Articles by Robert Whelan's Profile | Color Research & Application, Irish Daily Mail, Nature Journalist

Immune-related gene expression links anxiety, depression, and pain outcomes in adolescence

Oct 16, 2026 | | Nature

Abstract Chronic pain and internalising disorders such as anxiety and depression frequently co-occur during adolescence. Although prospective associations between internalising symptoms and later pain have been reported previously, the biological mechanisms underlying individual differences in this relationship remain poorly understood. Immune- and oxidative stress-related pathways, including the NRF2 gene, may contribute to such variability.

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Behavioural and brain volumetric changes associated with problematic substance use through the lifespan

Oct 11, 2026 | | Nature

Abstract Addiction stands as a critical public health concern, contributing substantially to morbidity, mortality and societal burden worldwide. It can be conceptualized along a developmental continuum, from risky substance use in adolescence to compulsive use and addiction in adulthood, yet the neural changes underlying this continuum remain poorly understood.

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Are Your Employee Benefits Still Right for Your Workforce?

Oct 09, 2026 |

By Robert Whelan

| hrheadquarters.ie

HRHQ Sponsored Content by Robert Whelan, founder and Managing Director of Rockwell An employee benefits package may still suit the workforce, even when the service supporting it needs to improve. For employers, the company pension scheme is often where those frustrations become apparent. When employees have pension questions, HR needs a reliable contact who can help.

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Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Sep 02, 2026 | | Nature

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but the mechanistic basis of individual variation in incentive salience attribution remains incompletely characterized. Here we show, using fMRI across five cohorts (N-total = 1251; N1 = 890; N2 = 245; N3 = 34; N4 = 48; N5 = 34), two reproducible imaging phenotypes mirroring sign- and goal-tracking (ST-like, GT-like).

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Personality variability during development predicts alcohol use before and during the COVID-19 pandemic

Aug 13, 2026 | | Nature

Abstract Changes in personality during adolescence may shape future alcohol use, especially in times of societal crisis. The COVID-19 pandemic disrupted social norms and stress regulation, making it a natural experiment to examine how early-life personality trajectories predict later substance use.

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Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies

Jul 21, 2026 | | Nature

Abstract The STRATIFY (Brain Network-Based Stratification of Reinforcement-Related Disorders) and ESTRA (Eating Disorders Stratification) studies were established as harmonised “sibling” cohorts to develop a mechanistically informed framework for stratifying psychiatric disorders. Here, we describe the study design, methodology, and cohort characteristics.

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Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity

May 20, 2026 | | Nature

Abstract Brain clocks are promising tools for evaluating brain health. However, most current methods rely on structural neuroimaging. Functionally based approaches remain scarce, especially for assessing age-related neurodegenerative diseases.

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Model-based analysis of stop-signal data reveals robust neural and clinical correlates of evidence accumulation but not inhibition

Apr 21, 2026 | | Nature

Abstract Poor inhibitory control and decision-making are often considered as risks for substance use and other adverse psychiatric outcomes. The Stop-Signal Task (SST) is a widely used protocol, from which inhibitory control is indexed by stop signal reaction time (SSRT). However, heretofore models of SSRT may be too simplistic to capture complex processes underlying task performance.

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Bullying victimization and brain development: a longitudinal structural magnetic resonance imaging study from adolescence to early adulthood

Apr 09, 2026 | | Nature

Abstract This study investigated associations between bullying victimization and brain development using longitudinal structural MRI data from the IMAGEN cohort (n = 2094; 1009 females) across three time points (∼14, ∼19, and ∼22 years).

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A longitudinal DNA methylation atlas and its link to brain structure and mental health

Mar 30, 2026 | | Nature

Abstract Epigenetic mechanisms are thought to contribute to neurodevelopmental vulnerability for psychiatric disorders, yet longitudinal evidence linking DNA methylation (DNAm) to brain maturation and psychopathology is limited. Using epigenome-wide DNAm (372,582 CpGs) and whole-brain structural MRI data from the IMAGEN cohort (n = 506, ages 14–19), we identified 18 co-regulated DNAm clusters, ten enriched for brain-expressed genes involved in neuronal development and signalling.

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Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders - Communications Biology

Feb 24, 2026 | | Nature

Abstract Childhood trauma (CT) is associated with cognitive impairment across major psychiatric disorders. We tested a novel transdiagnostic hypothesis that atypical connectivity of the default mode network (DMN) mediates the association between childhood trauma (CT) and cognitive impairment. The sample of 1851 individuals aged 18-25 included 433 patients with depression, eating disorders, alcohol use disorder, psychosis and ADHD) and were recruited as part of the ESTRA/STRATIFY/IMAGEN studies.

