Xiaolin Lin
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Articles by Xiaolin Lin
Rare metachronous advanced colorectal cancer coexisting with lymphoma: a case report with over 10-year survival
Abstract Background: Multiple primary malignancies (MPMs) are increasingly encountered in clinical practice as cancer survivorship improves. The coexistence of colorectal cancer (CRC) and lymphoma is rare, and long-term survival exceeding 10 years in such patients has seldom been reported. Case presentation: We report a 63-year-old male patient who presented with sigmoid colon adenocarcinoma with synchronous multiple liver metastases (cT4N1M1, Stage IV) in 2015.
Analysis and Control of an HIV Infection Model With Cell-to-Cell Transmission and Saturated Incidence Rate
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data used in this study were obtained from the research published in Mathematical Biosciences and Engineering (DOI: 10.3934/mbe.2019150). The original data source has been cited in the references section of this manuscript. References 1 World Health Organization, HIV/AIDS (World Health Organization, 2025), https://www.who.int/news-room/fact-sheets/detail/hiv-aids.
METTL14 modulates the nasopharyngeal carcinoma microenvironment via m6A-modified YWHAH identified through single-cell and machine learning analyses
1 Introduction Nasopharyngeal carcinoma (NPC) is a head and neck malignancy strongly associated with Epstein–Barr virus (EBV) infection. It demonstrates notable ethnic and geographic disparities. The incidence rate ranges from 15 to 50 cases per 100,000 people in southern China and Southeast Asia, compared to approximately 0.4 per 100,000 in Western countries. NPC is characterized by its insidious onset and prevalence of cervical lymph node metastasis (1, 2).
Optimizing anti-PD-1/PD-L1 therapy efficacy and fecal microbiota transplantation donor selection through gut mycobiome-based enterotype
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Keywords immunotherapy gut microbiome gut mycobiome enterotype fecal microbiota transplantation Research topic(s) CP: Microbiology Introduction Immunotherapy has demonstrated significant success in treating various hematological and metastatic solid malignancies.1,2,3,4 The impact of the gut microbiome on therapeutic responses has been validated through numerous clinical and preclinical trials.5 Ongoing investigations in gut microbiome profiling have opened avenues for its potential as a...
By Muni Hu, Xiaoqiang Zhu, Xiaowen Huang, Li Hua, Xiaolin Lin, Hangyu Zhang, Ye Hu, Tianying Tong, Lingxi Li, Baoqin Xuan, Ying Zhao, Yilu Zhou, Jinmei Ding, Yanru Ma, Yi Jiang, Lijun Ning, Yue Zhang, Zhenyu Wang, Jing-Yuan Fang, Youwei Zhang, Xiuying Xiao, Jie Hong, Huimin Chen, Jiantao Li, Haoyan Chen
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Cell Reports
Verified
Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses
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Keywords immunotherapy gut microbiome metabolomics enterotype phenylacetylglutamine fecal microbiota transplantation Introduction Cancer immunotherapy holds great promise in the treatment of cancer by harnessing the power of the immune system.1 Various strategies are employed, including antibodies targeting specific proteins such as cytotoxic T lymphocyte protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), and programmed death ligand 1 (PD-L1), known as immune checkpoints.2 While...
By Xiaoqiang Zhu, Muni Hu, Xiaowen Huang, Lingxi Li, Xiaolin Lin, Xiaoyan Shao, Jiantao Li, Xiaoyue Du, Xinjia Zhang, Rongrong Sun, Tianying Tong, Yanru Ma, Lijun Ning, Yi Jiang, Yue Zhang, Yuqi Shao, Zhenyu Wang, Yilu Zhou, Jinmei Ding, Ying Zhao, Baoqin Xuan, Hongyang Zhang, Youwei Zhang, Jie Hong, Jing-Yuan Fang, Xiuying Xiao, Bo Shen, Songbing He, Haoyan Chen
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Cell Metabolism
Verified
A Reaction-Diffusion SIR Model with Saturated Incidence Rate and Vaccination
A Reaction-Diffusion SIR Model with Saturated Incidence Rate and Vaccination () 1. Introduction Since infectious diseases can spread widely among people or animals, causing serious impacts on human life and health, infectious diseases have always been a major public threat to all humans and other species. Therefore, it is crucial to study the transmission mechanism, outbreak or extinction patterns, and prevention and control measures of infectious diseases.
Study of the Mechanical Properties of Beam-Column Joints in a New Type of Aluminum Alloy Portal Frame
5. Parameterized Analysis of Numerical Simulation 5.1. Basic Model Parameters Before conducting numerical simulation parameter analysis, the basic model information will be introduced, and subsequent models will adjust the response parameters based on the different analysis parameters of the basic model.
