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Articles by Christopher Ford
A live biotherapeutic product for adult allogeneic hematopoietic cell transplantation recipients: a partially randomized, placebo-controlled phase 1b trial
Abstract Gastrointestinal (GI) microbiome disruption and impaired GI barrier integrity increase the risk of bloodstream infection (BSI) following allogeneic hematopoietic cell transplant.
Exelon Reports Third Quarter 2026 Results Original
Exelon Reports Third Quarter 2026 Results CHICAGO--(BUSINESS WIRE)--Exelon Corporation (Nasdaq: EXC) today reported its financial results for the third quarter of 2026.
Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Dopamine D2 receptors (D2Rs) modulate reward learning and aversive behaviors, with dysfunction linked to addiction and psychiatric disorders.
When the world's at stake, go beyond the headlines.
During the Cold War, Europe kept asking whether Washington would risk an American city to save a European one. It was an impolite question, but a useful one, which is why it never quite left the room. It has now packed its bags and moved east. Earlier this year, French President Emmanuel Macron created quite a stir with an important speech on French nuclear weapons policy.
Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods
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Abstract Norepinephrine (NE) is a critical neuromodulator that dynamically shapes brain states and behavior. Genetically encoded fluorescent NE indicators have enabled in vivo visualization of NE release, yet their limited sensitivity and spectral flexibility constrain widespread use in complex experimental paradigms. Here we developed next-generation green and red fluorescent NE indicators, named nLightG2 and nLightR2, respectively.
By Valentin Rohner, Sebastiano Curreli, Paul J. Lamothe-Molina, Zacharoula Kagiampaki, Andrew Yee, Chiara Nardin, Lena S. Eschholz, Alexander Dieter, Georgios Foustoukos, Thomas E. Childs, Jan Dernic, Luca Ravotto, Musadiq A Bhat, Laura Wasielewski, Tim Ziebarth, Márton Molnár, Olivia Andrea Masseck, Bruno Weber, Andreas Reiner, Anita Lüthi, Christopher Ford, J. Simon Wiegert, Sarah Ruediger, Tommaso Fellin, Tommaso Patriarchi, Paola Milanese, Lila Banterle, Annika Canziani, Latife Sönmez, Gaoyang Huang
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Nature
Verified
PE report: 2026 outlook - intellectual property
(March 19, 2026) - Attorneys at Debevoise & Plimpton LLP discuss the 2026 outlook for private equity firms involved in copyright and trademark litigation over artificial intelligence, including class certification issues and defenses such as fair use. The past year brought major developments in intellectual property litigation over AI, including in the battle over fair use. Dozens of still-pending cases promise more to come in 2026.
The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome - Nature Medicine
Abstract VOWST (VOWST oral spores, VOS; fecal microbiota spores, live-brpk, formerly SER-109) is an FDA-approved, orally administered consortium of purified Firmicutes spores developed to prevent recurrent Clostridioides difficile infection (CDI).
Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration - npj Parkinson's Disease
Abstract In Parkinson’s disease (PD), imbalances in dorsal striatum pathways are thought to lead to motor dysfunction due to loss of dopamine (DA) and the disruption of coordinated modulation with acetylcholine (ACh). Here, we examined changes in cholinergic modulation of striatal direct pathway medium spiny neurons (dMSNs) in mice that were partially or completely depleted of DA, to model early and advanced stages of PD.
"On the Joint Role of Non-Hispanic Black Race/Ethnicity and Weight Stat" by Christopher N Ford, Shine Chang et al.
Keywords Aged, Black People, Body Mass Index, Hispanic or Latino, Humans, Middle Aged, Postmenopause, Race Factors, United States, Weight Gain, White People, Black or African American Abstract Objectives: To determine how baseline weight status contributes to differences in postmenopausal weight gain among non-Hispanic Blacks (NHBs) and non-Hispanic Whites (NHWs).
Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA-induced dyskinetic behaviors
Abstract A dynamic equilibrium between dopamine and acetylcholine (ACh) is essential for striatal circuitry and motor function, as imbalances are associated with Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID). Conventional theories posit that cholinergic signaling is pathologically elevated in PD as a result of increased ACh release, which contributes to motor deficits.