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Establishing a Neural Marker for Inhibitory Control During Balance Recovery

Dec 25, 2025 |

By Anne Z. Beethe, Sara Harper, Robert Whelan, Emmet McNickle

| Wiley Online Library

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description psyp70208-sup-0001-FigureS1.pdfPDF document, 419 KB Figure S1: Subtracted trace based on task success (lean and release). psyp70208-sup-0002-FigureS2.pdfPDF document, 414.3 KB Figure S2: Subtracted trace based on task success (seated).

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Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia - Nature Mental Health

Sep 17, 2025 |

By Hernán Hernández, Josephine Cruzat, Pedro A. Valdes-Sosa, Sol Fittipaldi, Robert Whelan, Raul Gonzalez-Gomez, Gustavo Deco, Pavel Prado, Patricio Orio

| Nature

Abstract Brain clocks track the deviations between predicted brain age and chronological age (brain age gaps, BAGs). These BAGs can be used to measure accelerated aging, monitoring deviations from the healthy brain trajectories associated with brain diseases and different cumulative burdens. However, the underlying biophysical mechanisms associated with BAGs in aging and dementia remain unclear.

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Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth - Molecular Psychiatry

Sep 04, 2025 | | Nature

Abstract Increases in impulsivity and negative affect (e.g., neuroticism) are common during adolescence and are both associated with risk for alcohol-use initiation and other risk behaviors. Whole-brain functional connectivity approaches—when coupled with appropriate cross-validation—enable identification of complex neural networks subserving individual differences in dimensional traits (hereafter referred to as ‘neural signatures’).

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Mapping the coupling between tract reachability and cortical geometry of the human brain - Nature Communications

Aug 11, 2025 | | Nature

Abstract The study of cortical geometry and connectivity is prevalent in human brain research. However, these two aspects of brain structure are usually examined separately, leaving the essential connections between the brain’s folding patterns and white matter connectivity unexplored. In this study, we aim to elucidate the fundamental links between cortical geometry and white matter tract connectivity.

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Genetic risk-dependent brain markers of resilience to childhood Trauma - Nature Communications

Jul 05, 2025 | | Nature

Abstract Resilience to developing emotional disorders is critical for adolescent mental health, especially following childhood trauma. Yet, brain markers of resilience remain poorly understood. By analyzing brain responses to angry faces in a large-scale longitudinal adolescent cohort (IMAGEN), we identified two functional networks located in the orbitofrontal and occipital regions.

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Redundancy in midlife: financial shock, emotional toll - and the path forward

Jun 25, 2025 |

By Robert Whelan

| Galway Advertiser

It’s not just a job. For many people in their 40s and 50s, their work is a key part of their identity – a source of purpose, confidence, and stability. So when redundancy strikes mid-career, it can be more than a financial disruption; it can shake your sense of who you are. It’s an emotional and financial event – and often the two are more closely linked than you might think. Redundancy at midlife can feel like a sudden and unexpected derailment.

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DYNAMIC CHANGES TO THE INTESTINAL ENVIRONMENT OCCUR THROUGHOUT RECOVERY FROM EXPERIMENTAL ISCHAEMIC STROKE

Apr 28, 2025 |

By Isobel C. Mouat, Robert Whelan, Lizi M. Hegarty, Christopher Anderson

| BioRxiv

Abstract Stroke survivors experience a plethora of complications during recovery, including gastrointestinal symptoms. Intestinal dysfunction is reported to occur rapidly following stroke in both humans and animal models and alterations such as reduced barrier integrity, lymphocyte loss, and an altered microbiota have been suggested to contribute to poor neurological outcomes.

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Opinion: Turbulence now, triumph later?

Mar 17, 2025 |

By Robert Whelan

| Cayman Compass

By Robert Whelan Markets are reeling from a whirlwind of tariff-driven chaos unleashed by President Donald Trump’s policy gambit, leaving US businesses paralysed with uncertainty. Caught in the crosshairs of relentless tariff threats, companies are slamming the brakes on investment and hiring, unable to pin down future costs or timelines.

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Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence - Molecular Psychiatry

Jan 31, 2025 | | Nature

Abstract Laboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular underpinnings are not well understood.

