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Articles by Qi Su
Gut microbiome of children with Autism Spectrum Disorder associates with clinical severity
Abstract Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition. Although the gut microbiome has been implicated in ASD, prior studies have insufficiently addressed clinical heterogeneity. Here, we perform shotgun metagenomic sequencing on stool samples from 720 children with ASD (median age 8 years, 87% male) and 151 matched controls.
Structure-coefficient theorem for evolutionary games on dynamic networks
Abstract Evolution unfolds in populations of reproducing individuals, with the dynamics shaped by numerous factors, including population structure, update rules, mutation rates, traits (‘strategies’) and the reproductive success derived from traits (‘payoffs’). Developing a unifying principle to predict which traits will evolve and when, remains a major challenge.
Explaining human cooperation through a dual mechanism of individual and social learning
Abstract Cooperation on social networks is crucial for understanding human survival and development. Human experiments have revealed that individual decision-making substantially influences whether network structure promotes cooperation, but how humans adjust behavior in game interactions remains unclear, especially for payoff-modulated non-imitative adjustments.
Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression
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Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer characterized by profound desmoplasia and cellular heterogeneity, which cannot be fully resolved using traditional bulk sequencing approaches.
By Despoina Kalfakakou, Daniel Cameron, Emily A. Kawaler, Motoyuki Tsuda, Lidong Wang, Qi Su, Sungsik Kim, Xiaohong Jing, Cristina H Hajdu, Amanda Ackermann, Matthew Beier, Dacia Dimartino, Shanmugapriya Selvaraj, Cynthia Loomis, Adriana Heguy, Amanda Lund, Hannah Carter, Rosalie C. Sears, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane Simeone, Elektra Manolakos, Dylan L. Tamayo, Yoona Shim, Daniel Weissinger, Hayley Zimny, Rosmel Hernandez, Peter Meyn, Kalina Rice
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Nature
Verified
Modulating the Gut–Ovarian Axis: Mechanistic Rationale and the Limits of Current Evidence for Probiotics in Female Reproductive Aging
The ovary is central to female reproductive and endocrine health throughout the lifespan. Beyond its essential roles in follicular development, ovulation, and steroidogenesis, the age-related loss of ovarian function is accompanied by progressive depletion of the follicular reserve, deterioration of oocyte quality, and endocrine decline, with consequences extending beyond fertility to broader aspects of women's health (Ahlborg et al. 2001; Galatidou et al. 2024; Hansen et al. 2008; Smits et al.
Noise-Induced Replicator Dynamics in Evolutionary Games
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Author Correction: Cooperation conflicts with equality when allocating public goods
Correction to: Nature https://doi.org/10.1038/s41586-026-10550-3 Published online 3 June 2026 In the version of this article initially published, there were typographical errors in the Fig. 3b,e and Fig. 3c,f colour bar y-axis labels. The labels that now read “Gu − Ge” and “Wu − We”, respectively, appeared originally as “Ge − Gu” and “We – Wu”. The figure is now amended in the HTML and PDF versions of the article. About this article Sheng, A., Su, Q., McAvoy, A. et al.
Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system
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The original Figure 1 in this paper included a world map featuring national boundary lines that were not germane to the subject of the figure. In response to recent reader concerns about some of these boundary lines, we have corrected Figure 1 in the original article so that it includes the relevant scientific data without the distraction of national boundary lines. The authors apologize for any confusion.
By Nian-Feng Wan, Siyuan Shen, Muyao Li, Yan Chen, Fei-Yi Pan, Xin Chen, Ben A. Woodcock, Yue-Qing Hu, Andy Hector, Michel Loreau, Bernhard Schmid, Nico Eisenhauer, David Crowder, Jacob Weiner, Carlos Martínez-Núñez, Teja Tscharntke, Qiming Li, Shiyun Qiu, Shengming Sun, Yingjuan Yao, Qi Su, Jun-Xiang Zhou, Yu-Tong Zhu, Tong-Li Jiang, Jie Liu, Jian-Jun Tang
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Cell Press
Verified
BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine
Abstract BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8+ T cell-dependent protection.
