Ping Li
Jiangsu Sheng
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Articles by Ping Li
TMEM184 proteins are Ca 2+ uptake transporters in lysosomes
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Inside every cell, lysosomes act as waste-processing centers, and calcium release helps them break down waste and restore themselves if damaged. However, how these organelles replenish their calcium remains unclear. Cai et al.
The discovery and validation of genes associated with lactylation in papillary thyroid cancer
Abstract Thyroid cancer is the most common endocrine malignancy. Lactic acid and acidification of the tumor immune microenvironment are key processes promoting carcinogenesis. This study was to identify genes related to lactylation in papillary thyroid cancer (PTC) and explore potential regulatory mechanisms. Lactylation-associated genes were identified by combining differential expression and regression analyses, and these genes were subsequently used to construct a risk model.
Distribution and development characteristics of loess seismic landslides induced by the 1622 M 7 earthquake in Northern Guyuan, Northwest China
Abstract Coseismic loess landslides induced by historical strong earthquakes represent the predominant seismogeological hazard across the Loess Plateau, and a thorough inventory of their distribution and kinematic behavior is fundamental to regional seismic hazard evaluation and to the mechanistic understanding of loess seismic disasters.
A rare TMEM175 mutation drives Parkinson’s disease pathology by disrupting proton gating and lysosomal acidification
Manuscript information Author contributions. HX and MH designing research studies. XY, PL, ML, LW, RS, ZJ, DC, FH, WC, LZ, ZG, XC and YW conducting experiments, acquiring data, and analyzing data. ZC, WY, WL, and LY providing reagents. XY, PL, XL, MH and HX writing the manuscript with critical input from all the coauthors. All authors reviewed and approved the manuscript. AI disclosure. The authors declare that no AI tools were used in the original research for or writing of this article.
Empirical dietary inflammatory pattern and cognitive-state transitions in older US adults: a multistate cohort study
Abstract Background: Dietary inflammatory potential may be associated with cognitive aging, but evidence on cognitive-state transitions is limited. We examined the association of the empirical dietary inflammatory pattern (EDIP) with transitions from normal cognition to survey-classified cognitive impairment.
Case Report: Metachronous multiple primary neoplasms in a carrier of germline MSH2 c.958dupA Lynch syndrome
Abstract Introduction: Lynch syndrome is an autosomal dominant hereditary cancer syndrome caused by germline mutations in DNA mismatch repair (MMR) genes, conferring elevated risks of colorectal, endometrial, gastric, ovarian and other malignancies. We report a 38-year-old woman with a germline MSH2 c.958dupA (p.Thr320Asnfs*13) pathogenic frameshift mutation who developed metachronous multiple primary neoplasms affecting four organ systems over eight years.
Author Correction: Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial
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Correction to: Nature Medicine https://doi.org/10.1038/s41591-021-01444-0, published online 2 August 2021. In the version of this article initially published, in the Results section, there was an error in the number and percentage of patients who continued maintenance treatment after chemotherapy, which should have read 233 (80.6%) rather than 231 (79.9%). The corresponding total in the legend to Extended Data Fig. 1 should have read 233 rather than 231. In Fig.
By Hai-Qiang Mai, Qiu-Yan Chen, Dongping Chen, Chaosu Hu, Kunyu Yang, Jiyu Wen, Jingao Li, Feng Jin, Ruilian Xu, Jianji Pan, Shenhong Qu, Ping Li, Chunhong Hu, Yi-Chun Carol Liu, Yi Jiang, Xia He, Hung-Ming Wang, Wan-Teck Lim, Wangjun Liao, Xiaohui He, Xiaozhong Chen, Zhigang Liu, Xianglin Yuan, Qi Li, Xiaoyan Lin, Shanghua Jing, Yanju Chen, Yin Lu, Ching-Yun Hsieh, Muh-Hwa Yang, Chia-Jui Yen, Jens Samol, Hui Feng, Sheng Yao, Patricia Keegan, Rui-hua Xu, Ying-Rui Shi
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Nature
Verified
MORB-Type Rocks From the Proto-Tethyan Nantinghe Ophiolite, Southwestern Yunnan: Implication for the Indian Ocean-Type Mantle Domain
Handling Editor: Shengsi Sun Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1999. “Petrogenesis of Boninites From the Betts Cove Ophiolite, Newfoundland, Canada: Identification of Subducted Source Component.” Journal of Petrology 40: 1853–1889. https://doi.org/10.1093/petroj/40.12.1853. , and . 2011.
