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Articles by Youngmin Ko
Incorporating brain-inspired mechanisms for multimodal learning in artificial intelligence
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Multimodal learning enhances the perceptual ability of intelligent systems by integrating information across sensory modalities.
Foveated light-field compound imager
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Artificial vision systems hold transformative potential for biomedical imaging, diagnostics, and translational research by emulating and extending the capabilities of biological eyes.
Observational constraints from global ice-phase fraction indicate moderate climate sensitivity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Cloud feedback remains the largest source of uncertainty in estimates of climate sensitivity. Among its components, the cloud optical depth (τ) feedback acts as a negative feedback that suppresses climate warming, yet it remains poorly constrained by observations.
Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A -mutated cancers
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract ARID1A (AT-rich interaction domain 1A), a key subunit of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, is frequently mutated in cancers.
The ligand preference of LRP1 is regulated by O-glycans
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The family of low-density lipoprotein receptor (LDLR) and LDLR-related proteins (LRPs) are endocytic receptors serving as essential regulators of multiple physiological processes including cholesterol clearance, protein reabsorption, and neuronal protein trafficking.
By Youngmin Ko, John Hintze, Luise Fast, Asli B. Topaktas, Thomas D. Madsen, Shifa Jebari-Benslaiman, Silvia D’Andrea, Noortje de Haan, Lasse H Hansen, Noé Quittot, Cesar Martin, César A. Martin, César Martín, Zhang Yang, Sergey Y. Vakhrushev, Rebecca Miller, Dudley K. Strickland, Bradley T. Hyman, Elisa Fadda, Katrine T. Schjoldager, Bethany H. Claridge, Rob Baars
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Near-inertial internal waves funneled into Taylor caps shape seamount tops, with implications for biodiversity in the deep ocean
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Internal waves are energetic and ubiquitous in the ocean and their interactions with submarine topography could drive sediment resuspension and reshape seafloor substrate. However, the mechanisms governing these interactions are largely unknown.
Biofunctionalized polymer semiconductors toward soft and stretchable transistor-based biosensors
Abstract INTRODUCTION RESULTS DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Organic materials with tunable chemical and mechanical properties are ideal for interfacing with skin and tissue in biomedical applications.
Mass-invariant universal optical conductivity from quantum geometry
Abstract INTRODUCTION RESULTS AND DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mass is a defining property of particles, shaping their fundamental nature and interactions. In condensed matter systems, the effective mass of electrons has long been regarded as a key factor influencing material properties, including their transport and optical responses.
The myokine irisin ameliorates the secretory dysfunction of pancreatic β cells in experimental and human type 2 diabetes
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Irisin is a myokine that enhances insulin secretion and β cell viability in both rodent and human β cells. Here, we investigated whether irisin preserves β cell functional mass in vivo in diabetic mice and ex vivo in human pancreatic islets from subjects with type 2 diabetes (T2D).
By Youngmin Ko, John Hintze, Luise Fast, Nicola Marrano, Anna Borrelli, Giuseppina Biondi, Martina Rella, Rossella D’Oria, Valentina Annamaria Genchi, Cristina Caccioppoli, Valerio Galasso, Giovanni Galluzzi, Luca Roberto, Anna Signorile, Leonardo Vincenti, Fabrizio Aquilino, Rita Nano, Federico Baruzzi, Antonio Moretti, Luigi Lupo, Piero Marchetti, Lorenzo Piemonti, Angelo Cignarelli, Sebastio Perrini, Luigi Laviola
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Genomic-to-space measurements reveal large-scale ocean nutrient stress
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Phytoplankton growth and ocean primary production depend on a nutrient supply that fluctuates across seasonal to millennial timescales. Because surface nutrients and phytoplankton biomass recycle rapidly, they obscure the large-scale pattern of nutrient stress.
Electrode-omics reveals epochs in silicon anode evolution underpinning electrochemomechanical resilience
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Here, we advance electrode-omics to identify evolutionary bursts by which ethereal locally superconcentrated electrolytes (LSCEs) mitigate silicon anode degradation through its epochs of electrochemical and chemical reactions.
Broadband and high-speed terahertz wireless sensing via vertical-transport Dirac-source detector
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract In the realm of wireless sensing, it is envisioned that sensing and communication functionalities will coexist and be fully integrated within a unified system.
Architecting three-dimensional reconfigurable matter from pop-up kirigami with programmable multistability
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mechanical pop-up systems, which reconfigure from two-dimensional (2D) into complex three-dimensional (3D) shapes, are promising for advanced manufacturing and deployable devices.
Light-based 3D printing of mechanoluminescent living gels loaded with dinoflagellates
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Dinoflagellates, a group of marine unicellular algae, are known for the fascinating glowing effects in coastal waters.
Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Chimeric antigen receptor (CAR) T cell therapy faces many challenges against solid tumors including T cell exhaustion and poor CAR durability.
Regulation of NAT1 activity in modern humans by a novel phosphorylation site
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract N-acetyltransferase 1 (NAT1) is an enzyme that acetylates certain drugs and carcinogens and is involved in folate metabolism. Some NAT1 variants are associated with susceptibility to cancer and birth defects.
Enteric viral infections promote systemic accelerated aging in Drosophila
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Do viral infections accelerate aging, and does this acceleration scale with pathogenicity?
Bioinspired spatiotemporal control of microhelix formation and actuation
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Helical structures provide critical functions in structural stability, locomotion, and mechanical flexibility.
The impactful role of the HDACs in the regulation of gene expression and as targets for disease therapy
Abstract INTRODUCTION RESULTS AND DISCUSSION Acknowledgments REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Histone deacetylases (HDACs) are potent regulators of gene expression, yet incomplete understanding of individual HDAC function coupled with the lack of selective inhibitors has impeded successful targeting of these proteins for the improvement of human health.
Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract EV-A71 has been responsible for recent severe HFMD outbreaks. We report structures for 12 potently neutralizing human anti–EV-A71 monoclonal antibody Fabs, alone and complexed with virus.
A minimal transcription factor network is sufficient to drive paclitaxel biosynthesis
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The supply of the anticancer drug paclitaxel is limited by its low natural abundance and complex chemical structure. We previously reported the development of a cultured Taxus cambial meristematic cell (CMC) system, where methyl jasmonate enhances paclitaxel production.
A sustained living coating for infectious keratitis therapy via probiotic consumption and production effects
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Excessive inflammation and infection are critical factors leading to biomaterial failure and delayed wound healing. Surface modification of biomaterials with drug-loaded coatings can effectively address these issues.
A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Helper NLRs function as central nodes in plant immune networks. Upon activation, they oligomerize into inflammasome-like resistosomes to initiate immune signaling, yet the dynamics of resistosome assembly remain poorly understood.
A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Pathogens counteract central nodes of NLR immune receptor networks to suppress immunity. However, the mechanisms by which pathogens hijack helper NLR pathways are poorly understood.
By Youngmin Ko, John Hintze, Luise Fast, Jogi Madhuprakash, AmirAli Toghani, Hsuan Pai, Madia Harvey, Adam R. Bentham, Benjamin A Seager, Juan Carlos de la Concepcion, David Lawson, Clare E. M. Stevenson, Angel Vergara-Cruces, Lida Derevnina, Tolga Bozkurt, Mark Banfield, Sophien Kamoun, Mauricio P. Contreras
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Reactive reconstruction and embedded passivation of heterointerfaces for intrinsically stable perovskite photovoltaics
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Heterointerface degradation under operational stress represents a critical limitation to perovskite solar cell longevity.
Enhanced chiral discrimination in mass spectrometry with orbital angular momentum beams
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Chirality, the absence of mirror symmetry, is a fundamental property observed from subatomic particles to molecules and macroscopic systems. Distinguishing molecular mirror images (enantiomers) is essential in pharmaceuticals and molecular diagnostics.
Massively parallel bead-free force spectroscopy with fluorescence
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Single-molecule force spectroscopy (SMFS) has transformed our understanding of biomolecular mechanics.
Erratum for the Research Article “Highly efficient light-gated COF membrane for precise multistage molecular separation” by L. Zhai et al .
Information & Authors Metrics & Citations View Options References Figures Tables Media Share In the original version of the Research Article, “Highly efficient light-gated COF membrane for precise multistage molecular separation” by L. Zhai et al., an error occurred during figure plotting. In Fig. 2E, the authors inadvertently used the same XRD data curve twice for two different samples. Figure 2 has been updated with the correct version of panel (E) and the raw XRD data for Fig.
Electric field–guided random-access DNA data storage
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract DNA offers the promise of high-density, long-term storage, yet current systems face limitations due to polymerase chain reaction–based manual workflows that are inherently slow, error prone, and difficult to scale for practical applications.
Evolution of a ZW sex determination system in sticklebacks
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The stickleback system offers a powerful model for investigating the evolutionary dynamics of sex chromosome differentiation. Although a ZW sex determination mechanism has previously been reported in sticklebacks, its origin and evolutionary history remain poorly resolved.
Genomic evidence for limited entomophagy in ancient Europeans
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract To meet the rising food demands of our growing population, the Food and Agriculture Organization proposed edible insects as sustainable sources of animal protein.
