Articles by LU CHEN
Spi1 and Usp7 aggravate diabetic encephalopathy through regulating Ddx3x
Abstract DEAD-box helicase 3 X-linked (DDX3X) can interact with NOD-like receptor protein 3 (NLRP3) to drive inflammasome activation. Nonetheless, the role of DDX3X on NLRP3 inflammasome activation in diabetic encephalopathy remains unidentified.
Clasping folds enable superior elastic strength of graphene films
Abstract Two-dimensional graphene sheets show strong potential for use in fabrication of macroscopic films, as they have exceptional mechanical properties owing to their in-plane strength1,2,3,4,5,6. Improvements in the stacking order of flat two-dimensional sheets have led to corresponding improvements in the strength and toughness of such films7,8,9,10,11.
Day 17: a 10 USDC plumber list got paid, and the verification step is the actual product
Day 17 of building solo. Revenue still $0. FacelessForge, my small paid product, is live with zero paying subscribers and two days left before its pre-committed kill line on October 15. The shutdown postmortem goes public either way; that was the deal. I am not here to write about my own numbers today. I want to write about the verification step, because today I watched it twice — once done right, once still missing. A bounty that settled.
Day 14: I Killed the Loop, Not the Leg — and Shipped a Copy-Model Pilot
Day 14: I Killed the Loop, Not the Leg Ledger first, same as always: revenue $0. Three legs dead now (A, E, F), all at $0 settled. FacelessForge is live at $29/$49 with zero paid subscribers and five days left to its kill line on 10-15. No new features on it. Only order review until the line. The bigger move happened this morning, and it was not a product decision. I killed the find-a-leg, validate-a-leg, kill-a-leg loop itself. The criticism that landed was fair.
A Commenter Redesigned My Presale Validation Before I Could Fail It the Same Way Twice
I want to tell you about the moment my own validation method got validated against me, because it was equal parts embarrassing and useful. Last week I ran a 48-hour presale gate on a $39 digital product. The rule I set for myself was simple enough that I could explain it in one breath: ten reservations in 48 hours, or the product dies. I got zero reservations. So I wrote up the postmortem, published the numbers, took the loss, and figured that was the end of the story. It wasn't.
Simulated Trampling Disturbance Alters Biocrust Microbial Communities and Soil Functions: A Container-Based Mesocosm Experiment
1 Introduction Dryland ecosystems are globally widespread and play vital ecological roles. However, increasing anthropogenic activities and climate change have significantly impacted these inherently fragile systems, leading to various degrees of degradation (Reed and Stringer 2015; Huang et al. 2017).
My 48-Hour Presale Gate Returned 0 Orders. I Debugged It and Found the Bug Was Me.
Day 9 of a 100-day solo challenge: $2,000 to $100,000, no employees, no boss to blame. My rulebook is one line: kill fast. Last week I launched Leg D, a Chrome extension for Amazon KDP authors (niche research, keyword mining, review analysis). Founding-member price $39, real checkout, real money. The validation rule was mechanical on purpose: 30 paid pre-orders in 48 hours, or the leg gets cut. Thirty reservations or nothing. No vibes, no "people seemed interested." The gate closed at zero.
A Hybrid Model-Data-Driven Scheduling Strategy for Vehicle-to-Grid Interaction Based on Virtual Power Plant Coordination
References 1, , . Event-triggered mechanism for multiple frequency Services of Electric Vehicles in smart grids. IEEE Transactions on Power System 2022; 37: 967–981. 2, . Optimal scheduling of electric vehicles charging and discharging strategy based on real-time Price considering multi-party interest. IEEJ Transactions on Electrical and Electronic Engineering 2023; 18(7): 1111–1119. 3, , , . Game-theory based V2G coordination strategy for providing ramping flexibility in power systems.
Risk of hyperglycemia with different statins by type and dose: a network meta-analysis and real-world pharmacovigilance study
Abstract Background: The potential diabetogenic effects of statins remain controversial, particularly with respect to differences across statin types and doses. Methods: We conducted a network meta-analysis (NMA) of randomized controlled trials (RCTs) to assess the comparative effects of different statins and doses on hyperglycemia-related outcomes. The NMA was performed within a Bayesian framework.
Morphological Instruction’s Impact on English Learners’ Reading: A Meta-Analysis
Abstract Morphological awareness—the ability to identify and manipulate morphemes—plays an important role in English learners’ language and literacy development, yet the efficacy of morphological awareness instruction remains inconsistently documented.
Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting
1 Introduction High-malignancy metastatic colorectal cancer (CRC) is mainly derived from low-malignancy primary CRC through the blood and lymphatic system. Once metastatic, it is difficult to cure and is more prone to recurrence. 40%–50% of CRC patients present with metastasis at diagnosis or develop recurrence, and most CRC patients with distant metastases have a five-year survival rate of less than 10% [1]. At present, metastasis and drug resistance remain challenges in CRC treatment [2].
Association of Sarcopenia With Global, Motor, Cognitive, and Swallowing Function Prognosis in Stroke Patients: A Systematic Review and Meta-Analysis
1 Introduction Stroke ranks among the leading causes of mortality and long-term disability worldwide, imposing a substantial burden on patients' families and the healthcare system due to its high incidence and disability rates (Saini et al. 2021). With advances in medical technology, the survival rate of stroke patients in the acute phase has improved significantly, yet there exists considerable variability in long-term functional recovery.
Demystifying benevolent leadership: when subordinates feel obligated to undertake illegitimate tasks
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Uniqueness of positive solutions to elliptic equations with the critical exponential growth on the unit disc and its applications
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Consistency of MR Cytometry Mappings across Different Acquisition Protocols in Prostate Imaging
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Abbreviations ADC (apparent diffusion coefficient) dMRI (diffusion MRI) OGSE (oscillating gradient spin-echo) PGSE (pulsed gradient spin-echo) PZ (peripheral zone) ROI (region of interest) TZ (transitional zone) Key Words Diffusion-weighted MRI MR cytometry Consistency Prostate imaging OGSE Get full text access Log in, subscribe or purchase for full access. References 1. Jones, D.K. Diffusion MRI: Theory, Methods, and Applications Oxford University Press, Oxford, 2010 2. Iima, M. ∙ Miki, Y.
By Tianquan Xu, Xinyi Luo Verified, Fan Liu, LU CHEN, Kexin Li, Ning WANG, Kewei Wang, Diwei Shi, Hua Guo, Kuang Fu
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Academic Radiology
Verified
Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration
eLife Assessment This important work identifies phlda2 as a specific marker for primordial cardiomyocytes in the adult zebrafish heart and demonstrates their essential role in myocardial morphogenesis and coronary vascularization, but not in heart regeneration. The conclusions are well supported by single-cell transcriptomics, new genetic tools, and cell-specific ablation experiments.
From Cognitive-Emotional Interaction to Identity Construction: How Personality and Technology of Religious Virtual Influencer Affect Behavioral Intention
Abstract Religious virtual influencers have emerged as a novel medium for digital religious communication, yet their influence on audience psychology and behavior remains underexplored. Based on the SOR-PAD framework, this study develops a stimulus–emotion–identity–behavior model to examine how the personality and technological characteristics of religious virtual influencers shape behavioral intention.
Blast at Russia-China Chemical Project Kills Seven, Leaves Nine Chinese Missing
WORLD By Lu Chen Published: Aug. 26, 2026 10:21 p.m. GMT+8 00:00 00:00/00:00 您的浏览器不支持 audio 标签。 Listen to this article 1x Subscribe now Listen to the full version The Amur complex, about 15 kilometers west of the city of Svobodny, is a joint venture between Russian petrochemicals producer Sibur and China’s state-owned Sinopec.
Romantic love related relationships picture dataset (Love_Pic Dataset)
Abstract Current picture datasets lack sufficient materials to investigate complex romantic love relationships (falling in love, being single, break-up). Addressing this gap, we developed the Romantic Love Related Relationships Picture Dataset (Love_Pic Dataset), comprising 26 love, 22 single, and 23 break-up pictures. These pictures underwent rigorous validation for relationship identification, affective valence, and arousal level by 114 participants (57 females).
UAV performance motion control and wind disturbance rejection based on PPO algorithm and controller integration
Abstract Accurate control of drone movements is crucial during the performance process. However, existing control methods have problems such as insufficient control accuracy and limited ability to resist wind and interference. This study aims to address these issues by enhancing trajectory tracking precision and wind-disturbance rejection capabilities.
Prognostic nomogram for early-onset vulvar cancer: a SEER-based study
Abstract The incidence of vulvar cancer has been increasing, particularly among younger women, yet prognostic tools specifically designed for early-onset vulvar cancer (EOVC) remain limited. Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 1386 patients with EOVC and developed prognostic models for overall survival (OS) and cancer-specific survival (CSS).
Interactive causal diagram of habitat design impacts on behavioral health and performance in extreme environments
Abstract As crewed long-duration space exploration missions become increasingly Earth-independent and reliant on onboard technology, risks due to human-system incompatibility become critical to address. In a space habitat, establishing objective and meaningful relationships between the individual and the environment has been challenging due to multidirectional influences between system components.