The non-inflammatory effect of neuronal NLRP3 on spatial memory after traumatic brain injury
Abstract The NLRP3 inflammasome has emerged as a critical regulator in neuroinflammatory responses to various brain insults from traumatic, ischemic and neurodegenerative conditions, an effect almost exclusively attributed to microglial NLRP3.
Probiotics for the prevention of antibiotic-associated diarrhea: an umbrella review and second-order meta-analysis of 21 systematic reviews covering 170 unique randomized controlled trials
Abstract Background: Antibiotic-associated diarrhea (AAD) is a common adverse event of antimicrobial therapy. Probiotics have been investigated for the prevention of AAD, but the evidence remains heterogeneous and fragmented. We conducted an umbrella review and second-order meta-analysis to comprehensively evaluate the efficacy and safety of probiotics for AAD prevention.
The efficacy and safety of dupilumab therapy in pediatric patients with refractory eosinophilic duodenal bulb ulcer: a retrospective cohort study
Abstract Background: Refractory eosinophilic duodenal bulb ulcer (REDU) is a rare and poorly characterized subtype of non–eosinophilic esophagitis eosinophilic gastrointestinal disease (non-EoE EGID). Standard therapies are often ineffective, and evidence for biologic treatment is limited. Objective: This study aims to evaluate the efficacy and safety of dupilumab in pediatric patients with REDU.
Correction: Better or worse food: Nutrition value of the prey fishes and the potential health implications for Indo-Pacific humpback dolphins
A Correction on Better or worse food: Nutrition value of the prey fishes and the potential health implications for Indo-Pacific humpback dolphins By Lin J, Liang Y, Zhao H, Gutang Q, Wu Z, Gao Y, Liu S, Li K, Wu Y, Zhang Z, Li P and Liu W (2023) Front. Mar. Sci. 10:1144398. doi: 10.3389/fmars.2023.1144398 There was a mistake in Figures 2 and 7 as published.
Large-scale plasma proteomics identifies proteins and pathways associated with incident interstitial lung disease
Abstract Objective: Reliable biomarkers for early interstitial lung disease (ILD) risk stratification are limited; therefore, we aimed to identify prediagnostic proteins associated with incident ILD and develop a long-term prediction model. Methods: We analyzed 52,743 UK Biobank participants without baseline ILD and measured 2,923 plasma proteins. Cox models were used to identify proteins associated with incident ILD.
Dietary Approaches to Stop Hypertension score is associated with depressive symptoms among Chinese adults: a cross-sectional study
Abstract Background: The relationship between diet and depressive symptoms is increasingly recognized. However, studies of the association between the Dietary Approaches to Stop Hypertension (DASH) diet and depressive symptoms are limited, and data from Chinese adults are lacking. Objective: The goal of this study was to explore the association between the DASH score and depressive symptoms in Chinese adults and to analyze the dose-response relationship and threshold effect.
Comparison of nutritional screening tools in pediatric patients undergoing hematopoietic stem cell transplantation
Abstract Background: Malnutrition is prevalent in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and is associated with elevated post-transplant infection risk. No standardized nutritional screening tool exists for this population.
Comparative analysis of taste profiles and metabolic characteristics in white tea processed from wild and cultivated tea plants
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. REFERENCES 1, , , , , et al., Where is tea grown in the world: a robust mapping framework for agroforestry crop with knowledge graph and sentinel images. Remote Sens Environ 303:114016 (2024). https://doi.org/10.1016/j.rse.2024.114016. 2, , , , , et al., Tea and tea drinking: China's outstanding contributions to mankind. Chin Med 17:27 (2022).
Early-onset digestive system cancers attributable to the GBD composite dietary risk in China, 1990–2023: burden, trends, and projections
Abstract Background: Digestive system cancers attributable to the aggregate dietary risk category defined by the Global Burden of Disease (GBD) study represent an important public health concern among Chinese adults aged 25–49 years. This study evaluated their burden, temporal trends, age-period-cohort patterns, and model-based projections.
Structural and functional insights into a Zn 2+ -transporting P-type ATPase
Abstract Zinc is essential for life yet toxic in excess, rendering homeostatic control vital for all organisms. Transition metal transporting P-type (PIB-) ATPase proteins are critical for this balance but remain poorly understood at the molecular level. Here, we present the inward-open structure of a dimeric zinc-transporting PIB-type ATPase, resolved at 3.6 Å resolution.
The identification of systemically important financial institutions from the aspect of “Too Connected to Fail”
Abstract This paper investigates the identification of Systemically Important Financial Institutions (SIFIs) from a “Too Connected to Fail” perspective by applying the K-shell algorithm to a dynamic tail-risk contagion network. The network is constructed for China’s financial system using the FARM-Selection method and CoVaR measure across the COVID-19 pandemic.
