Fan Xia
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Articles by Fan Xia
Oral succinate protects the heart in a temperature dependent manner in mice via gut microbiota
Abstract Ambient temperature profoundly influences cardiac metabolism and function, but whether it modulates the cardiac effects of an oral metabolite remains largely unexplored. Here, we investigated whether ambient temperature modulates the cardiac effects of oral succinate administration in a mouse model of abdominal aortic coarctation (AAC)-induced cardiac remodeling.
H 2 S-induced surface reconstruction enables efficient CsPbI 3 QLEDs with ultralow roll-off
Abstract Metal halide perovskite quantum dots (QDs) are promising materials for developing low-cost and high-performance quantum dot-based light-emitting diodes (QLEDs). Despite external quantum efficiency (EQE) comparable to II–VI/III–V QLEDs, perovskite QD counterparts achieve peak EQE at low luminance/current density and exhibit significantly more pronounced efficiency roll-off, owing primarily to their ionic character and soft lattice.
Smoke-Free Home Intervention in Permanent Supportive Housing : A Cluster Randomized Clinical Trial
Introduction Tobacco use is the leading cause of preventable death in the US, with over 490 000 deaths attributed to tobacco use annually, including 19 000 from secondhand smoke (SHS) exposure.1 While the prevalence of cigarette smoking is 9.9% nationally,2 an estimated 60% of the 400 000 people living in permanent supportive housing (PSH) smoke cigarettes,3,4 and tobacco-related chronic diseases are their leading cause of death.5 PSH is subsidized housing with voluntary supportive services...
Algebraic Theory of Inductive Mathematical Modeling: From Experimental Observations to State-Space Representations
Submitted: 02 September 2026 Posted: 03 September 2026 You are already at the latest version In empirical sciences, the inductive construction of mathematical models relies on observations from controlled experiments, yet the conditions under which such constructions yield well-defined deterministic dynamics remain largely implicit.
Contingency Management for Smoking Cessation Among Adults Experiencing Homelessness : A Pilot Randomized Clinical Trial
Supplement 1. Supplement 2. eFigure. Visual Representation of CO–Verified Abstinence Status Across Study Visits Among Participants, by Study Group eTable 1. Baseline Tobacco Use Characteristics of Participants eTable 2. Multiple Imputation Analysis for Missing Data: Logistic Models 1 and 2 for 7-Day Point Prevalence Abstinence and CO–Verified Abstinence at 6 Months eTable 3.
Angstrom-fluidic chemical synapses for accurate cancer diagnosis
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Abstract Artificial chemical synapses, which specifically identify, transmit, and process molecular information, find promising applications in precision medical diagnosis, neural-electronic interface, and in-memory computing. However, to implement biomarker-triggered neuronal excitability modulation with artificial iontronic devices remains a significant challenge.
By Jing Zhao, Qun Ma, Xueqin Luo, Hong liu, Shijun Xu, Yang Liu Verified, Huageng Liang, Lei Zhou, Meihua Lin, Wei Guo, Fan Xia, Gangping Lian
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Nature
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Nucleic acid probe-functionalized self-powered sensor for detection of biomarkers in clinical urine samples
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Triboelectric nanogenerator (TENG)-based self-powered biosensors can reduce ecological risks from energy storage device disposal and complex electronics manufacturing, offering cost-effective and eco-friendly diagnostic methods.
By Irene Varela-Martínez, Zhenlan Yao, Da-Hyun Kim, Qitao Zhou, Along Gao, Xiali Yang, Huageng Liang, Jing Pan Verified, Shaoguang Li, Hui Li, Caofeng Pan, Fan Xia
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Science Magazine
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A UHPLC-MS/MS method for the simultaneous quantification of BTK inhibitors and their active metabolite in human plasma and cerebrospinal fluid
ABSTRACT Background Bruton’s tyrosine kinase inhibitors (BTKis, ibrutinib, zanubrutinib, orelabrutinib) are key targeted therapies for B-cell lymphomas, but interindividual variability and adverse reactions limit their use. Metabolized by CYP3A, co-medications or hepatic dysfunction cause plasma fluctuations, necessitating therapeutic drug monitoring (TDM). Cerebrospinal fluid (CSF) distribution is also critical for CNS lymphoma treatment.
