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Articles by Linlin Chen
Longitudinal associations of dynamic transitions of multidimensional health vulnerability with cardiovascular disease risk: evidence from UK Biobank
Abstract Background: Health vulnerability (HV), an intrinsic multidimensional construct integrating physiological, psychological, and social domains, may be associated with cardiovascular disease (CVD) risk. However, existing HV assessments lack integration and temporal dynamics change. This study identifies the dynamic association between the HV and risk of CVD.
Grape seed-derived procyanidin alleviates gliadin p31–43-induced intestinal epithelial stress associated with ATF4 and autophagy–iron homeostasis
Abstract Gluten-derived gliadin p31–43 is a digestion-resistant peptide implicated in intestinal epithelial stress, but its mechanism of intestinal epithelial injury remains unclear.
Systematic evaluation of MAIT and iNKT abundance as checkpoint blockade biomarkers
Abstract Introduction: MAIT and iNKT cells are unconventional T cell lineages that bridge innate and adaptive immunity and have been implicated in antitumor immune responses and immunotherapy outcomes. However, evidence to date has largely derived from individual studies of selected cancer types or specialized immune profiling cohorts.
Benchmarking publicly accessible large language models for English-language patient-facing acute pancreatitis information: a cross-sectional study of quality, transparency, and readability
Abstract Background: Patients increasingly rely on large language models (LLMs) for health information, yet their suitability for decision-critical conditions such as acute pancreatitis remains unclear. Given that acute pancreatitis requires timely symptom recognition, severity assessment, treatment decision-making, recurrence prevention, and follow-up management, LLM-generated information should demonstrate reliability, transparency, and readability.
Gasdermin D Inhibition Attenuates Mitochondrial Damage and Cardiomyocyte Pyroptosis in Heart Failure with Preserved Ejection Fraction
Abstract Heart failure with preserved ejection fraction (HFpEF) represents the most prevalent subtype of heart failure globally, with its underlying pathogenesis remaining incompletely elucidated. Pyroptosis and mitochondrial dysfunction have been implicated in HFpEF progression. In addition, gasdermin D (GSDMD) has been shown to mediate both mitochondrial dysfunction and pyroptosis, yet the specific regulatory mechanisms involved in HFpEF remain to be elucidated.
Overcoming the Compatibility Challenge With a Biomimetic Mandala Heterostructure for Cross-Spectrum Electromagnetic Wave Absorption and Efficient Electrothermal Deicing
J.Zhang, L.Chen, J.Cai, et al. “Overcoming the Compatibility Challenge With a Biomimetic Mandala Heterostructure for Cross-Spectrum Electromagnetic Wave Absorption and Efficient Electrothermal Deicing.” Small (2026): e73816. https://doi.org/10.1002/smll.73816 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
A Dual-Role Transcription Factor FpCys3 Couples Glucose Sensing to Methionine Biosynthesis and Virulence in Fusarium pseudograminearum
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. The data of this study are available from the corresponding author (L.C.) upon request. Supporting Information References , , , et al. 2022. “Commodity Risk Assessment of Ligustrum Delavayanum Topiary Plants Grafted on Ligustrum Japonicum From the UK.” EFSA Journal 20: e07399. , and . 2006.
Managed hydrological connectivity as an ecological attribute in the Yellow River Delta in China
Abstract Hydrological connectivity plays a critical role in ecosystem functioning, yet it is rarely treated as an explicit ecological variable in management. Here, we combine satellite-derived connectivity estimates with multi-season environmental DNA metabarcoding to develop an ecohydrological framework that reveals how connectivity, filtered through water quality conditions, shapes invertebrate diversity and stability.
Life stage-specific heterogeneity in the effects of adiposity transition on hypertension incidence and resolution
Abstract Whether the effects of excess adiposity on the onset and resolution of hypertension and its subtypes differ across different life stages remains unclear. We aimed to explore age-related heterogeneity in the associations of excess adiposity transition with hypertension development and resolution over the life course in Chinese population. This dynamic cohort study included 24,104 participants aged 3 to 80 years from the China Health and Nutrition Survey.