Fine-tuned multimodal large language model for autonomous state cognition system of shape-recognition 6-bar tensegrity integrated with flexible sensors
Abstract Conducting dynamic exploration in complex and unpredictable environments, particularly in space exploration, reveals the great potential of systems based on tensegrity structures. However, the implementation of such systems faces a series of intelligent challenges, including the reliability of wireless monitoring, the efficiency of human-computer interaction, and the optimization of intelligent analysis and recommendation capabilities.
Cooperation conflicts with equality when allocating public goods
Abstract Cooperation is typically seen as the ideal outcome in a social dilemma. Because cooperators are vulnerable to exploitation, much of the literature has focused on mechanisms, such as spatial structure, that support prosocial behaviour and the production of public goods1,2,3,4,5,6,7,8,9,10,11. Yet the rules for distributing these goods also shape behaviour and long-term prosperity.
389 PROBIOTIC RESHAPES GUT MICROBIOME AND REDUCES HISTAMINE BURDEN IN LONG COVID PATIENTS
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Su1290 GUT MICROBIOME-MEDIATED HOST EPIGENETIC REGULATION INFLUENCES INFANTS’ NEURODEVELOPMENTAL OUTCOMES
Also available on ScienceDirect
Artificial intelligence-driven donor-recipient gut microbiome matching for optimized fecal microbiota transplantation
Keywords fecal microbiota transplantation artificial intelligence MOZAIC Research topic(s) CP: microbiology Introduction Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridioides difficile infections (CDIs) and is increasingly explored as a potential therapeutic intervention for various gastrointestinal and metabolic disorders.1,2,3 By restoring gut microbial diversity and metabolic function, FMT can help counteract dysbiosis-associated pathologies, thereby...
Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system
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Keywords agricultural sustainability path analysis rice-fish coculture top-down control trophic cascades Get full text access Log in, subscribe or purchase for full access. References 1. Loreau, M. ∙ Hector, A. Partitioning selection and complementarity in biodiversity experiments Nature. 2001; 412:72-76 2. Tilman, D. ∙ Reich, P.B. ∙ Knops, J.M.H. Biodiversity and ecosystem stability in a decade-long grassland experiment Nature. 2006; 441:629-632 3. Isbell, F. ∙ Calcagno, V. ∙ Hector, A. ...
By Nian-Feng Wan, Siyuan Shen, Muyao Li, Yan Chen, Fei-Yi Pan, Xin Chen, Ben A. Woodcock, Yue-Qing Hu, Andy Hector, Michel Loreau, Bernhard Schmid, Nico Eisenhauer, David Crowder, Jacob Weiner, Carlos Martínez-Núñez, Teja Tscharntke, Qiming Li, Shiyun Qiu, Shengming Sun, Yingjuan Yao, Qi Su, Jun-Xiang Zhou, Yu-Tong Zhu, Tong-Li Jiang, Jie Liu, Jian-Jun Tang
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Cell Press
Verified
Epigenome-microbiome interplay in early life associates with infants’ neurodevelopmental outcomes
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Keywords birth cohort microbiome DNA methylome vertical transmission neurodevelopment ASD ADHD Caesarean section DOHaD multi-omics Introduction The prenatal and early postnatal periods are critical periods for immune development orchestrated by an intricate interplay between host and environmental factors.1,2,3 Recent data suggest that epigenetic programming of gene expression profiles is sensitive to the early-life environment and can impact health outcomes in children.4,5,6 Unlike the human...