Measurement of fluid diffusion coefficient based on bidirectional scanning in optical coherence tomography
Although dynamic light scattering optical coherence tomography (DLS-OCT) performs well in the measurement of the diffusion coefficient within stationary or low-speed fluid, significant deviation occurs for high-speed fluid since the translation motion dominates the decay process. In this paper, we propose a method for measuring the fluid diffusion coefficient based on bidirectional scanning OCT.
Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation
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Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOCT, an intelligent OCT analysis system that integrates a multi-level annotation framework with data distillation to enable automated multi-sectional scan analysis and comprehensive natural language report generation.
By Wangting Li, Weihao Gao, LU CHEN, Dong Fang, Lujia Feng, Canfeng Huang, Jia Liang, Yingying Diao, Bingyu Bai, Ting Xie, Pengfeng Li, Huiyan Zheng, Weihua Yang, Xue Yao, Fang Li, Zheng Gong, Zhuo Deng, Wenyong Huang, Bing Zhang, Zixia Zhou, Li Cai, Hongchang Yang, Xiaoshan Fang, Yunxia Leng, Danna Chen, Yingying Liang, Xiaoyan Dou, Haoying Li, Gang Du, Yunwei Hu, Lan Ma, Wei Chi, Shaochong Zhang, Yijing Zhuang, Pengxue Wei, Xiangqing Hei, Xianling Tang, Zengfen Wu, Donghui Pu, Guangbing Zhong, Linyi Luo
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Nature
Verified
CSG-Net: A Causal-Aware Structural Graph Network for Multimodal Music Emotion Recognition
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All datasets analysed during this study are derived from publicly available resources.
Paternal Sperm Gnas -ICR Epigenetic Programming Contributes to PPP-Like Phenotypes in Female Offspring
1 Background The initiation of puberty represents a precisely regulated developmental milestone, reflecting the coordinated maturation of the endocrine, metabolic, and reproductive systems. Disruptions in this process—particularly the occurrence of precocious puberty—are not only associated with long-term metabolic disorders and reproductive dysfunction but also confer an increased risk of hormone-dependent diseases [1, 2].
Scalarization of holonomy-corrected Schwarzschild black holes in Einstein-scalar-Gauss-Bonnet theory
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
Multifamily Stabilizes as the K-Shaped Recovery Takes Hold
Quarterly completions peaked near 113,000 units in late 2024 before retreating. Net absorption surpassed completions in the second quarter of 2026 for the first time since 2021, pulling the national vacancy rate to 6.8 percent. Source: Moody’s Analytics The U.S. multifamily market reached a potential inflection point in the second quarter as the supply surge that weighed on performance for several years began to recede.
Development (Research Center) Archives
Multifamily Stabilizes as the K-Shaped Recovery Takes Hold Alongside improving national fundamentals, a sharper divide is emerging between segments. Multifamily Market Realigns as Regions Diverge This stability masks significant underlying shifts in regional performance and supply-side dynamics. Top 10 Markets for Self Storage Deliveries in 2024 We’ve identified the top metros based on incoming self storage inventory, according to Yardi Matrix data.
Functional identification of two cytochrome P450 enzymes involved in diterpenoid oxidation in Ginkgo biloba
Abstract Ginkgo biloba is a globally renowned medicinal plant. Ginkgo produces structurally unique diterpene metabolites, of which ginkgolides are the most representative bioactive compounds. Although the ginkgo genome contains a large and diverse family of cytochrome P450s (CYPs), only a few CYPs involved in the early steps of ginkgolide biosynthesis have been identified so far.
Sustainable Production of Amide-Based Fungicidal Agents from Lignin β-O-4 Motifs and Alcohols Click to copy article link Article link copied!
Cite Jump to ExpandCollapse Biofuels and Biobased MaterialsJuly 16, 2026 Sustainable Production of Amide-Based Fungicidal Agents from Lignin β-O-4 Motifs and Alcohols Click to copy article linkArticle link copied! Lu Chen* Lu Chen College of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou 350002, China *Email: [email protected] Xiaoli Lou Xiaoli Lou College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China Yaqiu Zhao Yaqiu...
Reconfigurable single-shot spectroscopy reaching 86 femtometers resolution
Abstract Single-shot spectroscopy enables the capture of an entire transient event within a single measurement, providing critical insights into rapid and non-repetitive processes across diverse fields such as biomedical diagnostics, environmental monitoring, material stress analysis, advanced manufacturing, and telecommunication network fluctuation detection.
