Lin Tan
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Articles by Lin Tan
Case Report: Early-onset Luminal B-like male breast cancer with perineural invasion
Abstract Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers and less than 1% of cancers in men. Compared with female breast cancer, MBC is characterized by a predominance of hormone receptor-positive luminal tumors, whereas evidence guiding individualized management remains largely extrapolated from female populations.
Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance
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Constructs and CRISPR-Cas9–mediated gene knockout and overexpression cell line generation Cell lines with knockout of target genes were generated as previously described.49,50 CRISPR-mediated KO plasmids containing gRNAs targeting FDX1, IRF1, STAT1, and JAK1 were generated in lentiCRISPR v2 (Addgene) according to the standard protocol. The sequences of sgRNAs used in the current study are listed in Table S3.
By Guang Lei, Zhengze Lu, Zhihao Xu, David Huo, Jian Hua Gao, Lin Tan, Ting Hong, Shengrong Wu, Mingchuang Sun, Xi Juan Zhao, Qidong Li, Xiong Chen, Yuelong Yan, Hyemin Lee, Li Zhuang, Li-Ting Ku, Nahum Puebla, Hampartsoum B. Barsoumian, Jun Yao, Lingzhi Hong, Jianjun Zhang, Hai L Tran, don gibbons, Ara A Vaporciyan, John Heymach, Chunru Lin, Eyal Gottlieb, Mingjian James You, James Welsh, Steven Lin, Xingxing Zang, Ziyi Li, Boyi Gan, Chen Braun, Jiun-Kae Jack Lee
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Cell Press
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Case Report: ETV6 c.744del gene mutation acute lymphoblastic leukemia in identical twins
Abstract Background: It is extremely rare for monozygotic twins to both develop leukemia. This paper reports a clinical case in which a pair of monozygotic twins with germline ETV6 gene mutations successively developed acute lymphoblastic leukemia (B-cell type, ALL-B). The ETV6:c.744del (p.S248fs) is a novel germline mutation associated with familial susceptibility to hematologic malignancies.
Dissecting the Genetic Basis of Low Back Pain Independent of BMI Throu
Back to Journals » Journal of Pain Research » Volume 19 Original Research Musculoskeletal Pain/Rehabilitation and Neuropathic Pain Authors Huo L, Tan L, Wang F, Sun J, Niu Y, Jiang Y, Wu M, Shi J, Hao Y, Wang J, Huang S, Chen Z Received 15 November 2025 Accepted for publication 1 February 2026 Published 3 March 2026 Volume 2026:19 581757 DOI https://doi.org/10.2147/JPR.S581757 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved...
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The ASNS inhibitor ASX-173 potentiates L-asparaginase anticancer activity
Abstract Cancer cells reprogram metabolic pathways to meet increased energy and biosynthetic demands. Among those pathways, elevated asparagine metabolism regulated by asparagine synthetase (ASNS) has been linked to tumor progression in various cancers, driving cell proliferation, chemoresistance, and metastasis. ASNS inhibition represents a promising therapeutic strategy, but inhibitors have shown limited efficacy due to poor specificity and cell permeability.
An Exploratory Study on Spatial Governance Toward Urban-Rural Integration: Theoretical Analysis with Case Demonstration
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Analysis of Spatial Vitality Characteristics and Influencing Factors of Old Neighborhoods: A Case Study of Ya’an Xicheng Neighborhood
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Ultra-Fast Multi-Organ Proteomics Unveils Tissue-Specific Mechanisms of Drug Efficacy and Toxicity
Abstract Rapid and comprehensive analysis of complex proteomes across large sample sets is vital for unlocking the potential of systems biology. We present UFP-MS, an ultra-fast mass spectrometry (MS) proteomics method that integrates narrow-window data-independent acquisition (nDIA) with short-gradient micro-flow chromatography, enabling profiling of >240 samples per day. This optimized MS approach identifies 6,201 and 7,466 human proteins with 1- and 2-min gradients, respectively.
Locating QTLs Controlling the Yield-Related Traits in Perennial Chinese Rice "Shendao3#"
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 4 September 2024 / Approved: 5 September 2024 / Online: 9 September 2024 (04:44:48 CEST) Yan, Y.; Gong, J.; Lu, J.; Tan, L.; Li, M.; Qin, X.; Nan, W.; Peng, T.; Liang, Y. Locating QTLs Controlling the Yield-Related Traits in Perennial Chinese Rice "Shendao3#". Preprints 2024, 2024090506. https://doi.org/10.20944/preprints202409.0506.v1 Yan, Y.; Gong, J.; Lu, J.; Tan, L.; Li, M.; Qin, X.; Nan, W.; Peng, T.; Liang, Y.
