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Articles by Hui Wu
An automated operon refactoring workflow for heterologous expression of non-ribosomal peptide biosynthetic gene clusters
Abstract Microbial genomes encode numerous biosynthetic gene clusters, yet most remain experimentally uncharacterized, particularly large non-ribosomal peptide synthetase (NRPS) clusters that resist conventional cloning. Existing refactoring approaches are labor-intensive, depend on de novo DNA synthesis and are difficult to scale.
AI-Driven Precision Oncology Startup aiPTO Unveils #1-Ranked DELPHAI Model, Bridging the "Scale Gap" From Virtual Cells to Virtual Tumors Original
AI-Driven Precision Oncology Startup aiPTO Unveils #1-Ranked DELPHAI Model, Bridging the "Scale Gap" From Virtual Cells to Virtual Tumors BASEL, Switzerland--(BUSINESS WIRE)--aiPTO TechBio today released a preprint [link] describing DELPHAI (Deep Explainable Perturbation Heterogeneity-Aware Inference), its virtual tumor model for perturbation prediction.
A functional investigation of the natriuretic peptide receptor 3 (NPR3) in glomerular stability and disease progression
Abstract Podocytes are essential for maintaining the structural and functional integrity of the glomerular filter. While the signaling properties of the natriuretic peptide receptor 3 (NPR3) have long been debated, emerging data suggest a signaling role in podocytes through interactions with slit diaphragm (SD) proteins. However, its functional contribution to glomerular homeostasis remains unclear.
The microbiota-gut-testis axis: microbial metabolites as endocrine signals in testosterone regulation
Abstract From a microbial endocrinology perspective, this review evaluates three metabolite classes as candidate testosterone signals. None yet satisfies the three criteria required to establish a microbiota-mediated endocrine role in testosterone regulation—tissue exposure, receptor engagement, and biological effect. Herbal medicines show parallel improvements, but causal evidence is limited. A multi-omics functional validation roadmap is proposed to close these gaps.
Industry’s First UALink-200G Controller and PHY Running in 3nm!
Explore Cadence IP here AI systems are running into a familiar problem. Compute keeps scaling, but the infrastructure connecting that compute is starting to dominate system behavior. Interconnect latency, bandwidth efficiency, and power now have as much impact on performance as the accelerators themselves.
Semicircular-ring- and rectangular-cavity-assisted refractive index sensor based on Fano resonance and its application in temperature sensing
In this work, a high sensitivity refractive index sensor utilizing metal-insulator-metal (MIM) waveguide coupled with two pairs of semicircular rings and rectangular resonators is proposed. Fano resonance and optical sensing characteristics are investigated by using COMSOL Multiphysics and analyzed based on multi-mode interference coupled mode theory (MICMT). The effects of geometric parameters on the Fano resonance peaks and sensor performance are investigated in detail.
A humanized anti-TNFR1 nanobody antagonist targeting the CRD3 region suppresses inflammation and necroptosis in vitro
Abstract Aberrant signaling through tumor necrosis factor receptor 1 (TNFR1) drives chronic inflammation and necroptotic cell death, yet selective therapeutic strategies remain limited. Here, humanized nanobodies targeting TNFR1 were developed and characterized. Biolayer interferometry and cell-based analyses showed that these nanobodies remained in the nanomolar affinity range to TNFR1 after humanization and showed no detectable binding to TNFR2 under the tested conditions.
Transpatial Modernity: Chinese Cultural Encounters with Russia via Japan (1880–1930) By Xiaolu Ma. Cambridge: Harvard University Asia Center, 2024. 360 pages. Hardcover, $59.95 USD, ISBN: 9780674295834.
Hostname: page-component-66d9dcfd78-xc4rl Total loading time: 0.006 Render date: 2026-08-05T05:59:19.632Z Has data issue: false hasContentIssue false Review products Transpatial Modernity: Chinese Cultural Encounters with Russia via Japan (1880–1930) By Xiaolu Ma. Cambridge: Harvard University Asia Center, 2024. 360 pages. Hardcover, $59.95 USD, ISBN: 9780674295834.
Association between different sodium–glucose co-transporter 2 inhibitors and the risk of dementia: a network meta-analysis
Abstract Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i), as key therapeutic agents for type 2 diabetes, have in recent years been recognized as potentially exerting neuroprotective effects on the central nervous system. However, systematic comparative evidence remains lacking regarding whether different SGLT2i exhibit differential effects on dementia risk.
Berberine prevents postoperative recurrence of colorectal cancer: a protocol for a multicenter, double-blind, randomized controlled trial
Abstract Introduction: Postoperative recurrence and metastasis of colorectal cancer (CRC) are critical factors affecting long-term survival, and how to prevent postoperative recurrence and metastasis remains an urgent clinical challenge. Studies indicate that berberine has a preventive effect against colorectal adenoma recurrence; however, no research has yet investigated its preventive efficacy against CRC.
