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Articles by John Walker
Neuroprotective transition metal dichalcogenide nanoflower treatments alleviate pathological cell stress associated with Parkinson’s disease
Abstract Parkinson’s disease (PD) is triggered by irreversible degeneration of dopaminergic neurons in the midbrain, hypothalamus, and thalamus. Although the molecular etiology of pathology remains unclear, progressive aggregation of alpha-synuclein (α-syn) and mitochondrial dysfunction are two mechanisms implicated in neuronal degeneration.
A Non-randomized Phase 2 Trial of Pembrolizumab in Untreated Patients with Carcinoma of Unknown Primary Site
Keywords CUP immunotherapy PD-L1 pembrolizumab Get full text access Log in, subscribe or purchase for full access. References 1. Raghav, K. Cancer of Unknown Primary Site N Engl J Med. 2025; 392:2035-2047 2. Rassy, E. ∙ Pavlidis, N. The currently declining incidence of cancer of unknown primary Cancer Epidemiol. 2019; 61:139-141 3. Wong, B. ∙ Liu, J. ∙ Yeo, S. ... Evolution in the diagnosis and treatment of carcinoma of unknown primary: a multicenter Canadian analysis Oncologist. 2025; 30:298 4. Lazaridis, G.
Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity
Results To avoid confounding from chromosomal abnormalities in prior PMSE patient iPSC lines (Dang et al., 2021), we used CRISPR/Cas9 to generate STRADA loss-of-function KO lines with compound heterozygous truncating variants and isogenic controls (Figures S1A and S1B). Lines expressed pluripotency markers (Figure S1C) and showed no karyotypic abnormalities (data not shown). Two STRADA KO (M1 and M2) and two isogenic control (C1 and C2) lines were used for all experiments.
Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses
Keywords ASCC2 ASCC3 replication stress PCNA ubiquitylation fork reversal ATR activation RAD51-dependent recombination genomic stability Research topic(s) CP: genomics Introduction Replication stress represents a major source of genomic instability that can drive tumorigenesis.1,2,3 Human cells have evolved several interconnected responses to replication stress.4,5,6 Upon fork stalling, the uncoupling of leading and lagging strand DNA synthesis generates single-stranded DNA (ssDNA).
Increased contributions of climate-driven wildfires to nitrogen deposition in the United States - Communications Earth & Environment
Abstract Climate change and increases in the frequency and severity of climate-driven wildfires, particularly in the western United States, has serious ramifications for enhanced downwind reactive nitrogen (Nr) emissions, deposition, and critical load exceedances.
Enhancing Care Through a Virtual Canadian Community of Practice for Managing Immune-Related Adverse Events
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The Influence of Structural Design on the Hydrodynamics of Floating Offshore Wind Turbine Platforms
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Syngeneic adipose-derived stromal cells modulate the immune response but have limited persistence within decellularized adipose tissue implants in C57BL/6 mice
Abstract The delivery of adipose-derived stromal cells (ASCs) on cell-instructive decellularized adipose tissue (DAT) scaffolds is a promising strategy for stimulating host-derived soft tissue regeneration. However, a better understanding of the mechanisms through which ASCs modulate regeneration in vivo is needed to harness these cells more effectively. In this study, DAT scaffolds, both with and without seeded syngeneic DsRED+ mouse ASCs, were implanted into immunocompetent C57BL/6 mice.
Probing the effects of polysaccharide hydrogel composition on the viability and pro‐angiogenic function of human adipose‐derived stromal cells
1 INTRODUCTION There are currently more than 230 million people worldwide suffering from peripheral arterial disease (PAD), and its prevalence continues to rise due to the increasing frequency of risk factors such as diabetes, obesity, and smoking, as well as the aging population.1 Critical limb ischemia (CLI) represents the most severe form of PAD and is associated with lower limb amputation rates exceeding 15–20% at 1-year post-diagnosis, and mortality rates greater than 50% by 5 years...