Staphylococcus simulans infections in a patient following high supracondylar osteotomy to treat osteoarthritis: a case report
Staphylococcus simulans (S. simulans) is a coagulase-negative staphylococcus (CNS), accidentally found on the skin and the urethra of healthy women [1]. Most CNS infections are caused by Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococci hominis, and so on. S. simulans have been isolated from clinical specimens, including blood, urine, fluids and exudates those were collected from wounds, abscesses, lesions and intravascular catheters [2–4].
Bacteria-responsive functional electrospun membrane: Simultaneous on-site visualized monitoring and inhibition of bacterial infection
Bacteria-responsive functional electrospun membrane: Simultaneous on-site visualized monitoring and inhibition of bacterial infection Skin infections are major threat to human health. Early diagnosis of bacterial infections is of great significance for implementing protective measures on the skin. Therefore, in this study, we designed an electrospinning membrane (PPBT) for visual monitoring of colonized bacteria and responsive antibacterial ability.
ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart
Abstract Background: Metabolic remodeling is a hallmark of the failing heart. Oncometabolic stress during cancer increases the activity and abundance of the ATP-dependent citrate lyase (ACL, Acly), which promotes histone acetylation and cardiac adaptation. ACL is critical for the de novo synthesis of lipids, but how these metabolic alterations contribute to cardiac structural and functional changes remains unclear.
Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells
Highlights • Pc-induced IFNγ boosts glycolysis in MODCs and itaconate accumulation in vivo • Itaconate disrupts mitochondria, leading to nucleic acid release and MODC restraint • mtDNA-mediated STING-IRF3/IRF7 pathway induces PD-L1 expression in MODCs • PD-L1 expression by MODCs impairs CD8+ T cell activation and control of parasitemia Summary Severe forms of malaria are associated with systemic inflammation and host metabolism disorders; however, the interplay between these outcomes is...
Residents' Travel Choice under Public Health Events and the Optimal Strategies of the Travel Environment for Active Mobility: A Case Study of Harbin, China
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 14 February 2024 / Approved: 14 February 2024 / Online: 14 February 2024 (14:24:29 CET) Tan, L.; Fang, D.; Zhao, L.; Xue, Y.; Sun, S.; Lan, J.; Wang, X. Residents' Travel Choice under Public Health Events and the Optimal Strategies of the Travel Environment for Active Mobility: A Case Study of Harbin, China. Preprints 2024, 2024020819.
Multi-Fracture Propagation Considering Perforation Erosion with Respect to Multi-Stage Fracturing in Shale Reservoirs
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells
Highlights • Pc-induced IFNγ boosts glycolysis in MODCs and itaconate accumulation in vivo • Itaconate disrupts mitochondria, leading to nucleic acid release and MODC restraint • mtDNA-mediated STING-IRF3/IRF7 pathway induces PD-L1 expression in MODCs • PD-L1 expression by MODCs impairs CD8+ T cell activation and control of parasitemia Summary Severe forms of malaria are associated with systemic inflammation and host metabolism disorders; however, the interplay between these outcomes is...
Palladium-Catalyzed Directed Carbon-Carbon Bond Activation of Aryl Nitriles for Cyano Transfer
Herein, we report the C–H cyanation of indoles via a palladium-catalyzed directed C–CN activation reaction using aryl nitrile as a cyano source. The employment of the phenoxy-oriented group is the key to the cleavage of the C–CN bond. This protocol features a broad substrate scope, good efficiency, and high regioselectivity.
Tryptophan Metabolites And Their Predicted Microbial Sources In Fecal Samples From Healthy Individuals
Abstract Gut microbiota produce tryptophan metabolites (TMs) important to homeostasis. However, measuring TM levels in stool and determining their microbial sources can be difficult.
A Probabilistic Assessment Framework for Submarine Landslide Susceptibility in Continental Slopes with Rich Gas Hydrates
1. Introduction Submarine landslides are widespread in hydrate-enriched continental slopes [1,2,3,4,5], such as the submarine landslides occurring in the north continental slope of the South China Sea, which are enriched with natural gas hydrates [1,6]. Submarine landslides have the potential to destroy submarine pipelines [7,8], cables [9,10], and offshore platforms [11] and to generate destructive waves, even causing tsunamis [12].
