Scott Ritchie
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Articles by Scott Ritchie
OmicsPred as a centralized resource for genetic prediction of multi-omic traits
We present OmicsPred, an open platform for the deposition and dissemination of genetic prediction models of multi-omic traits, with key metadata required for reproducibility and independent applications. We illustrate the utility of the resource for target discovery with a multi-omic multi-ancestry phenome-wide association analysis using data from the Million Veterans Program.
My wife and I are living daily with anxiety
The news report on the desperate need for affordable houses for the low income, disabled and elderly is so difficult to handle for my common law companion and myself. My partner and I have been living relatively comfortable together sharing a 3 bedroom home. Due to health issues I have my own, she has her room, and home office for her full time job. My wife has suffered a heat attack and is attending many follow up appointments.
Moving My Political Work Outside the Classroom
Ritchie, S. (2026). Moving My Political Work Outside the Classroom. Radical Teacher, 133. https://doi.org/10.5195/rt.2026.1474 Freire, P. (1973). Education, liberation, and the church. Study Encounter, IX(1), 1-15. World Council of Churches. Horton, M., & Freire, P. (1990). We make the road by walking: Conversations on education and social change (B. Bell, J. Gaventa, & J. Peters, Eds.). Temple University Press. Marx, K. & Engels, F. (1976). The German Ideology. In K. Marx & F.
Der lange Weg des Ringo Starr - Ex-Beatle zelebriert Country
Im vergangenen Jahr überraschte Ringo Starr seine Fans, als er mehr als 50 Jahre nach "Beaucoups Of Blues" wieder ein Country-Album veröffentlichte. Die Arbeit an "Look Up" mit T Bone Burnett machte dem Ex-Beatle so viel Spaß, dass er jetzt nachlegt. "Long Long Road" heißt sein 22. Studioalbum. Dafür ging der rastlose 85-Jährige, der eher unter seinem Vornamen als seinem Nachnamen bekannt ist, erneut mit der Country-Ikone ins Studio.
Der lange Weg des Ringo Starr - Ex-Beatle zelebriert Country
Nicht viele 85-Jährige sind so fit wie Ringo Starr. Schon wieder hat der Ex-Beatle ein neues Album. Darauf geht er seiner lebenslangen Country-Leidenschaft nach - mit prominenten Gästen. London/Los Angeles. Im vergangenen Jahr überraschte Ringo Starr seine Fans, als er mehr als 50 Jahre nach "Beaucoups Of Blues" wieder ein Country-Album veröffentlichte. Die Arbeit an "Look Up" mit T Bone Burnett machte dem Ex-Beatle so viel Spaß, dass er jetzt nachlegt. "Long Long Road" heißt sein 22. Studioalbum.
We're slow to build on artificial intelligence
Scott Ritchie The UK real estate sector is adopting AI too slowly, writes Scott Ritchie Everyone is talking about it – but is Artificial Intelligence really having an impact on how business is done in real estate? I recently took part in a round table of developers, operators, funders, and industry bodies to discuss whether its effects were being felt in Scotland and the rest of the UK.
AI In Real Estate - Nirvana Or New Bubble?
Shepherd and Wedderburn LLP are most popular: in United Kingdom Everyone is talking about it – but is artificial intelligence really having an impact on how business is done in real estate? To find out, real estate adviser Chris Dougray assembled a round table of key players in the sector including developers, operators, funders, and industry bodies at Shepherd and Wedderburn's Edinburgh office to see if its effects were being felt in Scotland and the rest of the UK.
AI in Real Estate - Nirvana or new bubble?
Everyone is talking about it – but is artificial intelligence really having an impact on how business is done in real estate? To find out, real estate adviser Chris Dougray assembled a round table of key players in the sector including developers, operators, funders, and industry bodies at Shepherd and Wedderburn’s Edinburgh office to see if its effects were being felt in Scotland and the rest of the UK.
Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction - Nature Communications
Abstract Blood cell phenotypes are routinely tested in healthcare to inform clinical decisions. Genetic variants influencing mean blood cell phenotypes have been used to understand disease aetiology and improve prediction; however, additional information may be captured by genetic effects on observed variance. Here, we mapped variance quantitative trait loci (vQTL), i.e. genetic loci associated with trait variance, for 29 blood cell phenotypes from the UK Biobank (N ~ 408,111).
The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes - Nature Genetics
Abstract The biological mechanisms through which most nonprotein-coding genetic variants affect disease risk are unknown. To investigate gene-regulatory mechanisms, we mapped blood gene expression and splicing quantitative trait loci (QTLs) through bulk RNA sequencing in 4,732 participants and integrated protein, metabolite and lipid data from the same individuals. We identified cis-QTLs for the expression of 17,233 genes and 29,514 splicing events (in 6,853 genes).
Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities - Nature Communications
Abstract Genomics can provide insight into the etiology of type 2 diabetes and its comorbidities, but assigning functionality to non-coding variants remains challenging. Polygenic scores, which aggregate variant effects, can uncover mechanisms when paired with molecular data. Here, we test polygenic scores for type 2 diabetes and cardiometabolic comorbidities for associations with 2,922 circulating proteins in the UK Biobank.
Discovery of drug targets for heart failure with preserved and reduced ejection fraction - Nature Cardiovascular Research
Drug targets that are supported by human genetics are more likely to lead to approved therapies. Research now identifies several promising drug targets and therapeutic repurposing opportunities for heart failure and its clinical sub-types.
Carrots And Sticks - Improving Energy Efficiency Of Non-Domestic Buildings
Both the Scottish and the UK governments have produced regulations that are intended to improve the energy efficiency of existing buildings in the UK, and so reduce carbon emissions, helping towards our national emissions reduction targets. But the respective administrations have approached the issue in very different ways.
Cybersecurity certification on the forefront for government contractors
Starting in early 2025, all government contractors' ability to win new bids could be at risk unless they have taken steps to meet anticipated requirements for Cybersecurity Maturity Model Certification (CMMC). Starting in early 2025, all government contractors' ability to win new bids could be at risk unless they have taken steps to meet anticipated requirements for Cybersecurity Maturity Model Certification (CMMC).
Enhancing the Polygenic Score Catalog with tools for score calculation and ancestry normalization - Nature Genetics
Polygenic scores (PGSs) have transformed human genetic research and have numerous potential clinical applications. Here we present a series of recent enhancements to the PGS Catalog and highlight the PGS Catalog Calculator, an open-source, scalable and portable pipeline for reproducibly calculating PGSs that democratizes equitable PGS applications.
Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score
During the course of this project G.A. became a full-time employee of CSL Ltd. All significant contributions to this study were made prior to this role and CSL Ltd had no input to the study. A.M. and M.I.M are both employees of Genentech Ltd, and holders of Roche stock. Genentech Ltd. had no input to the study.
Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease
A.S.B. reports institutional grants from AstraZeneca, Bayer, Biogen, BioMarin, Bioverativ, Novartis, Regeneron and Sanofi. J.D. serves on scientific advisory boards for AstraZeneca, Novartis, Our Future Health and UK Biobank, and has received multiple grants from academic, charitable and industry sources outside of the submitted work.
Julie Janson
FLORENCE, S.C. -- The Greater Florence Chamber will again host the Women in Commerce Luncheo…
Circulating proteomic profiles are associated with the onset of type 2 diabetes in a multi-ethnic Asian population - a longitudinal study
The authors have declared no competing interest.
Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction
M.I. is a trustee of the Public Health Genomics (PHG) Foundation, a member of the Scientific Advisory Board of Open Targets, and has research collaborations with AstraZeneca, Nightingale Health and Pfizer which are unrelated to this study. The authors are grateful to UK Biobank for access to data to undertake this study (Projects #30418).
Integration of polygenic and gut metagenomic risk prediction for common diseases - Nature Aging
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Abstract Multiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, in a prospective population-based cohort with ~18 years of e-health record follow-up, we investigated the incremental and combined value of genomic and gut metagenomic risk assessment compared with conventional risk factors for predicting incident coronary artery disease (CAD), type 2 diabetes (T2D), Alzheimer disease and prostate cancer.