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Relationships of eating behaviors with psychopathology, brain maturation and genetic risk for obesity in an adolescent cohort study - Nature Mental Health

Jan 09, 2025 | | Nature

Abstract Unhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional and behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from the longitudinal IMAGEN adolescent cohort, we investigated associations between eating behaviors, genetic predispositions for high body mass index (BMI) using polygenic scores (PGSs), and trajectories (ages 14–23 years) of ED-related psychopathology and brain maturation.

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Gold for stability, Bitcoin for growth

Nov 12, 2024 |

By Robert Whelan

| Cayman Finance

Robert Whelan, portfolio manager at Cayman Finance member firm NCB Cayman, provides his latest investment update. In the evolving investment landscape, two assets have stood out in 2024 for their performance: gold and Bitcoin. Both offer unique benefits, though their characteristics and risk profiles vary widely. Understanding how they fit into a portfolio is crucial in today’s dynamic financial environment, where balancing traditional and emerging assets could be a winning strategy.

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Investigating grey matter volumetric trajectories through the lifespan at the individual level - Nature Communications

Jul 14, 2024 | | Nature

Abstract Adolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on population averages, and the neurobiological basis underlying individual heterogeneity remains poorly understood.

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Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood - Molecular Psychiatry

Jul 01, 2024 |

By Tobias Banaschewski, Sylvane Desrivières, Herta Flor, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Frauke Nees, Dimitri Papadopoulos Orfanos, Nilakshi Vaidya, Michael N. Smolka, Henrik Walter, Robert Whelan, Jean-Luc Martinot, Eric Artiges, Rocco Marchitelli

| Nature

Abstract Perseverative negative thoughts, known as rumination, might arise from emotional challenges and preclude mental health when transitioning into adulthood. Due to its multifaceted nature, rumination can take several ruminative response styles, that diverge in manifestations, severity, and mental health outcomes. Still, prospective ruminative phenotypes remain elusive insofar.

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Greater physical fitness (VO2max$$ {\mathrm{VO}}_{2_{\mathrm{max}}} $$) in healthy older adults associated with increased integrity of the locus coeruleus–noradrenergic system

Jun 19, 2024 |

By Michael C. Melnychuk, Ralph Andrews, Rory Boyle, Robert Whelan

| Wiley Online Library

DATA AVAILABILITY STATEMENT The study was approved by the ethical review board of the University of Texas Southwestern Medical Center at Dallas, University of Texas at Dallas and The Cooper Institute. All participants were informed about the study protocol and provided informed written consent prior to scanning. The datasets used and/or analyzed during the current study available from author Jeffrey S. Spence, Center for BrainHealth, University of Texas at Dallas, on reasonable request.

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Afentra Acquired Assets Worth $255m, With Only $37m Cash: Here’s How: (OTCMKTS:STGAF) Original

Dec 14, 2023 |

By Robert Whelan

| Seeking Alpha

My last article on Afentra plc (OTCPK:STGAF) in August 2022 looked at the sale and purchase agreements signed with the government of Angola in April 2022 for 20% of oil production block 3/05 in shallow water offshore Angola.

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Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits - Molecular Psychiatry

Sep 22, 2023 | | Nature

Abstract Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear.

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Vassor v. USAA General Indemnity Company

Aug 30, 2023 |

By Robert Whelan, E Wayne Ridgeway

| Justia Dockets & Filings

Plaintiff: Brittney Vassor Defendant: USAA General Indemnity Company Case Number: 3:2023cv04358 Filed: August 30, 2023 Court: US District Court for the District of South Carolina Presiding Judge: Cameron McGowan Currie Nature of Suit: Insurance Cause of Action: 28 U.S.C. ยง 1441 Notice of Removal-Insurance Contract Jury Demanded By: Plaintiff RSS Track this Docket This docket was last retrieved on August 30, 2023. A more recent docket listing may be available from PACER.

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Savers suffer as banks reap big profits

Aug 27, 2023 |

By Robert Whelan

| Echo Live

WHILE the whole country was glued to Oireachtas TV, watching Ryan Tubridy and Noel Kelly get skewered by politicians, I was meeting someone who had just inherited a significant sum of money. The point of discussion was the fact it had been in the bank for more than six months and they felt they “simply had to do something with it as it’s earning nothing in the bank and inflation is very high”.

