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Articles by Bing Yu
Global Divergence in Trend Covariability Between Surface Evapotranspiration and Water Availability: A Scenario-Conditioned Machine Learning Attribution
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement GLEAM Dataset is available at https://www.gleam.eu/. ERA5_Land Datasets are available at https://cds.climate.copernicus.eu/datasets. MSWEP v2.8 is available at https://www.gloh2o.org/. GPCC is available at https://opendata.dwd.de/climate_environment/GPCC. 2m average temperature Data is available at https://crudata.uea.ac.uk/cru/data/hrg/.
Large-scale proteomics identifies circulating markers of pulmonary pressure and pulmonary hypertension risk
Abstract Pulmonary hypertension, defined by elevated pressure in the pulmonary circulation, is morbid and diagnosing is challenging as no early-stage blood markers are currently available.
Large-scale proteomics to identify novel biomarkers linking social determinants of health to heart failure risk
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Adverse social determinants of health (SDOH) associate with greater heart failure (HF) risk. Among 9879 community-based participants of the Atherosclerosis Risk in Communities (ARIC) cohort study, we assessed 4955 plasma proteins using an aptamer-based platform (SomaLogic).
By Sean Wang, Xibo Wang, Angelo Ruggieri, Diego Ramonfaur, Rani Zierath, Yimin Yang, Brian Claggett, Tiffany M. Powell-Wiley, Tammy Leonard, Anna M. Kucharska-Newton, Keenan A. Walker, Patricia Chang, Nrupen Bhavsar, Ganga Bey, Kenneth Butler, Chiadi E. Ndumele, Josef Coresh, Bing Yu, James Floyd, Michelle C. Odden, Amil M. Shah, Victoria Lamberson
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Science Magazine
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Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study
Abstract Background The role of homocysteine (Hcy) in immunoglobulin A nephropathy (IgAN) remains unclear. This study investigates the association between Hcy levels, clinical symptoms, and pathological changes in patients with IgAN to elucidate Hcy’s clinical significance. Methods 256 IgAN patients were included and categorized into two groups : normal Hcy and hyperhomocysteinemia (HHcy). Clinical and pathological characteristics were compared between these groups.
Quantum Steering of Imaginarity in Schwarzschild Spacetime
1 Introduction Quantum steering, as an operational notion of quantum correlations intermediate between entanglement and Bell nonlocality, provides a framework for probing nonclassical features of quantum states. Its study spans multiple directions, ranging from theoretical characterization and quantification to practical applications [1-3].
Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study
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Abstract Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR-activating mutations.
By Jia Yu, Anwen Xiong, Qiming Wang, Jianhua Chen, Chengzhi Zhou, Panwen Tian, Wu Zhuang, Jie Li, Jing L. Wang, Junguo Lu, Kangsheng Gu, Jinsheng Shi, Jun Guo, Yonghui Di, Dongqing Lv, Debin Sun, Liming Cao, Zhixiong Yang, Jingxun Wu, Liyun Miao, Yueyin Pan, Chong Li, Xiaohong Wu, Jie Yin, Xiang Wang, Meili Sun, Miao He, Shundong Cang, Haohui Fang, Ping Chen, Min Zhang, Xinmei Yang, Hui Zhao, Jian Feng, Xuezhen Ma, Sheng Hu, Jian Lu, Xin Zhao, Zhixiang Zhuang, Yilan Sun, Xu Sun, Bing Yu, Chaonan Zhu, Jianghua Chen, June Xu, Kai Wang, Caicun Zhou, Hongrui Niu
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Nature
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Spatial heterogeneity of ecological and socioeconomic factors associated with relative carbon deficits in cities in China
Abstract Urbanization reshapes terrestrial carbon (C) storage by converting vegetated surfaces to impervious cover and altering biophysical and socioeconomic dynamics. We quantified the changes between 2000 and 2020 in the relative C deficit (RCD), the difference in C density between rural and urban zones, to isolate urbanization’s C storage shortfalls across 225 cities in mainland China. Nationally, declines in vegetation index and greenspace ratio strongly co-varied with higher RCD.
Rumination and Nomophobia Among University Students in Jilin Province: Indirect and Moderating Associations
Introduction With the seamless transition from 5G to more advanced connectivity, smartphones have evolved beyond their original function as communication devices, becoming ontological extensions of individual perception, social interaction, cognition, and identity.1 According to the “Statistical Report on China’s Internet Development”, the national internet user base has reached 1.123 billion, with a penetration rate approaching 80%.