Mirror-enhanced 4Pi-SMLM with one objective enables isotropic nanoscale imaging
Abstract Dual-objective 4Pi single-molecule localization microscopy (4Pi-SMLM) offers isotropic nanoscale resolution; however, its broader adoption is limited by instrumental complexity and stringent alignment requirements. Here we introduce mirror-enhanced 4Pi-SMLM (me4Pi-SMLM), a single-objective configuration that uses mirror-based retroreflection of the illumination beam to generate phase-tunable interference fringes.
Optimising aircraft routing and fleet assignment with flight unit loops: a novel decision unit approach for reducing model complexity
Abstract Focusing on the optimisation of short-term aircraft routeing and fleet assignment, this study addresses the characteristic of airline operations typically being large-scale nonlinear programming problems. To reduce the model scale, the concepts of “flight unit string” and “flight unit loop” are introduced. Based on these concepts, an integrated optimisation model for aircraft routeing and fleet assignment prioritising flight unit loops is constructed.
4Pi-SIMFLUX: 4Pi single-molecule localization microscopy with structured illumination - Nature Methods
Abstract Single-molecule localization microscopy (SMLM) has transformed biological imaging by enabling nanoscale visualization of intricate subcellular structures. However, conventional three-dimensional SMLM techniques typically exhibit lower axial resolution than lateral resolution, hindering isotropic investigations.
Akkermansia muciniphila and its culture supernatant ameliorate colitis in interleukin-10 knockout mice via gut barrier and immune modulation
1 Introduction Interleukin-10 knockout (IL-10−/−) mice are a widely accepted model for studying the pathogenesis and treatment of inflammatory bowel disease (IBD), particularly Crohn’s disease (1–3). In the absence of the anti-inflammatory cytokine IL-10, these mice spontaneously develop chronic enterocolitis, typically between 7 and 15 weeks of age under specific pathogen-free (SPF) or conventional housing conditions (4–6).
Research on fault diagnosis of electric motor rolling bearings based on CMFSE-SVM
1. Introduction In the industrial field, electric motor equipment can be seen everywhere and is widely used. Rolling bearings, as the core components of electric motor equipment, play a crucial supporting role in the smooth operation of the equipment. Relevant statistics show that approximately 40 % of faults in rotating mechanical equipment are caused by rolling bearing failures [1, 2]. Such a high proportion indicates that the fault diagnosis of rolling bearings is extremely important.
The role of the North American continent in strengthening the Asian summer monsoon
Abstract Most studies on modern Asian monsoon formation focus on mechanisms arising within the Afro-Eurasian continent, while fewer compare the effects from remote continents. Here, we explore this question using a coupled climate model. We show that the existence of the North American continent is critical for the intensity of the Asian summer monsoon.
0D Zinc OIMHs with Pyridine Vapor‐Activated NIR Fluorescence Emission Behavior for Gas Sensing
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm71401-sup-0001-SuppMat.docx8.7 MB Supporting Information adfm71401-sup-0002-Data.zip1,001.8 KB Supporting Data References 1a) , , , , , , , , , , Sens. Actuators, B 2018, 254, 872; b) , , , , , , , , Sens. Actuators, B 2023, 377, 133104. 2a) , , , , , , , , I. A. f. R. o. C. M. W. Group, Lancet Oncol. 2017, 18, 1003; b) , , Dyes Pigm. 2016, 134, 198.
The Dyadic Relationship of Illness Uncertainty, Social Support, and Co
Back to Journals » Nature and Science of Sleep » Volume 17 Authors Niu Y , Shao Y, Chen L, Zhang X Received 6 August 2025 Accepted for publication 20 September 2025 Published 8 October 2025 Volume 2025:17 Pages 2501—2516 DOI https://doi.org/10.2147/NSS.S558190 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Prof.
