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Articles by Mark Coles
Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn’s disease
Abstract Stromal cell states are altered in active Crohn’s disease (CD), but their origin and phenotypic stability are unknown. Using single-cell spatial transcriptomics, RNA sequencing and ATAC sequencing of ~2,500,000 cells, we map 18 distinct stromal cell states within their cellular and cytokine signaling environments in human full-thickness CD bowel.
Oxford researchers awarded ARIA funding to develop transformative anti-viral therapies
The projects are supported as part of ARIA’s Sustained Viral Resilience programme, a £57 million initiative led by Programme Director Brian Wang. In this programme, 11 funded teams will explore and unlock ways to create sustained innate immunoprophylactics (SIIPs) - a new class of medicines that provide durable, broad-spectrum protection against respiratory viruses by engineering the innate immune system.
The embryonic origins of site-specific arthritis
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Abstract The cellular basis for site-specific inflammation remains unclear. In human fingers, proximal interphalangeal (PIP) joints are preferentially affected by inflammatory arthritis, whereas distal interphalangeal joints are spared, providing a model to investigate the predilection of inflammation to distinct sites.
By Sarah Davidson, Davide L. Simone, Kathrin U Jansen, Max Cowan, Caio Machado, Ian Reekie, Ananya Bhalla, Rowie Borst, Cesar Medina Verified, Joshua A. Bull, Zhi Yi Wong, Sarah Hill, Micon Garvilles, Sam Pledger, Patricia Reis Nisa, Dylan Windell, Moustafa Attar, Andrew J. Bodey, Alissa L Parmenter, Helen Byrne, Sharif U. Ahmed, Shashidhara Marathe, Peter Lee, Chris Mahony, Adam P Croft, Stephen N. Sansom, Mark Coles, Christopher Buckley, Nora Rebecca Schwingen
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Nature
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Tissue resident memory T cells populate the human uveal tract
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Abstract The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues. In immune-mediated inflammatory diseases, such as psoriasis and rheumatoid arthritis, tissue resident T cells trigger disease flares in the skin and joints.
By Andrew D. Foers, Ian Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas Buckley Verified, Moustafa Attar, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, Imran Masood, Mark Coles, Jonathan P. Sherlock, Andrew Dick, Sarah E. Coupland, Stephen N. Sansom, David Copland, Christopher Buckley, Srilakshmi Sharma, Soledad Aguilar-Munoa
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Nature
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Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvant
Keywords ex vivo human lymph node vaccines adjuvants single-cell transcriptomics mRNA-seq fluorescent imaging Research topic(s) CP: Immunology Introduction Much of our understanding of how the human immune system functions is extrapolated from studies in inbred mice.
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination - Nature Communications
Abstract In 2022, a global mpox outbreak occurred, and remains a concern today. The T cell memory response to MPXV (monkeypox virus) infection has not been fully investigated. In this study, we evaluate this response in convalescent and MVA-BN (Modified Vaccinia Ankara - Bavarian Nordic) vaccinated individuals using VACV-infected cells. Strong CD8+ and CD4+ T cell responses are observed, and T cell responses are biased towards viral early expressed proteins.
Quantitative Systems Pharmacology Models of Anti‐Amyloid Treatments for Alzheimer's Disease: A Systematic Review
1 Introduction The recent approval of the first disease modifying therapies (DMTs) for Alzheimer's disease (AD)—the anti-amyloid monoclonal antibodies (mAbs) aducanumab, lecanemab, and donanemab—marked a turning point in the field following decades of drug development without any new drug approvals [1].
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease - Nature Immunology
Abstract Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment response. We describe a therapeutic atlas for Crohn’s disease (CD) and ulcerative colitis (UC) following adalimumab, an anti-tumour necrosis factor (anti-TNF) treatment. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies (41 subjects), revealing disease-specific differences.
AI: Hero or villain?
By Mark Coles, Business Development Director – Head of National Accounts, Evelyn Partners Artificial intelligence (AI) is much more than designer robots, promising to bring automation and digitisation – and significant disruption – to multiple industries. It could deliver solutions to some of the world’s largest problems, from climate change to worsening demographics, but others see a darker side as AI grows in sophistication. AI requires vast computer power to store and analyse data.
A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution - Nature Communications
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Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues.
By Hamez Gacaferi, Jessica E. Ackerman, Peter Johnson, Ian Reekie, Moustafa Attar, Dylan Windell, Mariola Kurowska-Stolarska, Stefano Alivernini, Kathrin U Jansen, Angela Lee, James Charlesworth, Kate Powell, Dominic Furniss, Jonathan Rees, Derek W. Gilroy, Mark Coles, Andrew Carr, Stephen N. Sansom, Christopher Buckley, Carl-Philip Hackstein
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Nature
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Adipose tissue maintains healthy joint fibroblasts via cortisol signalling - Nature Reviews Immunology
The healthy synovial membrane is divided into a fluid-facing lining and a blood vessel-supporting sublining layer. Fibroblasts comprise the majority of cells in both layers and are important for maintaining structural integrity, homeostasis and lubrication. In the anterior knee compartment, the sublining layer is adjacent to the fat pads, and mainly consists of adipocytes.