Crystal Structures and Phase Evolutions of Potassium Decahydro- closo -Decaborate and Decahydro-1-Carba- closo -Decaborate: K 2 B 10 H 10 and K-1-CB 9 H 10 Click to copy article link Article link copied!
Crystal Structures of K2B10H10 The room-temperature XRD pattern of K 2 B 10 H 10 can be satisfactorily fit using a monoclinic structural model in space group P21/n ( Figure 1 a) with refined lattice parameters of a = 12.857(1) Å, b = 11.1874(9) Å, c = 6.8279(5) Å, β = 93.302(4)°, and V = 980.5(2) Å 3 .
Correction: Ecological construction status of photovoltaic power plants in China’s deserts
A Correction on Ecological construction status of photovoltaic power plants in China’s deserts by Wang Y, Liu B, Xing Y, Peng H, Wu H and Zhong J (2024). Front. Environ. Sci. 12:1406546. doi: 10.3389/fenvs.2024.1406546 There was a mistake in Table 2 as published. The column headings “Latitude” and “Longitude” were transposed, and the coordinate values in these two columns were incorrect. Both the column headings and coordinate values have been corrected based on the original records.
HIV infection exacerbates ischemic brain injury through dysregulating phagocytosis and neuroinflammatory signals in macrophages/microglia via C1ql2
Abstract The incidence of human immunodeficiency virus (HIV)-infected individuals is greater, and outcomes are worse following cerebral stroke, despite widespread access to antiretroviral therapy. As the major reservoir of HIV, resident microglia and infiltrative macrophages in the brain can be aberrantly activated by HIV after stroke. However, the underlying reason driving these pathological processes in poststroke brain injury remains unclear.
Long-term outcomes of adjuvant metronomic capecitabine in locoregionally advanced nasopharyngeal carcinoma: a randomized, controlled, multicenter, phase 3 study
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Abstract Here we report long-term outcomes of adjuvant metronomic capecitabine in patients with locoregionally advanced nasopharyngeal carcinoma. In this multicenter, open-label, parallel-group, randomized, controlled, phase 3 trial, 406 patients who had completed definitive chemoradiotherapy were randomly assigned (1:1) to receive either adjuvant metronomic capecitabine (650 mg m−2 twice daily for 1 year) or observation.
By Ya-Lan Tao, Dong-Hong Wu, Qin Zhou, Kun-Yu Yang, Feng Jin, Xiao-Dong Zhu, Mei Shi, Guo-Qing Hu, Yan Sun, Hong-fen Wu, Hui Wu, Qin Lin, Hui Wang, Ye Tian, Ning Zhang, Xi-Cheng Wang, Liang-Fang Shen, Zheng-zheng Liu, Jing Huang, Jian Zang, Bao-Min Zheng, Dan Yue, Jing Xu, San-Gang Wu, Lei Chen, Wen-Fei Li, Guan-Qun Zhou, Rui Sun, Rui Guo, YUAN ZHANG, Cheng Xu, Jia-Wei Lv, Ying Guo, Ling-Long Tang, Fang-Yun Xie, Xu Liu, Ying Sun, Jun Ma, Yan-Ping Mao, Yu-Pei Chen, Xiu-Ling Luo, Hui-Xia Feng
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Nature
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Nasal Continuous Positive Airway Pressure vs Nasal Intermittent Positive Pressure Ventilation in Preterm Infants With Respiratory Distress Syndrome : A Randomized Clinical Trial
Nasal Continuous Positive Airway Pressure vs Nasal Intermittent Positive Pressure Ventilation in Preterm Infants With Respiratory Distress Syndrome: A Randomized Clinical Trial Supplement 1. Trial Protocol and Statistical Analysis Plan Supplement 2. eTable 1. Procedure-Related Adverse Events During MISA eTable 2. Blood Gas Comparison Between 2 Groups at 4 Time Points eTable 3. Comparison of Vital Signs Within 72 h After Birth Between 2 Groups Supplement 3.
Rewiring of de novo serine synthesis supports tumorigenesis under deficiency of TET2
Abstract Ten-eleven translocation 2 (TET2) is initially identified as a mammalian DNA dioxygenase to orchestrate expression of numerous genes and diverse interplays of physiological and pathological processes. Beyond its canonical role, the moonlight functions of TET2 have been gradually uncovered. RNA-seq, qPCR and western blot are employed to validate expression of genes. ChIP and RIP analyses are conducted to test the enrichment of genes.