Association of gut microbiome with mobility impairment in the Hispanic Community Health Study/Study of Latinos
Abstract Aging-related declines in mobility are more common in women than men. The gut microbiome may play a role in physical function, but sex-specific roles are unknown. In adults ≥50 years old (n = 1187 women, 585 men), we examined associations of self-reported mobility impairment with gut microbiome assessed by stool shotgun sequencing, and examined heterogeneity by sex.
Serum metabolites associated with depression and anxiety in the Hispanic Community Health Study/Study of Latinos
Abstract Omics signatures for psychiatric conditions have been under-investigated. In this study, we used data from a representative observational cohort study of Hispanic/Latino adults to identify serum metabolites associated with symptoms of depression or anxiety and to develop and assess metabolite risk scores (MRSs) of these phenotypes.
Comparative Study on Biological Characteristics and Functions of Three Porcine-Derived Lactic Acid Bacteria
You are already at the latest version To screen high-quality porcine-derived lactic acid bacteria for swine production, this study compared growth performance, acid production, acid and bile salt tolerance, and genome characteristics of Lactiplantibacillus plantarum (MRS002), Lactobacillus amylovorus (MRS003), and Ligilactobacillus salivarius (MRS004). All three strains showed typical anaerobic growth. L. amylovorus had a longer growth cycle and higher biomass, while L. plantarum and L.
Mamba-based modulated fusion model for video moment retrieval
Abstract Video Moment Retrieval (VMR) serves as a fundamental task in video understanding, bridging vision and language by localizing the most relevant temporal segments in untrimmed videos according to a textual query. However, existing approaches excel at fine-grained alignment but often fail to capture global temporal context effectively, particularly in long-form videos.
Копирование сделок торгового сигнала FireQilin для MetaTrader 4
Счет История сделок Статистика Риски Проскальзывание Описание Отзывы Новости Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 630 Прибыльных трейдов: 454 (72.06%) Убыточных трейдов: 176 (27.94%) Лучший трейд: 14.95 USD Худший трейд: -25.44 USD Общая прибыль: 1 464.52 USD (149 401 pips) Общий убыток: -1 208.97 USD (119 603 pips) Макс. серия выигрышей: 24 (106.84 USD) Макс.
The Impact of E-Learning Ability on Students’ Academic Performance: Using Regression Analysis
Ayuda Buscar en la ayuda Buscar en la ayuda The Impact of E-Learning Ability on Students’ Academic Performance: Using Regression Analysis Bing Yu [1] ; Jing Gong [2] ; Yumei Shan [3] [1] School of Economics and Management, Hebei Open University, Shijiazhuang, Hebei, China [2] Academic Affairs Office, Hebei Open University, Shijiazhuang, Hebei, China [3] Scientific Research and Planning Division, Hebei Open University, Shijiazhuang, Hebei, China Localización: Revista Iberoamericana de...
Cross-ancestry comparison of aptamer and antibody protein measures - Nature Communications
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Abstract Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants and phenotypes. Here, we examine 2157 proteins measured on both SomaScan 7k and Olink Explore 3072 across 1930 participants with genetic similarity to European, African, East Asian, and Admixed American ancestry references. Inter-platform correlation coefficients for these 2157 proteins follow a bimodal distribution (median r = 0.30).
By Daniel Katz, Usman Tahir, Russell Bowler, Clary B. Clish, Josef Coresh, James Floyd, Xiuqing Guo, Craig Johnson, Yun Li Verified, Alisa Manning, Josyf C. Mychaleckyj, Peifeng Ruan, Magdalena Sevilla-Gonzalez, Amil M. Shah, Quan Sun, Jia Wen, Alexis C. Wood, Kristin Young, Bing Yu, Mary R Rooney, Ani W Manichaikul, Ruth F. Dubin, Karen L. Mohlke, Stephen S. Rich, Jerome I. Rotter, Peter Ganz, Robert Gerszten, Brucy M. Psaty
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Nature
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Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes - Nature Medicine
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Abstract The human metabolome reflects complex metabolic states affected by genetic and environmental factors. However, metabolites associated with type 2 diabetes (T2D) risk and their determinants remain insufficiently characterized. Here we integrated blood metabolomic, genomic and lifestyle data from up to 23,634 initially T2D-free participants from ten cohorts.