Increased activity of DRD1-MSNs in dorsolateral striatum underlies Cry1Δ11 mutation-induced repetitive behaviors
Abstract Repetitive behaviors are classically associated with autism spectrum disorder and obsessive compulsive disorder, but also occur prominently in attention-deficit/hyperactivity disorder (ADHD), yet the underlying mechanisms remain poorly understood. Our recent work identified ADHD-like behaviors in Cry1Δ11 mice, in which a mutation in a core circadian gene Cry1 produces a CRY1Δ11 protein that fails to inhibit the Gαs subunit, leading to hyperactive signaling of dopamine D1 receptor (DRD1).
Epigenetic priming with azacitidine-BEAM versus decitabine-BEAM conditioning for autologous transplantation in non-Hodgkin’s lymphoma
To the editor: Autologous stem cell transplantation (ASCT) remains a cornerstone strategy for patients with high-risk or relapsed/refractory lymphoma. Although carmustine, etoposide, cytarabine, and melphalan (BEAM) is widely recognized as the standard conditioning regimen, post-transplantation relapse remains the primary cause of treatment failure. Recent evidence [1, 2] suggested that simply substituting traditional cytotoxic drugs has reached a therapeutic bottleneck.
Effects of physical activity on depressive symptoms in middle-aged and younger-old adults: a systematic review and meta-analysis
Abstract Background: Depression is a common mental health issue in middle-aged and younger-old adults. It can substantially impair their well-being and daily functioning. Physical activity is often recommended to help with depression, but its effectiveness for middle-aged and younger-old adults is not clear. The most effective exercise prescription also remains to be determined. This systematic review aims to answer two questions: Does physical activity reduce depressive symptoms in this group?
Monitoring by Monitoring: Third-Party Auditing and Monitoring Data Authenticity
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Since our data are obtained under a confidentiality agreement, we anonymize and aggregate the data before making them publicly available. Replication files are available at Zenodo (https://doi.org/10.5281/zenodo.20023052).
Nucleic acid fluorescent probes for telomerase assay
Abstract Telomerase is a critical enzyme that maintains chromosomal stability and cellular proliferative activity, playing a crucial role in cell division, aging, and carcinogenesis. Nucleic acid fluorescent probe technology, celebrated for its high specificity and sensitivity, has become an essential tool for telomerase detection. This review comprehensively explores the application and recent advancements of nucleic acid fluorescent probes in telomerase sensing.
Improve the Thermal Conductivity, Insulation Performance and Mechanical Properties of Silicone Rubber by Constructing EG-PDA-Cu Hybrid Nanoparticles
1 Introduction With the rapid advancement of modern microelectronics, electronic devices are increasingly trending toward higher integration, miniaturization, and power efficiency [1-4]. Owing to their favorable attributes—including chemical resistance, low density, and processability—polymer composites have gained significant attention as promising thermal management materials [5-9].
Targeted reflex RNA sequencing for enhanced variant classification on exome and genome sequencing improves patient outcomes
Abstract RNA sequencing (RNA-seq) has been utilized to provide functional evidence regarding the impact of splicing variants. This study explores the utility of targeted reflex RNA-seq to inform classification of predicted splicing variants identified through clinical exome sequencing (ES) and genome sequencing (GS).
The Logic Structure Behind Mathematical Models：An Axiomatic Framework for System Dynamics
You are already at the latest version Modeling complex systems typically involves multiscale analysis, multiphysics coupling, and cross-domain integration. However, existing methodologies predominantly focus on constructing and solving specific equations, lacking a unified, explicit expression for underlying logical structures, which limits model comparison and combination.
Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Modulating ferroptosis, a form of cell death driven by uncontrolled lipid peroxidation, is of interest in numerous diseases. Here, we found that the deletion of phosphoglycolate phosphatase (PGP), an essential enzyme that safeguards high glycolytic flux, suppresses ferroptosis.