Author Correction: DNA nanodevices detect an acidic nanolayer on the lysosomal surface
Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-025-01855-y, published online 21 January 2026. Since the version of the article initially published, the authors have added discussion of relevant articles published during consideration of the manuscript at Nature Cell Biology. An additional sentence has been added to the end of the second paragraph in the Discussion, and three new references have been added as refs. 45–47.
Asymmetric architecture and adaptation of Treponema flagella
Abstract Spirochetes exhibit a distinctive corkscrew-like motility driven by periplasmic flagella that wrap around the cell body in a supercoiled configuration, yet the structural basis of this propulsion remains poorly understood. Here we combine cryo-electron microscopy, cryo-electron tomography, and genetic and biochemical analyses to determine the assembly and adaptation principles of the supercoiled flagellar filament in Treponema denticola, a major periodontal pathogen.
Targeting AVEN Liquid-Liquid Phase Separation in Colorectal Cancer: Insights From a Raddeanin A-Based Chemical Probe
Xichao Yu, Hui Wu and Kezhen Guo have contributed equally to this work. , , , et al., “Targeting AVEN Liquid-Liquid Phase Separation in Colorectal Cancer: Insights From a Raddeanin A-Based Chemical Probe,” Basic & Clinical Pharmacology & Toxicology139, no. 1 (2026): e70257, https://doi.org/10.1111/bcpt.70257. Conflicts of Interest The authors declare no conflicts of interest.
Iron overload disrupts bone homeostasis via dual pathways: inducing ferroptosis of preosteoblastic cells and shaping a proinflammatory immune milieu
Abstract Iron overload is regarded as an independent risk factor for osteoporosis, yet the underlying molecular mechanisms remain incompletely understood. In this study, we systematically investigated the impact of iron overload on bone homeostasis using a combination of in vivo and in vitro models. An iron overload rat model was established, and investigations were complemented by cellular assays utilizing mouse embryonic osteoblast precursor cells (MC3T3-E1) and macrophages.
Complete elliptic Fourier descriptor normalization and its application in quantitative morphological analysis
1 INTRODUCTION Morphological variations, both within and between species, occur pervasively throughout life on Earth. Accurately capturing and comprehensively analysing biological morphology and its variations are crucial for understanding their interconnections with developmental and environmental forces.
The relationship between physical activity and quality of life among community-dwelling middle-aged and older adults with type 2 diabetes: a chain mediation model of psychological resilience and exercise self-efficacy
Abstract Background: Middle-aged and older adults with type 2 diabetes mellitus (T2DM) often experience insufficient physical activity (PA) and reduced quality of life (QOL). Understanding how psychosocial factors are associated with this relationship is important for developing effective nursing interventions.
Enterococcus hirae QT4713-derived dopamine ameliorates intestinal inflammation and MPTP-induced Parkinson’s disease in mice
Abstract Gut microbiota dysbiosis contributes to Parkinson’s disease (PD) pathology by altering dopamine metabolism in the gut–brain axis. Although probiotics and other functional strains have been proposed as microbiome-based interventions, few naturally occurring gut microbes show therapeutic potential for PD. Here, we isolated Enterococcus hirae QT4713 (QT4713) from the hypoxic, low-pressure Qinghai–Tibet Plateau (4713 m altitude).
Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption
Abstract Microbial dysbiosis is the root cause for many diseases. The acidogenic Streptococcus mutans (S.m.) forms a exopolysaccharide-rich biofilm (EPS), mediated by species-specific glucosyltransferases (Gtf), which synthesizes both soluble and insoluble glucans directly on the bacterial surface. GtfC was selected as the primary druggable target since its activity is essential for biofilm initiation and cohesion.
Semiconductor IP News and Trends Blog
Cadence Demonstrates PCIe 8.0 PHY at PCI-SIG DevCon 2026 Explore Cadence IP here The accelerated growth in data processing and storage demands across HPC datacenters and AI factories is expediting PCIe innovation as PCIe links form a foundational fabric for xPU and storage connectivity. While PCIe 6.x is now being deployed in AI factories and HPC datacenters, PCIe 7.0 is advancing through product and platform development.
Research on multi-sensor fusion architecture for highway area hazard monitoring based on UAVs
Citation: Wu H, Li S, Shan H, Lu Y, Hu K, Zheng W, et al. (2026) Research on multi-sensor fusion architecture for highway area hazard monitoring based on UAVs. PLoS One 21(5): e0348241. https://doi.org/10.1371/journal.pone.0348241 Editor: Xuecai Xu, Huazhong University of Science and Technology, CHINA Received: September 8, 2025; Accepted: April 13, 2026; Published: May 7, 2026 Copyright: © 2026 Wu et al.
From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late-Onset Hypogonadism by Targeting Leydig Cell Senescence
1 Introduction The global trend of population aging is exacerbating the burden of age-related diseases worldwide and has sparked widespread concern regarding aging-related health issues. Late-onset hypogonadism (LOH), an underrecognized public health problem, significantly affects the quality of life of middle-aged and elderly men.