Call it by its Name: Communist Chinese Imperialism
By Dr. Christopher Ford • November 21, 2024 Below is the prepared text upon which Dr. Ford drew in his remarks to the Bicameral Bipartisan Member Briefing on Arms Control, in the Russell Senate Office Building on November 21, 2024.
Project Atom 2024: Intra-War Deterrence in a Two-Peer Environment
There is a growing risk that the United States and its allies could face scenarios in which one or more adversaries might resort to nuclear weapons use in a regional conflict. In response to these growing risks, U.S. decisionmakers are revisiting the concept of intra-war deterrence, which is about influencing enemy actions during an ongoing conflict.
Spider-Man: Homecoming
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» Spidey macht einen tollen Job « Beschreibung Nachdem Peter Parker den Avengers im Kampf zur Seite gestanden hat, kehrt er zurück nach Hause. Im Alltag mit seiner Tante May muss Peter allerdings feststellen, dass er sich verändert hat und dass ihm der Nervenkitzel fehlt. Vor allem geht es dem Nachwuchshelden jedoch darum, seinem Mentor Tony Stark zu beweisen, dass er es mit großen Gefahren aufnehmen kann. Als seine Heimatstadt von "The Vulture" angegriffen wird, fackelt Peter nicht lang.
By Jonathan Goldstein, John Daley Verified, Jon Watts, Christopher Ford, Chris McKenna Verified, Chris Mckenna Verified, Erik Sommers
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hoerzu.at
The Most Important Thing
World leaders who embrace this system of what I call legalized dishonesty and sensory rape: you should know that it is being used in such devious ways that you are probably unaware of and probably feel too busy to pay attention to.
Just Tell Me Now
By Christopher Ford Is it pointless for me to write/rewrite these scripts? Instead of pointless busy work. Do these scripts have legitimate potential? Based both on the merit of the writing, and also based on whatever society's plans are for me - to whatever extent that may matter. Just tell me now. Is it pointless for me to write these or what?
Ultimate Spider-Man, MCU Movies, Star Trek: The Next Generation, F.R.I.E.N.D.S.
Ultimate Spider-Man, MCU Movies, Star Trek: The Next Generation, F.R.I.E.N.D.S. I feel like you tried to reach out to me and connect with me with these things. If only we could have spoken truthfully and directly. This is all stupid and illegal. And it fucking sucks, huh? It’s not the country or ideals I grew up on so I think it’s strange for them to drop this all on me. How old were you when you figured this all out?
1, 3, 4, 5
1: I’m sorry. I never knew I was being loud. If this was going on, the system should have found a bigger place for us to live. In general, for both of us, that was NOT how the adults were supposed to handle the situation. And now I’m a creepy geek to you for the rest of my life. But I’ll say it again, both of us deserved better. I’m not totally innocent, though. Fairly innocent. Innocent enough I guess. But not totally innocent. So here I am apologizing.
Integrity?
I have a paperback version of “The Illustrated Star Wars Univers” By Kevin J. Anderson and Ralph McQuarrie. It’s in pretty good condition but not “great.” I bought it from Amazon for ten bucks, twelve years ago. Apparently, it’s signed by the writer, Anderson. I never knew until I looked it up today. A while ago, I tried to sell it to that bookstore that I bitch about sometimes. They didn’t buy it from me and I always wondered why. Did they know that it was signed, even though I didn’t know?
Sam I Scam
On a Sunday morning, the first rays of yellow slip through the overcast curtains of Orange County, California. Grey glaciers waltz above into a gloomy, shifting patchwork of radiation moderation — incidentally provided for the land-dwellers. As flowers in the garden below lean into the sun, Samantha’s eyes peel open with the first sensations of cosmically-provided energy. She stirs, her blankets crinkle. Her foggy mind still weighs with slumber, contaminating the ability to conjure thoughts.
What The Future Holds For AI And IP
AI dominated the news in 2023 – and will again in 2024. Debevoise experts Megan Bannigan, Chris Ford and Sam Allaman examine the future of class action copyright claims, the fair use defence, and other pressing issues. Forukọsilẹ fun opin wiwọle Forukọsilẹ lati gba iwe iroyin wa ki o si ni iraye si opin si akoonu alabapin. Forukọsilẹ bayi Alabapin lati ṣii iraye si ailopin Gba awọn iroyin, asọye alailẹgbẹ, itupalẹ iwé ati awọn orisun pataki lati ọdọ awọn amoye WTR. alabapin bayi Ti ni iwọle tẹlẹ?
