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Articles by Ze Chen
Interleukin-1α (IL-1α) in pancreatic ductal adenocarcinoma: implications for immunotherapy and molecular biomarkers
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate of only 12%, driven by late diagnosis, rapid metastasis, and an immunosuppressive tumor microenvironment (TME). Current therapies, including chemotherapy and immune checkpoint blockade, show limited efficacy due to the “cold” TME. Interleukin-1α (IL-1α) plays a central role in PDAC progression.
Decoupling Volume and Magnetic Anisotropy for the Enhancement of Thermal Stability in CoFeB Multilayered Structures
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding authors upon reasonable request.
Unintentional man-made disasters, risk preferences, and insurance demand
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description jori70071-sup-0001-Online_Appendix_20260616.docx45 KB Online Appendix_20260616. REFERENCES , , , & (2019). Impact of violent crime on risk aversion: Evidence from the Mexican drug war. Review of Economics and Statistics, 101(5), 892–904. , & (2015).
Minimizing Societal Cost of Epidemics: Optimal Catastrophe Insurance Compensation Allocation
References , , and . 2024. “ The P2p Pandemic Swap: Decentralized Pandemic-Linked Securities to Develop Health Emergency Financing Solutions.” Available at SSRN. https://ssrn.com/abstract=4753211. https://doi.org/10.2139/ssrn.475321. , , , et al. 2020. “Epidemiology, Causes, Clinical Manifestation and Diagnosis, Prevention and Control of Coronavirus Disease (COVID-19) During the Early Outbreak Period: A Scoping Review.” Infectious Diseases of Poverty 9: 1–12. , and . 2020.
Coordination electrochemistry taming reversible hypervalent bromine redox for energetic six-electron-transfer lithium-bromine battery
Abstract Conversion-type static bromine batteries demonstrate promise in high output voltage and large capacity for rechargeable energy storage due to the inherent polyvalent reaction potential. Nevertheless, the combination of the limited two-electron 2Br-/Br2 redox couple and the redox-inactive organic ligands presents a fundamental bottleneck for the overall specific energy.
Zwitterionic Gel Electrolyte Stabilized Multivalent Tellurium Redox for High-Energy Lithium Batteries
Lithium batteries based on multivalent chalcogen conversion chemistries offer a promising route toward high-energy, practical energy storage, but their development is impeded by the limited accessibility and instability of high-valence intermediates. Here we report a quasi-solid-state lithium||tellurium battery in which a zwitterionic gel polymer electrolyte (GPE) stabilizes multivalent tellurium redox, enabling reversible six-electron conversion under practical conditions.
Zwitterionic Gel Electrolyte Stabilized Multivalent Tellurium Redox for High-Energy Lithium Batteries
1 Introduction Rechargeable batteries, particularly lithium-ion batteries (LIBs), have emerged as a leading solution for electrical energy storage [1, 2]. However, the widespread use of intercalation-type cathode materials, such as lithium nickel manganese cobalt oxide (NMC) or lithium cobalt oxide (LiCoO2), presents inherent limitations to further performance improvements [3].
Balanced electrochemical reaction kinetics and mass transfer for stable zinc negative electrode
Abstract The formation of zinc dendrites is a significant obstacle to commercializing zinc-ion batteries. Although the discrepancy between the fast electrochemical reaction kinetics and the comparatively sluggish mass transfer leads to the formation and growth of dendrites, a profound understanding of how the relationship between the two factors influences dendrite formation is essential.
Whole blood epigenomic and transcriptomic characterization identifies vulnerable molecular subtypes of chronic coronary disease
Abstract Chronic coronary disease (CCD) remains a leading cause of morbidity and mortality worldwide. However, current clinical assessments, including tests of inducible ischemia or coronary artery disease severity poorly discriminate risk for future cardiovascular (CV) disease events among this population with established CCD.
PARP1 suppression drives ROS resistance in aneuploid cancer cells
Keywords aneuploidy cancer PARP1 oxidative stress cell death Introduction Aneuploidy, a hallmark of cancer,1 correlates with tumor progression, poor survival, and therapeutic resistance.2,3,4 The role of aneuploidy in cancer, however, remains incompletely understood.
Aerobic exercise reduces lactate accumulation and improves cardiac function after myocardial infarction
Abstract Objective: This study aimed to investigate the role of lactate in the progression of cardiac dysfunction after myocardial infarction (MI) and clarify the effect of aerobic exercise (AE) on improving post-infarction cardiac function by regulating lactate metabolism, so as to provide experimental evidence for the clinical improvement of cardiac function after MI. Methods: NIH 3 T3 mouse embryonic fibroblasts and C57BL/6 J mice were used as research subjects.