By Xiao Yu, Fan Xia, Bolan Gan, Marian Brenner, Sina Höhlein, Paul J. Wirth, Leon Neidt, Melina Lappe, Elisa Hopke, Eirini Sfakianaki, Martina Fischer, Kerstin Hadamek, Angelika Keller, Sebastian Bothe, Anna M Schmoker, Arminja N. Kettenbach, Agnes Fekete, Ágnes A Fekete, Werner Schmitz, Ingrid Tessmer, Elisabeth Jeanclos, Antje Gohla
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Science Magazine
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Promoting direct C─N coupling via NO intermediate modulation for highly selective electrochemical urea synthesis
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The electrochemical synthesis of urea from carbon dioxide (CO2) and nitrate (NO3−) is a sustainable route yet remains challenging, primarily due to slow carbon-nitrogen (C─N) coupling and competing ammonia (NH3) formation.
Structural insights into a conserved mechanism of choline translocation through CHT
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Choline is an essential nutrient critical for cellular homeostasis across all domains of life. In humans, choline uptake in cholinergic neurons for its recycling into acetylcholine is mediated by the high-affinity Na+-dependent transporter SLC5A7 (CHT1).
By Xiao Yu, Fan Xia, Bolan Gan, Jesus Vilchez-Garcia, Adrián Martínez-Jiménez, Hanxing Jiang, Miguel Luengo, Borja Ochoa-Lizarralde, Jorge Pedro López-Alonso, Jerónimo Pérez-Lorente, Paola Bartoccioni, Raúl Estévez Verified, Victor Guallar, Ekaitz Errasti-Murugarren, Iban Ubarretxena-Belandia, Igor Tascón
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Science Magazine
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Contrast-sparing CT using renal-clearable gold nanoclusters for early spatial mapping of renal dysfunction
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Early, noninvasive, and spatially resolved assessment of renal dysfunction is essential for theranostics of kidney diseases, yet clinical biomarkers are criticized for averaging whole-kidney function and missing focal or unilateral injury.
Redirection and reshaping of intense extreme-ultraviolet radiation
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The goal to control short-wavelength radiation for the investigation and manipulation of ultrafast dynamics in quantum systems coevolves with the growing availability of extreme-ultraviolet (XUV) and x-ray sources from high-harmonic generation and free-electron lasers.
By Xiao Yu, Fan Xia, Bolan Gan, Yu He, Alexander Magunia, Harijyoti Mandal, Muwaffaq Ali Mourtada, Carlo Kleine, Arikta Saha, Marc Rebholz, Gergana Borisova, Lina Hedewig, Hannes Lindenblatt, Florian Trost, Ulrike Frühling, Christina Papadopoulou, Elisa Appi, Stefan Düsterer, Skirmantas Alisauskas, Christoph M. Heyl, Steffen Palutke, Markus Braune, Dietrich Krebs, Tino Lang, Christina Bömer
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Science Magazine
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Unlocking the performance limits of 2T0C DRAM with Ω-shaped-gated single-crystal In 2 O 3 FETs
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract This study demonstrates high performance Ω-shaped-gated single-crystal In2O3 field-effect transistors (Ω-SC In2O3 FETs), which push the performance boundaries of oxide-based electronics.
Unveiling solitonic collisions in mechanical metamaterials
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Interactions between solitary waves are crucial for understanding nonlinear phenomena in systems such as optics, fluid dynamics, and mechanical metamaterials. Rarefaction solitary waves, in particular, offer insight into nonlinear wave dynamics in strain-softening media.
Reconfigurable and nonvolatile photo-pyroelectricity in a ceramic-like biaxial molecular ferroelectric via polarization engineering
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Photo-pyroelectric effect provides a promising avenue to enhance optoelectronic device performance, in which reconfigurable and nonvolatile characteristics enable newly conceptual photoelectric memories.
Oceanic mesoscale eddies enhance the Pacific Decadal Oscillation and its predictability
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The Pacific Decadal Oscillation (PDO) profoundly influences marine ecosystems, fisheries, and global hydroclimate.