Weighted Trajectory Analysis and Application to Clinical Outcome Assessment
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1, 2, 3 and 3,* 1 Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R7, Canada 2 Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada 3 Division of Medical Oncology, University of Alberta, Cross Cancer Institute, 11560 University Ave NW, Edmonton, AB T6G 1Z2, Canada * Author to whom correspondence should be addressed.
CSB Regulates Pathway Choice in Response to DNA Replication Stress Induced by Camptothecin
Altmetric share Share announcement Help format_quote Cite thumb_up ... Endorse textsms ... Comment Need Help? Support Find support for a specific problem in the support section of our website. Get Support Feedback Please let us know what you think of our products and services. Give Feedback Information Visit our dedicated information section to learn more about MDPI. Get Information clear Font Type: Arial Georgia Verdana Line Spacing: Column Width: Open AccessArticle by Nicole L.
Coatings | Free Full-Text | Nanostructures and Thin Films of Poly(Ethylene Glycol)-Based Surfactants and Polystyrene Nanocolloid Particles on Mica: An Atomic Force Microscopy Study
Open AccessArticle by John Walker 1, Andrew B. Schofield 2 and Vasileios Koutsos 1,* 1 School of Engineering, Institute for Materials and Processes, The University of Edinburgh, Robert Stevenson Road, Edinburgh EH9 3FB, UK 2 SUPA, School of Physics and Astronomy, The University of Edinburgh, Edinburgh EH9 3FD, UK * Author to whom correspondence should be addressed.
Yosemite Women's Fire Internship program opens career doors through the CCC | Vida en el Valle
Search Home Classifieds Place An Ad Jobs Cars Homes Rentals News Yosemite Women's Fire Internship, the first-ever California Conservation Corps internship program of its kind, brings women together for a 10-week intensive program where they learn to be firefighters & how to protect and manage landscape with fire. RELATED STORIES TRENDING Copyright Privacy Policy Do Not Sell My Personal Information Terms of Service
Teen arrested in Fresno CA street vendor killing | Vida en el Valle
Search Eedition Home Classifieds Place An Ad Jobs Cars Homes Rentals Fresno Fresno Police Chief Paco Balderrama leads a news conference to announce the arrest of a suspect in the killing of street vendor Lorenzo Perez, 45, of Fresno. Demarcus Jaime Vega, 18, of Palmdale was taken into custody. RELATED STORIES TRENDING Copyright Privacy Policy Do Not Sell My Personal Information Terms of Service
Walker: I know that our redeemer lives
“Each of us is an innkeeper who decides if there is room for Jesus.” – Neal A. Maxwell This has been a challenging year. A microscopic virus brought our great nation to its knees. I testify that the only way to get our beloved country fully back on its feet is for us to get down on our knees in humble prayer. Some needed divine intervention would not harm any of us.
Walker: Movies that will help you better appreciate Christmas
“Look, Daddy! Teacher says every time a bell rings, an angel gets his wings.” – Zuzu Bailey, “It’s A Wonderful Life” While serving as a missionary in California, I was assigned to be a zone leader for the Santa Rosa Zone. This was the largest geographical zone in our mission. In March 1978, my missionary companion (Tom Payne) and I began driving to and exploring various locations within the zone. We needed to familiarize ourselves with the communities and people that we were called to serve.
The Princess Alice - gone, but not forgotten
So, the ground floor of one of Forest Gate's most recognisable buildings has finally closed as a drinking/eating establishment. The Princess Alice, and its supping and catering heirs, is no more, as the space is now occupied by the latest national chain-store addition to Woodgrange Road area - Superdrug. From Alice to Superdrug Below is the briefest of histories and a photographic trip down memory lane, to mark its passing.