Ixodes pavlovskyi (synurbic, avian-associated tick)
Get full text access Log in, subscribe or purchase for full access. References 1. Rar, V. ... Spectrum of Ixodidae ticks attacking humans in Novosibirsk province, Russian Siberia, and their association with tick-borne bacterial agents Pathogens. 2025; 14:315 2. Kartashov, M. ... Genotyping of tick-borne pathogens and determination of human attacking tick species in Novosibirsk and its suburbs Russ. J. Infect. Immun. 2022; 12:1103-1112 3. Obaid, M.K. ...
Highly Efficient Chlorine Fixation Based on Organic Selenium for 3.7-V Aqueous Batteries Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleMarch 16, 2026 Highly Efficient Chlorine Fixation Based on Organic Selenium for 3.7-V Aqueous Batteries Click to copy article linkArticle link copied! Ze Chen* Ze Chen Wu Jieh Yee School of Interdisciplinary Studies, Lingnan University, 8 Castle Peak Road, Tuen Mun, Hong Kong 999077, China *Email: [email protected] Yiqiao Wang Yiqiao Wang Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong...
Comparative dosimetric and radiobiological assessment of a hybrid-VMAT strategy incorporating supplemental short-arcs for left-sided postmastectomy radiotherapy
Abstract Purpose: Postmastectomy radiotherapy (PMRT) for left-sided breast cancer poses persistent dosimetric challenges due to the complex target geometry and its proximity to critical organs at risk (OARs), particularly the heart and the left anterior descending (LAD) coronary artery.
NIR-II Nanomedicine Engineered CAR-NK Cells for Precision Navigation and Potentiating Lung Cancer Immunotherapy by Remodeling Tumor Microenvironment
Introduction Click to copy section linkSection link copied! Natural killer (NK) cells, as innate lymphoid cells with easy access and expansion, are capable of spontaneously recognizing target cells and eliciting a powerful cytotoxicity accompanied by cytokine release to selectively kill aberrant cells without strict human leukocyte antigen (HLA) matching and without producing cytokine release syndromes (CRS).
NIR-II Nanomedicine Engineered CAR-NK Cells for Precision Navigation and Potentiating Lung Cancer Immunotherapy by Remodeling Tumor Microenvironment
In order to obtain phototherapeutic agents with high NIR-II fluorescence performances, Stille coupling polymerization was performed for synthesis of semiconducting polymers (SP1, SP2, SP3) by adjusting the donor doping ratios ( Scheme S1 ), using long alkyl side chain-modified bithiophene (TC) and planar 2,5-bis(trimethylstannyl) thieno [3,2- b ]thiophene (DT) as donor units as well as electron-deficient...
From gateway to value ladder-The curious case of online mutual aid in China
1 INTRODUCTION The rise of InsurTech has profoundly transformed the insurance landscape, with emerging platforms harnessing digital technologies to transform industry practices. Among these innovations, the provision of information to participants stands out as a defining characteristic that differentiates InsurTech models from traditional insurance operations.
Dual-tuned terahertz cloaking via two-layer semiconductor
Recently, electromagnetic cloaking has received great attention and become a research hotspot for scientific and technological workers. This work has designed and studied a plasmonic cloak made of two-layer isotropic and homogeneous semiconductors (GaAs and InAs), based on the scattering cancelation cloaking (SCC) technology and the finite element method.
Coagulation Factor Consumption and Medium‐ to Long‐Term Outcomes of Achilles Tendon Lengthening With and Without External Fixation in Haemophilia
Conflicts of Interest The authors stated that they had no interests that might be perceived as posing a conflict or bias. Data Availability Statement The data in this study can be obtained from the corresponding author upon reasonable request. References 1, , , et al., “Haemophilia,” Lancet 405, no. 10480 (2025): 736–750. 2, , , et al., “Arthropathy of the Ankle in Hemophilia,” Journal of Bone and Joint Surgery American Volume 73, no. 7 (1991): 1008–1015.
Catalytic electrolytes enable fast reaction kinetics and temperature adaptability for aqueous zinc-bromine flow batteries - Nature Communications
Abstract Catalysts are widely used to improve electrode reactions in static batteries. However, due to aqueous flow batteries utilizing large volumes of electrolytes, previously reported non-flowable solid-phase catalysts are inadequate for addressing challenges such as low conversion ratios and electrolyte failure, especially under low-temperature conditions. Herein, we develop functionalized carbon quantum dot–based colloidal catalytic electrolytes for Zn–Br flow batteries.
