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Articles by Weiping Chen
16S rRNA Datasets of Gut Microbiota in Stent-Based Diverting Technique and Ileostomy from A Prospective, Open-Label, Multicenter Randomized Controlled Trial
Abstract Accumulating evidence implicates gut dysbiosis in postoperative complications and delayed intestinal recovery after rectal cancer surgery. Although stent-based diverting technique (SDT) and conventional ileostomy exert divergent impacts on gut microbial balance, high-quality comparative microbiome data from randomized trials are lacking.
PFKM acts as a metabolic switch initiating donut-shaped mitochondrial remodeling to promote osteogenesis
Abstract Osteogenic differentiation requires sophisticated mitochondrial adaptation to meet bioenergetic demands, yet regulatory checkpoints governing this organelle reorganization remain poorly defined. Through single-cell RNA sequencing reanalysis and metabolic intervention, this study unveils a non-canonical signaling role for PFKM, traditionally recognized solely as a glycolytic enzyme, in orchestrating mitochondrial remodeling during bone formation.
Curcumin Attenuates Decidual Stromal Cell Ferroptosis and Restores Impaired Decidualization in Recurrent Spontaneous Abortion by Targeting BRD4
1 Introduction Recurrent spontaneous abortion (RSA), defined as two or more consecutive pregnancy losses before 20 weeks of gestation, has emerged as a significant global reproductive health concern affecting approximately 1%–3% of reproductive-age couples worldwide (Bender et al. 2023; Quenby et al. 2021).
Digital Therapist or Pressure Inducer: How GenAI Usage Affects the Research Pressure of Doctoral Students—A Multi-Method Quantitative Study Based on SEM-PLS and fsQCA
Abstract Doctoral students are facing an unprecedented research pressure crisis, which seriously threatens the sound development of higher education. However, existing studies have generally overlooked the impact of Generative Artificial Intelligence (GenAI) on research pressure.
Bank specialization and radical innovation of technology-based SMEs: evidence from technology branches establishment
This paper exploits the staggered establishment of technology branches across prefecture-level cities and employs a multi-period difference-in-differences design to examine the effect of bank specialization on radical innovation among Chinese technology-based SMEs. The results show that bank specialization significantly promotes radical innovation among technology-based SMEs. Mechanism analyses provide suggestive evidence that this effect is associated with banks’ risk tolerance, firms’...
Physical symptoms and psychological distress among cancer patients: a moderated mediation model involving rumination
Abstract Background: Cancer is a disease with a high fatality rate. In recent years, patients’ psychological problems associated with cancer have attracted much attention. Identifying the psychological distress of cancer patients, formulating and implementing psychological interventions, and satisfying the humanistic care needs of patients have become popular topics in cancer nursing research.
Endocrine-metabolic crosstalk in erectile dysfunction: mechanistic insights and therapeutic implications
Abstract Erectile dysfunction (ED) is a prevalent male sexual disorder frequently coexisting with cardiometabolic diseases. Although phosphodiesterase type 5 inhibitors remain the first-line therapy, limited efficacy or safety concerns in some patients highlight the need for alternative approaches. Emerging evidence demonstrates that endocrine abnormalities—including dysregulation of testosterone, estradiol, prolactin, and thyroid hormones—play crucial roles in the pathogenesis of ED.
Cell-free DNA fragmentomics for preeclampsia risk assessment
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Abstract Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited. Here we show that generating relatively stable cell-free DNA (cfDNA) fragmentomic metrics, including transcription start site (TSS) coverage, TSS score, and Gini coefficient, required 600 million whole-genome sequencing reads of plasma cfDNA.
By Wenqiu Xu, Songchang Chen, Jia Li, Si Zhou, Yanning Yin, Zhixu Qiu, Jianguo Zhang, Cong Liu, Qiang Zhao, Gefei Xiao, Yan Zhou, Zhiguang Zhao, Xiao Zhang, Wenzhi Yang, Yunfang Wang, Huiqin Li, Zhen Yang, Suihua Feng, Qun Zhang, Weiping Chen, Huahua Li, Xiaohong Ruan, Hua Li, Sufen Zhang, Liqing Hu, Jie Qin, Zhongzhe Li, Xianling Cao, Xuanyou Zhou, Naixin Xu, Dongxia Hou, Hong Dong, Jie Wang, Yaxian Liu, Xiaohua Wang, Lijian Zhao, Hefeng Huang, Chenming Xu, Wuyan Huang, Quanfu Zhang
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Nature
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Monetising social capital: how online social capital influences social commerce performance - evidence from WeChat online stores
ABSTRACT Online social capital is a critical factor for successful business operations. However, there is a scarcity of research exploring the impact of online social capital on the performance of online stores. Therefore, this study examines the effect of bridging online social capital (BRSC) and bonding online social capital (BOSC) on the performance of WeChat online stores.