Walker: Please strive to be thankful for what you have
“I cried because I had no shoes until I met a man who had no feet.” – Helen Keller In July 2007, the retina in my left eye detached, and I lost all vision in the eye. Shortly thereafter, I underwent surgery to repair the detached retina. After consulting with my eye surgeon and conducting some online research, I had to accept the fact that it was unlikely that my vision would ever be fully restored. kAmsFC:?8 E96 DFC86CJ[ >J A9JD:4:2? 86?E=J C6EFC?65 E96 C6E:?2 E@ :ED AC@A6C A@D:E:@? 2?5 E96?
Walker: Love your enemies: A profound and challenging commandment
“Ye have heard that it hath been said, Thou shalt love thy neighbor and hate thine enemy. But I say unto you, Love your enemies, bless them that curse you, do good to them that hate you, and pray for them which despitefully use you and persecute you.” – Jesus Christ, the Son of the Living God It has taken me 63 years, but I believe that I have learned, at least at a rudimentary level, how to truly forgive those who have trespassed against me.
Creek Fire battle continues despite cooler weather
Search Eedition Newsletters Coronavirus Local Deals Jobs Classifieds Senior Resources Legal Notices Place an Ad Advertise Mobile & Apps Archives Fires Cal Fire Battalion Chief Seth Brown talks about the efforts being made Saturday as the Creek Fire rages on. RELATED STORIES TRENDING Copyright Commenting Policy Corrections Policy Privacy Policy Do Not Sell My Personal Information Terms of Service
Creek Fire battle continues despite cooler weather
Search Eedition Home Coronavirus Class of 2020 Business Obituaries The Cambrian Classifieds Legals Jobs Real Estate Weekly Place An Ad About Us Mobile & Apps Archives Fires Cal Fire Battalion Chief Seth Brown talks about the efforts being made Saturday as the Creek Fire rages on. RELATED STORIES TRENDING Copyright Privacy Policy Do Not Sell My Personal Information Terms of Service
A history of the American Board of Surgery: vignettes from the certifying examination
Abstract The American Board of Surgery was established in 1937 to certify surgeons who through training, experience, and examination meet the highest standards of surgical care. This lecture was given as the Edgar Poth lecture at the April 2015 meeting of the Southwestern Surgical Congress. Dr Poth was a surgical educator from the University of Texas Medical Branch, Galveston who was President of the Southwestern in 1963.
Walker: One nation under God, indivisible, with liberty and justice for all
“Patriotism is not short, frenzied outbursts of emotion, but the tranquil and steady dedication of a lifetime.” – Adlai Stevenson My daughter-in-law Macarena (yes, just like the dance) grew up in a quaint, mountainous and beautiful town known as Lago Ranco, Chile. My son, Joshua, first met Macarena (“Maca”) when he was serving as a missionary in southern Chile. kAm$9@CE=J 27E6C 9:D >:DD:@? 6?565[ y@D9F2 2?5 x EC2G6=65 E@ r9:=6 7@C 2 723F=@FD G242E:@?] x 7:CDE >6E |242 H96?
EXPERIMENTAL OBSERVATIONS ON THE PROPHYLAXIS AND TREATMENT OF SYPHILIS
Author information Article notes Copyright and License information Disclaimer From the Laboratory Division of the Army Medical School, Washington, D. C. Copyright © Copyright, 1923, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms).
Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health
Islet Studies Abstract Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated with islet β-cell dysfunction, we investigated LD accumulation in the intact human and mouse pancreas over a range of ages and states of diabetes. Very few LDs were found in normal human juvenile pancreatic acinar and islet cells, with numbers subsequently increasing throughout adulthood.
Letter to the editor: Rep. McClintock, why won’t you speak up about fire protection?
Rep. Tom McClintock debates challenger Jessica Morse at Mariposa High last fall. JOHN WALKER Sierra Star file Where’s our congressman on fire protection? Will Congressman McClintock go to bat for his constituents? In its ongoing battle with California the Trump administration is now threatening to renege on its agreement to reimburse the state for firefighting costs. The California Fire Assistance Agreement (CFAA) is a five-year agreement, expiring in 2020.
