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Articles by Xin Yi
Toward high-quality genomes: Standards, challenges, and strategies for assembly and annotation
1 Introduction A high-quality genome is fundamental to understanding both the genetic architecture and the evolutionary dynamics of biodiversity. Over the past two decades, advances in sequencing technologies, as well as assembly and annotation algorithms, have driven rapid progress in animal and plant genomics.
Computer Science > Computation and Language
Large language model (LLM) driven multi-agent systems have shown promise in complex clinical reasoning, yet existing approaches rely on static strategies and lack persistent clinical memory, preventing self-evolving from prior diagnostic successes and failures. We present EMR, a self-evolving medical multi-agent system via Experience Mining and Reuse.
Study on the failure mechanism and cutting efficiency of rebar in linear cutting based on the finite-discrete element method
Abstract The design of cutter parameters plays a key role in the successful cutting of large-diameter reinforced concrete building piles by shield machines. However, the cutting mechanism of the shield machine in cutting rebar is not clear. Based on the shield pile cutting project of Wuhan Metro Line 12, the finite-discrete element method (FDEM) numerical models of rebar cutting are established.
Case Report: Rare brainstem involvement in anti-metabotropic glutamate receptor 1 encephalitis
Abstract Anti–metabotropic glutamate receptor 1 (mGluR1) encephalitis is a rare form of autoimmune encephalitis that typically presents with cerebellar dysfunction. Predominant brainstem involvement has seldom been reported. We report an 87-year-old man who presented with a subacute onset of fever, dysarthria, limb weakness, and altered mental status.
Comparative genomics reveals adaptive evolution of
在这里添加一些文本 RIS (ProCite, Reference Manager) BibTeX Comparative genomics reveals adaptive evolution of Latilactobacillus sakei across diverse ecological niches XIN Yi, LI Weicheng, WU Qiong, SUN Jiaqi, DENG Shuo, SUN Zhihong Food and Fermentation Industries ›› 2026, Vol. 52 ›› Issue (15) : 21-28. Food and Fermentation Industries ›› 2026, Vol. 52 ›› Issue (15) : 21-28.
Chronic conditions and aortic disease risk: a prospective cohort study with predictive and etiological analyses
Abstract Aortic diseases are often clinically silent until advanced stages, and risk determinants beyond traditional cardiovascular factors remain incompletely characterised. Here, we investigate associations of 42 chronic conditions and multimorbidity with incident aortic disease in UK Biobank (UKB), with external validation in China Kadoorie Biobank (CKB).
The limits of eGFR in renal donor selection
Living kidney donation is a rare paradox in medicine, operating on a healthy person to benefit someone else, so ethical justification hinges on “minimal harm,” which in practice centers on rigorous, accurate assessment of the donor’s renal function. The glomerular filtration rate (GFR) assessment in donor evaluation is less a diagnostic snapshot than a prognostic gauge of a donor’s lifelong “renal runway” after nephrectomy.
Where the river turns old: urbanized deltas imprint a fossil signature on black carbon exported to the ocean
Abstract Black carbon (BC) from biomass burning is a key component of the global carbon cycle, and radiocarbon (14C) age of riverine BC is commonly used to constrain its terrestrial residence time. However, whether 14C-free BC from fossil sources significantly contributes to riverine BC and biases these ages remains unclear. Here, we track dissolved and particulate BC (DBC, PBC) along a river continuum from forested headwaters to an urbanized estuary.
Computer Science > Computation and Language
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Dalpiciclib plus endocrine therapy in women with HR + /HER2 − advanced breast cancer and visceral crisis: a multicenter, nonrandomized, phase 2 DARVIN trial
Abstract Visceral crisis in advanced breast cancer (ABC) represents a major challenge. Here we conducted a phase 2 study to evaluate dalpiciclib plus endocrine therapy (ET) in women with HR+/HER2− ABC experiencing visceral crisis.