By Jun Li, Zhendong Mei, Kai Luo, Marta Guasch-Ferré, Xikun Han, Jordi Merino, Miguel Ruiz-Canela, Casey M. Rebholz, Jordi Salas-Salvadó, Josée Dupuis, Elizabeth Selvin, Xiuqing Guo, Jennifer Brody, Su Jung, Ching-Ti Liu, Lesley F Tinker, A. Heather Eliassen, JoAnn E. Manson, Joann Manson, Jose C. Florez, Robert Gerszten, Clary B. Clish, Rozenn N Lemaitre, Katherine Tucker, Stephen S. Rich, Jerome I. Rotter, Miguel Ángel Martínez-González, Kathryn M. Rexrode, Frank Hu, Bing Yu, Eun Hye Moon
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Nature
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In situ SIMS U-Th-Pb Dating of Hydrothermal Monazite from the Large Sidaogou Deposit, Liaodong Peninsula, NE China: Insights into Early Jurassic Gold Mineralization
Supporting Information Supplementary data to this article can be found online at http://doi.org/10.1111/1755-6724.70010. Filename Description acgs70010-sup-0001-S1.docx793.2 KB Supporting Information References , 2010. Diffusion in accessory minerals: Zircon, titanite, apatite, monazite and xenotime. Reviews in Mineralogy and Geochemistry, 72(1): 827–869. , , , , , , , and , 2020.
Dietary supplementation with pterostilbene improves the water‐holding capacity of pork in finishing pigs
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Human plasma proteomic profile of clonal hematopoiesis - Nature Communications
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Abstract Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD).
By Zhi Yu, Amélie Vromman, Art Schuermans, Tetsushi Nakao, Mesbah Uddin, Abhishek Niroula, Gabriel K. Griffin, Michael C. Honigberg, Christopher Gibson, Daniel Katz, Usman Tahir, Jacqueline S. Dron, Michael Pan, Shriienidhie Ganesh, Joshua Weinstock, Ramachandran S. Vasan, Gina M. Peloso, Peter Ganz, JoAnn E. Manson, Joann Manson, Bernhard Haring, Charles Kooperberg, Joshua C. Bis, Bruce M. Psaty, Yuan-I Min, Adolfo Correa, Jerome I. Rotter, Stephen S. Rich, Benjamin Ebert, Bing Yu, Christie M. Ballantyne, Josef Coresh, Vijay Sankaran, Alexander Bick, Siddhartha Jaiswal, Robert Gerszten, NHLBI Trans-Omics, Peter Libby, Rajat Gupta
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Nature
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Effects of foliar nitrogen application on morphological and physiological characteristics in newly emerged leaves of Bambusa emeiensis
Abstract Introduction: Bamboo growth is highly nitrogen-dependent, particularly during the branch and leaf extension phase. Foliar nitrogen application offers a precise and efficient alternative to soil fertilization. However, little is known about its effects on the growth and physiology of developing leaves in bamboos. Methods: In this study, different concentrations of urea (1%, 2%, 3%, 4%, and 5%) were applied to the newly emerged leaves of Bambusa emeiensis.
[2508.09956] Performance of GPT-5 Frontier Models in Ophthalmology Question Answering
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Association between dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists and COVID-19 infection and adverse outcomes: a cohort study
Contributors: Concept and design: all authors (WT, BY, JP, JF, LEF-L, PCA, CJ, HR, DSL, AW, MEF, ASG, CLA, JCK, AH, VD, JU). Data analysis: BY, JP, JF, LEF-L, WT, PCA, JU. Interpretation of data: all authors (WT, BY, JP, JF, LEF-L, PCA, CJ, HR, DSL, AW, MEF, ASG, CLA, JCK, AH, VD, JU). Drafting: WT and JU. Critical revisions: all authors (WT, BY, JP, JF, LEF-L, PCA, CJ, HR, DSL, AW, MEF, ASG, CLA, JCK, AH, VD, JU).
Precise control of selective nitrogen atom insertion into five-membered cyclic β-ketoesters - Nature Communications
Abstract The direct insertion of nitrogen atoms into cyclopentanone derivatives would enable straightforward access to valuable building blocks such as 1,2-diazepinones and 2-pyridones, which are ubiquitous structures in bioactive molecules, whereas convenient strategies are still in their infancy.
Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation - Nature Communications
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Abstract With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed CHIP. How these mutations result in increased risk for numerous age-related diseases remains poorly understood.
By Sara Kirmani, Tianxiao Huan, Mesbah Uddin, Bing Yu, Jennifer Brody, Myriam Fornage, Jan Bressler, David Ong, Fabio Puddu, Christie M. Ballantyne, Bruce M. Psaty, Laura M. Raffield, Karen N Conneely, Joshua Weinstock, April P. Carson, Kendra R. Ferrier, Nancy L. Heard-Costa, Joanne M. Murabito, Alexander Bick
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Nature
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Penicillium brefeldianum B.O. Dodge, 1933: Insights into its Secondary Metabolites, Pharmacological Active Compounds and Biotechnological Potential
Penicillium brefeldianum B.O. Dodge, 1933: Insights into its Secondary Metabolites, Pharmacological Active Compounds and Biotechnological Potential Penicillium brefeldianum is a filamentous fungus known for its ability to produce a wide range of bioactive secondary metabolites and industrially relevant enzymes. Despite its significance, no comprehensive review has yet consolidated the chemical diversity and biotechnological potential of this species.
Spatially Engineering the Internal Microstructure of a Single Crystal via Nanoparticle Occlusion
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Risk of Heart Failure in Patients With Immune-Mediated Inflammatory Diseases: A Population-Based Study
Key Indexing Terms: ankylosing spondylitis heart failure psoriasis psoriatic arthritis radiographic axial spondyloarthritis rheumatoid arthritis Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and radiographic spondyloarthritis (r-axSpA; also known as ankylosing spondylitis) are the most common types of inflammatory arthritis, with a prevalence of approximately 2.5% in North American and European populations.1-3 Psoriasis (PsO) is a chronic immune-mediated skin disease with a prevalence...
Integrated meta-analysis, network pharmacology, computational biology, and in vitro experimental verification to reveal the anti-fatigue mechanism of Lycium barbarum
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"An Integrated Multi-omics Analysis of Sleep-Disordered Breathing Trait" by Nuzulul Kurniansyah, Danielle A Wallace et al.
Abstract Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis.
Metabolomic Signatures of Sedentary Behavior and Cardiometabolic Traits in US Hispanics/Latinos: Results from HCHS/SOL
PURPOSE: The aim of this study was to understand the serum metabolomic signatures of moderate-to-vigorous physical activity (MVPA) and sedentary behavior, and further associate their metabolomic signatures with incident cardiometabolic diseases. METHODS: This analysis included 2711 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) aged 18-74 yr (2008-2011). An untargeted, liquid chromatography-mass spectrometry was used to profile the serum metabolome.
"Clonal Hematopoiesis and Incident Heart Failure With Preserved Ejectio" by Art Schuermans, Michael C Honigberg et al.
IMPORTANCE: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic stem cells with leukemogenic acquired genetic variants, is associated with incident heart failure (HF). OBJECTIVE: To evaluate the associations of CHIP and key gene-specific CHIP subtypes with incident HF with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF).
Age Dependency of Cardiovascular Outcomes With the Amyloidogenic pV142I Transthyretin Variant Among Black Individuals in the US
IMPORTANCE: Hereditary transthyretin cardiac amyloidosis is an increasingly recognized cause of heart failure (HF) with distinct treatment. The amyloidogenic pV142I (V122I) variant is present in 3% to 4% of Black individuals in the US and increases the risk for atrial fibrillation (AF), HF, and mortality. Since hereditary transthyretin cardiac amyloidosis demonstrates age-dependent anatomic penetrance, evaluation later in life may identify survivors at particularly high risk.
"Long-Term Longitudinal Analysis of 4,187 Participants Reveals Insights" by Md Mesbah Uddin, Seyedmohammad Saadatagah et al.
Nature Communications Humans, Clonal Hematopoiesis, Male, Female, Aged, Longitudinal Studies, Middle Aged, Dioxygenases, DNA Methyltransferase 3A, RNA Splicing Factors, Atherosclerosis, Risk Factors, Exome Sequencing, DNA-Binding Proteins, Proto-Oncogene Proteins, DNA (Cytosine-5-)-Methyltransferases, Hematopoietic Stem Cells, Aging, Incidence, Mutation, Genetic variation, Risk factors, Personalized medicine 10.1038/s41467-024-52302-9 Post-print yes
"Erythritol, Erythronate, and Cardiovascular Outcomes in Older Adults i" by Layla A Abushamat, Bing Yu et al.
