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Articles by Xiawei Wei
Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter
Abstract Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system whose mechanism has remained unclear. Here we determine cryo-EM structures of Acinetobacter baylyi LolDF in substrate-bound, AMP-PNP-bound, and LolA-bound states.
Conformational hijacking of lipoprotein transporter LolDF enables precision antimicrobial activity against Acinetobacter baumannii
Abstract Acinetobacter baumannii is a critical-priority pathogen with increasing antibiotic resistance. Here, we define the mechanism of abaucin, a first-in-class narrow-spectrum antibiotic that selectively targets A. baumannii by inhibiting its essential lipoprotein transporter, LolDF. Extending prior studies of archived strains, we demonstrate potent activity against clinically isolated carbapenem-resistant A. baumannii (CRAB) strains both in vitro and in a murine pneumonia model.
Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets
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Abstract Fibrosis is a severe pathological outcome of many chronic diseases, yet the therapeutic potential of targeting the altered major histocompatibility complex (MHC) class I immunopeptidome remains largely unexplored. Here we characterized the MHC class I immunopeptidomes from both fibrotic foci of human idiopathic pulmonary fibrosis lung explants and bleomycin-treated mice, identifying a diverse repertoire of fibrosis-associated peptides.
By Ziyi Bai, Tianxia Lan, Weiqi Hong, Haiying Que, Min Zhu, Xin Xiao, Jiayuan Ai, Shaoxiong Huang, Jiayu Wang, Qiaonan Hong, Yanyan Liu, Chengxin Xiao, Chengjian Zhao, Xin Wang, Xiaolong Zhang, Ting Yang, Heng Xu, Lunzhi Dai, Charles Powell, Luca Richeldi, Fengming Luo, Haohao Dong, Yong Yuan, Qiang Pu, Xiawei Wei, Dandan Wan
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Nature
Verified
Unsafe drinking water and human health: A global umbrella review of disease outcomes, intervention effectiveness, and policy implications
Keywords unsafe drinking water umbrella review health outcome intervention effectiveness Introduction Access to safe drinking water is fundamental to human health.
Bioengineered nanovesicles for efficient siRNA delivery through ligand-receptor-mediated and enzyme-controlled membrane fusion - Nature Communications
Abstract A major obstacle in knocking down oncogenes for tumor therapy is the efficient delivery of siRNA into the cytosolic spaces of cancer cells. Here, we genetically bioengineer biomimetic nanovesicles with tumor-recognition and enzyme-controlled membrane fusion functions for efficiently delivering small interfering RNA into cancer cells towards gene silencing tumor therapy.
Wnt/β-catenin mediated signaling pathways in cancer: recent advances, and applications in cancer therapy - Molecular Cancer
Clinical trials of agents targeting the Wnt/β-catenin signaling pathway was summarized in Table 4, and Fig. 5 shown the timeline of clinical trials of drugs targeting Wnt/β-catenin signaling pathway. Timeline of clinical trials of drugs targeting Wnt/β-catenin signaling pathway. This figure illustrates Part 5: Clinical applications of drugs targeting the Wnt/β-catenin signaling pathway, emphasizing the advancement of clinical trials for these pharmacological agents.
cGAS‐STING pathway agonists are promising vaccine adjuvants
1 INTRODUCTION Vaccines are a crucial invention for preventing and controlling both infectious and noninfectious diseases, including cancers.
Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development
Abstract : Vaccination is one of the most effective strategies to control epidemics. With the deepening of people’s awareness of vaccination, there is a high demand for vaccination. Hence, a flexible, rapid, and cost-effective vaccine platform is urgently needed. The baculovirus expression vector system (BEVS) has emerged as a promising technology for vaccine production due to its high safety, rapid production, flexible product design, and scalability.
Targeting PI3K in cancer: mechanisms and advances in clinical trials - Molecular Cancer
References Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2001;17:615–75. Article CAS PubMed Google Scholar Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7:606–19. Article CAS PubMed Google Scholar Martini M, De Santis MC, Braccini L, Gulluni F, Hirsch E.
Structural basis of BAM-mediated outer membrane β-barrel protein assembly - Nature
Abstract The outer membrane structure is common in Gram-negative bacteria, mitochondria and chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential interchange portals of materials1,2,3. All known OMPs share the antiparallel β-strand topology4, implicating a common evolutionary origin and conserved folding mechanism.
Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing - Nature Catalysis
Author notes These authors contributed equally: Bingnan Luo, Chong Zhang.
Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence - Cell Research
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PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma - Nature Communications
Study approval All animal studies were performed in accordance with guidelines provided by the Institutional Animal Care and Treatment Committee of Sichuan University. The animals were treated in accordance with relevant institutional and national guidelines and regulations. The maximal allowable tumor size/burden (diameter less than 1.5 cm) was not exceeded. The HCC tissues used in this study were obtained from West China Hospital, Chengdu, with informed written consent from patients.
Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine - Nature Communications
SSTRs Gi-mediated cAMP inhibition assay The levels of the intracellular 3′, 5′-cyclic AMP (cAMP) were measured by the GloSensor cAMP assay (Promega) as described in the previous studies28,41 which has been widely used. The human full-length SSTRs and mutants were cloned into the pcDNA3.1+ vector with a HA signal sequence followed by a Flag tag at the N-terminus.
Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants - Signal Transduction and Targeted Therapy
Abstract The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain or increase the immune responses owing to waning immunity and the emergency of new variant strains. The deficiency of intramuscularly delivered vaccines to induce mucosal immunity urged the development of mucosal vaccines.
Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant have a reduced ability to induce the immune response - Signal Transduction and Targeted Therapy
Dear Editor, The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has attracted great concerns since its identification in South Africa. Omicron is the fifth variant of concern (VOC) after Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2), and set a record with the shortest duration from variants of interest (VOI) to VOC so far.
Publisher Correction: Heat stress activates YAP/TAZ to induce the heat shock transcriptome
Publisher Correction: Heat stress activates YAP/TAZ to induce the heat shock transcriptome Min Luo ORCID: orcid.org/0000-0002-6875-79451,2,3, Zhipeng Meng3,4, Toshiro Moroishi ORCID: orcid.org/0000-0001-6419-38825,6,7, Kimberly C.
Heat stress activates YAP/TAZ to induce the heat shock transcriptome
Abstract The Hippo pathway plays critical roles in cell growth, differentiation, organ development and tissue homeostasis, whereas its dysregulation can lead to tumorigenesis. YAP and TAZ are transcription co-activators and represent the main downstream effectors of the Hippo pathway. Here, we show that heat stress induces a strong and rapid YAP dephosphorylation and activation. The effect of heat shock on YAP is dominant to other signals known to modulate the Hippo pathway.
Structure-Mediated Degradation of CircRNAs
Yingli Guo Yingli Guo Affiliations Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China Search for articles by this author Xiawei Wei Xiawei Wei Correspondence Correspondence: Affiliations Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation...
Malignant Pleural Effusion and ascites Induce Epithelial-Mesenchymal Transition and Cancer Stem-like Cell Properties via the Vascular Endothelial Growth Factor (VEGF)/Phosphatidylinositol 3-Kinase (PI3K)/Akt/Mechanistic Target of Rapamycin (mTOR) Pathway
Malignant pleural effusion (PE) and ascites, common clinical manifestations in advanced cancer patients, are associated with a poor prognosis. However, the biological characteristics of malignant PE and ascites are not clarified. Here we report that malignant PE and ascites can induce a frequent epithelial-mesenchymal transition program and endow tumor cells with stem cell properties with high efficiency, which promotes tumor growth, chemoresistance, and immune evasion.
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