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Articles by Man Lu
Hashimoto’s thyroiditis in differentiated thyroid cancer: autoimmune inflammation, immune surveillance, and tumor escape
Abstract Hashimoto’s thyroiditis (HT) and differentiated thyroid cancer (DTC) frequently coexist, yet their biological relationship remains paradoxical.
Staged purpose-blinded evaluation of provenance risk from a general-purpose generator in breast ultrasound
Abstract Commercial general-purpose image generators may create medical-looking content outside controlled medical-AI research, raising provenance concerns. We evaluated a general-purpose generator that produced breast ultrasound images without medical-specific development or patient-image inputs.
Ultrasonography of the recurrent laryngeal nerve in thyroid cancer: advances in clinical application and research progress
Abstract The rising incidence and detection rate of thyroid cancer have led to a concomitant increase in the number of thyroidectomy procedures performed annually. Among the postoperative complications, recurrent laryngeal nerve injury (RLNI) remains a major factor affecting patients’ quality of life. In pursuit of precision therapeutic strategies and reduced nerve injury rates,clinicians have shown growing interest in the recurrent laryngeal nerve(RLN).
An rRNA-depleted full-length transcriptome strategy using nanopore sequencing for identification of novel lncRNA isoforms
Abstract Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation, but their full-length isoforms are often missed because of the limitations of poly(A)-based enrichment and short-read sequencing. Here, we aim to establish a comprehensive transcriptome profiling that captures both poly(A)+ and poly(A)- RNA isoforms using Oxford Nanopore Technologies (ONT) R10.4.1 flowcells.
Comparative Evaluation of Four-Group Matched Design: Transoral Versus Percutaneous Core Needle Biopsy with Conventional Ultrasound and Contrast-Enhanced Ultrasound Guidance for Oropharyngeal and Adjacent Space Lesions
Abbreviations CNB (Core Needle Biopsy) US (Ultrasound) VAS (Visual Analog Scale) PLC (Pharyngeal and laryngeal cancer) CEUS (Contrast-enhanced ultrasound) US-CNB (Ultrasound-guided core needle biopsy) Perc-CEUS (Percutaneous CEUS-guided) Perc-US (Percutaneous US-guided) Trans-CEUS (Transoral CEUS-guided) Trans-US (Transoral US-guided) Key Words Contrast-enhanced ultrasound US-guided biopsy Oropharynx Transoral biopsy Core needle biopsy Get full text access Log in, subscribe or purchase for...
Tissue-specific inflammation induces cell state plasticity with oncogenic addiction in mucosal melanoma
Abstract Mucosal melanoma (MM), an aggressive melanoma subtype arising in mucosal tissues, displays resistance to therapies effective in cutaneous melanoma.
Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt
Abstract The hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Although most infections are self-limiting, zoonotic genotypes can persist in immunocompromised individuals. Transmitted via the fecal-oral route, HEV has been suggested to directly infect the intestinal epithelium, a tissue with high regenerative capacity.
Dynamic shift in the dominant transmission route of clade Ib monkeypox virus across networks with sexual and nonsexual contacts
Abstract The intensifying outbreaks of the novel monkeypox virus clade Ib in the Democratic Republic of the Congo have raised global concern about the potential for wider epidemic spread. Some clade Ib mpox outbreaks have shown a distinct transmission pattern in which transmission associated with both sexual and nonsexual contacts coexist.
A periplasmic protein complex mediates arabinofuranosyltransferase activity and intrinsic drug resistance in Mycobacterium tuberculosis
Abstract The intrinsic drug resistance of Mycobacterium tuberculosis (Mtb) is a major barrier to effective tuberculosis (TB) treatment and is largely due to its complex, impermeable cell envelope. We identified a periplasmic protein complex comprising FecB and Rv3035 that is essential for maintaining envelope integrity and mediating intrinsic multidrug resistance in Mtb. FecB interacts with Rv3035, forming a stable heterodimer that associates with the cell envelope biosynthesis protein AftB.
Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophages
Abstract Bacteriophage auxiliary metabolic genes (AMGs) alter host metabolism by hijacking reactions, but previous studies mostly inferred their roles from annotations, ignoring system-wide impacts and phage production. Here we integrate AMGs and phage assembly into a genome-scale metabolic model of Prochloroccocus marinus MED4 infected by P-HM2.
