Jalees Rehman
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Articles by Jalees Rehman
NicheProt: Cell-type-resolved proteomics of tissue compartments
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Spatial proteomics uncovers the molecular basis of cellular function in intact tissues.
Computer Science > Computation and Language
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Telomerase-mediated immortalization preserves the anti-inflammatory activity of dental pulp stem cell extracellular vesicles
Abstract Background: Extracellular vesicles (EVs) derived from dental pulp stem cells (DPSCs) exhibit immunomodulatory activity in multiple inflammatory models. However, the limited replicative lifespan of primary DPSCs and passage-dependent functional variability restrict scalable and reproducible EV production. Approaches that stabilize EV bioactivity during extended cell expansion are therefore needed.
Ionic regulation of cancer cell stiffness and metastatic colonization via the MRTFA-KCNMB1 axis
Keywords MRTFA SRF KCNMA1 KCNMB1 cancer metastasis cell stiffness ion channels mechanobiology mechanosurveillance Introduction Cellular stiffness is a dynamically regulated property that allows cells to deform with external force and respond to biochemical and mechanochemical stimuli in the microenvironment.1 Maintenance and regulation of cellular stiffness and mechanoadaptation play key roles in various physiological and pathological states.
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease
Abstract The existence of human hippocampal neurogenesis has long been disputed1,2,3,4,5,6,7,8,9,10,11,12 and its relevance in cognition remains unknown. Recent studies have established the presence of proliferating progenitors and immature neurons and a reduction in the latter in Alzheimer’s disease (AD)11,13. However, their origin and the molecular networks that regulate neurogenesis and function are poorly understood.
Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation
Keywords chromatin assembly histone deposition histone chaperone histone supply nucleotide metabolism PRPS PRPSAP chromatin metabolism Introduction Chromatin formation is central to the organization and spatiotemporal regulation of the genome. Vital cellular processes such as replication, transcription, and DNA repair, which all use DNA as a template, necessitate the eviction of histones followed by immediate restoration of chromatin via redeposition of histones.
Vaccines hold tantalizing promise in the fight against dementia
Over the past two centuries, vaccines have been critical for preventing infectious diseases. The World Health Organization estimates that vaccination prevents between 3 million and 5 million deaths annually from diseases like diphtheria, tetanus, influenza, measles and, more recently, COVID-19.
Vaccines hold tantalizing promise in the fight against dementia
An April 2025 study published in the prominent journal Nature found tantalizing evidence that the herpes zoster – or shingles – vaccine could lower the risk of dementia in the general population by as much as 20%. We are a team of physician scientists with expertise in the clinical and basic science of neurodegenerative disorders and dementia.
Vaccines hold tantalizing promise in the fight against dementia
Over the past two centuries, vaccines have been critical for preventing infectious diseases. The World Health Organization estimates that vaccination prevents between 3 million and 5 million deaths annually from diseases like diphtheria, tetanus, influenza, measles and, more recently, COVID-19.
The vaccine that could lower the risk of dementia by 20 per cent
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Vaccines hold tantalizing promise in the fight against dementia Original
Over the past two centuries, vaccines have been critical for preventing infectious diseases. The World Health Organization estimates that vaccination prevents between 3 million and 5 million deaths annually from diseases like diphtheria, tetanus, influenza, measles and, more recently, COVID-19.
Vaccines hold tantalizing promise in the fight against dementia
Over the past two centuries, vaccines have been critical for preventing infectious diseases. The World Health Organization estimates that vaccination prevents between 3 million and 5 million deaths annually from diseases like diphtheria, tetanus, influenza, measles and, more recently, COVID-19. kAm(9:=6 E96C6 92D =@?8 366?
Vaccines hold tantalizing promise in the fight against dementia
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Muscle weakness in cancer survivors may be caused by treatable weakness in blood vessels: new research
Tumors can destroy the blood vessels of muscles even when the muscles are nowhere close to the tumor. That is the key finding of a new study that my colleagues and I recently published in the journal Nature Cancer. Muscle loss in cancer patients is a major health problem, but the exact causes of how precisely tumors affect muscles remain an active area of research.