By Siew Chien Ng, Ye Peng, Lin Zhang, Shilin Zhao, Oscar Wong, Xin A. Liu, Hang Li, Jie Zhu, Yingzhi Liu, Qi Su, Tak Yeung Leung, Sandra S. M. Chan, Patrick Leung, Jessica Ching, Xi Zhang, Xueqi Wu, Yuzhou Chen, Shuai Yan, Whitney Tang, Ting Fan Leung, Hein Min Tun, Pui-Kuan Cheong, Long Ip, Chun Pun Cheung
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Cell Press
Verified
Study protocol for a pragmatic randomized controlled trial evaluating coarse-cereal intake intervention for obesity prevention among primary school students in suburban Beijing, China
Abstract Background: The rising prevalence of childhood obesity poses a significant public health challenge in China, with rates among primary school students increasing from 6.8% in 2002 to 19% in 2020. Concurrently, coarse-cereal intake—a source of dietary fiber and bioactive compounds with potential protective effects against obesity—has declined markedly. School-based interventions represent a feasible strategy to address this issue.
Gut microbiome composition and strain-sharing in multiplex autism spectrum disorder families - Nature Communications
Abstract Autism spectrum disorder (ASD) is associated with alteration of gut microbiome, but the influence of familial structure on it remains poorly understood. We investigate gut microbiota across 429 children from multiplex families with multiple affected children, simplex families with one affected child, and single-child ASD families, alongside typically developing controls. We found that children from multiplex families exhibit the most distinct microbiome compositions.
M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass
ArticleOnline now102812Open access Affiliations & Notes 1Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA 2Regeneron Genetics Center, Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA Article Info Publication History: Received August 4, 2025; Revised January 12, 2026; Accepted January 13, 2026; Published online February 12, 2026 DOI: 10.1016/j.stemcr.2026.102812 External LinkAlso available on ScienceDirect External Link Copyright: © 2026 The Author(s). Published by Elsevier Inc.
Genetic diversity and population structure of three Schizothorax curvilabiatus populations in the Yarlung Zangbo River based on mitochondrial genes
ORIGINAL RESEARCH article Volume 13 - 2025 | https://doi.org/10.3389/fevo.2025.1742741 This article is part of the Research TopicInsights in Evolutionary and Population Genetics: 2025View all 4 articles 1 Introduction Schizothorax curvilabiatus is a freshwater fish species belonging to the order Cypriniformes, family Cyprinidae, subfamily Schizothorinae, and genus Schizothorax.
Distinct diet-microbiome associations in autism spectrum disorder - Nature Communications
Abstract Autism spectrum disorder (ASD) is linked to both altered gut microbiota and unhealthy diets; however, the mechanistic connections remain elusive. In this study, we conducted a systematic analysis of fecal microbiome metagenomic data, paired with granular dietary assessments and phenotypic profiles, across a cohort of 818 children (462 with ASD, 356 without ASD; mean age = 8.4 years; 27.3% female).
Homophily: a possible factor for the lack of minorities in the faculty pipeline
Advanced search Journal of Teaching in Travel & Tourism Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/15313220.2025.2591747?needAccess=true ABSTRACT This study examines how homophily, an individual’s preference for affiliating with those of similar backgrounds, shapes faculty-student mentorship patterns in hospitality graduate education.
HUMORCHAIN: Theory-Guided Multi-Stage Reasoning for Interpretable Multimodal Humor Generation
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects
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Keywords microbiome FMT small bowel microbiota metabolism regional ecosystem intestine jejunum mucosa regional mismatch engraftment Get full text access Log in, subscribe or purchase for full access. References 1. Bartlett, J.G. Clinical practice. Antibiotic-Associated Diarrhea N. Engl. J. Med. 2002; 346:334-339 2. Baunwall, S.M.D. ∙ Lee, M.M. ∙ Eriksen, M.K. ...
By Orlando DeLeon, Alan Khee-Jin Tan, Ashley M. Sidebottom, Hugo D Ceccato, Sarah E. Kralicek, John Colgan, Joash Lake, Michael Cooper, Jingwen Xu, Julia Moore, Qi Su, Zhilu Xu, Siew C Ng, Francis Chan, Hein M. Tun, Candace Cham, Cambrian Y. Liu, David T. Rubin, Kristina Martinez-Guryn, Eugene B. Chang, Mora Mocanu, Jason Koval
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Cell Press
Verified
Quantitative geomorphological analyses reveal late Cenozoic uneven tectonic expansion at the North Qilian Shan
REFERENCES , , & (2017) Surface tracks and slip rate of the fault along the southern margin of the Wuwei Basin in the late quaternary. Seismology and Geology, 39(2), 408. Available from: https://doi.org/10.3969/J.ISSN.0253-4967.2017.02.010 (1998) The evolution of the great river systems of southern Asia during the Cenozoic India-Asia collision: Rivers draining southwards. Geomorphology, 22(3–4), 285–312. Available from: https://doi.org/10.1016/S0169-555X(97)00082-2 & (2011) Tectonic Geomorphology.