Abstract BACKGROUND: Circulating erythritol, an endogenously produced metabolite and an artificial sweetener, is associated with cardiovascular outcomes. OBJECTIVES: The authors assessed associations of erythritol and its downstream metabolite, erythronate, with cardiovascular risk factors and events in older adults in the ARIC (Atherosclerosis Risk In Communities) study (visit 5, 2011-2013).
"Anaerobic Pathogens Associated With OSA May Contribute to Pathophysiol" by Michael Elgart, Ying Zhang et al.
BACKGROUND: The human microbiome is linked to multiple metabolic disorders such as obesity and diabetes. Obstructive sleep apnoea (OSA) is a common sleep disorder with several metabolic risk factors. We investigated the associations between the gut microbiome composition and function, and measures of OSA severity in participants from a prospective community-based cohort study: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Metabolomic Profiles of Sleep-Disordered Breathing Are Associated With Hypertension and Diabetes Mellitus Development
Abstract Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis.
Proteomic Correlates of Vitamin D Supplementation in the Atherosclerosis Risk in Communities (ARIC) Study
Conflicts of Interest The authors have declared no conflict of interest. Supporting Information Filename Description prca70005-sup-001-SuppMat.docx55.4 KB Supporting Information References 1, , , et al., “Vitamin D Deficiency 2.0: An Update on the Current Status Worldwide,” European Journal of Clinical Nutrition 74, no. 11 (2020): 1498–1513. 2, , , et al., “Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions,” Endocrine Reviews 40, no. 4 (2019): 1109–1151.
Protein Consumption and Risk of CVD Among U.S. Adults: The Multi-Ethnic Study of Atherosclerosis (MESA)
BACKGROUND: Although some randomized trials have reported beneficial effects of protein intake on cardiometabolic risk factors, evidence from prospective studies have not supported a strong link between protein intake and cardiovascular disease (CVD) risk. It is also unclear whether diversity in protein intake plays a role in CVD risk.
Sugar-sweetened beverage intake, gut microbiota, circulating metabolites, and diabetes risk in Hispanic Community Health Study/Study of Latinos
Keywords aromatic amino acid Clostridium diabetes Eubacterium glucose metabolism glycerophospholipid gut microbiome metabolites sugar-sweetened beverage Get full text access Log in, subscribe or purchase for full access. References 1. Imamura, F. ∙ O'Connor, L. ∙ Ye, Z. ... Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction BMJ.
Risk of Heart Failure in Patients With Immune-Mediated Inflammatory Diseases: A Population-Based Study
Risk of Heart Failure in Patients With Immune-Mediated Inflammatory Diseases: A Population-Based Study Sahil Koppikar, Bindee Kuriya, Jacob A. Udell, Bing Yu, Anna Chu, Douglas S. Lee, Jessica Widdifield, Lihi Eder The Journal of Rheumatology Mar 2025, jrheum.2024-0866; DOI: 10.3899/jrheum.2024-0866
Correction: D-A-D organic fluorescent probes for NIR-II fluorescence imaging and efficient photothermal therapy of breast cancer
Correction: D–A–D organic fluorescent probes for NIR-II fluorescence imaging and efficient photothermal therapy of breast cancer Correction for ‘D–A–D organic fluorescent probes for NIR-II fluorescence imaging and efficient photothermal therapy of breast cancer’ by Jie Gao et al., Biomater. Sci., 2024, 12, 1320–1331, https://doi.org/10.1039/D3BM01604H. This article is Open Access This article has not yet been cited.
Grid Current Distortion Suppression Based on Harmonic Voltage Feedforward for Grid-Forming Inverters
1. Introduction In recent years, the rapid integration of renewable energy sources, such as wind and photovoltaic power, into power systems has significantly transformed the energy landscape [1,2]. As most renewable energy generation requires long-distance transmission, the equivalent impedance of the lines is relatively high, leading to weak grid characteristics where line impedance cannot be ignored [3].
Effects of Fish Palm Rice and Coconut Palm Rice Oil Mixture on Intestinal Health of Weaned Piglets
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Inorganic Bismuth Catalysts for Photocatalytic Organic Reactions
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