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Bennett v. State Farm Fire and Casualty Company Inc

Aug 24, 2023 |

By William Hogan, Robert Whelan, Charles Norris, James Robinson Gilreath

| Justia Dockets & Filings

Plaintiff: Ortagus D Bennett Defendant: State Farm Fire and Casualty Company Inc Case Number: 6:2023cv04234 Filed: August 24, 2023 Court: US District Court for the District of South Carolina Presiding Judge: Donald C Coggins Nature of Suit: Insurance Cause of Action: 28 U.S.C. ยง 1332 Diversity-Insurance Contract Jury Demanded By: Both RSS Track this Docket This docket was last retrieved on August 24, 2023. A more recent docket listing may be available from PACER.

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A stable and replicable neural signature of lifespan adversity in the adult brain - Nature Neuroscience

Aug 21, 2023 |

By Seyed Mostafa Kia, Sebastian Siehl, Sylvane Desrivières, Herta Flor, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Andreas Meyer-Lindenberg, Jan Buitelaar, IMAGEN Consortium, Nathalie E. Holz, Mariam Zabihi

| Nature

Abstract Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated.

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Crohn's disease: bacteria in the mouth may be a cause – here's why Original

Jul 25, 2023 |

By Gwo-tzer Ho, Robert Whelan

| The Conversation

Crohn’s disease affects four million people worldwide. The condition causes debilitating symptoms such as chronic fatigue, diarrhoea, abdominal pain, weight loss and malnutrition. Once symptoms develop, Crohn’s is a lifelong condition – and while there are ways to manage symptoms during flare-ups, there’s currently no cure.

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Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior - Molecular Psychiatry

Jun 28, 2023 | | Nature

Abstract Leveraging ~10 years of prospective longitudinal data on 704 participants, we examined the effects of adolescent versus young adult cannabis initiation on MRI-assessed cortical thickness development and behavior. Data were obtained from the IMAGEN study conducted across eight European sites. We identified IMAGEN participants who reported being cannabis-naïve at baseline and had data available at baseline, 5-year, and 9-year follow-up visits.

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Workman et al v. State Farm Mutual Automobile Insurance Company et al

May 19, 2023 |

By Justin Kahn , Wes Allison, Robert Whelan

| Justia Dockets & Filings

May 19, 2023 Filing 2 Local Rule 26.01 Answers to Interrogatories by State Farm Mutual Automobile Insurance Company.(sshe, ) May 19, 2023 Filing 1 NOTICE OF REMOVAL from Charleston County Court of Common Pleas, case number 2023-CP-10-01832. (Filing fee $ 402 receipt number ASCDC-11110186), filed by State Farm Mutual Automobile Insurance Company. (Attachments: #1 State Court Documents)(sshe, )

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Underberg et al v. USAA Casualty Insurance Company

May 09, 2023 |

By Kevin Barth, Robert Whelan, Jonathan Graham

| Justia Dockets & Filings

May 9, 2023 Filing 3 Local Rule 26.01 Answers to Interrogatories by USAA Casualty Insurance Company.(hcic, ) May 9, 2023 Filing 1 NOTICE OF REMOVAL from Darlington County Court of Common Pleas, case number 2023-CP-16-00238 (filing fee $402 receipt number ASCDC-11092072), filed by USAA Casualty Insurance Company. (Attachments: #1 State Court Documents)(hcic, )

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Anxiety onset in adolescents: a machine-learning prediction - Molecular Psychiatry

Dec 08, 2022 |

By Tobias Banaschewski, Sylvane Desrivières, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Frauke Nees, Tomas Paus, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jean-Luc Martinot, Eric Artiges, Betteke van Noort, Dimitri Papadopoulos Orfanos

| Nature

This is the first report of anxiety onset prediction in European adolescents at age 18–23, using regional gray matter volumes and clinical features obtained at age 14. The predictive value of gray matter volumes alone for future anxiety disorders was also investigated. Prediction performance was above chance level when all future anxiety diagnoses were pooled together, with the most contributing features being neuroticism and hopelessness scores.

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Developments in scalable strategies for detecting early markers of cognitive decline - Translational Psychiatry

Nov 09, 2022 |

By Robert Whelan, Claire M. Gillan, Florentine M. Barbey, Marcia R. Cominetti

| Nature

Abstract Effective strategies for early detection of cognitive decline, if deployed on a large scale, would have individual and societal benefits. However, current detection methods are invasive or time-consuming and therefore not suitable for longitudinal monitoring of asymptomatic individuals.

