signaling contributes to tumor progression. OTUD4 is frequently downregulated in melanoma, but the functional significance of this alteration remains unclear. Here, we identify OTUD4 as a dual-mode deubiquitinase that suppresses melanoma progression by coordinating K48- and K63-linked polyubiquitination.
Case Report: Successful treatment of verruciform acanthotic vulvar intraepithelial neoplasia with 5-aminolevulinic acid photodynamic therapy
Abstract Verruciform acanthotic vulvar intraepithelial neoplasia (vaVIN) is a rare, human papillomavirus (HPV)-independent, p53 wild-type intraepithelial precursor of the vulva, and standardized therapies for this disease are currently lacking.
A programmable fungal platform for engineered living textiles
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract A central challenge in engineered living materials (ELMs) is the seamless integration of macroscopic structural assembly with sustained cellular viability and programmable function.
Ramona Ileana Pistol. Novelty in Metaphors: A Semiotic Approach to the Creativity of Mind and Emotions . Berlin & Boston: De Gruyter Mouton. 2025. ISBN 978-3-111-56712-9 (Hardcover). 230 pp.
Advanced search Studia Neophilologica Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/00393274.2026.2694363?needAccess=true Click to increase image sizeClick to decrease image size Disclosure statement No potential conflict of interest was reported by the author(s).
From Biomass to Functional Gels: Multiscale Topology Reconstruction and High-Performance Applications
1 Introduction Driven by fossil resource depletion and the ecological crisis of >400 million tons of annual plastic waste (<10% recycled), materials science is urgently shifting toward renewable alternatives to achieve carbon neutrality [1, 2].
Efgartigimod in the treatment of immune checkpoint inhibitor-related myasthenia gravis -myositis overlap syndrome: a case report
Abstract Background: A subset of cancer patients receiving monoclonal antibody PD-1/PD-L1 inhibitors may develop immune checkpoint inhibitor (ICI)-related neurological complications, such as ICI-related myasthenia gravis(MG)-myositis overlap syndrome and ICI-related myocarditis. Standard management typically involves intravenous immunoglobulin (IVIG), plasma exchange (PE), and high-dose corticosteroids.
Keto–Enol Tautomerism-Driven Efficient Gold Recovery by Azo Covalent Organic Frameworks Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJuly 15, 2026 Keto–Enol Tautomerism-Driven Efficient Gold Recovery by Azo Covalent Organic Frameworks Click to copy article linkArticle link copied! Tingting Huang Tingting Huang School of Chemical Science and Engineering, Tongji University, Siping Road 1239, Shanghai 200092, China Ke Li Ke Li School of Chemical Science and Engineering, Tongji University, Siping Road 1239, Shanghai 200092, China Yin-Sheng Liu Yin-Sheng Liu School of Chemical Science and...
A Biomimetic Nanocomposite Hydrogel Cross-Linked by Calcium Phosphate Oligomers for Bone Regeneration Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJuly 13, 2026 A Biomimetic Nanocomposite Hydrogel Cross-Linked by Calcium Phosphate Oligomers for Bone Regeneration Click to copy article linkArticle link copied! Lingfei Liu Lingfei Liu Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China Ke Li Ke Li Department of Prosthodontics, Peking...
Selective Gold Recovery via Thermally Generated Water Microdroplets at Oil–Water Interfaces Click to copy article link Article link copied!
Introduction Click to copy section linkSection link copied! Gold is indispensable in electronics, catalysis and advanced medical technologies. (1−3) Declining ore grades and increasing global demand (4,5) have intensified reliance on secondary sources such as industrial effluents and electronic waste leachates.
Glucolipid metabolic dysfunction in ankylosing spondylitis: inflammatory mechanisms, immune–metabolic crosstalk and therapeutic implications of natural products and traditional Chinese medicine
Abstract Ankylosing spondylitis (AS) is increasingly recognized as a systemic inflammatory disease accompanied by substantial glucolipid metabolic disturbances and an elevated risk of diabetes. Beyond articular inflammation, persistent immune activation reshapes metabolic homeostasis through interconnected mechanisms involving chronic cytokine signaling, immune-cell metabolic reprogramming, gut microbiota dysbiosis and endocrine disruption.
