Keyi LI
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Articles by Keyi LI
Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease
Abstract Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal monitoring to resolve these challenges. We identify metabolic and transcriptomic dysregulation in PMD, deriving a robust 7-feature multi-omics diagnostic panel (6 metabolites, 1 transcript).
SATB1 lowers the T cell receptor signaling threshold for thymocyte positive selection via super-enhancer reprogramming
Abstract In early T cell development, thymocytes undergoing positive selection receive relatively weak T cell receptor (TCR) signals. However, the mechanisms by which thymocytes translate weak and transient TCR signals into lineage-defining transcriptional programs remain unclear. Here, we show that SATB1 plays a key role in enhancer activation during positive selection, as it promotes the expression of positive selection-associated genes by enhancing super-enhancer (SE) activation.
A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell alteration in human lymph nodes
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To investigate senescence-associated and age-related changes in human LNs, we analyzed whole LN resections or needle biopsy tissue blocks from 65 donors (41 males and 24 females; 108 total samples) obtained through the Yale Pathology Tissue Service. LN tissue samples were stratified into three age groups: group 1 (<50 years, n = 26), group 2 (50–69 years, n = 15), and group 3 (≥70 years, n = 10), with median ages of 32, 56, and 75 years, respectively (Figures 1 and S1; Table S1).
By Negin Farzad, Archibald Enninful, Yao Lu Verified, Fabio Parisi, Anthony Fung, Yumi Kwon, yajuan Li, Mingyu Yang, Francesco Strino, Liang Chen, Junchen Yang, Mei Zhong, Fu Gao, Bo Tao, Joseph Cunningham, Zhiliang Bai, Haikuo Li, Fang Wang, Michael C Stankewich, Dongjoo Kim, Mingze Dong, Lisa M. Bramer, Keyi LI, Meera Bhat, Joseph Craft, Ljiljana Paša-Tolić, Stephanie Halene, Lingyan Shi, Yuval Kluger, Mina L. Xu, Rong Fan, Margaux Labrosse, Evan J. Loe
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Cell Press
Verified
Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT
Abstract While formalin-fixed paraffin-embedded (FFPE) samples are invaluable for human non-Hodgkin B-cell lymphoma translational research, effective methods for spatial profiling of chromatin accessibility and histone modifications in these tissues remain limited.
Nonlinear association between physical activity and bone mineral density in adolescents
Abstract This study aimed to examine the association between physical activity (PA) and bone mineral density (BMD) and to explore potential non-linear and threshold relationships in adolescents aged 12–19 years. Data from the National Health and Nutrition Examination Survey 2005–2010 were used for this cross-sectional analysis. Statistical analyses included weighted multivariate linear regression, restricted cubic spline (RCS) analysis, threshold effect evaluation, and sensitivity analyses.
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Abstract Age-related inflammation or ‘inflammaging’ increases disease burden and controls lifespan. Adipose tissue macrophages (ATMs) are critical regulators of inflammaging; however, the mechanisms involved are not well understood in part because the molecular identities of niche-specific ATMs are unknown.
NUSAP1 regulates mitotic processes via KIF2C interaction and AURKA phosphorylation in primary microcephaly
The authors have declared no competing interest.
Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury - Nature Materials
Abstract Traumatic brain injury (TBI) is associated with life-threatening and permanent disabilities. Given the limited capacity of neurons to regenerate, effective treatments for TBI are lacking. Neural stem cells (NSCs) can differentiate into fully functioning neurons and thus hold promise for TBI treatment. Nonetheless, NSC differentiation and proliferation are slow and inefficient.
Whose history is it? When statues are toppled and memories are rewritten
In 2020, a massive ‘Black Lives Matter’ demonstration broke out in Bristol, England. During this, protesters pulled down a bronze statue of Edward Colston, a 17th century slave trader, in the city centre with a rope and dragged it down to the harbour to sink it. Inspired by actions to remove Confederate-era monuments across the U.S., protesters in the U.K. and elsewhere have also begun to bring down statues of controversial historical figures.
Descart: a method for detecting spatial chromatin accessibility patterns with inter-cellular correlations - Genome Biology
To capture spatial accessibility pattern of each peak, Descart construct a spatial graph based on spatial locations of spots (can also be replaced by cells).
Exploring the Factors Influencing Tourists’ Satisfaction and Continuance Intention of Digital Nightscape Tour: Integrating the Design Dimensions and the UTAUT2
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Every Component Counts: Rethinking the Measure of Success for Medical Semantic Segmentation in Multi-Instance Segmentation Tasks
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Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation
Abstract Age-related inflammation or inflammaging is a key mechanism that increases disease burden and may control lifespan. How adipose tissue macrophages (ATMs) control inflammaging is not well understood in part because the molecular identities of niche-specific ATMs are incompletely known.
Detection of spatial chromatin accessibility patterns with inter-cellular correlations
Abstract Recent advances in spatial sequencing technologies enable simultaneous capture of spatial location and chromatin accessibility of cells within intact tissue slices. Identifying peaks that display spatial variation and cellular heterogeneity is the first and key analytic task for characterizing the spatial chromatin accessibility landscape of complex tissues.
Enhancing Stability and Performance in Mobile Robot Path Planning with PMR-Dueling DQN Algorithm
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
UNIVERSE ANTIMATTER 2
Facebook Twitter WhatsApp SMS Email Print Save In an undated image provided by Keyi "Onyx" Li/U.S. National Science Foundation, an artist’s conceptual rendering of the antihydrogen atoms contained within the magnetic trap of the ALPHA-g apparatus. As the field strength at the top and bottom of the magnetic trap is reduced, the antihydrogen atoms escape, touch the chamber walls and annihilate.
Cofea: correlation-based feature selection for single-cell chromatin accessibility data
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Building a genetic and epigenetic predictive model of breast cancer intrinsic subtypes using large-scale data and hierarchical structure learning
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Correction: An ultrasound-induced MXene doped PAM-SA super-tough hydrogel
Correction: An ultrasound-induced MXene doped PAM–SA super-tough hydrogel Keyi Li,a Yong Liu,b Yaqing Ge,b Hongyan Cao,b Shujuan Zhuang,a Xueting Yang,*b Yanyan Zhao*b and Xiangling Gu*ab Abstract Correction for ‘An ultrasound-induced MXene doped PAM–SA super-tough hydrogel’ by Keyi Li et al., J. Mater. Chem. C, 2023, 11, 1908–1918, https://doi.org/10.1039/D2TC04665B. This article is Open Access Please wait while we load your content... Something went wrong. Try again?
An ultrasound-induced MXene doped PAM-SA super-tough hydrogel
An ultrasound-induced MXene doped PAM–SA super-tough hydrogel Keyi Li,a Yong Liu,b Yaqing Ge,b Hongyan Cao,b Shujuan Zhuang,a Xueting Yang,*b Yanyan Zhao*b and Xiangling Gu *ab Abstract Here we reported a novel ultrasound-induced polymerization to achieve a polyacrylamide–sodium alginate (SA) dual network hydrogel via a redox reaction with MXene (Ti3C2) as a reductant and potassium persulfate (KPS) as an oxidant.
Endodontic treatment of various palatal roots in maxillary molars
Abstract Background and Overview The purpose of this article is to present the variations in maxillary molar palatal root canals and provide a reference for the possible variations in root canal treatment. Case Description Five rare cases with palatal canal variation presented in this case series received nonsurgical endodontic treatment successfully.
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