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Highlights • OXR1A interacts with histone arginine methyltransferase PRMT5 • OXR1A stimulates PRMT5/MEP50-mediated H3 methylation in vitro • OXR1A promotes GH expression in pituitary via H3R2 symmetric demethylation • Depletion of Oxr1A results in GH deficiency and fatty liver in adult male mice Summary Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver.
CBIRC Issues Notices Allowing ‘Foreign-Invested’ Insurance Agencies and Loss Adjusters | Lexology
On 28 June 2018, the China Banking & Insurance Regulatory Commission (CBIRC) issued two new notices – (i) ‘Notice Allowing Foreign-Invested Insurance Agencies’; and (ii) ‘Notice Allowing Foreign-Invested Loss Adjusters’.
C-BIRC’s Guidance on the Development of Personal Income Tax-Deferred Pension (Insurance) Products_CH | Lexology
银保监会于2018年5月7日发布了《个人税收递延型商业养老保险产品开发指引》（以下称为“指引”）。 指引主要规定了以下几个方面： 税延养老保险产品开发应当遵循“收益稳健、长期锁定、终身领取、精算平衡”的原则。 税延养老保险产品可提供三项保险责任，分别为养老年金给付、全残保障和身故保障。 按照积累期养老资金收益类型的不同，税延养老保险产品分为收益确定型、收益保底型和收益浮动型三类产品。 给予参保人产品选择权和产品转换权。参保人在开始领取养老年金前，可进行产品转换，包括同一保险公司内的产品转换，或跨保险公司的产品转换，也可在开始领取养老年金前申请变更养老年金领取方式。 参与税延养老保险试点的保险公司应当按照指引要求和有关保险产品监管规定,开发设计税延养老保险产品，开发产品时可以在此基础上按有利于参保人的原则进一步提高保险保障水平，符合要求的税延养老保险产品获得批准后才能上市销售。
C-BIRC’s Guidance on the Development of Personal Income Tax-Deferred Pension (Insurance) Products | Lexology
On 7 May 2018, the China Banking & Insurance Regulatory Commission (C-BIRC) issued its Guidance in Respect of the Development of Personal Income Tax-Deferred Pension (Insurance) Products (the Guidance). The Guidance’s key requirements are: The development of personal income tax-deferred pension (insurance) products (Pension Products) should adhere to the principles of ‘steady & sure returns; long-term lock-in; guaranteed life-long drawings; and actuarial balance & equivalence’.
China maps out specific measures for further opening its insurance sector to foreign participants_CH | Lexology
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China maps out specific measures for further opening its insurance sector to foreign participants | Lexology
On 11 April 2018, the People’s Bank of China (PBOC) announced 11 measures (FS Measures) aimed at further opening China’s financial services sector to foreign participants. Of these 11 Measures, 4 were specifically aimed at China’s insurance sector (Insurance Measures) . PBOC stated that these 11 FS Measures would be implemented “…in the coming months, and no later than year end”.
The New Insurer Shareholder Regulations - Shareholder Qualifications (Chinese) | Lexology
新《保险公司股权管理办法》— 股东要求 保监会于2018年3月7日发布了修订后的《保险公司股权管理办法》（以下简称“《办法》”），《办法》将保险公司现有股东和新增股东根据持股比例分为财务Ⅰ类（0-5%（不含））、财务Ⅱ类（5%-15%（不含））、战略类（15%-1/3（不含））和控制类（1/3及以上）四类。由于《办法》同时规定单一股东（股东与其关联方、一致行动人的持股比例合并计算）持股比例上限最高为公司注册资本的三分之一，对于新增股东来说，“控制类股东”即意味着持有保险公司1/3股权的股东。 《办法》对各类股东需要的资质条件（“资质条件”）作出了正面规定，具体的： 财务Ⅰ类股东，应当具备以下条件： (一) 经营状况良好，有合理水平的营业收入； (二) 财务状况良好，最近一个会计年度盈利； (三) 纳税记录良好，最近三年内无偷漏税记录； (四) 诚信记录良好，最近三年内无重大失信行为记录； (五) 合规状况良好，最近三年内无重大违法违规记录。 财务Ⅱ类股东除满足财务Ⅰ类股东条件外，还应当具备以下条件： (一) 信誉良好，投资行为稳健，核心主业突出； (二)...
CIRC Issues Amended Insurer Shareholder Regulations (Chinese) | Lexology
2018?3?7?????????????????????????????“????”????????2016?12?29??2017?1?31????2017?7?20??8?21????????????????????????????????????????????????????????????? ????????????????????????????????????????????????? ????????????????I??0-5%????????II??5%-15%??????????15%-1/3??????????1/3?????? ????????????????????????????????????? ?????????????????????????????????????????????? ??????2018?4?10?????
CIRC Issues Amended Insurer Shareholder Regulations | Lexology
On 7 March 2018, the China Regulatory Insurance Commission (‘CIRC’) issued its amended Insurer Shareholder Regulations (‘Regulations’). Two rounds of public discussion drafts of the Regulations had available for public consultation 29 December 2016 through 31 January 2017, and again 20 July 2017 through 21 August 2017. The Regulations amend and enhance earlier versions of the original ‘Insurer Shareholder Regulations” and its related rules and regulations.