Drainage divides migration of the Heihe River in the Qilian Mountains, northeastern Tibet: Insights for the drainage reorganization in an orogenic belt
CONFLICT OF INTEREST STATEMENT The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supporting Information Filename Description esp70084-sup-0001-TableS1.docxWord 2007 document , 17.2 KB Table S1: The ksn values of 20 pairs of upstream channel heads and the steady-state of drainage divides. esp70084-sup-0002-FigureS1.tifapplication/tiff, 16 MB Figure S1.
Evolutionary dynamics of behavioral motivations for cooperation - Nature Communications
Abstract Human decision-making is shaped by underlying motivations, which reflect both subjective well-being and fundamental biological needs. Different needs are often prioritized and traded off against one another. Here we develop a theoretical framework to study the evolution of behavioral motivations, encompassing both philanthropic (cooperating after personal needs are met) and aspirational (cooperating to fulfill personal needs) motivations.
An Off‐the‐Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment
1 Introduction Regenerative medicine uses live therapeutic cells to repair or replace damaged organs or tissues via injection or implantation into a patient.[1] Bone marrow- or adipose-derived stem cells, and immune cells including T cells and macrophages, have been adopted for in vivo transplantation after modification in vitro.[2] Specially, macrophages, a subset of phagocytes within the innate immune system, are derived from monocytes and greatly involved in maintaining tissue homeostasis...
Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile - Nature Communications
Abstract Idiopathic pulmonary fibrosis (IPF) is a severe lung disease occurring throughout the world; however, few clinical therapies are available for treating this disorder. Overactivated fibroblasts drive abnormal fibrosis accumulation to maintain dynamic balance between inflammation and extracellular matrix (ECM) stiffness. Given pulmonary cell can regenerate, the lung may possess self-repairing abilities if fibrosis is removed via clearance of overactivated fibroblasts.
Power-free knee rehabilitation robot for home-based isokinetic training - Nature Communications
Abstract Robot-assisted isokinetic training has been widely adopted for knee rehabilitation. However, existing rehabilitation facilities are often heavy, bulky, and extremely energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. In this study, we introduce a highly integrated and lightweight (52 kg) knee rehabilitation robot that can provide home-based isokinetic training without external power.
A plant virus manipulates both its host plant and the insect that facilitates its transmission
Abstract Tomato yellow leaf curl virus (TYLCV), a devastating pathogen of tomato crops, is vectored by the whitefly Bemisia tabaci, yet the mechanisms underlying TYLVC epidemics are poorly understood. We found that TYLCV triggers the up-regulation of two β-myrcene biosynthesis genes in tomato, leading to the attraction of nonviruliferous B. tabaci. We also identified BtMEDOR6 as a key whitefly olfactory receptor of β-myrcene involved in the distinct preference of B.
Printed Two-Dimensional Materials for Flexible Photodetectors: Materials, Processes, and Applications
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
20 Gbps real-time source-independent quantum random number generator based on a silicon photonic chip
Quantum random number generator (QRNG) allows for the production of truly unpredictable random numbers, thanks to the inherent randomness available in quantum mechanics. However, its practical implementation is facing several challenges, including the practical security loophole, high-speed real-time randomness extraction, and large-scale production.
Low-FODMAP Diet for Irritable Bowel Syndrome: Insights from Microbiome
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Microbiome-Based Therapeutics for Insomnia
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Author Correction: Multikingdom and functional gut microbiota markers for autism spectrum disorder - Nature Microbiology
Correction to: Nature Microbiology https://doi.org/10.1038/s41564-024-01739-1, published online 8 July 2024. In the version of the article initially published, the following text was missing from the Data availability section and has now been added to the HTML and PDF versions of the article: “Participant metadata cannot be made publicly available via repositories as outlined in the patient consent form to protect participant privacy.