Abrupt eruptive instability of ice adhered to solid surfaces
Abstract Violent ice fracture events often trigger rapid climatic or geomorphic changes, including Antarctic ice shelf collapse, glacial outbursts, and frost quakes. Existing models of sequential crack propagation inadequately explain the sudden, explosive nature observed in natural events. Here, we uncover a previously unidentified eruptive fracture of ice adhered to solid surfaces upon quasistatic cooling, which can even cause the underlying substrate fragmentation.
Focusing on color: How the eye chooses which wavelength to see best
Abstract Humans can see in exquisite detail despite the fact that the eyes’ optics can only focus light at a single wavelength at a time. It remains an open question what wavelength is brought into best focus by the human eye. Here, we investigate this question. We used a custom optical apparatus to measure the eye’s focusing response (accommodation) to a range of stimuli with different wavelength compositions. We then developed a biologically informed model of the measured responses.
Enhancing halide ion homogeneity in blade-coated wide-bandgap perovskite for perovskite-organic tandem solar cells
Abstract The shared processing technologies of perovskite and organic semiconductors make them ideal partners for constructing perovskite-organic tandem solar cells. However, the different crystallization rates of bromide and iodide ions lead to inhomogeneous vertical halide distribution within wide-bandgap (WBG) perovskite films, causing notable open-circuit voltage (VOC) loss.
Multimillennial climate-freshwater legacy beneath a large-river delta-front estuary
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Abstract Offshore relatively fresh groundwater (ORFG; <10 grams per liter) represents an underexplored frontier in addressing global freshwater scarcity, yet its origin, persistence, and vulnerability remain poorly constrained. Here, we reveal a vast climate-driven freshwater reservoir beneath the Pearl River estuary and adjacent shelf.
By Munjung Kim, Man Lu, Xuhui Ma, Chong Sheng, Jiu Jimmy Jiao, Xin M Luo, Jinchao Zuo, Kai Xiao, Christian Hensen Verified, Liuting Yuan, Pinghe Cai
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Science Magazine
Verified
The Global Deep Sea Exploration Goals: A representative approach to visually observing the deep seafloor
Abstract The Global Deep Sea Exploration Goals strategy is a spatially balanced, probability-based, actionable global sampling design identifying 10,000 target locations for deep-sea visual observation (≥200 m). This sampling approach integrates four seafloor characteristics: bathymetry, geomorphology, sediment composition, and particulate organic carbon flux, while accounting for documented historical deep-submergence deployments.
Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants
Abstract Psychedelic indolethylamines with therapeutic potential are naturally produced in plants, fungi, and animals. Here, we elucidated the complete N,N-dimethyltryptamine (DMT) biosynthetic pathway in hallucinogenic plant species traditionally used in shamanic rituals for spiritual healing.
Scalable entangling gates on ion qubits via structured light addressing
Abstract A central challenge in developing practical quantum processors is maintaining low control complexity while scaling to large numbers of qubits. Trapped-ion systems excel in small-scale operations and support rapid qubit scaling via long-chain architectures. However, their performance in larger systems is hindered by spectral crowding in radial motional modes, a problem that forces reliance on intricate pulse-shaping techniques to maintain gate fidelities.
Stomatin encapsulates aquaporin-1 and urea transporter–B in the erythrocyte membrane
Abstract Stomatin is a ubiquitous and highly expressed protein in erythrocytes, which associates with cholesterol-rich microdomains in the plasma membrane and is known to regulate the activity of multiple ion channels and transporters, but the structural basis of association with stomatin targets remains unknown.
Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies
Abstract The underlying immunopathogenesis of inflammatory arthritis (IA) immune-related adverse event (irAE) remains obscure. Unlike rheumatoid arthritis (RA), where autoantibodies and B cell dysfunction are central features, the contribution of humoral immunity to IA-irAE is unclear.
Reset-free DNA logic circuits for real-time input processing and memory
Abstract DNA logic circuits have great potential for biocompatible and programmable computations; however, current designs require reset processes, which restrict real-time data processing and memory functionality. This study proposes a reset-free approach on the basis of toehold-mediated chain reaction (TCR), which enables continuous and reversible strand migration within dual-rail units.