Why does understanding the biology of fibroblasts in immunity really matter?
Myofibroblasts An activated fibroblast state characterized by expression of α-smooth muscle actin and contractile capability, associated with fibrosis across multiple organs and wound healing. Fig 1. The past, present, and future of fibroblasts. Classical immunology generally views fibroblasts as the cells that provide structure and stiffness to tissues.
Fibroblasts as immune regulators in infection, inflammation and cancer
1. Duvall, M. Atlas d’Embryologie (Masson, France, 1879). 2. Tarin, D. & Croft, C. Ultrastructural features of wound healing in mouse skin. J. Anat. 105, 189–190 (1969). CAS PubMed Google Scholar 3. Pierer, M. et al. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J. Immunol. 172, 1256–1265 (2004). CAS PubMed Article Google Scholar 4. Bombardieri, M. et al.
Inducible ablation of CD11c+ cells to determine their role in skin wound repair
Summary Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.
Sana Mir: the athlete, the person and the champion
https://www.womenscriczone.com/wcz-admin-login/?action=logout&redirect_to=https%3A%2F%2Fwww.womenscriczone.com&_wpnonce=6f1282d4db Sana Mir. © Getty Images The author worked as the head coach of Pakistan between October 2017 to October 2019. My first meeting with Sana Mir was at our first camp at the Lahore Country Club after Pakistan’s 2017 World Cup disaster. I had just taken up the role of coach, and ahead of the camp there were reports that Sana wasn’t going to turn up.
'Munster' Muneeba Ali ready to have fun and hit big
I was first told about Muneeba Ali or “Munster”, as she came to be known to me, on my arrival into Pakistan in 2017. While I didn’t get a chance to work with her immediately – she had been dropped from the side for the series against New Zealand that October and was taking some time away from cricket – Sana Mir, the Pakistan skipper at the time, suggested Muneeba was as talented a batter as she had seen. A few months later, in January 2018, I saw Muneeba at a domestic tournament.
Ready-made cellular plugs heal skin wounds
NEWS AND VIEWS 27 November 2019 The finding that a thin sheet of fibrous tissue under the skin contains a prefabricated, movable cellular sealant that can heal deep wounds might have implications for the treatment of scars and ulcers. Skin consists of an outer epidermal layer (the epidermis) and an inner dermal layer (the dermis).
Pathogenic stromal cells as therapeutic targets in joint inflammation
Abstract Knowledge of how the joint functions as an integrated unit in health and disease requires an understanding of the stromal cells populating the joint mesenchyme, including fibroblasts, tissue-resident macrophages and endothelial cells. Knowledge of the physiological and pathological mechanisms that involve joint mesenchymal stromal cells has begun to cast new light on why joint inflammation persists.
Plaza and Hop Fest and Parking
To the editor — For all the people pointing out that the Fresh Hop festival shows that the plaza will not affect parking, can I just point out that many of the attendants don’t actually drive to the festival? Thanks.
BBC - Radio 4 - Today - Finisterre
Dogger, Fisher, Rockall and German Bight - the names are more than familiar to listeners to BBC Radio 4's Shipping Forecast. Most of the 30 names that make up the daily roll-call of weather conditions at sea have been in place for more than half a century. But from lunchtime on February 4 one of the best known areas Finisterre will disappear for good. It's being renamed after complaints from Spain. The name Finisterre has been part of the UK Shipping Forecast since 1949.
MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells
Programmed death ligand-1 (PD-L1) is a critical regulator of T cell function contributing to peripheral immune tolerance. Although it has been shown that posttranscriptional regulatory mechanisms control PD-L1 expression in cancer, it remains unknown whether such regulatory loops operate also in non-transformed cells. Here we studied PD-L1 expression in human dermal lymphatic endothelial cells (HDLECs), which play key roles in immunity and cancer.
MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells
Programmed death ligand-1 (PD-L1) is a critical regulator of T cell function contributing to peripheral immune tolerance. Although it has been shown that posttranscriptional regulatory mechanisms control PD-L1 expression in cancer, it remains unknown whether such regulatory loops operate also in non-transformed cells. Here we studied PD-L1 expression in human dermal lymphatic endothelial cells (HDLECs), which play key roles in immunity and cancer.
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Non-Mendelian inheritance of SNP markers reveals extensive chromosomal translocations in dioecious hops (Humulus lupulus L.)
Non-Mendelian inheritance of SNP markers reveals extensive chromosomal translocations in dioecious hops (Humulus lupulus L.) Dong Zhang, Nicholi Pitra, Mark Coles, Edward S. Buckler, Paul Matthews bioRxiv 069849; doi: http://dx.doi.org/10.1101/069849
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