Uncovering functional variants using a high-efficiency PE3-based screening platform
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Prime editing (PE) enables precise nucleotide changes but has limited utility in high-throughput functional screening due to low editing efficiency.
Tropical impacts of the Southern Ocean underestimated by mean-state biases
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Observed sea-surface temperature (SST) trends over recent decades feature cooling in the tropical eastern Pacific and the Southern Ocean (SO). Growing evidence suggests that tropical cooling may partly stem from remote impacts of the SO.
The natural killer–cellular humoral activation test as a functional biomarker of antibody-mediated rejection after kidney transplantation
Abstract Antibody-mediated rejection (ABMR) is a major cause of graft failure after kidney transplantation, yet current diagnostics do not directly assess effector immune activity. Natural killer (NK) cells contribute to ABMR through antibody-dependent cell-mediated cytotoxicity, but clinically applicable functional assays are lacking.
Opioid Use as a Predictor of Pancreas Transplant Outcomes
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Research data are available from the corresponding author on reasonable request. Supporting Information Filename Description ctr70453-sup-0001-tableS1-S3.docx22.2 KB Supplement Table 1: Cause of patient death. Supplement Table 2: Cause of graft failure.
Clinical impact of prophylactic antibiotics in kidney transplantation: A retrospective observational cohort study with historical comparison
Citation: Lee SA, Kim J-M, Kwon HE, Ko Y, Jung JH, Shin S, et al. (2025) Clinical impact of prophylactic antibiotics in kidney transplantation: A retrospective observational cohort study with historical comparison. PLoS One 20(11): e0337578. https://doi.org/10.1371/journal.pone.0337578 Editor: Justyna Gołębiewska, Medical University of Gdansk, POLAND Received: November 26, 2024; Accepted: November 11, 2025; Published: November 21, 2025 Copyright: © 2025 Lee et al.
Tacrolimus-Sirolimus Combined Exposure and Acute Rejection in Kidney Transplant Recipients Undergoing Early Conversion to Sirolimus: A Multicenter Retrospective Cohort Threshold Analysis[v1] | Preprints.org
Submitted: 01 October 2025 You are already at the latest version Background/Objectives: Combining calcineurin inhibitors (CNIs) with mTOR inhibitors has been explored to reduce CNI exposure. However, the safety of this early conversion approach remains uncertain, and the optimal therapeutic targets for tacrolimus and sirolimus trough concentrations in such patients have not been clearly established.
Redox mediators for oxygen reduction reactions in lithium-oxygen batteries: Governing kinetics and its implications
Redox mediators for oxygen reduction reactions in lithium–oxygen batteries: Governing kinetics and its implications Despite the high theoretical energy density, the realization of lithium–oxygen batteries with practically high energy density is limited by the nature of oxygen reduction reactions generating insulating lithium peroxide and inevitable electrode passivation.
A prospective, randomized, non-blinded, non-inferiority pilot study to assess the effect of low-dose anti-thymocyte globulin with low-dose tacrolimus and early steroid withdrawal on clinical outcomes in non-sensitized living-donor kidney recipients (pdf)
PLOS ONE, Mar 2023 This is a preview of a remote PDF: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280924&type=printable Youngmin Ko, Yu-Mee Wee, Sung Shin, Mi Joung Kim, Monica Young Choi, Dong Hyun Kim, Seong Jun Lim, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Duck Jong Han. , PLOS ONE, 2023, Volume 18, Issue 3, DOI: 10.1371/journal.pone.0280924
Pure T-cell mediated rejection following kidney transplant according to response to treatment
Loading metrics Open Access Peer-reviewed Research Article Hyunwook Kwon, Young Hoon Kim, Youngmin Ko, Seong Jun Lim, Joo Hee Jung, Chung Hee Baek, Hyosang Kim, Su-Kil Park, Sung Shin , Yong-Pil Cho Hyunwook Kwon, Young Hoon Kim, Youngmin Ko, Seong Jun Lim, Joo Hee Jung, Chung Hee Baek, Hyosang Kim, Su-Kil Park, Sung Shin, Yong-Pil Cho Published: September 3, 2021 https://doi.org/10.1371/journal.pone.0256898 Figures Abstract The focus of studies on kidney transplantation (KT) has largely...
Anchored mediator enabling shuttle-free redox mediation in lithium-oxygen batteries
Communication Kisuk Kang Corresponding Author E-mail address: matlgen1@snu.ac.kr Seoul National University, Materials Science and Engineering, 1 Gwanak-ro, Gwanak-gu, 08826 Seoul, KOREA, REPUBLIC OF Search for more papers by this author PDF PDF Share Abstract Redox mediators (RMs) are considered an effective countermeasure to reduce the large polarization in lithium–oxygen batteries.
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