Programming chaotic centers for shaping light branching in topological nematic vortices
Abstract Chaotic behaviors, epitomized by the butterfly effect where small causes have outsized consequences, are ubiquitous in light-matter interactions yet remain challenging to localize and even harder to engineer. Here, we demonstrate and model the direct light interacting with a programmable chaotic center—the core of photopatterning liquid-crystal topological vortices—where chaos reshapes into symmetry-protected light branching.
Decoupled phenotypic constraints framed by respiratory adaptation in the rise of land vertebrates
Abstract Land vertebrates today comprise amniotes and lissamphibians, which have highly different modes of gas exchange, and distinct skull shapes and body size distributions. A central hypothesis of tetrapod evolution proposes a connection between these traits during their initial divergence, 335 million years ago. However, this has yet to be tested in a broad phylogenetic context.
Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and restricted repetitive behaviors, yet the contribution of trace elements remains poorly defined. We profiled 21 trace elements in individuals with ASD and identified significantly reduced copper levels, which negatively correlated with social symptom severity.
Dynamic disordering in discrete states: Disconnected hopping boosts anharmonicity in CuInP 2 S 6
Abstract Delineation of matter into solid and fluid (liquid and gas) phases is grounded in the contrasting localization and mobility of atomic/molecular aggregates, with the fluid phase distinguished by connected pathways for these entities. Here, we demonstrate that CuInP2S6, a layered material, manifests as a unique system differing from both solid and fluid: It is solid but contains disconnected pathways of highly mobile Cu species.
Structure and mechanism of the heterotetrameric ADP-glucose pyrophosphorylase essential for starch synthesis in plants
Abstract ADP-glucose pyrophosphorylase (AGPase) catalyzes the conversion of glucose-1-phosphate and adenosine 5′-triphosphate (ATP) to ADP-glucose (ADPG), the dedicated precursor of starch in plants. It is a rate-limiting enzyme of the starch biosynthesis pathway, and its activity is closely linked to crop productivity.
Bridging electron microscopy and materials analysis with an autonomous agentic platform
Abstract Electron microscopy (EM) reveals atomic-scale structures that underpin catalysis, energy storage, and semiconductor reliability, yet current workflows remain fragmented across segmentation, crystallographic reconstruction, property modeling, and literature review, often requiring weeks of expert effort.
Self-regulating hydrogel for diabetic wound healing: From animal models to a pilot clinical study
Abstract Chronic diabetic wounds affect millions and often fail to heal due to infection, inflammation, and poor angiogenesis, leading to high rates of amputation. Current treatments offer limited control over the wound microenvironment. Here, this work develops GPP@ZnBG hydrogels that can respond to elevated glucose and oxidative stress in diabetic wounds to release therapeutic ions in a self-pH–regulated and sequential manner.
Phengite-mediated fluorine and chlorine fluxes from subduction zones to the deep mantle
Abstract The cycling of volatiles through subduction zones fundamentally shapes Earth’s chemical evolution, yet how fluorine (F) and chlorine (Cl) are processed in the deep mantle remains enigmatic. Here, we use high-pressure experiments (5 to 11 gigapascals and 850° to 1200°C) on altered oceanic crust analogs to track deep halogen behavior. We show that phengite remains stable to 11 gigapascals and 1050°C, efficiently transporting F and Cl to ~330-kilometer depth.
Massive wildfires followed oceanic anoxic events during the Late Devonian Frasnian-Famennian mass extinction
Abstract Extensive wildfire profoundly influences Earth system feedback and can drive major ecosystem disturbances, yet its timing and role in the Late Devonian Frasnian-Famennian (F-F) mass extinction remain unclear. To determine whether wildfires were a driver or consequence of contemporaneous oceanic anoxic events (OAEs), we present a high temporal resolution multiproxy record (biomarkers, microfossils, and trace metals) from the Chattanooga Shale in the southeastern United States.
Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction
Abstract Cytoskeleton-tethered mechanosensitive channels (MSCs) use compliant gating springs to convert mechanical stimuli into electrical signals for sensations like sound and touch. The mechanical properties of these gating springs are poorly understood. We investigated the homotetrameric NompC channel, which contains long ankyrin-repeat domains (ARDs), using a toehold-mediated strand displacement method to tether single membrane proteins.