Science around the world
1Department of Transfusion Medicine, Precision Medicine Lab, Biological Resource Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy 2International Collaboration On Repair Discoveries (ICORD) Centre, Department of Pathology and Laboratory Medicine, British Columbia Professional Firefighters’ Burn and Wound Healing Laboratory, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada 3Centre for Heart Lung Innovation,...
Evolution of Duplicated Glutathione Metabolic Pathway in Gossypium hirsutum and Its Response to UV‐B Stress
1 Introduction Ultraviolet-B (UV-B, 280–315 nm), a component of the solar electromagnetic spectrum that reaches the Earth's surface, has received widespread attention in recent years because anthropogenic carbon dioxide emissions are destroying the ozone layer, resulting in increasing UV-B radiation (Liaqat et al. 2023).
Elucidating Bile Acid Tolerance in Saccharomyces cerevisiae: Effects on Sterol Biosynthesis and Transport Protein Expression
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Inflammasome-Driven Fatal Acute-on-Chronic Liver Failure Triggered by Mild COVID-19
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Harnessing the Gut Microbiome: To What Extent Can Pre-/Probiotics Alleviate Immune Activation in Autism Spectrum Disorder?
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Multikingdom and functional gut microbiota markers for autism spectrum disorder - Nature Microbiology
Abstract Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial component of the microbiome. Whether gut archaea, fungi and viruses, or function of the gut microbiome, is altered in ASD is unclear. Here we performed metagenomic sequencing on faecal samples from 1,627 children (aged 1–13 years, 24.4% female) with or without ASD, with extensive phenotype data.
Human Periodontal Ligament Stem Cells (hPDLSCs) Spontaneously Differentiate into Myofibroblasts to Repair Diabetic Wounds
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Combined aerobic and resistance exercise training alters the spatial transcriptome of skeletal muscle in young adults
Abstract Chronic exercise training substantially improves skeletal muscle function and performance. The repeated demands and stressors of each exercise bout drive coordinated molecular adaptations within multiple cell types in muscle tissue, leading to enhanced neuromuscular recruitment and contractile function, stem cell activation, myofiber hypertrophy, mitochondrial biogenesis, and angiogenesis, among others.
The gut microbiome associates with phenotypic manifestations of post-acute COVID-19 syndrome
Davis H.E. McCorkell L. Vogel J.M. Topol E.J. Long COVID: major findings, mechanisms and recommendations. Nat. Rev. Microbiol. 2023; 21: 133-146https://doi.org/10.1038/s41579-022-00846-2 Nalbandian A. Sehgal K. Gupta A. Madhavan M.V. McGroder C. Stevens J.S. Cook J.R. Nordvig A.S. Shalev D. Sehrawat T.S. et al. Post-acute COVID-19 syndrome. Nat. Med. 2021; 27: 601-615https://doi.org/10.1038/s41591-021-01283-z Huang L. Yao Q. Gu X. Wang Q. Ren L. Wang Y. Hu P. Guo L. Liu M. Xu J. et al.
Strategy evolution on higher-order networks - Nature Computational Science
Abstract Cooperation is key to prosperity in human societies. Population structure is well understood as a catalyst for cooperation, where research has focused on pairwise interactions. But cooperative behaviors are not simply dyadic, and they often involve coordinated behavior in larger groups. Here we develop a framework to study the evolution of behavioral strategies in higher-order population structures, which include pairwise and multi-way interactions.
Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC
Abstract The protein kinase C (PKC) family of serine/threonine kinases, which consist of three distinctly regulated subfamilies, have long been established as critical for a variety of cellular functions. However, how PKC enzymes are regulated at different subcellular locations, particularly at emerging signaling hubs such as the ER, lysosome, and Par signaling complexes, is unclear.
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