The Effects of Low-Dose Esketamine Combined with Dexmedetomidine as an
Longyi Zhang,* Yunzi He,* Linlin Chen, Xianchun Liu, Ting Zhang, Xuelei Zhou, Wei Mao, Li Zhao, Linji Li, Ying Xie Department of Anesthesiology, Beijing Anzhen Nanchong Hospital (Nanchong Central Hospital), The Second Clinical Medical College, North Sichuan Medical College, Nanchong, People’s Republic of China *These authors contributed equally to this work Correspondence: Ying Xie, Department of Anesthesiology, Beijing Anzhen Nanchong Hospital (Nanchong Central Hospital), The...
Emerging Trends and Research Hotspots of Remote Ischemic Preconditioning in Cardiac Surgery: A Bibliometric Analysis
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Full article: Spatiotemporal Trends in the Prevalence of Obstructive Sleep Apnoea Across China: A Multilevel Meta-Analysis Incorporating Geographic and Demographic Stratification (2000-2024)
Abstract Purpose China bears the highest global burden of obstructive sleep apnea (OSA), yet its spatiotemporal and occupational patterns remain unclear. We quantified OSA prevalence across Chinese subpopulations, focusing on geographic disparities, temporal trends, and occupational risks. Methods Following PRISMA guidelines, we systematically searched six databases (2000–2024) for population-based OSA studies using polysomnography or validated portable monitoring.
Insights into the effects of phenolic acids on rice starch properties via noncovalent interactions
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description jfds70097-sup-0001-SuppMat.docx1.2 MB Appendix A. Supplementary data REFERENCES (2009). Structural transitions and related physical properties of starch. In Starch (Third Edition), Chapter 8 (pp. 293–372). Academic Press. https://doi.org/10.1016/B978-0-12-746275-2.00008-2 , , , & (2013). Properties of wheat starch film-forming dispersions and films as affected by chitosan addition.
Spatiotemporal trends in the prevalence of obstructive sleep apnoea ac
Introduction Obstructive sleep apnoea (OSA) is a significant chronic disorder characterized by upper airway obstruction during sleep. It presents as nocturnal apnoea and recurrent hypoventilation events.
The analysis of the overall failure of practical Zn−Ni battery
To meet the growing demand driven by the rapid development of electric vehicles and portable electronic devices, as well as the increasingly severe environmental and energy issues, there is an increasing need for high-performance, safe, and reliable advanced energy storage systems [1], [2], [3], [4]. Over the past few decades, advanced energy storage technologies have received widespread attention [5], [6], [7], [8].
A NH2-Cu-MOF for promising antibacterial application - Scientific Reports
Abstract A copper-based metal-organic framework named NH2-Cu-MOF has been synthesized and utilized as an effective broad-spectrum antimicrobial material in this article. The obtained NH2-Cu-MOF exhibits satisfying antibacterial activity against both gram-positive bacteria (S. aureus and S. epidermidis) and gram-negative bacteria (E. coli and K. peneumoniae).
EAT‐Lancet Diet Pattern, Genetic Predisposition, Inflammatory Biomarkers, and Risk of Lung Cancer Incidence and Mortality
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description mnfr4866-sup-0001-SuppMat.docx4.2 MB Supporting Information References 1, , , , , , , CA Cancer J. Clin. 2021, 71, 209. 2, , , , , , , , , , , , , , , , , , , , , , , , , , , , Lancet. 2019, 394, 1145. 3, , , , , , , , , , , , , , , , , , , , , , , , JAMA Oncol. 2020, 6, e194107. 4, , , , , , Iran J. Public Health 2019, 48, 1566. 5, , , , , , Mol. Nutr. Food Res. 2018, 62, e1700936.