Lysosome as a central hub in ferroptosis-driven pathologies
Keywords ferroptosis lysosome neurodegenerative disorder cancer cardiometabolic disorder Get full text access Log in, subscribe or purchase for full access. References 1. Dixon, S.J. ... Ferroptosis: an iron-dependent form of nonapoptotic cell death Cell. 2012; 149:1060-1072 2. Zhou, Q. ... Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies Signal Transduct. Target. Ther. 2024; 9:55 3. Wang, Y. ...
Clinical application study of neuromuscular electrical stimulation for premature ejaculation
español La eyaculación prematura (EP) es una disfunción sexual masculina altamente prevalente que afecta significativamente el bienestar psicológico, las relaciones interpersonales y la calidad de vida. Aunque los tratamientos farmacológicos como los inhibidores selectivos de la recaptación de serotonina y los anestésicos tópicos siguen siendo la base principal del tratamiento, su utilidad clínica suele estar limitada por efectos adversos, eficacia subóptima y mala adherencia a largo plazo.
Computer Science > Computation and Language
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
CRISPR/Cas9 in cancer therapy: clinical translation, mechanistic strategies, and therapeutic directions
Abstract The advent of CRISPR/Cas9 genome editing has significantly transformed the landscape of cancer therapeutics by facilitating precise and programmable manipulation of disease-associated genetic modifications. This review comprehensively evaluates the current clinical and translational landscape of CRISPR/Cas9-based cancer therapies through an analysis of published literature and registered clinical trials.
Physical activity and teacher burnout: parallel and serial mediation by mindfulness and spiritual wellbeing
Abstract Objective: Based on the job demands–resources model and conservation of resources theory, this study examines the association between physical activity and teacher burnout among primary and secondary school physical education teachers, focusing on the mediating roles of mindfulness and spiritual wellbeing. Methods: A cross-sectional design was employed to conduct a questionnaire survey among 313 primary and secondary school physical education teachers.
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability
Abstract Engrams are formed by activity-dependent recruitment of subsets of excitatory principal neurons, whereas inhibitory neurons mediate memory lability and stability. It remains elusive whether specific types of interneurons are preferentially engaged in determining the fate of memory.
VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation - Nature Communications
Abstract Enterocytes mediate both nutrient absorption and antimicrobial peptide (AMP) secretion while constantly exposed to osmotic fluctuations. However, the role of volume-regulated anion channel (VRAC), a key osmo-sensitive ion channel, in enterocytes and inflammatory bowel disease (IBD) remains unclear. Here, we show that intestinal epithelial cell (IEC)-specific knockout of LRRC8A, the essential VRAC subunit, exacerbates colitis and inflammation-associated colorectal cancer.
Human hepatic cell line 5: In-vitro model for hepatic immunobiology - Molecular Biology Reports
Moris D, Martinino A, Schiltz S, Allen PJ, Barbas A, Sudan D, King L, Berg C, Kim C, Bashir M, Palta M, Morse MA, Lidsky ME (2025) Advances in the treatment of hepatocellular carcinoma: an overview of the current and evolving therapeutic landscape for clinicians. CA Cancer J Clin 75(6):498–527. https://doi.org/10.3322/caac.70018 Article PubMed PubMed Central Google Scholar Liu M, Jiang L, Guan XY (2014) The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update.
Trotz Zollstreits: Chinas Außenhandel mit Rekordüberschuss
2025 prägen US-Zölle und globale Konflikte den Welthandel. Chinas Exportmotor stockte ob dieser Probleme nicht. Viele Länder, darunter auch Deutschland, bekamen das zu spüren. Peking. Chinas Außenhandel hat trotz des Zollkonflikts mit den USA und globaler Handelsstreitigkeiten im vergangenen Jahr einen Rekordüberschuss erreicht.