Bidirectional crosstalk between ER stress and lipid metabolism: From proteostasis to tumor adaptation - Cell Death Discovery
Abstract Endoplasmic reticulum (ER) stress is a central adaptive response that maintains proteostasis under diverse metabolic and environmental challenges. In cancer, ER stress and lipid metabolism form a tightly coupled, bidirectional regulatory network that integrates protein quality control with lipid remodeling. Through the unfolded protein response (UPR), ER stress reprograms lipid synthesis, oxidation, and storage to sustain energy balance and membrane integrity.
Salvianolic Acid A From Salvia miltiorrhiza Suppresses Endometrial Carcinoma Progression via CD40‐AKT‐NF‐κB Pathway
Supporting Information Filename Description sji70017-sup-0001-FigS1.jpgJPEG image, 105.3 KB Figure S1. The effects of SA treatment on human NECs. MTT assay was used to evaluate the viability of NECs treated with indicated concentrations of SA for 48 h. References 1, , , et al., “Trends in Uterine Cancer Mortality in the United States: A 50-Year Population-Based Analysis,” Obstetrics and Gynecology 142 (2023): 978–986. 2, , , , , and , “Endometrial Cancer,” Lancet 399 (2022): 1412–1428.
Recent Advances in Co-Occurrence Network of Super-Wetting Materials and Their Application in Agricultural Engineering: A Critical Review
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Embracing the Digital Network: How Net-Entrepreneurs Acquire Online Social Capital?-A Mixed Empirical Study Based on SEM-PLS and fsQCA
Abstract Online social capital is a determinant of success for net-entrepreneurs. However, there has been limited research on how net-entrepreneurs acquire online social capital through social media. Therefore, this study aims to explore whether different digital behaviors of net-entrepreneurs lead to differences in acquiring online social capital.
Ensemble intelligence algorithms and soil environmental quality to model economic quantity of land resource allocation and spatial inequality
Gao, Feng [1] ; Yi, Shiyi [2] ; Li, Xiaonuo [2] ; Chen, Weiping [2] [1] Economic and Management College, Xinjiang University, Urumqi 830046, China [2] Laboratory of Soil Environmental Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Localización: Land use policy: The International Journal Covering All Aspects of Land Use, ISSN 0264-8377, ISSN-e 1873-5754, Nº.
Optimization of β-carotene production by a newly isolated Serratia marcescens strain
Bohua Wang [1] ; Liping Lin [2] ; Lei Lu [3] ; Weiping Chen [2] [1] Hunan University of Arts and Science Zoology Key Laboratory of Hunan Higher Education [2] Jiangxi Agricultural University [3] Northeast Forestry University Localización: Electronic Journal of Biotechnology, ISSN-e 0717-3458, Vol. 15, Nº. 6, 2012, págs. 3-3 Idioma: inglés Enlaces Texto completo Resumen β-carotene is a commonly used food colorant.
Applications and Development of Multi-Core Optical Fibers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Long-term efficacy of transanal local excision versus total mesorectal excision after neoadjuvant treatment for rectal cancer: A meta-analysis
Loading metrics Open Access Peer-reviewed Research Article Citation: Lei Y, Lin L, Shao Q, Chen W, Liu G (2023) Long-term efficacy of transanal local excision versus total mesorectal excision after neoadjuvant treatment for rectal cancer: A meta-analysis. PLoS ONE 18(11): e0294510.
Microstructural evolution and mechanical behavior of Co‐free (Fe40Ni30Cr20Al10)100‐x Ti x high‐entropy alloys
In this work, microstructural evolution and mechanical behavior of Co-free (Fe40Ni30Cr20Al10)100-x Ti x (x = 0, 2, 4, 6 and 8 at.%) high-entropy alloys (HEAs) were investigated. All as-cast HEAs consist of face-centered cubic (FCC) and body-centered cubic (BCC) structured phases, wherein the BCC-structured phase is composed of disordered BCC (A2) and ordered BCC (B2) phases. The HEAs show FCC dendrite and BCC inter-dendrite microstructure when x ≤ 4.
Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti‐inflammatory actions
1 INTRODUCTION Sepsis is a syndrome of a series of reactions such as immune dysfunction caused by infection, it can further deteriorate to multiple organ failure, septic shock and even death.1 Its mortality for critically ill patients is very high, it has been estimated that sepsis accounted for almost 20% of all deaths worldwide in 2017. One of the typical symptoms of sepsis is intestinal dysfunction.
Acquisition and Utilization of Chinese Peasant e-Entrepreneurs’ Online Social Capital: The Moderating Effect of Offline Social Capital
Open AccessArticle by Yan Li and Weiping Chen * School of Agricultural Economics and Rural Development, Renmin University of China, Beijing 100872, China * Author to whom correspondence should be addressed.
An Interface ASIC Design of MEMS Gyroscope with Analog Closed Loop Driving
Abstract : This paper introduces a digital interface application-specific integrated circuit (ASIC) for a micro-electromechanical systems (MEMS) vibratory gyroscope. The driving circuit of the interface ASIC uses an automatic gain circuit (AGC) module instead of a phase-locked loop to realize a self-excited vibration, which gives the gyroscope system good robustness.