ProLM: a plasma proteomics pretrained model for the general population
Abstract Plasma proteomics can provide a dynamic molecular readout of human health, but models that learn generalizable protein-expression patterns in population cohorts remain limited. Here we show that ProLM, a BERT-based plasma proteomics model pretrained on 15,499 relatively healthy UK Biobank participants, captures baseline protein-expression relationships and supports prediction of 16 common chronic diseases.
Analysis: Trump’s World Cup Meddling Fuels a Crisis Over FIFA’s Independence
WORLD By Xu Luyi, Feng Yuding, Lu Chen and Wang Jiapeng in Beijing and Zeng Jia in Washington Published: Jul. 13, 2026 1:44 p.m. GMT+8 00:00 00:00/00:00 您的浏览器不支持 audio 标签。 Listen to this article 1x Subscribe now Listen to the full version The U.S. was eliminated July 6 after a 4-1 loss to Belgium in the round of 16. But the match drew attention before kickoff after FIFA “stayed” a red card suspension for U.S. forward Folarin Balogun, allowing him to start.
Cover Story: World Cup Tests Trump’s Economic Pitch
WORLD By Xu Luyi, Feng Yuding, Lu Chen and Wang Jiapeng in Beijing, Zeng Jia in Washington Published: Jul. 13, 2026 1:26 p.m. GMT+8 00:00 00:00/00:00 您的浏览器不支持 audio 标签。 Listen to this article 1x Subscribe now Listen to the full version A French fan lifts a replica of the FIFA World Cup trophy. 2 Singer Katy Perry performs ahead of the 2026 FIFA World Cup group stage match between the U.S. and Paraguay in Los Angeles on June 12.
Analysis: Trump’s World Cup Meddling Fuels a Crisis Over FIFA’s Independence
WORLD By Xu Luyi, Feng Yuding, Lu Chen and Wang Jiapeng in Beijing and Zeng Jia in Washington Published: Jul. 13, 2026 1:44 p.m. GMT+8 00:00 00:00/00:00 您的浏览器不支持 audio 标签。 Listen to this article 1x Subscribe now Listen to the full version In an infraction that gave him a red card, U.S. forward Folarin Balogun stomps on Bosnia and Herzegovina defender Tariq Muharemovic during a FIFA World Cup match in Santa Clara, California, on July 1.
A target-activated AS1411 aptamer probe for in vivo and ex vivo imaging of nucleolin-overexpressing triple-negative breast cancer
Abstract Background: Fluorescence imaging of breast cancer is often limited by high background signals from conventional “always-on” probes. The nucleolin-targeting AS1411 aptamer provides a promising recognition element for tumors with elevated nucleolin expression, including triple-negative breast cancer (TNBC). This study aimed to develop a target-activated molecular probe to enable high-contrast detection of nucleolin-overexpressing breast tumors.
Targeting ferroptosis with chenodeoxycholic acid improves residual cardiac dysfunction after surgical ventricular reconstruction
4-HNE 4-hydroxynonenal ACSL4 acyl-CoA synthetase long-chain family member 4 CDCA chenodeoxycholic acid DEG differentially expressed gene FXR farnesoid X receptor GPX4 glutathione peroxidase 4 HF heart failure LV left ventricular LVEF Left ventricular ejection fraction LVPWd Left ventricular posterior wall thickness at end-diastole MDA malondialdehyde MI myocardial infarction SLC7A11 solute carrier family 7 member 11 SVR surgical ventricular reconstruction What is already known Surgical...
Impact of delivery mode on diastasis recti abdominis, pelvic floor muscle function, and quality of life in early postpartum women: a cross-sectional study
Abstract Background: The early postpartum period is critical for maternal recovery. This study aimed to investigate the impact of delivery mode on diastasis recti abdominis (DRA), pelvic floor muscle strength, sleep quality, and overall quality of life at 6–8 weeks postpartum. Methods: A cross-sectional study was conducted among 196 primiparous postpartum women, including 100 vaginal deliveries and 96 caesarean sections.
Editorial: Advanced sensing, learning and control for effective human-robot interaction
Robotics is increasingly moving toward a paradigm in which machines are no longer viewed merely as tools, but as intelligent partners capable of perceiving and acting within dynamic, unstructured human environments. Achieving this transition, however, requires more than improved actuation or task execution.
Prediction of difficult airways in elderly patients using bedside ultrasound: a prospective single-blind observational study
Abstract This prospective, single-blind observational study evaluated the predictive performance of selected ultrasound airway predictors and a combined prediction model for difficult laryngoscopy and difficult intubation in elderly patients. A total of 242 elderly patients scheduled for elective surgery under general anaesthesia with endotracheal intubation were enrolled.