Trotz Zollstreits: Chinas Außenhandel mit Rekordüberschuss
Chinas Außenhandel hat trotz des Zollkonflikts mit den USA und globaler Handelsstreitigkeiten im vergangenen Jahr einen Rekordüberschuss erreicht. Nach Daten des chinesischen Zolls stiegen die Exporte 2025 im Vergleich zum Vorjahr um 5,5 Prozent auf einen Gesamtwert von rund 3,8 Billionen US-Dollar (derzeit rund 3,26 Billionen Euro) an. Die Importe betrugen unverändert rund 2,6 Billionen Dollar, womit der Handelsüberschuss auf einen Rekordwert von knapp 1,2 Billionen Dollar stieg.
Chinas Außenhandel erreicht 2025 Rekordüberschuss
Chinas Außenhandel hat im vergangenen Jahr erneut einen Rekordüberschuss erreicht. Nach Daten des chinesischen Zolls stiegen die Exporte 2025 im Vergleich zum Vorjahr um 5,5 Prozent auf einen Gesamtwert von rund 3,8 Billionen US-Dollar (derzeit rund 3,26 Billionen Euro) an. Die Importe blieben unverändert bei rund 2,6 Billionen Dollar, womit der Handelsüberschuss auf einen Rekordwert von knapp 1,2 Billionen Dollar stieg. 2024 hatte der Überschuss bereits fast eine Billion US-Dollar betragen.
Chinas Außenhandel erreicht 2025 Rekordüberschuss
Trotz globaler Konflikte wächst Chinas Außenhandel weiter. Die Volksrepublik erreicht einen Handelsüberschuss in Rekordhöhe. Auch die Exporte nach Deutschland sind deutlich angestiegen. Peking. Chinas Außenhandel hat im vergangenen Jahr erneut einen Rekordüberschuss erreicht. Nach Daten des chinesischen Zolls stiegen die Exporte 2025 im Vergleich zum Vorjahr um 5,5 Prozent auf einen Gesamtwert von rund 3,8 Billionen US-Dollar (derzeit rund 3,26 Billionen Euro) an.
Intergenerational approach of community dance program for older adults in singapore: a feasibility cluster-controlled trial - BMC Geriatrics
Abstract Dance interventions encompass an inexpensive and engaging alternative to promote healthy ageing among older adults compared to pharmacological interventions. This study aims to refine the Community Dance Program (CDP) protocol and assess the feasibility and acceptability of implementing and evaluating the program for promoting physical, cognitive, and psychosocial health of older adults.
Recent Progress in Liquid Crystal Elastomer Actuators: Mechanisms, Fabrication, and Multifunctional Applications
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ARena of Privacy: Exploring Augmented Reality in Enhancing Smart Home Privacy Awareness and Control
Abstract The rapid emergence of smart homes offers convenience but also raises significant privacy concerns, such as challenges in comprehending privacy-related statuses, information, and settings. This study aims to mitigate these concerns by leveraging augmented reality technology to enhance privacy protection user experiences.
A Cascaded Segmentation-Classification Deep Learning Framework for Preoperative Prediction of Occult Peritoneal Metastasis and Early Recurrence in Advanced Gastric Cancer
Abbreviations DL (deep learning) OPM (occult peritoneal metastasis) GC (gastric cancer) ROC (receiver operating characteristic) DCA (decision curve analysis) PM (peritoneal metastasis) PR (peritoneal recurrence) NIPS (neoadjuvant intraperitoneal and systemic chemotherapy) HIPEC (hyperthermic intraperitoneal chemotherapy) EIPL (extensive intraoperative peritoneal lavage) PLC (peritoneal lavage cytology) NLR (neutrophil-to-lymphocyte ratio) LAGC (locally advanced gastric cancer) VOI (volume of...
12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis - Molecular Medicine
Abstract Disturbed flow regions in the vasculature are predisposed to endothelial dysfunction and atherosclerotic plaque formation. The enzyme 12/15-lipoxygenase (12/15-LOX, encoded by ALOX15) has emerged as a promising therapeutic target for atherosclerosis. However, the relationship between 12/15-LOX and disturbed flow-induced atherosclerosis remains uncharacterized. Expression of 12/15-LOX in endothelial cells (ECs) exposed to steady flow and disturbed flow was compared in vivo and in vitro.