A Classification System for the Sustainable Management of Contaminated Sites Coupled with Risk Identification and Value Accounting
Abstract : Currently, site contamination is considered to be a sustained, international environmental challenge, and there is an urgent practical need to build a core theoretical system and technical methodology for the sustainable risk management of soil contamination, together with its prevention and control. We aim to improve the risk management of contaminated sites in the post-remediation era, in line with the current trend of sustainable development.
Improved the surface properties of carbon fiber through hyperbranched polyaryletherketone sizing
RESEARCH ARTICLE Wei Ma, Wei Ma School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, China Search for more papers by this author Xiang Wang, Corresponding Author Xiang Wang wxwhut@whut.edu.cn orcid.org/0000-0003-2243-1103 School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, China Correspondence Xiang Wang, School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China.
How marketer-generated content characteristics affect consumer engagement? Empirical evidence from China's WeChat food marketing
Abstract Purpose Leveraging marketer-generated content (MGC) can increase firms' success. However, few studies uncover the effects of MGC-related attributes on consumer engagement in the context of food marketing. This paper aims to explore the influence of MGC characteristics (valence, content types, vividness and interactivity) on consumer engagement.
Photoredox Organocatalysts with Thermally Activated Delayed Fluorescence for Visible-Light-Driven Atom Transfer Radical Polymerization
Download Hi-Res ImageDownload to MS-PowerPointCite This:Macromolecules 2021, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Zhongwei Zhang Zhongwei Zhang College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, China , Weiping Chen*, Yuewei Zhang Yuewei Zhang State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China , Yue Wang, Yuelan Tian Yuelan Tian College of Chemistry and Environmental...
Polyamines Stimulate the Level of the σ
Manas K. Chattopadhyay‡1, Chithra N. Keembiyehetty§, Weiping Chen§ and Herbert Tabor‡ From the ‡Laboratory of Biochemistry and Genetics and the §Genomic Core Facility, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 ↵1 To whom correspondence should be addressed: NIDDK, NIH, 8 Center Dr., Bldg. 8, Rm. 219, Bethesda, MD 20892-0830. Tel.: 301-496-1058; Fax: 301-402-0240; E-mail: manasc{at}intra.niddk.nih.gov. Background: Polyamines are ubiquitous compounds present in most organisms.
Mesenchyme homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors
Differentiation of smooth muscle cells (SMCs) is critical for proper vasculogenesis and angiogenesis. However, the molecular mechanisms controlling SMC differentiation are not completely understood. During embryogenesis, the transcription factor mesenchyme homeobox 1 (Meox1) is expressed in the early developing somite, which is one of the origins of SMCs. In the present study, we identified Meox1 as a positive regulator of SMC differentiation.
Mesenchyme Homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors
Differentiation of smooth muscle cells (SMCs) is critical for proper vasculogenesis and angiogenesis. However, the molecular mechanisms controlling SMC differentiation are not completely understood. During embryogenesis, the transcription factor mesenchyme homeobox 1 (Meox1) is expressed in the early developing somite, which is one of the origins of SMCs. In the present study, we identified Meox1 as a positive regulator of SMC differentiation.
Journal of Environmental Quality Abstract - Plant and Environment Interaction Manganese, Zinc, and pH Affect Cadmium Accumulation in Rice Grain under Field Conditions in Southern China | Digital Library
Very little has been reported on the effects of pH, Zn, and Mn on Cd uptake in rice (Oryza sativa L.) and their levels under field conditions. Rice accumulates a high concentration of Cd in acid soils, even at low soil Cd levels. Lime (CaO) was spread at 1200 kg ha?1 on the topsoil of a rice field during the tillering stage. Effects of liming on rice Cd, soil pH, and amorphous Mn (MnO –AM) were then investigated.
Abstract | Digital Library
The distribution of trace elements (TEs) in water, sediment, riparian soil and dominant plants was investigated in the Fenghe River, Northwestern China. The Fenghe River ecosystem was polluted with Cd, Cr, Hg and Pb. There was a high pollution risk in the midstream and downstream regions and the risk level for Cd was much higher than that of the other elements.
N-type cathode interlayer based on dicyanomethylenated quinacridone derivative for high-performance polymer solar cells
A new π-conjugated electrolyte bis(dicyanomethylene)-quinacridone with two octyl-pyridium (DCNQA-PyBr) has been synthesized and employed as a solution-processed cathode interlayer (CIL) for polymer solar cells (PSCs). The PSCs exhibited simultaneously incresed open-circuit voltage, short-circuit current and fill factor.
Perceived value in community supported agriculture (CSA): A preliminary conceptualization, measurement, and nomological validity
Abstract Purpose The purpose of this paper is threefold: to conceptualize a construct of the perceived value in CSA and its dimensions, to operationalize and validate the construct, and to empirically investigate the influence of perceived value in CSA on consumer satisfaction and loyalty. Design/methodology/approach This research begins by reviewing relevant literature that frames the concept of perceived value in CSA and integrates this construct into a nomological network.
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