Transcriptomic Insights into the Developmental Dynamics of Eimeria acervulina: A Comparative Study of a Precocious Line and the Wild Type
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Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Improving Computer Vision-Based Wildfire Smoke Detection by Combining SE-ResNet with SVM
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Tailoring Type III Porous Ionic Liquids for Enhanced Liquid‐Liquid Two‐Phase Catalysis
Preparation of Porous Ionic Liquids Preparation of ZIF-8 Confined HPMo Porous Frameworks: ZIF-8 confined HPMo porous frameworks, denoted as HPMo@ZIF-8, were synthesized via the following procedure: Zn(NO3)2·6H2O (0.7380 g) and 2-methylimidazole (1.6430 g) were individually weighed and dissolved in methanol (50 mL). The solutions were then mixed and stirred using a heating-controlled magnetic stirrer at 50 °C for 1 h.
Style-Enhanced Transformer for Image Captioning in Construction Scenes
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
LLFWCNN: A Light-Weighted Low Frequency Wave-Based Network for Hyperspectral Image Classification
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 3 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (08:03:38 CET) Chen, L.; Wei, Z.; Xu, Y.; Shuai, H. LLFWCNN: A Light-Weighted Low Frequency Wave-Based Network for Hyperspectral Image Classification. Preprints 2024, 2024020243. https://doi.org/10.20944/preprints202402.0243.v1 Chen, L.; Wei, Z.; Xu, Y.; Shuai, H.
Analysis of Rock Burst Mechanism in Extra-Thick Coal Seam Controlled by Thrust Fault under Mining Disturbance
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Empirical-Likelihood-Based Inference for Partially Linear Models
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Targeted Metabolomics Study on the Effect of Vinegar Processing on the Chemical Changes and Antioxidant Activity of Angelica sinensis
1. Introduction China stands as a pioneer in spice utilization, producing nearly 200 spice varieties [1,2]. These spices are essential in various culinary applications, from home cooking to food processing. Technological advancements have introduced diverse processing techniques like dehydration and both high and low-temperature processing [2,3].
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells
Background: Bladder cancer is one of the most common type of cancers globally, and the majority of cases belong to urothelial bladder carcinoma (UBC) type. Current researches have demonstrated that multiple genomic abnormalities are related to the sensitivity of cisplatin-based chemotherapy in bladder cancer patients. Previous findings have indicated a controversial role of Ubiquitin Carboxy-Terminal Hydrolase L1 (UCHL1) in malignancy, so we aimed to further explore the role of UCHL1 in UBC.
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells
Research Paper Volume 15, Issue 19 pp 10593—10606 1 Department of Pathology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China * Equal contribution https://doi.org/10.18632/aging.205097 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | Copyright: © 2023 Zheng et al.
Building Energy Saving for Indoor Cooling and Heating: Mechanism and Comparison on Temperature Difference
Abstract : Reducing the heat transfer temperature difference via reasonable indoor temperature determination and air conditioning system design is a confirmed building energy-saving approach for space cooling and heating. However, the energy-saving mechanism cannot be explained scientifically and comprehensively while maintaining the cognitive level of the heat transfer law.
Cell Wall Pectin Content Refers to Favored Delivery of Negatively Charged Carbon Dots in Leaf Cells
In this work, we systematically investigated how cell wall and cell wall components affect the delivery of charged carbon quantum dots (CDs, from −34 to +41 mV) to leaf cells of cucumber and Arabidopsis plants.
The Potential of Edible and Medicinal Resource Polysaccharides for Prevention and Treatment of Neurodegenerative Diseases
Abstract : As natural medicines in complementary and alternative medicine, edible and medicinal resources are being gradually recognized throughout the world. According to statistics from the World Health Organization, about 80% of the worldwide population has used edible and medicinal resource products to prevent and treat diseases.
Study on the Deformation Mechanisms of the Surrounding Rock and Its Supporting Technology for Large Section Whole Coal Cavern Groups
Abstract : The control difficulty of whole coal cavern groups is greatly increased due to the characteristics of soft rock with low strength, large sections, and the mutual influence of crossed cavern groups. The large section gas storage cavern group is taken as the research background.