Integrated Mechanisms of Soil–Plant System Resilience to Drought–Flood Abrupt Alternation in Maize
ABA abscisic acid DF drought–flood abrupt alternation Eh soil redox potential JA jasmonic acid ROC root organic carbon RTN root total nitrogen SA salicylic acid SAG SA-2-O-β-glucoside 1 Introduction Global climate change has led to frequent extreme precipitation events, the uneven spatiotemporal distribution of which has rendered “drought–flood abrupt alternation” (DF stress) an increasingly prominent agricultural meteorological disaster (Liang et al. 2026).
Dancing with AI: how human-AI interaction affects employee task performance
Abstract The rapid increase in generative artificial intelligence (Gen AI) products has revolutionised the interaction between humans and artificial intelligence. However, the conceptualisation, measurement, and performance implications of human-AI interaction in the workplace remain underexplored. This study utilised a grounded theory approach to explore the multidimensional construct of human-AI interaction.
Case Report: Targeted therapy for TIF1γ-positive dermatomyositis with possible macrophage activation syndrome, cardiac and gastrointestinal involvement: a case-based review
Abstract Dermatomyositis (DM) is an autoimmune disorder characterized primarily by cutaneous and muscular inflammation. Although the TIF1γ antibody-positive variant frequently correlates with an underlying malignancy, instances of severe multisystem compromise lacking a neoplastic association remain exceptionally uncommon. Macrophage activation syndrome (MAS), a lethal cytokine storm, poses substantial diagnostic and therapeutic challenges in DM.
Transparent Topological Meta-Diplexer via Tightly Confined Valley Surface States
1 Introduction Topological photonics, inspired by the discovery of topological states of matter in condensed matter physics, has emerged as a powerful platform for manipulating electromagnetic waves robustly and unconventionally [1-6].
Co-hydrothermal carbonization of sewage sludge and coffee grounds: combustion characteristics and hydrochar properties
Abstract To simultaneously address the pressing challenges of sewage sludge (SS) disposal and coffee grounds (CG) valorization, herein, co-hydrothermal carbonization (Co-HTC) of SS and CG was performed at a dry mass ratio of 1:2 over a temperature range of 180–260 °C to evaluate hydrochar properties and synergistic interactions.
Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study
Abstract Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. This study aimed to investigate the associations between plasma 25(OH)D concentrations and serum Hcy levels, as well as the odds of hyperhomocysteinemia (HHcy), in Chinese adults.
Laparoscopic ureteral anastomosis to a bladder diverticulum for the treatment of postoperative ureteral fistula: a case report
Abstract Objective: To investigate the feasibility and potential indications of laparoscopic ureteral anastomosis to a bladder diverticulum for the treatment of ureteral fistula in the setting of complex reoperative pelvic surgery.
Siglec Ligand Profiling on Extracellular Vesicles Reveals a Cancer-Related Signature with Immunosuppressive Function in Pancreatic Cancer
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll75407-sup-0001-SuppMat.docx17.2 MB Supporting File: smll75407-sup-0001-SuppMat.docx. References 1, , , and , “Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment,” Gastroenterology 163, no.
From genomic conflict to ecological adaptation: reconstructing higher-level phylogenetic relationships of water mites (Hydrachnidia) based on mitochondrial genomes
Conflict of interest statement The authors declare that they have no conflicts of interest. Data availability All sequence data used in this study have been deposited in the GenBank database. Supporting Information Filename Description cla70061-sup-0001-FigureS1.docxWord 2007 document , 9.9 MB Fig. S1. Phylogenetic trees inferred from the nine combinations of three sequence matrices and three substitution model strategies. cla70061-sup-0002-FigureS2.docxWord 2007 document , 1.5 MB Fig. S2.
Sudden suspected anaphylactic shock after multiple tolerated doses of piperacillin-tazobactam: a case report and literature review
Abstract Background: The most well-known adverse reaction of penicillins is anaphylactic shock, which mostly occurs within the first few minutes of the initial administration. However, cases of sudden anaphylactic shock that develop after multiple consecutive doses with no prior adverse events are extremely rare.
Quantum Chemical Insights Into Glycine-Mediated Stepwise Transformation of Halobenzoquinones
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supporting information of this article.
Photochemical interactions between iron minerals and dissolved organic matter
Abstract Interactions between iron minerals and dissolved organic matter (DOM) are ubiquitous across environmental systems, but the global effects of photochemical synergies between DOM and iron minerals in surface environments remain to be comprehensively elucidated.