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Afentra Stock: Closing Catalyst Offers A Compelling Opportunity Original

Aug 24, 2022 |

By Robert Whelan

| Seeking Alpha

Summary Afentra is capitalised at $73 million. Brent price deck value of the 2P reserves acquired is $185m. Sustained oil price scenario values those reserves 50% higher again. Management are buying shares… a lot. Closing expected in early Q4 2022. My last article on Afentra plc (OTCPK:STGAF) in early 2021 (formerly known as Sterling Energy plc) focused on the opportunity to buy into a new quality management team at essentially cash value.

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Book review: Cities and Communities Beyond COVID-19: How Local Leadership Can Change Our Future for the Better

Sep 21, 2021 |

By Robin Hambleton, Robert Whelan

| urbanstudiesonline.com

Book review: Cities and Communities Beyond COVID-19: How Local Leadership Can Change Our Future for the Better By Robin Hambleton and reviewed by Robert K Whelan Bristol: Bristol University Press, 2020; 171 pp.: ISBN: 978-1-52921-585-4, £9.99 (pbk) COVID-19 has been a global disaster of the greatest possible magnitude. Research papers, articles and books are examining the implications of COVID-19 in most fields of inquiry. Journalism is said to be the first cut of history.

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Book review: Cities and Communities Beyond COVID-19: How Local Leadership Can Change Our Future for the Better

Jul 27, 2021 |

By Robert Whelan

| Memory Studies

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Don't YOLO On OLO Stock (NYSE:OLO)

Jun 30, 2021 |

By Robert Whelan

| Seeking Alpha

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Volume of β-Bursts, But Not Their Rate, Predicts Successful Response Inhibition

Jun 09, 2021 |

By Kathy L. Ruddy, Laura M. Rueda-Delgado, Robert Whelan

| JNeurosci

Research Articles, Behavioral/Cognitive Nadja Enz, Kathy L. Ruddy, Laura M. Rueda-Delgado and Robert Whelan Journal of Neuroscience 9 June 2021, 41 (23) 5069-5079; DOI: https://doi.org/10.1523/JNEUROSCI.2231-20.2021 Abstract In humans, impaired response inhibition is characteristic of a wide range of psychiatric diseases and of normal aging. It is hypothesized that the right inferior frontal cortex (rIFC) plays a key role by inhibiting the motor cortex via the basal ganglia.

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Roblox: Expensive Gaming Stock With Avenues For Growth (NYSE:RBLX)

Jun 09, 2021 |

By Robert Whelan

| Seeking Alpha

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InMode: A Profitable Growth Story With Lots Of Potential (NASDAQ:INMD)

May 21, 2021 |

By Robert Whelan

| Seeking Alpha

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Garmin: Excellent Execution, Weak Economic Moat (NASDAQ:GRMN)

May 04, 2021 |

By Robert Whelan

| Seeking Alpha

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Chegg: Expensive Now, But Add On Weakness Throughout The Year (NYSE:CHGG)

Apr 28, 2021 |

By Robert Whelan

| Seeking Alpha

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Volume of beta bursts, but not their rate, predicts successful response inhibition

Apr 28, 2021 |

By Kathy L. Ruddy, Robert Whelan, Laura M. Rueda-Delgado

| JNeurosci

Research Articles, Behavioral/Cognitive Nadja Enz, Kathy L. Ruddy, Laura M. Rueda-Delgado and Robert Whelan Journal of Neuroscience 29 April 2021, JN-RM-2231-20; DOI: https://doi.org/10.1523/JNEUROSCI.2231-20.2021 Abstract In humans, impaired response inhibition is characteristic of a wide range of psychiatric diseases and of normal aging. It is hypothesised that the right inferior frontal cortex plays a key role by inhibiting the motor cortex via the basal ganglia.

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Time for new response inhibition models

Mar 18, 2021 |

By Michael Funk , Robert Whelan

| Science Magazine

Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.

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Transformation At Sterling Energy Represents A Re-Rate Opportunity (OTCMKTS:STGAF)

Mar 01, 2021 |

By Robert Whelan

| Seeking Alpha

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Commentary on Afzali et al. (2019): Two data sets are better than one

Mar 10, 2019 |

By Robert Whelan

| Color Research & Application

The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Commentary Commentary on Afzali et al.

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Articles by Robert Whelan

Afentra Acquired Assets Worth $255m, With Only $37m Cash: Here’s How: (OTCMKTS:STGAF) Original

Crohn's disease: bacteria in the mouth may be a cause – here's why Original

Afentra Stock: Closing Catalyst Offers A Compelling Opportunity Original

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