Mosses of the Pacific Northwest
The transmission of our aging state-issue F-150 pickup wails in protest as we buck and roll along the U.S. Forest Service road. From the passenger seat, I squint at a dash-mounted GPS unit while Washington Department of Natural Resources enforcement officer Jared Eison steers around a Douglas fir limb jutting out onto the pocked gravel surface. “You hear that buzzing behind your seat?” he says. “It’s the 140-watt linear kicking in to boost the radio signal. But we’re too far out for that to help.
Searching for answers: How well do depression websites answer the public’s questions about treatment choices?
Article in Press Searching for answers: How well do depression websites answer the public’s questions about treatment choices?, , Kristin A. ReynoldsxKristin A.
New Tax On Foreign Buyers Of Australian Real Estate
New Tax On Foreign Buyers Of Australian Real Estate By John Walker and Jun Au · May 4, 2018, 11:29 AM EDT Victoria, Queensland and New South Wales have all introduced new foreign investor stamp duty surcharges for transactions involving direct and indirect acquisitions of residential property.In all three states, the surcharge is imposed on a "foreign person," which generally includes a foreign natural person, corporation or trustee of a foreign trust.
City marketing job cost not finalized - Shelby News: Local News
Shelbyville Mayor Tom DeBaun said an estimated two-year cost of $634,000 for a new marketing director and related items is not set in stone. In the Thursday edition, The Shelbyville News reported that a budget for the proposed new marketing job would be $374,500 for the first year and $259,500 for the second. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service.
City marketing position could cost $634K - Shelby News: Local News
A marketing person to promote the city of Shelbyville for economic and community development could potentially cost more than one-half million dollars over two years. The matter came up for discussion at a meeting of the City Council Monday evening. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now. kAm|2J@C %@> s6q2F?
Council approves PK tax abatement - Shelby News: Local News
One of the city’s largest employers is adding more than $7.2 million in new equipment next year. As a result, PK USA will receive a 10-year abatement on personal property taxes for the new manufacturing machinery, logistical, IT and R&D inventory. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
City looks at creating new marketing position - Shelby News: Local News
City leaders have proposed hiring a director of marketing and communications to spur local economic and community development. The proposal came up during the premeeting of the Shelbyville Common Council on Monday evening. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now. kAmr@F?4:=>2?
City okays funding for art project - Shelby News: Local News
River Road, starting from the intersection with Tompkins Street behind the Porter Center (pictured) to Habig Street just past Donald L. Johnson Memorial Park, is now one-way westbound. The city made the change to accommodate the riverway bike-pedestrian trail which starts in Blue River Memorial Park on the eastside of town and will go all the way to Habig Street connecting four parks. Part of the dark asphalt trail is visible in the middle right of the photo.
County moving to electronic deed recording - Shelby News: Local News
Currently, when a real estate property changes hands in Shelby County, deeds and related documents are filed by hand at the recorder’s office. Beginning in January, some of those filings will be done online. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
Tax abatement committee to recommend changes - Shelby News: Local News
A committee of the Shelbyville Common Council plans to suggest proposed changes in how tax abatement is done to the full council. Members of the council’s Tax Abatement Committee talked Monday morning with Mayor Tom DeBaun about, essentially, streamlining the process. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
Enrollment surges for Advantage college program - Shelby News: Local News
An effort to boost education in Shelby County is making the grade, according to the latest numbers. Launched in 2015, the Advantage Shelby County program offers publicly-funded scholarships to high school graduates to take classes at Ivy Tech Community College. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now. kAm%96 7:CDE p$r 4=2DD 3682?
Ag business seeks tax abatement for new facility - Shelby News: Local News
Premier Ag Co-op has applied for a 10-year property tax abatement on its proposed farm store. The company is based in Seymour and has farm retail operations and CountryMark Fuel stations in about a dozen Indiana communities. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now. kAmx? |2J[ E96 $96=3J r@F?EJ !=2? r@>>:DD:@?