The New Insurer Shareholder Regulations - Shareholder Qualifications | Lexology
On 7 March 2018 the China Insurance Regulatory Commission (CIRC) issued its amended "Insurer Shareholder Regulations" (the Regulations).
CIRC issues Consultation Paper on Rules for Discounting of Policies of Life Insurance
The China Insurance Regulatory Commission (CIRC) issued the Consultation Paper on Rules for Discounting of Policies of Life Insurance (Consultation Paper) on 8 January 2018.
CIRC issues Consultation Paper on Rules for Discounting of Policies of Life Insurance (Chinese)
??????2018?1?8?????????????????????????????????“???????”?? ?????????????? ????????????????????????????????????????????????????????????????????????????????????? ??????????????????????????5?????????????????????? ??????????????????????????????????? ??????????????? ?????????????2?????????????????????????????????????????????????????????????????????3???????????????? ???????????????????????????????????? ???????????????????????????????????????????????????????????????
CIRC issues consultation paper on draft rules governing insurers’ independent directors
The China Insurance Regulatory Commission (CIRC) issued the Consultation Paper on draft rules governing insurers' independent directors (Consultation Paper) on 26 December 2017. Key points of the Consultation Paper are: It is recommended that the board of directors of all CIRC-regulated insurers (Insurers) is comprised of at least 2 independent directors, and that in any event the total number of independent directors comprises at least one third of all directors on an Insurer's board.
Standardisation of ‘Domestic-Security + Offshore-Borrowing’ Activities by PRC Insurers | Lexology
On 5 January 2018, the China Insurance Regulatory Commission (CIRC) and the PRC’s State Administration of Foreign Exchange (SAFE) jointly published the Notice on Standardisation of 'Domestic-Security + Offshore-Borrowing' Activities by PRC Insurers (the Notice).
CIRC issues Notice requiring internal review of solvency data integrity (Chinese)
????2017?6?5???????????????????????????????????????????????????? 1. ???? ????????????1?2016??????????????2?2017??1??????????????????????????????2017?6?30????????????? 2. ???? ??????????????????????? ??????????????????????? ???????????????????????????????????? ???????????????????????? ?????????????????????????????????????????????????????? ????????????????????????????? 3. ?????
CIRC issues Notice requiring internal review of solvency data integrity
On 5th June 2017 the China Insurance Regulatory Commission (CIRC) published its 'Notice Requiring the Launching of Internal Review Work in Respect of Solvency Data Integrity' (the Notice).
CIRC’s call for comments on draft changes to four regulations (Chinese)
2017?4?24??????????????????????????????????“???”?????????<?????????????????????>?????????????????????????????????? ????????????????????????????????????????????????????? ?????????????????????????????????????????????????????????????????????????????????????????? ???????????????????????????????????????????????????????????????????????????????????? ???????????????????????????????????????????????????????????????????? ????????????????2017?6?1??
CIRC’s call for comments on draft changes to four regulations
On 24th April 2017, the China Insurance Regulatory Commission (CIRC) released the FII Draft Regs, and calling for comments from the public by 1st June 2017. The FII Draft Regs propose four key changes: A repeal of the requirement in Article 26 of current FII Regs that all documentation submitted in respect of establishment of an FII must be publicly notarised.
CIRC Guidance on Insurance Companies’ Articles of Association
On 24th April 2017, the China Insurance Regulatory Commission published the 'Guidance on Insurance Companies' Articles of Association (the Guidance). The Guidance is only enforceable against joint-stock insurance: Other types of non-Mandated Companies and insurance entities (e.g. most foreign-invested insurance companies) are however encouraged to implement the Guidelines.
CIRC announces planning for C-ROSS Phase II (Chinese)
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R/L, a double reporter mouse line that expresses luciferase gene upon Cre-mediated excision, followed by inactivation of mRFP expression
The Cre/loxP system has become an important tool for the conditional gene knockout and conditional gene expression in genetically engineered mice. The applications of this system depend on transgenic reporter mouse lines that provide Cre recombinase activity with a defined cell type-, tissue-, or developmental stage-specificity.
Social media for developing health services
Abstract Purpose The purpose of this paper is to explore in depth how Web 2.0 (focusing on social media) contributes to create a better communication channel to provide information, support and assistance to patients. Social relationships of individuals on the Internet through social media have created added value for many industries.
From e-learning to social learning - a health care study
Abstract Purpose The emergence of Web 2.0 opened a new route for education to use the values derived from this development. The future of e-learning is social learning, where individuals can learn online due to the facility of social media. Social media such as online communities are places for social interactions between users. These social interactions are the way forward and can drive social support in an online context.
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