A novel nutritional immune risk score model for long-term prognosis in colorectal cancer using clustering and principal component analysis
Abstract Background: Survival outcomes among patients with colorectal cancer (CRC) often differ despite identical disease stages, partly due to variations in nutritional and immune status. Malnutrition can impair immune defense, exacerbate inflammatory responses, and influence tumor progression, ultimately contributing to a poorer prognosis.
Deep learning-enhanced spectral ghost imaging with accelerated and high-fidelity reconstruction
Ghost imaging is an indirect imaging method that utilizes the correlation properties of light to reconstruct the real-space image of an object. While originally developed in the spatial and temporal domains, its principles can be extended into the spectral domain by spatially dispersing broadband light and pseudo-randomly modulating its spectral components.
Association of dietary vitamin E intake with lipid accumulation product: A population‐based study in the United States
INTRODUCTION The lipid accumulation product (LAP), serving as an indicator to estimate the extent of excessive lipid accumulation in the body, is determined by considering two factors: waist circumference (WC) and fasting plasma triglyceride (TG) levels.1-3 Presently, numerous studies have provided proof indicating that LAP could potentially function as an indicator for various health issues, such as type 2 diabetes, insulin resistance, Metabolic Syndrome (MetS), heart diseases, and...
Global burden of colorectal cancer from 1990 to 2021: a systematic analysis from the Global Burden of Disease Study 2021
Department of Proctology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China Background: Colorectal cancer (CRC), currently the second leading cause of cancer-related mortality worldwide, poses a significant burden on public health.
Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystem - Nature Communications
Abstract Helicobacter pylori (H. pylori) manipulates the host immune system to establish a persistent colonization, posing a serious threat to human health, but the mechanisms remain poorly understood. Here we integrate single-cell RNA sequencing and TCR profiling for analyzing 187,192 cells from 11 H. pylori-negative and 12 H. pylori-positive individuals to describe the human gastric ecosystem reprogrammed by H.
Fluorinated-oligomeric Ionic Liquids for High-performance Wide-temperature Solid Zinc Batteries
Fluorinated-oligomeric Ionic Liquids for High-performance Wide-temperature Solid Zinc Batteries Zn-based solid polymer electrolytes (SPEs) hold immense potential for developing high-performance and safe zinc ion batteries (ZIBs) that can operate effectively even at high temperatures.
Prominin 2 knockdown inhibits the growth, migration, and invasion of non-small cell lung cancer cells by repressing phosphatidylinositol 3 kinase/protein kinase B pathway
Translate this page into: doi: 10.25259/Cytojournal_118_2024 , , , 1Department of Laboratory, Guangdong Gaozhou People’s Hospital, Maoming, Guangdong Province, China. 2Department of Medical Administration, Guangdong Gaozhou People’s Hospital, Maoming, Guangdong Province, China. 3Department of Oncology, Guangdong Gaozhou People’s Hospital, Maoming, Guangdong Province, China.
Field theory of non-Hermitian disordered systems
The interplay between non-Hermiticity and disorder gives rise to unique universality classes of Anderson transitions. Here, we develop a field-theoretical description of non-Hermitian disordered systems based on fermionic replica nonlinear sigma models.
Intranasal Immunization with DNA Vaccine HA-CCL19/Polyethylenimine/Chitosan Composite Provides Immune Protection Against H7N9 Infection
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Yuqing Xiang 1,2,3,4, Hongbo Zhang 1,3,4,*, Youcai An 1,3,4 and Ze Chen 1,2,3,4,* 1 Department of Basic Research, Ab & B Bio-Tech Co., Ltd.
We propose a comprehensive theory to analyze the Goos–Hänchen (GH) shift for an arbitrarily polarized Airyprime beam reflected at the air–dielectric interface. We derive general expressions for the spatial and angular GH shifts and establish a close relationship between the GH shift of the Airyprime beam and the GH shift of the Airy beam.
Supramolecular Crystals based Fast Single Ion Conductor for Long‐cycling Solid Zinc Batteries
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Mutational Landscape of Gastric Adenocarcinoma of the Fundic Gland Type Revealed by Whole Genome Sequencing
ACRG Asian Cancer Research Group CNAs Copy number alterations CRC Colorectal cancers DBS doublet-base substitutions Del-MH Deletions with microhomology FFPE formalin-fixed paraffin-embedded GA-FG Gastric adenocarcinoma of the fundic gland type H.