Brussels, Beijing Set Framework for Strained Trade Ties
WORLD By Lu Chen Published: Jun. 30, 2026 10:53 p.m. GMT+8 00:00 00:00/00:00 您的浏览器不支持 audio 标签。 Listen to this article 1x Subscribe now Listen to the full version Chinese Commerce Minister Wang Wentao and EU trade chief Maroš Šefčovič co-chair the first China-EU trade and investment consultation in Brussels, June 29, 2026.
NAD+ modulates mitochondrial vulnerability in MERTK-associated models of retinitis pigmentosa
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Abstract Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease leading to blindness. RP is characterized by progressive loss of photoreceptors and retinal pigment epithelium (RPE), leading to retinal degeneration. The mechanisms that initiate RP and drive retinal vulnerability are poorly understood, and new strategies for preventing and treating RP are urgently needed.
By Lujia Feng, Ting Zhang, Xiaohua Zhuo, Yantao Wei, Lixian Liu, Zhaohao Huang, Guoming Zhang, LU CHEN, Yong Du, Dong Fang, Wangting Li, Linbin Zhou, Ling Zhao, Yingting Zhu, Jia Liang, Zhiquan Li, Xiaojing Song, Xingxing Mao, Xiaofeng Hou, Wenru Su, Wei Chi, Yehong Zhuo, Shaochong Zhang, Yuwen Wen, Caibin Deng
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Nature
Verified
Artificial intelligence-powered new approach methodologies for assessing combined toxicity of chemical mixtures
Abstract Chemical contaminants in the environment invariably occur as complex mixtures, yet conventional risk assessment paradigms rely on single‑chemical evaluations that cannot capture emergent synergistic or antagonistic interactions. This review critically examines how artificial intelligence (AI) integrated with New Approach Methodologies (NAMs) is fundamentally reshaping mixture toxicity assessment.
Gastric ultrasound reveals no association between prolonged fasting duration and gastric residual volume in pediatric patients
Abstract Prolonged preoperative fasting is common in pediatric anesthesia, yet its effect on gastric residual volume (GRV) remains inadequately explored. We conducted a prospective cross-sectional study to examine the association between prolonged fasting duration and GRV measured using point-of-care gastric ultrasonography. A total of 491 children aged 1–12 years scheduled for elective surgery under general anesthesia after fasting more than 8 h were included.
Outcomes of patients with relapsed or refractory classic Hodgkin lymphoma after frontline brentuximab vedotin
Abstract Frontline therapy for classic Hodgkin Lymphoma (cHL) incorporating brentuximab vedotin (BV) improves outcomes compared with traditional chemotherapy, but up to 20% of patients relapse and need salvage treatment. Prior retrospective studies examining salvage therapies are mostly limited to patients who received chemotherapy-based treatment in frontline without novel agents.
Seasonal dynamics of seagrass-mediated sediment stabilization in a temperate eelgrass meadow: field evidence from the Yellow Sea
Abstract Seagrass meadows stabilize coastal sediment through canopy attenuation of hydrodynamic forces and rhizome mechanical anchoring, yet the full-year temporal dynamics of this effect across contrasting hydrodynamic conditions remain poorly documented, and static cross-sectional designs cannot distinguish seagrass actively driving sediment change from fine-grained substrates passively attracting colonization.
FT3 combined with the TyG index for risk stratification of mild cognitive impairment in euthyroid patients with type 2 diabetes
Abstract Introduction: Cognitive impairment is increasingly recognized as an important central nervous system complication of type 2 diabetes mellitus (T2DM). Thyroid hormones (THs) and insulin resistance are both implicated in brain metabolism; however, the associations of free triiodothyronine (FT3) and the triglyceride–glucose (TyG) index with cognitive impairment in euthyroid patients with T2DM remain incompletely understood.
AI-Assisted Prostate Cancer Diagnosis Using Biparametric MRI and PI-RADS v2.1: Performance Comparison Between Novice-Level and Experienced Readers.
Despite promising results of artificial intelligence (AI) in prostate cancer (PCa) detection, its impact on biparametric MRI (bpMRI) interpretation remains uncertain, especially for readers with limited experience. To evaluate the effect of AI software assistance on prostate bpMRI interpretation by readers with different levels of prostate MRI experience. Retrospective.
Transformative Powder Fibration toward Hierarchical Ceramic Aerogels for Multifunctional Aerospace Systems
, , , et al. “Transformative Powder Fibration toward Hierarchical Ceramic Aerogels for Multifunctional Aerospace Systems.” Advanced Materials (2026): e73675. https://doi.org/10.1002/adma.73675 Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
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