Uncovering simultaneous breakthroughs with a robust measure of disruptiveness
Abstract Progress in science and technology is punctuated by disruptive innovation and breakthroughs. To understand disruptive innovations and their drivers, the ability to operationalize and estimate “disruptiveness” is critical. Yet, this task remains difficult because scientific influence propagates through both direct and indirect citation paths, and discoveries are often fragmented across multiple papers. Here, we introduce an embedding-based metric of disruptiveness.
Artificial intelligence-enabled ultrasound diagnosis and stratification of follicular thyroid neoplasms: a multi-center study - npj Digital Medicine
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Abstract Preoperatively distinguishing follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA) remains a significant clinical challenge. Current ultrasound risk stratification systems show limited efficacy for follicular neoplasms, and existing artificial intelligence (AI) approaches lack sufficient validation. We developed and validated a deep learning model using ultrasound images to differentiate FTC from FTA and classify FTC into invasion subtypes.
By Jianming Li, Haoyan Zhang, Huan Zheng, Lin Qian, Ligang Cui, Xinping Wu, Baoding Chen, Man Lu, Yong Xu, Desheng Sun, Liping Liu, Ping Li, Changsong Xu, Li Ma, Shengnan Huo, Yanjun Liu, Weide Dai, Kexin Lou, Xiang Xie, Liping Yang, Fang C. Mei, Bo Ping, Xin Yang, Jie Yu, Kun Wang, Ping Liang, Yuancheng Cang, Runqin Miao, Guoyong Hua
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Nature
Verified
The Impact of the Digital Economy on New Energy Vehicle Export Trade: Evidence from China
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Prognostic value of diffusion-weighted imaging to cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for patients with gastric cancer and peritoneal metastases | BMC Cancer | Full Text
This retrospective study was approved by the Institutional Review Board of Affiliated Cancer Hospital & Institute of Guangzhou Medical University. The requirement for informed consent was waived off as it is a retrospective study.
Efficacy and safety of ultrasound-guided percutaneous thermal ablation for abdominal wall metastases: a retrospective study - BMC Cancer
This retrospective analysis received approval from the ethics committees of the Sichuan Cancer Hospital (Reference No. SCCHEC-032017-008). A total of 12 patients received MWA treatment. One male patient was excluded because of missing follow-up data. This study was a single-center retrospective study, including 11 patients with metastatic nodules of abdominal wall who received MWA treatment from January 2020 to September 2024.
A bibliometric analysis on laparoscopic pelvic floor surgery from 1996-2022
Pelvic organ prolapse is a common condition in middle-aged and older women. Laparoscopic pelvic floor surgery is frequently researched as a treatment for this issue. However, the effectiveness of this procedure has only been the subject of a few studies. To quantitatively evaluate and display the relevant literature from the Web of Science database, we set the publication period of the literature from 1996 to 2022 and used VOSviewer and CiteSpace for visual analysis.
Lipid biomarkers recording marine microbial community structure changes through the Frasnian‐Famennian mass extinction event
Corresponding Author YongGe Sun Organic Geochemistry Unit, Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province, School of Earth Sciences, Zhejiang University, Hangzhou, China Correspondence YueHan Lu, Molecular Eco-Geochemistry (MEG) Laboratory, Department of Geological Sciences, The University of Alabama, Tuscaloosa, AL 35485, USA.
Bioavailability of levothyroxine | TCRM
Back to Journals » Therapeutics and Clinical Risk Management » Volume 19 Authors Liu H, Lu M, Hu J, Fu G, Feng Q, Sun S , Chen C Received 27 March 2023 Accepted for publication 19 June 2023 Published 23 June 2023 Volume 2023:19 Pages 503—523 DOI https://doi.org/10.2147/TCRM.S414460 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Deyun Wang Hanqing Liu,1,* Man Lu,1,* Jiawei Hu,1 Guangzhao Fu,2 Qinyu Feng,3...
Geochemical Evidence of First Forestation in the Southernmost Euramerica from Upper Devonian (Famennian) Black Shales
Abstract The global dispersal of forests and soils has been proposed as a cause for the Late Devonian mass extinctions of marine organisms, but detailed spatiotemporal records of forests and soils at that time remain lacking. We present data from microscopic and geochemical analyses of the Upper Devonian Chattanooga Shale (Famennian Stage).
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