By Yang Liu Verified, Scott Ritchie, Karin Verspoor, Veikko Salomaa, Aki S Havulinna, Guillaume Meric
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Nature
Verified
Author Correction: Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort - Nature Genetics
Correction to: Nature Genetics https://doi.org/10.1038/s41588-021-00991-z, published online 3 February 2022. In the version of the article initially published, the descriptions of two FUT2 genotypes were inverted. In Fig. 4c and Extended Data Fig. 7b and their legends, “rs601338:GG/GA” and “rs601338:AA” previously read “rs601338:AG/AA” and “rs601338:GG”, respectively.
Cruise Ship, Motorhome, And Camping Levies
Following recent Visitor Levy Bill consultation updates, the Scottish Government and councils are now considering levies for cruise ships, motorhomes, and camping. Proposed legislation would allow councils to tax those staying overnight, operating in much the same manner as the Visitor Levy would.
Taxing times ahead for tourists with visitor levies
Can you ever have too much of a good thing? In certain areas of Scotland, there’s a feeling that you can when it comes to tourism. Local authorities in hotspots such as Edinburgh and Skye have been lobbying central government for extra resources to cope with the surge in visitors arriving on their doorstep each year. In response, the Scottish Government’s Visitor Levy (Scotland) Bill has recently been through a public consultation process.
Leases v Licences – The Penalty For Poor Drafting Is Litigation - Landlord & Tenant - Leases - UK
"The penalty for poor drafting is litigation" is a remark made by a Scottish judge in a recent property related dispute. As slogans go, it's not bad. It's maybe not as catchy as Nike's "Just Do It" but it's a good one for real estate lawyers. The court case in question (Sheriff v O'Rourke - 13 April 2023 - Sheriff Appeal Court) involved a disagreement as to the nature of a contract for the use of a residential property. Was it only a "licence to occupy" or was it a "lease"?
Leases v Licences - The penalty for poor drafting is litigation
In this article, Scott Ritchie, Partner in our Property and Infrastructure Team, examines a recent property court case in which a Scottish judge remarked that "the penalty for poor drafting is litigation" to demonstrate the key differences between a "lease" and a "licence" and why this matters. "The penalty for poor drafting is litigation" is a remark made by a Scottish judge in a recent property related dispute. As slogans go, it's not bad.
An atlas of genetic scores to predict multi-omic traits - Nature
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Abstract The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics1.
By Yu Xu, Scott Ritchie, Maik Pietzner, Loïc Lannelongue, Samuel A. Lambert, Sebastian May-Wilson, Carles A. Foguet, Åsa Johansson, Elodie Persyn, James Peters, Bram P. Prins, Jian’an Luan, Nicole Soranzo, E. Shyong Tai, Dirk S. Paul, Christopher W. H. Yau, Robert Gerszten, Anders Mälarstig, Xueling Sim, Claudia Langenberg, James WIlson, James Wilson, Adam S. Butterworth
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Nature
Verified
Genetically personalised organ-specific metabolic models in health and disease - Nature Communications
INTERVAL cohort INTERVAL is a cohort of approximately 50,000 participants nested within a randomised trial studying the safety of varying the frequency of blood donation (https://clinicaltrials.gov/ct2/show/NCT01610635). Participants were blood donors aged 18 years and older (median 44 years of age; 50% women) recruited between 2012 and 2014 from 25 NHS Blood and Transplant centres35,36.
Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease
Assessment of polygenic score in the UK Biobank test set Within the UK Biobank testing dataset, we first assessed the risk of Alzheimer’s disease for participants in the top 1%, top 5%, top 10% and top 20% of the polygenic score distribution compared to those in the middle quintile.
Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort - Nature Genetics
Abstract Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations associated with microbial abundances in a single large-scale population-based cohort of 5,959 genotyped individuals with matched gut microbial metagenomes, and dietary and health records (prevalent and follow-up). We identified 567 independent SNP–taxon associations.