Autoantibodies in chronic non-infectious respiratory diseases: a scoping review
Abstract We performed a scoping review assessing autoantibodies across chronic non-infectious respiratory diseases including idiopathic pulmonary fibrosis, idiopathic interstitial pneumonias, chronic obstructive pulmonary disease, cystic fibrosis, asthma, bronchiectasis, sarcoidosis, and silicosis. Databases were searched for case-control and cohort studies investigating autoantibodies in the context of these respiratory diseases from inception to 13 September 2024.
A multilayered skin-fat-muscle phantom embedded with thermocouples for non-ablative RF heating: numerical simulation and experimental validation
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. Abstract Background Non-ablative radiofrequency (RF) skin rejuvenation relies on controlled volumetric heating of skin and subcutaneous tissues. Clinical validation is costly and ethically constrained, while simulations require experimental validation.
Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategies
Abstract Cancer stem cells (CSCs) are a subpopulation of tumor cells with stem cell-like properties, which are endowed with unique self-renewal capacity and heterogeneity. Specifically, they drive tumor initiation, progression, recurrence, and therapeutic resistance. As the core drivers of tumor development and treatment resistance, CSCs exhibit distinct metabolic characteristics that sustain their self-renewal and differentiation potential.
Routine Metabolic Laboratory Profile and Time-Stratified Machine-Learning Risk Stratification of Rosacea: A Combined Retrospective-Prospective Cohort Study
Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 19 Authors Wu M, Li K , Liao Y, Li L, Xiao X, Guo J, Feng H Received 26 June 2026 Accepted for publication 12 October 2026 Published 25 October 2026 Volume 2026:19 634954 DOI https://doi.org/10.2147/CCID.S634954 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Jeffrey Weinberg Meng Wu, Ke Li, Yangying Liao, Lan Li, Xiao Xiao, Junweichen...
A high-energy hydrogen radical initiates efficient electrosynthesis of urea from CO 2 and N 2
Abstract The electrochemical co-reduction of CO2 and N2 to urea presents a sustainable alternative to conventional synthesis but faces substantial challenges. Here we design a catalyst by anchoring the ionic liquid (IL) 1-ethyl-2,3-dimethylimidazolium bromide onto a CuBi surface. The IL@CuBi catalyst delivers an exceptional Faradaic efficiency toward urea (FEurea) of 73.0% and a current density of 27.4 mA cm−2 in an H-type cell, with a production rate of 124.7 μmol cm−2 h−1.
Screening ASb 2 O 6 (A = Mg, Ca, Sr, Ba, or Cd) for High-Performance Transparent Conducting Oxides Click to copy article link Article link copied!
Introduction Click to copy section linkSection link copied! Antimonates have attracted attention over several decades for their notable photocatalytic properties, primarily due to their wide band gaps and chemical stability. These characteristics have enabled their use in photodegradation processes, (1−4) as well as in water splitting (5,6) and gas sensing applications.
Computer Science > Robotics
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Bayesian Matrix Factorization for Electricity Load Imputation
You are already at the latest version The missing values in the electricity load are a critical issue in grid applications. The electricity demand time series data are usually large-scale with complicated patterns, which cause difficulties for imputation. This paper presents a Bayesian matrix factorization (BMF)-based imputation method for large-scale electricity load missing value imputation.
Computer Science > Machine Learning
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Mechanical properties of steel fiber concrete modified with nano-TiC and nano-SiO 2
Abstract The incorporation of admixtures into concrete is a common method to improve its mechanical properties, and this study investigates the effects of nano-SiO2 (NS) and nano-TiC (NT) on steel fiber concrete (SFRC). In this paper, 1%, 2%, and 3% of NS, and 0.5%, 1.0%, and 1.5% of NT were individually mixed into SFRC, and their effects on the compressive, split tensile, and flexural strengths of SFRC at 7 and 28 days were investigated.
Utilizing virus genomic surveillance to predict vaccine effectiveness
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Kwon J, Li K, Warren JL, Pandya S, Hahn AM, Yale SARS-CoV-2 Genomic Surveillance Initiative, et al. (2026) Utilizing virus genomic surveillance to predict vaccine effectiveness. PLoS Comput Biol 22(5): e1014329. https://doi.org/10.1371/journal.pcbi.1014329 Editor: Joel O.
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