Muscle weakness in cancer survivors may be caused by treatable weakness in blood vessels, says new study
Tumors can destroy the blood vessels of muscles even when the muscles are nowhere close to the tumor. That is the key finding of a new study that my colleagues and I recently published in the journal Nature Cancer. Muscle loss in cancer patients is a major health problem, but the exact causes of how precisely tumors affect muscles remain an active area of research.
Muscle Weakness in Cancer Survivors May Be Caused by Treatable Weakness in Blood Vessels
Tumors can destroy the blood vessels of muscles even when the muscles are nowhere close to the tumor. That is the key finding of a new study that my colleagues and I recently published in the journal Nature Cancer. Muscle loss in cancer patients is a major health problem, but the exact causes of how precisely tumors affect muscles remain an active area of research.
Muscle weakness in cancer survivors may be caused by treatable weakness in blood vessels - new research
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) Jalees Rehman, University of Illinois Chicago (THE CONVERSATION) Tumors can destroy the blood vessels of muscles even when the muscles are nowhere close to the tumor. That is the key finding of a new study that my colleagues and I recently published in the journal Nature Cancer.
Muscle weakness in cancer survivors may be caused by treatable weakness in blood vessels - new research Original
Tumors can destroy the blood vessels of muscles even when the muscles are nowhere close to the tumor. That is the key finding of a new study that my colleagues and I recently published in the journal Nature Cancer. Muscle loss in cancer patients is a major health problem, but the exact causes of how precisely tumors affect muscles remain an active area of research.
Muscle weakness in cancer survivors may be caused by treatable weakness in blood vessels - new research
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) kAmW%wt r~}'t#$p%x~}X %F>@CD 42? 56DEC@J E96 3=@@5 G6DD6=D @7 >FD4=6D 6G6? H96? E96 >FD4=6D 2C6 ?@H96C6 4=@D6 E@ E96 EF>@C] %92E :D E96 k2 9C67lQ9EEADi^^5@:]@C8^`_]`_bg^Dcb_`g\_ad\__hfd\eQm<6J 7:?5:?8 @7 2 ?6H DEF5Jk^2m E92E >J 4@==628F6D 2?5 x C646?E=J AF3=:D965 :? E96 ;@FC?2= }2EFC6 r2?46C]k^Am kAm|FD4=6 =@DD :?
Muscle weakness in cancer survivors may be caused by treatable weakness in blood vessels - new research
Tumors can destroy the blood vessels of muscles even when the muscles are nowhere close to the tumor. That is the key finding of a new study that my colleagues and I recently published in the journal Nature Cancer. kAm|FD4=6 =@DD :? 42?46C A2E:6?ED :D 2 >2;@C 962=E9 AC@3=6>[ 3FE E96 6I24E 42FD6D @7 9@H AC64:D6=J EF>@CD 27764E >FD4=6D C6>2:? 2? 24E:G6 2C62 @7 C6D62C49]k^Am kAm$4:6?E:DED :? >J =23 H6C6 4FC:@FD H96E96C @?6 6IA=2?2E:@? 7@C E96 >FD4=6 =@DD :?
Opinion: What medical researchers want to know from Trump's NIH pick
Congratulations, Dr. Jayanta Bhattacharya, on your nomination as director of the National Institutes of Health! This is clearly one of the most impactful positions within the federal government.
Limited diffusion of scientific knowledge forecasts collapse - Nature Human Behaviour
Abstract Market bubbles emerge when asset prices are driven unsustainably higher than asset values, and shifts in belief burst them. We demonstrate an analogous phenomenon in the case of biomedical knowledge, when promising research receives inflated attention. We introduce a diffusion index that quantifies whether research areas have been amplified within social and scientific bubbles, or have diffused and become evaluated more broadly.
The importance of patient-partnered research in addressing long COVID: Takeaways for biomedical research study design from the RECOVER Initiative’s Mechanistic Pathways taskforce
Patient motivation to partner with researchers K.C., a patient representative from Vermont, learned about long COVID in August 2020 after having symptoms that started in early March 2020 and suddenly worsened. Simultaneously, her two daughters were also experiencing similar health impacts.
Limited Diffusion of Scientific Knowledge Forecasts Collapse
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Demystifying Pakistan’s high electricity prices
In the last decade, we have addressed our power shortfall and blackout woes by doubling installed electricity from 22,813 MW in June 2013 to 41,557 MW in May 2022, according to the finance ministry’s economic survey. In addition to this, the generation mix is being diversified by reducing dependence on residual fuel oil (RFO) by replacing it with regasified liquefied natural gas (RLNG).