Do brief motivational interventions increase motivation for change in drinking among college students? A two‐step meta‐analysis of individual participant data
Abstract Background Brief motivational interventions (BMIs) are one of the most effective individually focused alcohol intervention strategies for college students. Despite the central theoretical role of motivation for change in BMIs, it is unclear whether BMIs increase motivation to change drinking behavior. We conducted a two-step meta-analysis of individual participant data (IPD) to examine whether BMIs increase motivation for change. N = 5903;59% women, 72% White) from Project INTEGRATE.
One Stone, Two Birds: Spidroin‐Inspired Nanogels for High‐Performance Fibers and Photothermal Actuators
Abstract The exciting development of hydrogels makes it a promising candidate to be applied in various fields. However, it remains a great challenge to store the precursors of hydrogels and to process them after gelation, like synthetic polymer materials. Herein, spidroin-inspired novel nanogels with extraordinary processability, which can be spun into fibers via direct drawing and fabricated into thermal actuators easily after gelation are prepared.
[2105.07311] When Automated Program Repair Meets Regression Testing -- An Extensive Study on 2 Million Patches
[Submitted on 15 May 2021 ( v1 ), last revised 2 Jul 2024 (this version, v2)] Title:When Automated Program Repair Meets Regression Testing -- An Extensive Study on 2 Million Patches View a PDF of the paper titled When Automated Program Repair Meets Regression Testing -- An Extensive Study on 2 Million Patches, by Yiling Lou and 7 other authors View PDF HTML (experimental) Abstract:In recent years, Automated Program Repair (APR) has been extensively studied in academia and even drawn wide...
3D hierarchical defect-rich C@MoS2 nanosheet arrays developed on montmorillonite with enhanced performance on Pb(II) removal
3D hierarchical defect-rich C@MoS2 nanosheet arrays developed on montmorillonite with enhanced performance on Pb(II) removal As an emerging material for environmental remediation, MoS2 with various dimensional nanostructure has attracted much attention.
Becoming A Leader Who Coaches: Three Things You Need To Know To Get Started
Award-winning global coaching leader and Master Certified Coach (ICF). Trains coaches and coaching leaders under Collective Change Institute Tempura One of the most commonly used coaching quotes was said by Bill Gates: “Everyone needs a coach.” But how did Bill end up a champion for coaching? There’s a lesser-known story that sets the stage for his brilliance he is known for today: When Bill Gates was in fourth grade, he was a nerdy introvert. He did his best to keep to himself.
A Coaching Culture Is No Longer A Choice, It's A Necessity
Photo: Getty Within two weeks of COVID-19 hitting Singapore in January, many companies began activating their business continuity programs and shifting teams into remote working pods. Employees found themselves working at home among family, with leaders missing physical exchanges with half or more of their teams for months. While we weren't hit with a sudden lockdown like other countries, we very quickly learned to expect new government measures every week.
Network analysis infers the wilt pathogen invasion associated with non-detrimental bacteria
Abstract The microbiota colonizing the root endophytic compartment and surrounding rhizosphere soils contribute to plant growth and health. However, the key members of plant soil and endophytic microbial communities involved in inhibiting or assisting pathogen invasion remain elusive.
How Much Of What Will China Buy? They’re Not Sure. - DTN
While the U.S. celebrated the signing of the first phase of the U.S.-China trade deal at the White House, Chinese commodity buyers are still confused about their role in how to make the deal happen. “I do not know how the government will manage to import the required agricultural products,” said China Agricultural University professor Jun Wang. “Chinese policymakers normally set a goal first, then they will try to figure out the way to solve the problem.
Chinese Grain Trade Waiting on Official Rules, Guidance on How to Implement Trade Deal
Chinese Grain Trade Waiting on Official Rules, Guidance on How to Implement Trade Deal 1/22/2020 | 8:51 AM CST Given the steep increases in agricultural imports under the first phase of the trade deal, Chinese trade experts say they are waiting for policymakers to explain how they'll make it happen.
Chinese Grain Trade Waiting on Official Rules, Guidance on How to Implement Trade Deal
Chinese Grain Trade Waiting on Official Rules, Guidance on How to Implement Trade Deal 1/27/2020 | 6:07 AM CST Given the steep increases in agricultural imports under the first phase of the trade deal, Chinese trade experts say they are waiting for policymakers to explain how they'll make it happen.