What The Future Holds For AI And IP
AI dominated the news in 2023 – and will again in 2024. Debevoise experts Megan Bannigan, Chris Ford and Sam Allaman examine the future of class action copyright claims, the fair use defence, and other pressing issues. Regístrese para acceso limitado Regístrese para recibir nuestro boletín y obtenga acceso limitado al contenido de los suscriptores.
Could pre-surgical genomic testing inform neoadjuvant chemotherapy decision making in breast cancer and increase patient individualised surgical options?
Background: Oncotype Dx testing is a risk stratification tool used to predict the likelihood of distant recurrence and to inform the benefit of post-operative adjuvant chemotherapy for women with oestrogen receptor positive, HER2-negative breast cancer and an intermediate 10-year risk of recurrence.
Comparison of 2 Smart Watch Algorithms for Detection of Atrial Fibrillation and the Benefit of Clinician Interpretation: SMART WARS Study
JACC Journals › JACC: Clinical EP › Archives › Vol. 8 No. 6 Abstract Background Smart watches and wearable technology capable of heart rhythm assessment have increased in use in the general population. The Apple Watch Series 4 (AW4) and KardiaBand (KB) are devices capable of obtaining single-lead electrocardiographic recordings, presenting a novel opportunity for the detection of paroxysmal arrhythmias.
Divergent properties and independent regulation of striatal dopamine and GABA co-transmission
The difference in calcium sensitivity could instead be due to differences in the coupling efficiency of Ca2+ entry to DA or GABA release. We compared the relative Ca2+ coupling distance of DA or GABA release using exogenous membrane-permeable Ca2+ chelators BAPTA-AM and EGTA-AM, which act through fast and slow binding kinetics, respectively, to determine whether sources of Ca2+ are tightly or loosely coupled to transmitter release ( ).
Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study
Research Healthy lifestyle and...
Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors
Bello E.P. Mateo Y. Gelman D.M. Noaín D. Shin J.H. Low M.J. Alvarez V.A. Lovinger D.M. Rubinstein M. Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nat. Neurosci. 2011; 14: 1033-1038 Besson M. Pelloux Y. Dilleen R. Theobald D.E. Lyon A. Belin-Rauscent A. Robbins T.W. Dalley J.W. Everitt B.J. Belin D. Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats. Neuropsychopharmacology.
The ‘Lab Leak’ Inquiry at the State Department
The following essay was originally posted at the author’s Medium blog here. In both journalism and policymaking—if not always in politics, or in the sordid world of score-settling by unemployed, second-rate apparatchiks—facts matter, and intellectual integrity matters.
The "Lab-leak" inquiry at the State Department:
An Open Letter by former Assistant Secretary Christopher Ford (June 10, 2021) In both journalism and policymaking - if not always in politics, or in the sordid world of score-settling by unemployed, second-rate apparatchiks - facts matter, and intellectual integrity matters.
On the joint role of non-Hispanic Black race/ethnicity and weight status in predicting postmenopausal weight gain
Loading metrics Open Access Peer-reviewed Research Article Christopher N. Ford , Shine Chang, Alexis C. Wood, JoAnn E. Manson, David O. Garcia, Helena Laroche, Chloe E. Bird, Mara Z. Vitolins Christopher N. Ford, Shine Chang, Alexis C. Wood, JoAnn E. Manson, David O. Garcia, Helena Laroche, Chloe E. Bird, Mara Z.
Intervention Strategies for Microbial Therapeutics in Cancer Immunotherapy
Highlights Gut microbiome impacts cancer treatment outcomes by influencing host immunosurveillance Modulation of microbiota represent a novel therapeutic strategy to improve responses Incongruent beneficial bacterial signatures complicate the design of modulators Reverse translation processes can be used to characterize candidate bacteria Rationally designed microbial consortia catalyze transition to a healthy ecology Abstract Immunotherapies have drastically improved clinical outcomes in a...