A longitudinal observational study of demoralization within 6 months following cancer diagnosis: a cross-lagged panel network analysis - Supportive Care in Cancer
Abstract To identify the dynamic change and explore the longitudinal correlates of demoralization in patients after cancer diagnosis, provide comprehensive references for interventions targeting demoralization at different time points. This study included 127 cancer patients from a tertiary hospital in Guangzhou, China. Demoralization was assessed at three time points: 1 (T1), 3 (T2), and 6 (T3) months after cancer diagnosis.
LGRPv2: A high‐value platform for the advancement of Fabaceae genomics
Introduction The legume family (Fabaceae/Leguminosae), as the second largest economically important group of edible plants in the world, includes numerous essential food, oil, ornamental, and medicinal crops (Murray et al., 2017; Smýkal et al., 2015; Yi et al., 2022; Yurkevich et al., 2024).
Manipulation of host-plant preference by virus-induced changes to its insect vector’s olfactory system
Introduction The transmission dynamics of arthropod-borne viruses (arboviruses) are intricately linked to the interactions among these viruses, their hosts, and the behaviors of their insect vectors.1,2 In order to effectively acquire the virus, a healthy insect vector must locate and feed on an infected host to obtain viral particles.3 For successful transmission, the infected vector must then identify and transmit the virus to a new susceptible host during its feeding activities.4 A...
Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model
Loading metrics Open Access Peer-reviewed Research Article Citation: Yi X, Abas R, Raja Muhammad Rooshdi RAW, Yan J, Liu C, Yang C, et al. (2025) Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model. PLoS ONE 20(4): e0321078.
Loss of the Auxiliary α2δ1 Voltage-Sensitive Calcium Channel Subunit Impairs Bone Formation and Anabolic Responses to Mechanical Loading
α2δ1 subunit, mechanotransduction, voltage-sensitive calcium channel, bone formation, loading 10.1093/jbmrpl/ziad008 Post-print Kelly, Madison M; Sharma, Karan; Wright, Christian S; Yi, Xin; Reyes Fernandez, Perla C; Gegg, Aaron T; Gorrell, Taylor A; Noonan, Megan L; Baghdady, Ahmed; Sieger, Jacob A; Dolphin, Annette C; Warden, Stuart J; Deosthale, Padmini; Plotkin, Lilian I; Sankar, Uma; Hum, Julia M; Robling, Alexander G; Farach-Carson, Mary C; and Thompson, William R, "Loss of the...
Cognitive Risk Stratification Score in Middle-aged and Older Adults with Type 2 Diabetes: a Cross-Sectional Study
Cognitive impairment (CI) affects approximately 45% of middle-aged and older adults with Type 2 Diabetes Mellitus (T2DM) globally. Although formal comprehensive neuropsychological tests are the gold standard for diagnosing CI, they are often time-intensive and may not be feasible in primary care.
Fire Behavior Characteristics and Computational Simulation Research on Historic Wooden Structures
3. Results and Discussion 3.1. Wood-Burning Experiment 3.1.1. Heat-Release Rate The heat-release rate (HRR) is an essential metric indicative of fire propagation in historic timber structures. It represents the temporal variation of heat emission at the location of the fire and influences the temperature generated by the blaze [34]. The HRR profiles for FP and 240C are presented in Figure 5.
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice - Molecular Neurodegeneration
Human blood was collected from patients from the National Neuroscience Institute of Singapore (NNI), who were recruited for this study with fully informed written consent. All methods and protocols used in this study were performed following the institutional and relevant guidelines and regulations. The clinical diagnosis and pathological features were carefully examined by clinicians and pathologists from NNI. This study was also approved by the Institutional Review Board of NNI (2017/2602).