As US Trade Dispute Lingers, China Gives Argentina Soy Meal a Second Look
As US Trade Dispute Lingers, China Gives Argentina Soy Meal a Second Look 8/30/2019 | 1:31 PM CDT A ship on the Parana River near Rosario, Argentina, passes another ship at port. Argentina has built a large soy-crushing industry for exports and tax policy has encouraged crushing soybeans for meal or oil before export. China is now looking harder at importing more soymeal after years of resisting meal to satisfy its own domestic crush needs.
AFS Reduces Demand and Questions Remain About Buying US Beans
AFS Reduces Demand and Questions Remain About Buying US Beans 8/21/2019 | 11:38 AM CDT There are still a lot of questions about China soybean buys for the 2019-20 marketing year, but China will likely need fewer beans because of African Swine Fever. (DTN/Progressive Farmer file photo by Jim Patrico) BEIJING, China (DTN) — China is likely to finish the 2018-19 marketing year for soybeans importing less than official projections.
ASF Outbreak Shifts in China
By Lin Tan DTN China Correspondent BEIJING, China (DTN) — The impact of China’s African swine fever outbreak has grown, as the disease arrived in one of the country’s largest production areas while pork stockpiles are rapidly falling as well. The Ministry of Agriculture and Rural Affairs (MOA) announced on Tuesday that an African swine fever (ASF) case was found in Bobai County in South China’s Guangxi Province.
China: African Swine Fever Outbreak Worsens - DTN
Photo: United Soybean Board The impact of China’s African swine fever outbreak has grown, as the disease arrived in one of the country’s largest production areas while pork stockpiles are rapidly falling as well. The Ministry of Agriculture and Rural Affairs (MOA) announced on Tuesday that an African swine fever (ASF) case was found in Bobai County in South China’s Guangxi Province. It was just one hog infected within a small farm, but the location created immediate concerns for the industry.
ASF outbreak shifts in China
The impact of China’s African swine fever (ASF) outbreak has grown, as the disease arrived in one of the country’s largest production areas while pork stockpiles are rapidly falling as well. The Ministry of Agriculture and Rural Affairs (MOA) announced on May 28 that an ASF case was found in Bobai County in South China’s Guangxi Province. It was just one hog infected within a small farm, but the location created immediate concerns for the industry.
Signs of Pork Shortage Now Showing Up in Major Chinese Cities
Signs of Pork Shortage Now Showing Up in Major Chinese Cities 5/29/2019 | 11:38 AM CDT A meat stand in Harbin, China, the capital city of Heilongjiang Province in northeast China. After a glut of pork hit the China market earlier this year, China is starting to see shortages.
China’s Bout With African Swine Flu - Fewer Hogs, Lower Soy Prices - DTN
Photo: United Soybean Board China’s Ministry of Agriculture said last week that African swine fever (ASF) was tentatively under control. But the ag industry believes that the situation is much worse than what the government reported, and the impact of ASF on China’s hog industry may last for a long time. In a national video conference, Ministry of Agriculture Vice Secretary Kangzhen Yu declared tentative control of the virus.
Swine Fever Impact on China
By Lin Tan DTN China Correspondent BEIJING (DTN) — China’s Ministry of Agriculture said last week that African swine fever (ASF) was tentatively under control. But the ag industry believes that the situation is much worse than what the government reported, and the impact of ASF on China’s hog industry may last for a long time. In a national video conference, Ministry of Agriculture Vice Secretary Kangzhen Yu declared tentative control of the virus.
African Swine Fever Situation May be Worse Than Expected
African Swine Fever Situation May be Worse Than Expected 3/29/2019 | 4:30 PM CDT There are fewer sows, and therefore fewer piglets, available to build up stocks again after African swine fever led to declining numbers in China. (DTN photo by Lin Tan) BEIJING (DTN) -- China's Ministry of Agriculture said last week that African swine fever (ASF) was tentatively under control.
Duplex-specific nuclease-mediated target recycling amplification for fluorescence detection of microRNA
L. Tan, L. Xu, J. Liu, L. Tang, H. Tang and R. Yu, Anal. Methods, 2019, Advance Article , DOI: 10.1039/C8AY02265H If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.
China Rumored to Buy US Soybeans Soon, but Unclear When and How Much
According to China market rumors, the Chinese government had given permission to Sinograin, China's national strategic grain reserve company, to buy 3 million metric tons (mmt) of U.S. soybeans, and to COFCO, China's largest state-owned grain import and export company, to buy another 2 mmt. There are also rumors that the two companies are negotiating with some U.S. sellers on soybean basis. But private importers may not be able to get involved.
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