Systematic temporal analysis of peripheral blood transcriptomes using TrendCatcher identifies early and persistent neutrophil activation as a hallmark of severe COVID-19
Systematic temporal analysis of peripheral blood transcriptomes using TrendCatcher identifies early and persistent neutrophil activation as a hallmark of severe COVID-19 Xinge Wang, Mark Sanborn, Yang Dai, Jalees Rehman bioRxiv 2021.05.04.442617; doi: https://doi.org/10.1101/2021.05.04.442617
Systematic temporal analysis of transcriptomes using TrendCatcher identifies early and persistent neutrophil activation as an early hallmark of severe COVID-19
Abstract Studying the dynamic shifts in gene expression during disease progression may provide important insights into the biological mechanisms that distinguish adaptive and maladaptive responses. Existing computational tools for the analysis of transcriptomic data are not designed to optimally identify distinct temporal patterns when analyzing dynamic differentially expressed genes (DDEGs).
Machine learning plus insights from genetic research shows the workings of cells
The Research Brief is a short take about interesting academic work. The big idea We combined a machine learning algorithm with knowledge gleaned from hundreds of biological experiments to develop a technique that allows biomedical researchers to figure out the functions of the proteins that turn genes on and off in cells, called transcription factors. This knowledge could make it easier to develop drugs for a wide range of diseases.
Machine learning plus insights from genetic research shows the workings of cells
We combined a machine learning algorithm with knowledge gleaned from hundreds of biological experiments to develop a technique that allows biomedical researchers to figure out the functions of the proteins that turn genes on and off in cells, called transcription factors. This knowledge could make it easier to develop drugs for a wide range of diseases.
Machine learning plus insights from genetic research shows the workings of cells - and may help develop new drugs for COVID-19 and other diseases
Country United States of AmericaUS Virgin IslandsUnited States Minor Outlying IslandsCanadaMexico, United Mexican StatesBahamas, Commonwealth of theCuba, Republic ofDominican RepublicHaiti, Republic ofJamaicaAfghanistanAlbania, People's Socialist Republic ofAlgeria, People's Democratic Republic ofAmerican SamoaAndorra, Principality ofAngola, Republic ofAnguillaAntarctica (the territory South of 60 deg S)Antigua and BarbudaArgentina, Argentine RepublicArmeniaArubaAustralia, Commonwealth...
Machine learning plus insights from genetic research shows the workings of cells - and may help develop new drugs for COVID-19 and other diseases Original
The Research Brief is a short take about interesting academic work. The big idea We combined a machine learning algorithm with knowledge gleaned from hundreds of biological experiments to develop a technique that allows biomedical researchers to figure out the functions of the proteins that turn genes on and off in cells, called transcription factors. This knowledge could make it easier to develop drugs for a wide range of diseases.
Why is there still no contraceptive pill for men? – Jalees Rehman | Aeon Essays
‘I am too young to die,’ said my patient. ‘My kids are small. They still need me.’ I explained that having a heart attack did not mean that she would die. We had caught it early. Within the next minutes, she would have an angiogram to remove the blood clot in her coronary artery, and we had already started her on a nitroglycerine drip and an infusion with a blood thinner. But I understood her fear. Women in their early 40s and in good health are not supposed to have heart attacks.
The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury
Abstract Macrophages demonstrate remarkable plasticity that is essential for host defense and tissue repair. The tissue niche imprints macrophage identity, phenotype and function. The role of vascular endothelial signals in tailoring the phenotype and function of tissue macrophages remains unknown. The lung is a highly vascularized organ and replete with a large population of resident macrophages.
Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation
Abstract Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but little is known about their characteristic gene expression profiles. RNA-Sequencing of the brain, lung, and heart endothelial translatome identified specific pathways, transporters and cell-surface markers expressed in the endothelium of each organ, which can be visualized at http://www.rehmanlab.org/ribo.
The Moral Logic of Nationalism
by Jalees Rehman Charlottesville Unite the Right Rally in 2017, Anthony Crider, via Wikimedia Commons Why do people endorse political violence such as military attacks even if such violence is detrimental to their own self-interests?