Metabolomics analysis reveals the effects of high dietary copper on mitochondria-mediated autophagy and apoptosis in spleen of broiler chicken
ABSTRACT Copper (Cu) is a necessary micro-element and plays important roles in many biochemical processes. However, excessive Cu intake can lead to multi-organ toxicity, especially in the spleen. To gain further insights into the specific mechanisms of splenic toxicity associated with Cu-induced metabolic disorders, 192 one-day-old chickens were selected and randomly divided into four groups for this study.
Analysis of Genomic and Immune Intratumor Heterogeneity in Linitis Plastica via Multiregional Exome and T-Cell Receptor Sequencing
Abstract The molecular landscape and the intratumor heterogeneity (ITH) architecture of gastric linitis plastica (LP) are poorly understood. We performed whole-exome sequencing (WES) and T-cell receptor (TCR) sequencing on 40 tumor regions from four LP patients. The landscape and ITH at the genomic and immunological levels in LP tumors were compared with multiple cancers that have previously been reported. The lymphocyte infiltration was further assessed by immunohistochemistry (IHC) in LP tumors.
Gabapentin Disrupts Binding of Perlecan to the α 2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation
Home > UTHealth > GSBS > Journal Articles > 736 perlecan, voltage-sensitive calcium channels, α2δ1, gabapentin, mechanosensation, bone, osteocytes DOWNLOADS Included in Bioinformatics Commons, Biomedical Informatics Commons, Medical Molecular Biology Commons, Oncology Commons COinS
Loss of the Auxiliary α 2δ1 Voltage-Sensitive Calcium Channel Subunit Impairs Bone Formation and Anabolic Responses to Mechanical Loading
Abstract Voltage-sensitive calcium channels (VSCCs) influence bone structure and function, including anabolic responses to mechanical loading. While the pore-forming (α1) subunit of VSCCs allows Ca2+ influx, auxiliary subunits regulate the biophysical properties of the pore. The α2δ1 subunit influences gating kinetics of the α1 pore and enables mechanically induced signaling in osteocytes; however, the skeletal function of α2δ1 in vivo remains unknown.
Market Participation and Farmers’ Adoption of Green Control Techniques: Evidence from China
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PANoptosis: a novel target for cardiovascular diseases
Highlights PANoptosis displays the collective mechanistic hallmarks of pyroptosis, apoptosis, and necroptosis, thus making it a pivotal target against diseases. Current research has primarily focused on the role of PANoptosis in cancer and infectious and inflammatory diseases. However, its role in cardiovascular diseases has not been comprehensively discussed.
Magnetic-Controlled Microrobot: Real-Time Detection and Tracking through Deep Learning Approaches
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An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
Abstract Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, we reveal its impact on the thalamic nucleus reuniens (RE) and interconnected hippocamposeptal circuits during fear extinction. Systemic or RE-specific administration of remimazolam impedes fear extinction by reducing RE activation through A type GABA receptors.
Fermentation | Free Full-Text | Effect of Total Mixed Ration on Growth Performance, Rumen Fermentation, Nutrient Digestion, and Rumen Microbiome in Angus Beef Cattle during the Growing and Fattening Phases
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Control of Self-Winding Microrobot Using an Electromagnetic Drive System: Integration of Movable Electromagnetic Coil and Permanent Magnet
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Effect of Yucca schidigera Extract on Serum Metabolites of Angus Crossbreed Steers with Metabolomics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Optimization of Three Extraction Methods and Their Effect on the Structure and Antioxidant Activity of Polysaccharides in Dendrobium huoshanense
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Unravelling the enigma of the human microbiome: Evolution and selection of sequencing technologies
INTRODUCTION The microbiome represents the aggregate of microbial species in a specific environment, along with their genetic information and functions, also known as the metagenomic element of the microbiota. This includes interactions among microbes in the environment and between microbes, other species within that environment, and the environment itself (Berg et al., 2020).
A female-specific odorant receptor mediates oviposition deterrence in the moth Helicoverpa armigera
Oviposition is one of the essential elements of reproductive behavior in insects.1,2 Considering non-social insects lacking parenting behaviors, finding an eligible site for egg laying is the gravid female’s last contribution to favor her progeny.
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