Effects of Processing Variables on the Quality Characteristics of Wheat Gluten/ Morchella esculenta Mycelium-Based High-Moisture Extrudate
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description jtxs70109-sup-0001-Supinfo.docxWord 2007 document , 43.1 KB Figure S1: Sample configuration for measuring shear force.
Comparative Study on Mental Health Outcomes in Patients with Rheumatoid Arthritis and Knee Osteoarthritis
Abstract Objective: To analyze the current situation and differences in the mental health levels of patients with rheumatoid arthritis (Rheumatoid arthritis, RA) and knee osteoarthritis (Osteoarthritis, OA), so as to provide a reference for clinical nursing interventions.
RIS-shield: intelligent reflecting surface-aided physical layer security with deep reinforcement learning for 6G massive IoT
Abstract This paper proposes RIS-Shield, an intelligent defense architecture for secure 6G massive Internet of Things (MIoT) deployments. By integrating Reconfigurable Intelligent Surface (RIS) technology with deep reinforcement learning (DRL), RIS-Shield addresses critical physical layer security (PLS) challenges that traditional mathematical optimization methods fail to solve under high-dimensional non-convex conditions.
Component Self-Initiated Photopolymerization for Gel Polymer Electrolytes in Zinc–Air Batteries
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description ange74081-sup-0001-SuppMat.pdf6.2 MB Supporting File 1: ange74081-sup-0001-SuppMat.pdf. ange74081-sup-0002-MovieS1-S8.zip143 MB Supporting File 2: ange74081-sup-0002-Movie_S1–S8.zip.
Component Self-Initiated Photopolymerization for Gel Polymer Electrolytes in Zinc–Air Batteries
Ping Li and Dagang Zhou contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description anie74081-sup-0001-SuppMat.pdf6.2 MB Supporting File 1: anie74081-sup-0001-SuppMat.pdf. anie74081-sup-0002-MovieS1-S8.zip143 MB Supporting File 2: anie74081-sup-0002-Movie_S1–S8.zip.
A new control method for uncertain switched systems under replay attacks
For uncertain switched systems subjected to unknown but bounded disturbances and replay attacks, a robust predictive control technique based on multi-constraint event triggering is proposed. Firstly, a hybrid switching mechanism incorporating attack detection information is constructed. Dwell-time and state-dependent switching are employed to prevent frequent switching, while the integration of detection information avoids malicious switching triggered by replay attacks.
Metabolic correlates of endoscopy-confirmed reflux esophagitis in hospital-based patients with type 2 diabetes mellitus
Abstract Background: Reflux esophagitis (RE) is an endoscopy-defined manifestation of gastroesophageal reflux disease and may be related to metabolic disturbance in type 2 diabetes mellitus (T2DM). The clinical-metabolic characteristics associated with endoscopy-confirmed RE in T2DM remain incompletely defined, particularly with regard to glycemic control, 25-hydroxyvitamin D [25(OH)D] status, and insulin-related indicators.
Midkine-activated TRPA1+ cancer-associated fibroblasts promote immunotherapy resistance in gastric cancer through a WNT5A-mediated treg circuit
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Abstract Gastric cancer (GC) derives limited benefit from immune checkpoint blockade (ICB), in part due to stromal-mediated immune suppression. To investigate the underlying mechanisms, we performed single-cell RNA sequencing on 14 GC specimens from patients treated with neoadjuvant ICB. We identified a distinct subset of TRPA1+ cancer-associated fibroblasts (CAFs) maintained by tumor-derived midkine (MDK) through LEF1-dependent transcription under ICB pressure.
By Hualong Zheng, Xiaoqian Ye, Linyong Zheng, Xiaobo Huang, Haidan Yan, Zhilong Lin, Qing Zhong, Ruhong Tu, Zhiquan Zhang, Qiang Huang, Yifan Li, Yi Li, Xinpeng Yang, Chenyang Jiang, Xiaojing Guo, Maosen Wang, Chaohui Zheng, Ping Li, Jiabin Wang, Changming Huang, Qiyue Chen, Jianwei Xie, Youxin Gao, Jianxian Lin
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Nature
Verified
Dietary Inflammatory Index, cardiovascular health, and long-term outcomes in hypertension: external validation in a Chinese percutaneous coronary intervention cohort
Abstract Background: Hypertension frequently coexists with poor cardiovascular health (CVH), yet whether the inflammatory potential of habitual diet, captured by the Dietary Inflammatory Index (DII), relates to CVH and to subsequent adverse cardiovascular events in this population remains unclear. Methods: A discovery analysis was performed in 12,376 hypertensive adults from NHANES (2005–2018), with suboptimal CVH defined as a Life’s Essential 8 (LE8) score < 80.