Water doping sodium battery electrolyte controls nanostructure, interactions, and electrochemical properties
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Salt-in-ionic liquids (SiILs) are promising electrolytes for batteries.
By Xiao Yu, Fan Xia, Bolan Gan, Xuhui Zhang, Qianlu Zheng, Hua Li, Zachary Goodwin, Alexis G. Hoane, Alexander Deptula, Owen Johnson, Juhyun Song, Daniel M. Markiewitz, Martin Bazant, Cecilia Gontijo Leal, Cecília G. Leal, Filippo Mangolini, Andrew A. Gewirth, Rob Atkin, Mark W. Rutland, Rosa M. Espinosa-Marzal
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Science Magazine
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Silicon carbonate, Si[CO 3 ] 2 , is a potential carbon host in the deep Earth
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The transport of carbon into the deep Earth is governed by the stability and properties of carbon-bearing phases.
DHX36 is a regulatory switch in the interferon-mediated antiviral response
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Innate immune and stress responses must be tightly regulated to prevent aberrant activation in the absence of pathogens. The RNA helicase DHX36 has been implicated in viral RNA sensing, but its role in immune regulation is not fully understood.
Excess nitric oxide alters cellular pH to restrict salicylic acid movement and systemic immunity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Plants carrying a mutation in S-nitrosoglutathione reductase 1 (GSNOR1) accumulate high nitric oxide (NO) and exhibit impaired immunity characterized by reduced pathogen-responsive salicylic acid (SA) accumulation and failure to activate normal SA signaling.
Dual-function acoustic-to-optical transducers for underwater encrypted communication and subwavelength distance measurement
Abstract INTRODUCTION RESULTS DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The development of next-generation communication networks with integrated multifunctional capabilities across diverse environments—spanning space, air, land, and sea—requires efficient transduction between disparate information carriers.
UBA1-CDK16 : A female-specific chimeric RNA emerging through evolution and involved in immune regulation
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Chimeric RNAs resulting from intergenic splicing represent a distinct mechanism for transcriptome expansion.
By Xiao Yu, Fan Xia, Bolan Gan, Xinrui Shi, Loryn Blackburn, Sandeep Singh Verified, Anam Tajammal, Shafaque Zahra, Shailesh Kumar, Robert Cornelison, CHEN LIANG, Fujun Qin, Aiqun Liu, Shitong Lin, Yue Tang, Justin Elfman, Thomas Manley, Timothy N Bullock, Peng Wu, Hui Li, Martyna Glowczyk-Gluc, Doris M. Haverstick
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Science Magazine
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Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle–mediated infection in humanized liver chimeric mouse models
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract A major challenge in hepatitis C virus (HCV) research is the lack of an in vivo model that supports robust infection, antiviral testing, and vaccine development.
Certified quantum randomness within purity constraints
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Quantum random number generators (QRNGs) exploit quantum mechanics to produce true randomness, but practical implementations suffer from device imperfections that can compromise security.
Bioinspired milliscale near-boundary undulatory motion for fluid transport and adhesive locomotion
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Gastropods use pedal waves to transport thin fluid films at the body-substrate interface. Inspired by this strategy, we present a near-boundary pumping mechanism using magnetically actuated, prebuckled undulatory sheets.
International multisite implementation of distributed cell-free protein biomanufacturing to advance health and research equity
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Limitations in global access to research and health care capacity undermine equity, sustainability, and resilience, particularly in resource-limited settings.
By Xiao Yu, Fan Xia, Bolan Gan, Quinn Matthews, Séverine Marianne Cazaux, Justin R. J. Vigar, Bárbara Santos, Deyse Carvalho, Lauren Cranmer, David Duplat, Serena Singh, Mohammad Simchi, Paula Benitez-Bolivar, Kaiyue Wu, Tanvi Kale, Jennifer Doucet, Anibal Arce, Cielo León, Jessica Nguyen, Anson Ho, Renata P. G. Mendes, Ana L. L. Divarzak, Kristof Bozovicar, Valentina Ferrando, Suelen C. de Lima
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Science Magazine
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The cerebellum implements structured representation of valence to support adaptive behavior control
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Animals are thought to form internal models in the brain representing safety and danger, enabling avoidance through learned associations. Although the cerebellum has been implicated in active avoidance, its role in constructing internal models remains unclear.