Excel exceeds expectations - Shelby News: Local News
Goodwill officials are thrilled. City officials are thrilled. Students are thrilled. In a little more than a year, and almost exactly one year to the day of opening at its Harrison Street location, Shelbyville’s Excel Center has done just that – excelled. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
Excel student grateful for new beginnings - Shelby News: Local News
Before starting classes at the Shelbyville Excel Center last year, Amy Cooper hadn’t been in school since 1983. A native of New Jersey, Cooper, who’s 52, went to a school her stepmother chose for her but, as it turned out, the school wasn’t accredited, so she never got a high school diploma. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account?
City prepares for first downtown project - Shelby News: Local News
Butler Fairman Seufert will do the design work for the East Washington Street portion of the city’s downtown redevelopment. On Tuesday, the Shelbyville Board of Works reviewed a $120,000 contract with the Indianapolis firm presented by city engineer Matt House. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
Committee to recommend new ambulance, building fees - Shelby News: Local News
A committee of the Shelbyville Common Council will recommend to the full council fee increases for ambulance services and planning and building projects. Fire Chief Tony Logan presented a new fee schedule for ambulance runs to the Ordinance Committee of the council at a meeting Tuesday. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
City OKs BRCF racino grants, fee increases - Shelby News: Local News
Nine local nonprofits have received early Christmas presents, courtesy of the city’s racino funds. Both the city and the county give a portion of their racino revenues to the Blue River Community Foundation which reviews grant applications and recommends the recipients. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
County to let bids for next bridge repair - Shelby News: Local News
County to let bids for next bridge repair Submitted photoAccording to the county’s 2016 “bridge book” reference guide, Bridge 92 was built in 1930 and reconstructed in 1970. The 40-foot, two-lane concrete slab bridge spans Deer Creek on Michigan Road near County Road 800 East. It was rated in “poor” condition.
Indiana Grand sale likely postpones live dealers - Shelby News: Local News
Caesars Entertainment Corporation has placed a big bet on the future of gaming in Shelbyville and Indiana. The Las Vegas-based company wants to buy Indiana Grand Racing & Casino along with Hoosier Park Racing & Casino in Anderson, Ind., as well as three Indiana off track betting locations in Indianapolis, New Haven and Clarksville. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service.
Historical Society marks successful year at Grover Museum - Shelby News: Local News
Facility improvements, more events and a new book were among the highlights showcased at the Shelby County Historical Society’s annual dinner. This year’s dinner, held at the Grover Museum, featured professional storyteller Stephanie Holman who entertained the crowd with a reading of letters home from service members during World War II. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service.
Counselor offers grim outlook for tobacco users - Shelby News: Local News
Images in the video were tough for the audience to see. The stories told tough to hear. There was the young man who lost one of his legs below the knee to poor circulation caused by smoking. He held up a plastic bag with the ashes of his leg noting he could see bone chips in it. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
Women's group prepares for December baby boom - Shelby News: Local News
Talk about Christmas stocking stuffers. Next month, some 45 babies are expected to arrive at the MHP Medical Center. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now. kAmx?
Friends of the Library plan bookstore, start online giving - Shelby News: Local News
Library patrons will have a permanent space in which to shop for used books once current renovations are done early next year. Friends of the Library, a nonprofit group that supports the library through fundraising and events, is planning to start a bookstore in the Carnegie East Wing of the library. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account?
City preps for Christmas parade with eye on sky - Shelby News: Local News
The tree is up. The lights are strung. And the Santa House on the Public Square is about ready to welcome Old Saint Nick and Mrs. Claus. Meanwhile, parade floats, bands and marchers are gearing up for the city’s annual Christmas Parade scheduled to begin at 7 p.m. on Friday. An online service is needed to view this article in its entirety. You need an online service to view this article in its entirety. Choose an online service. Current print subscribers Need an account? Create one now.
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