Polyphyllins ameliorate imiquimod-induced psoriatic skin barrier disruption and lesions in mice by inhibiting inflammatory infiltration with accelerated recovery effects
Abstract Background: Psoriasis is a chronic inflammatory skin disorder that significantly compromises patients’ quality of life. While dexamethasone (DEX) is effective as a first-line treatment, its adverse effects highlight the need for alternatives. Effective therapies for prolonging clinical remission and reducing relapse rates remain limited.
Clinical and Genetic Study of a Pseudo-Dominant Primary Ciliary Dyskinesia Pedigree: The First DNAAF1-Associated Family Reported in Chinese Population
CNKI China National Knowledge Infrastructure CT Computerized tomography HSVA High-Speed Video Analysis IDA Inner dynein arm ODA Outer dynein arm PCD Primary ciliary dyskinesia TEM Transmission electron microscopy WES Whole Exome Sequencing 1 Introduction Primary ciliary dyskinesia (PCD) is a group of rare genetically heterogeneous disorders (~0.2/10,000–7/100,000 live birth), characterized by neonatal respiratory distress, recurrent respiratory tract infections, subfertility, and laterality...
B-type host stars revealed by exoplanets around massive secondary-clump giant stars
Abstract Exoplanets around massive young stars, including hot spectral-class B (B-type) stars, are rare but important for understanding how planets form and survive. Most known examples are either very distant companions found by direct imaging or extremely close-in planets found by transit surveys, leaving planets at intermediate orbital distances largely unexplored. Here, we show that this missing population can be revealed through evolved stars.
The RhMPK3-RhLOB41-RhWRKY9 module orchestrates ethylene-induced petal abscission via dual control of ROS homeostasis in rose
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Organ abscission represents a critical adaptive strategy for plant survival, yet the post-translational mechanisms ensuring its irreversible remain poorly understood.
Intelligent optimization of personalized learning path based on transformer and reinforcement learning
Abstract Smart education platforms accumulate large volumes of learning resources and interaction logs. However, fixed recommendation sequences are often unable to adapt to differences in knowledge foundations, learning behaviors, and cognitive progress among learners. Existing learning path recommendation methods primarily focus on static matching and single-step ranking, while providing limited support for modeling learning state evolution and long-term path benefits.
Italy's IP Reform: A Narrow Window To Challenge Existing Preliminary Injunctions
Thomas Bouvet ’s articles from Jones Day are most popular: in European Union Jones Day are most popular: within Strategy topic(s) In Short The Situation: The Court of Justice of the European Union ("CJEU") ruled that national laws cannot allow preliminary injunctions to remain in force indefinitely where the claimant never started proceedings on the merits and the defendant seeks discharge.
Moving to the Good Occupations across Generations Sociotechnical Factors Promoting Economic Growth
1. Introduction Economic growth is often unbalanced, occurring in sectors differentially, and de-pendent on sector specific technology such as agricultural technology or in more recent times, artificial intelligence (AI) and information technology (IT). Less recognized, but important empirically and theoretically, is household technology for non-market productivity. The needed changes for diffusion can operate through both occupational or industrial composition.
Author Correction: The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production
Correction to: Nature Communications https://doi.org/10.1038/s41467-022-28044-x, published online 19 January 2022 In the version of this article initially published, due to a data transfer error, the Source Data and plot of Fig. 1c were incorrect, while Source Data for Figs. 3g, 6a, 7h had duplication errors and Supplementary Fig. 3a had missing values. In Fig. 4b, representative images in the third column were duplicates of the third column of Fig. 4c.
Association between prognostic nutritional index and prognosis in non-small cell lung cancer patients receiving PD-1/PD-L1 inhibitors: a meta-analysis
Abstract Objective: This study aimed to comprehensively evaluate the predictive value of prognostic nutritional index (PNI) for long-term survival in non-small cell lung cancer (NSCLC) patients treated with programmed death receptor-1 and its ligand (PD-1/PD-L1) inhibitors through systematic review and meta-analysis. Methods: A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library databases up to January 2026.
EASIX as a moderately effective prognostic marker for mortality in severe acute pancreatitis: a retrospective study
Abstract Introduction: The endothelial activation and stress index (EASIX) has been proposed as a surrogate laboratory index reflecting endothelial activation and stress. This study aimed to evaluate the prognostic value of EASIX in patients with severe acute pancreatitis (SAP). Methods: This retrospective observational study analyzed 340 SAP patients hospitalized between December 2015 and December 2023. EASIX was calculated as LDH (U/L) × creatinine (mg/dL) / platelet count (109/L).
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