Shared Responsibilities for Climate Change Mitigation
The dangers of climate change pose a threat to all of humankind and to ecosystems all over the world. Does this mean that all humans need to equally shoulder the responsibility of mitigating climate change and its effects? The concept of CBDR (common but differentiated responsibilities) is routinely discussed at international negotiations about climate change mitigation.
Help Citizens with Disabilities Participate in the Political Process
The World Health Organization (WHO) estimates that over a billion people live with some form of disability, expressed as impairments, activity limitations and participation restrictions. Disabilities are often manifestations of health conditions and as such, people suffering from disabilities not only require general medical care such as immunizations and preventive screenings but also need additional care to address the underlying health conditions.
Does Reading Hateful Comments Increase Prejudice and Hatred?
How should social media platforms address hate speech and abusive comments while also maintaining a commitment to freedom of expression? The platform Twitter, for example, evaluates whether posts by individual users constitute abusive behavior, which it defines as “an attempt to harass, intimidate, or silence someone else’s voice”.
Open Science and Access to Medical Research
It is rather odd how often I hear the expression paradigm shift during contemporary scientific presentations and seminars. The expression was popularized by Thomas Kuhn’s book The Structure of Scientific Revolutions. In that book, Kuhn referred to ground-breaking and revolutionary changes in scientific thought as paradigm shifts, but the expression is so over-used today that even minor discoveries are sometimes marketed as paradigm shifts.
Escape The Tyranny Of Algorithms By Leading A Life Of Poiesis
“Accused not of crimes they have committed, but of crimes they will commit. It is asserted that these men, if allowed to remain free, will at some future time commit felonies.” In the science fiction short story “The Minority Report” by Philip K. Dick, mutant “precogs” are able to see one to two weeks into the future. Their precognitive prophecies are decoded and analyzed by a computer, and used by the Precrime police unit pre-emptively arrest would-be perpetrators before they commit crimes.
Cesarean Sections in the U.S.: The Trouble with Assembling Evidence from Data
Pregnancy, labor, and delivery have become increasingly medicalized in recent decades, leading to criticism from multiple factions. For instance, the rate of cesarean section in the U.S. (and in many other developed nations) draws fire from the World Health Organization (WHO), which suggests that the c-section rate should not rise above 15% [1]. There’s no doubt that the rate of c-section is high in the United States compared to elsewhere in the world.
In Search of Lost Ambiguity
Probably. Possible. Perhaps. Indicative. Researchers routinely use such suggestives in scientific manuscripts, because they acknowledge the limitations of the inferences and conclusions one can make when analyzing scientific data. The results of individual experiments are often open to multiple interpretations and therefore do not lend themselves to making definitive pronouncements.
The Psychology of Collective Memory
Do you still remember the first day of school when you started first grade? If you were fortunate enough (or in some cases, unfortunate enough) to run into your classmates from way back when, you might sit down and exchange stories about that first day in school. There is a good chance that you and your former classmates may differ in the narratives especially regarding some details but you are bound to also find many common memories.
The Science of Tomato Flavors
Don’t judge a tomato by its appearance. You may salivate when thinking about the luscious large red tomatoes you just purchased in your grocery store, only to find out that they are extremely bland and lack flavor once you actually bite into them after preparing the salad you had been looking forward to all day. You are not alone. Many consumers complain about the growing blandness of fruits. Up until a few decades ago, it was rather challenging to understand the scientific basis of fruit flavors.
“Hype” or Uncertainty: The Reporting of Initial Scientific Findings in Newspapers
One of the cornerstones of scientific research is the reproducibility of findings. Novel scientific observations need to be validated by subsequent studies in order to be considered robust. This has proven to be somewhat of a challenge for many biomedical research areas, including high impact studies in cancer research and stem cell research.
The Science of Tomato Flavors
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“It Is An Opportunity For Great Joy”
I was about 12 years old when I found out that my grandfather was born on 12/12/12. If he were alive, he would be exactly 100 years old today. I found out about his birthday, when he came to stay with us in Munich for an eye surgery. He was a diabetic and had been experiencing deterioration in his vision. At that time, it was very difficult to find an eye surgeon in Pakistan who would be able to perform the surgery.
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