Corrected theory for transmitted Goos–Hänchen and Imbert–Fedorov shifts
We analyze the role of the energy flow coefficient in beam shifts and develop the theory of the angle spectrum method to calculate the beam shifts of polarized beam reflection and transmission. By applying the self-consistency between the law of conservation of momentum and the angular Goos–Hänchen (GH) shift, we prove the necessity of the correcting energy flow coefficient of the transmitted light fields.
Recent Trends in Polymer Matrix Solid Buoyancy Materials: A Review
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
MXene Supported Electrodeposition Engineering of Layer Double Hydroxide for Alkaline Zinc Batteries
Introduction Aqueous zinc batteries (AZBs) are attracting intensive attention benefiting from the merits of Zn anode such as high theoretical capacity (820 mAh g−1 or 5854 mAh cm−3), low redox potential (−0.76 V vs. standard hydrogen electrode (SHE) in mild/acid electrolyte and −1.26 V vs.
Quality and efficiency assessment of five extracellular vesicle isolation methods using resistive pulse sensing strategy
Quality and efficiency assessment of five extracellular vesicle isolation methods using resistive pulse sensing strategy Extracellular vesicles (EVs) have attracted great interest due to their great potential in disease diagnosis and therapy. The separation of EVs from complex biofluids with high purity is essential for the accurate analysis of EVs. Despite various methods, there is still no consensus on the best method for high-quality EVs isolation and reliable mass production.
A Live Attenuated H1N1 Influenza Vaccine Based on the Mutated M Gene
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Photo‐Electro‐Thermal Textiles for Scalable, High‐Performance, and Salt‐Resistant Solar‐Driven Desalination
1 Introduction Solar steam generation (SSG) is a green, cost-effective, and sustainable solution for water desalination and purification.
Highly Reversible Positive‐Valence Conversion of Sulfur Chemistry for High‐Voltage Zinc‐Sulfur Batteries
Sulfur is a promising conversion-type cathode for zinc batteries (ZBs) due to its high discharge capacity and cost-effectiveness. However, the redox conversion of multivalent S in ZBs is still limited, only having achieved S0/S2− redox conversion with low discharge voltage and poor reversibility.
Exosomes derived from antler mesenchymal stem cells promotes wound hea
Introduction Skin, the largest organ of the human body, performs crucial physiological functions such as regulating body temperature, conducting sensory impulses, maintaining water and electrolyte balance, and protecting against UV rays, radiation, environmental hazards, and infections.1,2 Skin injuries can result from trauma, burns, surgery, or complications from diseases like diabetes.
3D Shape Measurement of Aeroengine Blade Based on Fringe Projection Profilometer Improved by Multi-Layer Concentric Ring Calibration
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A timely helping hand: China‐U.S. Trade War, government subsidy, and firm innovation
CONFLICT OF INTEREST STATEMENT We do not have any potential conflict of interest. REFERENCES , , , , & (2018). Innovation, reallocation, and growth[J]. American Economic Review, 108(11), 3450–3491. https://doi.org/10.1257/aer.20130470 , , , , , & (2015). Industrial policy and competition[J]. American Economic Journal: Macroeconomics, 7(4), 1–32. https://doi.org/10.1257/mac.20120103 , & (1992). A model of growth through creative destruction[J]. Econometrica, 60(2), 323–351.
Unveiling global research trends and hotspots on mitochondria in NAFLD from 2000 to 2023: A bibliometric analysis
1 INTRODUCTION Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition that affects the liver worldwide. It is a chronic liver disease characterized by the accumulation of lipids, inflammation, and insulin resistance (IR).1 NAFLD is closely linked to obesity, cardiovascular disease, and metabolic syndrome.
Fringe Projection Profilometry for Three-Dimensional Measurement of Aerospace Blades
1. Introduction Aero-engine blades, as one of the most crucial components of the engine, directly impact the efficiency and reliability of the entire engine through their design and performance [1,2]. With the aviation industry’s increasing emphasis on environmental impact and fuel efficiency, higher requirements are placed on the materials, design, and manufacturing technology of aero-engine blades.
Pressure Pulsation Characteristics on the Bulb Body of a Submersible Tubular Pump
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Numerical Investigations of Pile Group Foundations under Different Pile Length Conditions
1. Introduction Pile foundations are widely used in various infrastructure engineering fields due to their numerous advantages, including high vertical bearing capacity, stability, and adaptability to different site conditions. In many building foundations, the pile group-cap system is commonly adopted, where both the piles and the cap work together to support the loads from the superstructure and soil deformation.
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