The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation
We present the Polygenic Score (PGS) Catalog (https://www.PGSCatalog.org), an open resource of published scores (including variants, alleles and weights) and consistently curated metadata required for reproducibility and independent applications. The PGS Catalog has capabilities for user deposition, expert curation and programmatic access, thus providing the community with a platform for PGS dissemination, research and translation.
Daily Legal News
Bankruptcy 2020-51766 Case Number 2020-51766 Date Filed Tuesday, September 22, 2020 Chapter & Region 7 & 475 Debtor Scott R. Ritchie 2357 Suncrest Drive Cuyahoga Falls, OH 44221 About your information and the public record.
The Polygenic and Monogenic Basis of Blood Traits and Diseases
Under a Creative Commons license open access Highlights • Largest genome-wide association study of blood cell traits to date • Empiric assessments of omnigenic and infinitesimal models of polygenic variation • Functional insights into how genetic variants impact human hematopoiesis • Assessment of the effect of polygenic trait scores upon blood diseases Summary Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and...
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Abstract Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid cells and CD4+ T cells from cord blood samples, as well as in response to lipopolysaccharide (LPS) or phytohemagglutinin (PHA) stimulation, respectively.
Loss of cytoplasmic incompatibility in Wolbachia-infected Aedes aegypti under field conditions
Loading metrics Open Access Peer-reviewed Research Article Perran A. Ross , Scott A. Ritchie, Jason K. Axford, Ary A. Hoffmann Perran A. Ross, Scott A. Ritchie, Jason K. Axford, Ary A. Hoffmann Published: April 19, 2019 https://doi.org/10.1371/journal.pntd.0007357 ? This is an uncorrected proof. Figures Abstract Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control.
Explainer: what is Murray Valley encephalitis virus?
Western Australian health authorities recently issued warnings about Murray Valley encephalitis, a serious disease that can spread by the bite of an infected mosquito and cause inflammation of the brain. Thankfully, no human cases have been reported this wet season. The virus that causes the disease was detected in chickens in the Kimberley region. These “sentinel chickens” act as an early warning system for potential disease outbreaks. What is Murray Valley encephalitis virus?
Gregg Rolie: The Keyboard Interview
“I think style is everything when playing in a band,” says acclaimed keyboardist Gregg Rolie. “Learning tons of notes and being able to play in a myriad of different time signatures is cool, but you’ve got to do it in your own way. Otherwise, you might as well become a studio musician.” If anyone knows a thing or two about making lasting musical impressions, it’s Gregg Rolie.
Predicting Wolbachia invasion dynamics in Aedes aegypti populations using models of density-dependent demographic traits
The introduction of self-spreading infections of the endosymbiotic bacteria Wolbachia into field populations of Aedes aegypti mosquitoes is a novel strategy for the biocontrol of arboviruses that is currently undergoing field trials in disease-affected regions across multiple countries [1]. Infection with Wolbachia reduces the capacity of A. aegypti to transmit dengue [2, 3] and other arboviruses, including zika [4] and chikungunya [5].
An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
This study used data from two population-based cohorts, the Dietary, Lifestyle, and Genetic determinant of Obesity and Metabolic syndrome (DILGOM; N?=?518) and the Cardiovascular Risk in Young Finns Study (YFS; N?=?1650), which have been described in detail elsewhere [13, 51]. All subjects enrolled in these studies gave written informed consent.
Mozzies are evolving to beat insecticides - except in Australia
Chemical pesticides have been used for many years to control insect populations and remain the most important method of managing diseases carried by pests, including mosquitoes. However, insects have fought back by evolving resistance to many pesticides. There are now thousands of instances of evolved resistance, which make some chemical classes completely ineffective.
How we kept disease-spreading Asian Tiger mozzies away from the Australian mainland
Spring floods and summer heatwaves. There is nothing mosquitoes love more than warm weather and water. In many regions of Australia, these extreme conditions can increase the risk of mosquito-borne disease. Outbreaks of Ross River virus in some parts of the country have been as record-breaking as the heatwaves. The virus has even started encroaching on suburban Sydney and Melbourne.
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