New USPTO Trademark Rules Seek to Streamline Filing and Crack Down on Fraud, But Could Increase Spam
By Megan Bannigan & Christopher Ford February 17, 2020 “Spam letters to trademark applicants and registrants have long been a plague of the industry, and the much lower barrier to sending unsolicited email [as a result of the email rule change] likely means this problem will continue.” New rules governing all trademark filings with the United States Patent and Trademark Office (USPTO) went into effect two days ago, on February 15.
The Federal Reserve’s Entry into Real-Time Payments | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Fed announces plans to develop real-time settlement service to support faster payments | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Cholinergic Interneurons Provide a Link to Balance Excitation across Striatal Output Neurons
D1-MSNs and D2-MSNs mediate output from the accumbens. How activity of one regulates the other is poorly understood. In this issue of Neuron,show that D1-MSN firing induces D2-MSN LTP via the recruitment of cholinergic interneurons.
Cholinergic Transmission at Muscarinic Synapses in the Striatum Is Driven Equally by Cortical and Thalamic Inputs
Highlights • Thalamic inputs drive firing in cholinergic cells and increase acetylcholine release • While cortical inputs do not affect mean cholinergic activity, some cells do respond • Cholinergic cells showing strong cortical responses have higher cortical connectivity • Thalamic and cortical inputs drive equal acetylcholine release at muscarinic synapses Summary The release of acetylcholine from cholinergic interneurons (ChIs) directly modulates striatal output via muscarinic receptors on...
Coordinated host-pathogen transcriptional dynamics revealed using sorted subpopulations and single macrophages infected with Candida albicans
Abstract The outcome of fungal infections depends on interactions with innate immune cells. Within a population of macrophages encountering Candida albicans, there are distinct host-pathogen trajectories; however, little is known about the molecular heterogeneity that governs these fates. Here we developed an experimental system to separate interaction stages and single macrophage cells infected with C. albicans from uninfected cells and assessed transcriptional variability in the host and fungus.
White House issues executive order on artificial intelligence | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate
The release of acetylcholine (ACh) from ChIs regulates striatal activity by presynaptic modulation of dopamine and GABA inputs to MSNs via nicotinic ACh receptors (nAChRs) and muscarinic receptors ( Cachope et al., 2012 Cachope R. Mateo Y. Mathur B.N. Irving J. Wang H.-L. Morales M. Lovinger D.M. Cheer J.F. Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing.Cell Rep.
Tallahassee museums offer educational fun
Tallahassee museums offer educational fun By Christopher Ford On December 20, 2017 Need a way to spend your free time? Tallahassee has several museums featuring an array of exhibits that are both family-friendly and educational. VIDEO The Museum of Florida History shows off the Sunshine State's past from prehistoric times to the twenty-first centrury. The Call-Collins House at the Grove Museum preserves the history of civil rights and American history.
Thrift stores replenish clothes and the community
Thrift stores replenish clothes and the community By Shay Simon On December 18, 2017 The thrift store is a place where one man’s trash becomes another man’s treasure. VIDEO Thrift stores are known for selling used items at great prices, but thrifting isn’t just good for clothing, but for the community. Local thrift stores like City Walk Urban Mission use its profits to assist those in need.
Revealing a Role for NMDA Receptors in Regulating STN Inputs following the Loss of Dopamine
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. PreviewRevealing a Role for NMDA Receptors in Regulating STN Inputs following the Loss of Dopamine, Christopher P. FordxChristopher P.
Spider-Man: Homecoming Review
This may be the third reboot of this franchise in 15 years, risking audience exhaustion, but there are plenty of reasons not to miss this one. Most notably, this is the first Spider-Man movie that's part of Marvel's Avengers franchise, which places it in a larger story with lots of cameo possibilities. But more importantly, young British actor Tom Holland seems to have been born to play the role, infusing the entire film with cheeky teenage energy.
Differential Regulation of Duplicate Light-Dependent Protochlorophyllide Oxidoreductases in the Diatom Phaeodactylum tricornutum
Diatoms (Bacilliariophyceae) encode two light-dependent protochlorophyllide oxidoreductases (POR1 and POR2) that catalyze the penultimate step of chlorophyll biosynthesis in the light. Algae live in dynamic environments whose changing light levels induce photoacclimative metabolic shifts, including altered cellular chlorophyll levels. We hypothesized that the two POR proteins may be differentially adaptive under varying light conditions.
Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. Online Now Article ArticleSpontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing, Christopher P. FordxChristopher P.
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