CsAKT1 is a key gene for the CeO2 nanoparticle's improved cucumber salt tolerance: a validation from CRISPR-Cas9 lines
CsAKT1 is a key gene for the CeO2 nanoparticle's improved cucumber salt tolerance: a validation from CRISPR-Cas9 lines† Yuquan Peng,a Linlin Chen,b Lan Zhu,b Lvjun Cui,a Li Yang,a Honghong Wu *bcd and Zhilong Bie*a Abstract Salinity is one of the main factors limiting the crop growth and yield. The application of nanomaterials such as cerium oxide nanoparticles (nanoceria) improves salt tolerance in many plant species.
Interlinked Carbon Nanocages-Coated Separator as an Efficient Trap for Soluble Polysulfides in a Lithium-Sulfur Battery
The utilization of carbon-coating materials to inhibit the shuttle effect of the polysulfides is an important theme for lithium–sulfur (Li–S) batteries. However, the structure of carbon materials and the way that they are packed are important factors, because they determine the number and size of pores of future layers and, consequently, the permeability of ions. This work presents interlinked carbon nanocages (IL-CNCs) as the coating materials for the separators of Li–S batteries.
Engineering a Tandem Leaching System for Highly-Selective Recycling of Valuable Metals from Spent Li-ion Batteries
Engineering a Tandem Leaching System for Highly-Selective Recycling of Valuable Metals from Spent Li-ion Batteries Linlin Chen, Yanhong Chao, Xiaowei Li, Zhou Guolang, Qingqiang Lu, Ming-Qing Hua, Hongping Li, Xiaoguang Ni, Peiwen Wu and Wenshuai Zhu Abstract With the rapid development of lithium-ion batteries (LIB), selective recovery of lithium and other valuable metals from spent LIBs is in urgent need because of the shortage of Li and valuable metals along with the toxicity of the...
Hitchhiking Behavior in Bacteriophages Facilitates Phage Infection and Enhances Carrier Bacteria Colonization
Interactions between bacteriophages (phages) and biofilms remain poorly understood despite the broad implications for microbial ecology, water quality, and microbiome engineering. Here, we demonstrate that lytic coliphage PHH01 can hitchhike on carrier bacteria Bacillus cereus to facilitate its infection of host bacteria, Escherichia coli, in biofilms. Specifically, PHH01 could adsorb onto the flagella of B.
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses
Under a Creative Commons license open access Highlights • NSP16 binds mRNA recognition domains of U1/U2 snRNAs and disrupts mRNA splicing • NSP1 binds in the mRNA entry channel of the ribosome to disrupt protein translation • NSP8 and NSP9 bind the signal recognition particle and disrupt protein trafficking • These disruptions of protein production suppress the interferon response to infection Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified...
Rapid 129Xe–Rb spin-exchange rate measurement by using an atomic magnetometer
Abstract We propose a fast and accurate method for $^ {129} {\rm Xe}{-}{\rm Rb}$ spin-exchange rate determination based on an atomic magnetometer at low magnetic field and low pressure. The $^ {129} {\rm Xe}{-}{\rm Rb}$ spin-exchange rate can be estimated via the product of the maximum transverse spin polarization of $^ {129} {\rm Xe}$ nuclei and the corresponding Rabi frequency.
Recording the age of RNA with deamination
Recording the age of RNA with deamination Samuel G Rodriques, Linlin M Chen, Sophia Liu, Ellen D Zhong, Joseph R Scherrer, Edward S Boyden, Fei Chen bioRxiv 2020.02.08.939983; doi: https://doi.org/10.1101/2020.02.08.939983
Reply to the ‘Comment on “Synthesis and properties of a high dielectric constant copolymer of a copper phthalocyanine oligomer grafted to amino-capped polyimide”’ by G. Mezei, Journal of Materials Chemistry C, 2019, 7, DOI: 10.1039/C8TC04076A
Reply to the ‘Comment on “Synthesis and properties of a high dielectric constant copolymer of a copper phthalocyanine oligomer grafted to amino-capped polyimide”’ by G. Mezei, Journal of Materials Chemistry C, 2019, 7, DOI: 10.1039/C8TC04076A You have access to this article Please wait while we load your content... Something went wrong. Try again?
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