Eco-evolutionary dynamics of massive, parallel bacteriophage outbreaks in compost communities
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Bacteriophages play critical roles in microbial ecosystems, yet their dynamics in complex natural communities remain poorly understood compared to simplified laboratory systems. Here, we tracked viral dynamics in 20 compost-derived microbial communities over 1 year.
Ion-shielding ultrathin encapsulation with hot-press bonded interface enables chronic stretchable bioelectronics
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Stretchable physiological electrodes are indispensable for continuous, high-fidelity bio-signal monitoring, yet liquid water and ions invade nano/microscopic interfacial defects and silence signals within weeks.
Holographic lasing with dielectric metasurfaces
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Light-emitting metasurfaces provide a compact, integrated solution for simultaneous light generation and beam shaping, making them a promising candidate for advanced photonic applications.
Gel-confined strain amplifies FRET efficiency toward red emission enhancement beyond pressure quenching
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Manganese (Mn)–based metal halides, with their rich and well-defined emission mechanisms, have garnered substantial attention in luminescent materials.
When wet meets dry: An Ivuna-like impactor triggered volatile loss on the angrite parent body
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Angrite meteorites remain the “driest” known planetary materials in the Solar System. Recent mineralogical and oxygen (O) isotope data suggest that the angrite parent body (APB) experienced a major impact, raising questions about the identity of the impactor.
Lymph node–targeted DNA engages TBK1/IFN-I–driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Adjuvants are immunoactivators capable of shaping the magnitude and quality of antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable and balanced humoral and cellular responses.
EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: A translational epigenetic approach
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Atherosclerosis drives cardiovascular morbidity in diabetes, with endothelial-to-mesenchymal transition (EndMT) as a key contributor.
Erratum for the Research Article “Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread” by S. Dagar et al .
Information & Authors Metrics & Citations View Options References Figures Tables Media Share There were errors in the originally published versions of the reference list, Fig. 8B, and the Fig. 8B caption in the Research Article “Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread” by S. Dagar et al. The following corrections have been implemented: • The following reference has been added as reference 80 in the reference list: E. Boedtkjer, J.
CEMs-SELEX: DNAzyme-powered de novo biomarker discovery and noninvasive cancer diagnosis
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The ability to interrogate complex biological environments without prior target knowledge is a key challenge in chemical sensing. Conventional methods are limited in discovering previously unidentified biomarkers.
An antiswelling biodegradable hydrogel reshapes electro-microenvironment to drive endogenous neuroregeneration after brain defect
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Bioactive matrix filling is a promising strategy for treating acute traumatic brain injury (TBI)–related substantial brain defects, requiring a dual-functional matrix that resists swelling and remodels microenvironments for endogenous regeneration.
SRSF3 determines T reg cell fate in antitumor immunity and autoimmunity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Human FOXP3 shows two isoforms due to exon 2 skipping, and the exon 2 is critical for FOXP3 function in Treg cells. However, the factor(s) regulating its splicing remain unknown.
De novo promoters emerge more readily from random DNA than from genomic DNA
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Promoters are DNA sequences that initiate transcription. We studied the propensity of both random and genomic DNA to initiate transcription. To this end, we assayed the promoter activity of 17,129 random, synthetic DNA sequences and 91,866 Escherichia coli genomic sequences.
Dimensionality junctional Janus nanocrystals with heterogeneous stacking fault–lined interface achieve tandem electroreduction of nitrate
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Electrocatalytic nitrate reduction reaction (NO3RR) holds substantial potential to close nitrogen cycle, while the selectivity toward ammonia in NO3RR is still too low to meet practical applications.
Platelet-derived vesicles restore fertility in endometrial injury by modulating the endometrial immune niche in mice
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Uterine infertility is a substantial global health challenge, imposing profound physical and emotional burdens on affected individuals, with endometrial injury being a key contributing factor.
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