When body image and fear collide: a fuzzy-set qualitative comparative (fsQCA) and mediation analysis of sufficient pathways to post-traumatic stress in breast cancer survivors
Abstract Background: Breast cancer survivors frequently experience significant posttraumatic stress symptoms (PTSS). Using the Conservation of Resources (COR) theory as a framework, this study aimed to investigate the configurational patterns and underlying psychological associations linked to high PTSS in post-operative patients. Methods: A cross-sectional study was conducted with 172 post-operative breast cancer patients.
CD55-expressing myeloid-derived suppressor cells (MDSCs) drive cancer immunoevasion
Myeloid-derived suppressor cells (MDSCs) are key drivers of tumor immune evasion and contribute to resistance to cancer immunotherapies. Targeting surface molecules on MDSCs is an attractive strategy because they can serve as both biomarkers and functional regulators. Identifies CD55 as a conserved surface marker broadly overexpressed on tumor-associated MDSCs across eight cancer types.
Engineering antibody-armed oncolytic viruses: design strategies, synergistic mechanisms, and clinical translation
Abstract Therapeutic antibodies are widely used in cancer biotherapy due to their target specificity, mediating tumor cell inhibition, angiogenesis suppression, and immune modulation. However, systemic administration often leads to off-target effects, as many antibody targets are also expressed in normal tissues, limiting intratumoral drug concentration and causing adverse events.
Computer Science > Machine Learning
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Comparison between sufentanil and hydromorphone for postoperative analgesia after cesarean section: a propensity-score matched analysis
Abstract Background: Cesarean delivery often causes significant postoperative pain, which can affect recovery and increase the risk of chronic pain and prolonged opioid use. This study compared commonly used hydromorphone and sufentanil regarding postoperative outcomes after cesarean delivery.
Neuroinflammation and NeuroHIV: understanding the role of HIV-1 related factors in microglial activation
Abstract NeuroHIV has emerged as a significant unmet challenge, manifesting as impairments in learning, memory, sensorimotor, and language in people living with HIV (PLWH). Despite the widespread use of antiretroviral therapy, the incidence of NeuroHIV remains high among PLWH. Microglial cells, as the main targets and reservoirs for HIV-1 infection, play crucial roles in sustaining HIV-1 persistence and contributing to neuroinflammation and neuroHIV pathogenesis.
[2603.03766] Representations of the modular shifted super Yangian $Y_{1|1}(σ)$
arXiv:2603.03766 (math) View PDF Subjects: Representation Theory (math.RT) Cite as: arXiv:2603.03766 [math.RT] (or arXiv:2603.03766v1 [math.RT] for this version) https://doi.org/10.48550/arXiv.2603.03766 Submission history From: Ruiying Hou [ view email] [v1] Wed, 4 Mar 2026 06:24:19 UTC (25 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps Toggle Litmaps (What is Litmaps?) scite.ai...
Persistent CD8+ T cell-driven immune dysregulation despite normalized CD4+ T cell recovery in ART-treated people living with HIV
1 Introduction Human immunodeficiency virus (HIV) infection leads to acquired immune deficiency syndrome (AIDS), a systemic disease that remains a major public health challenge.
Scale-Up and Scale-Out IP for Optical Interconnect for Accelerated Computing
6 Feb 2026 • 4 minute read Optical connectivity is foundational to modern data centers, enabling high-bandwidth, low-latency data movement across switches, routers, servers, and racks. With the rise of AI factories, its importance has increased dramatically. Optical links provide the massive bandwidth, ultra-low latency, and scalability required for GPU clusters, overcoming the physical limits of copper and eliminating bottlenecks in large-scale AI training and inference workloads.
The gut-brain axis mediates precocious puberty induced by environmentally relevant low-dose endocrine-disrupting chemical mixtures
1Child Healthcare Department, PanYu District Maternal and Child Health Care Hospital, Guangzhou (PanYu District He Xian Memorial Hospital), Guangzhou, China 2Child Healthcare Department, Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children’s Hospital (Longgang)] of Shantou University Medical College, Shenzhen, China 3Department of Pediatrics, Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated...
Arsenic Enrichment in Groundwater Aquifers over Geological Carbon Storage Sites: A Potential Concern
Tine Buffel, Patty Doran and Sophie Yarker (eds), Reimagining Age-Friendly Communities: Urban Ageing and Spatial Justice Policy Press, Bristol, 2024, 266pp, pbk £23.25, ISBN 13: 9781447368557 | Ageing & Society | Cambridge Core
Hostname: page-component-68c7f8b79f-lvtpz Total loading time: 0 Render date: 2026-01-16T14:00:01.297Z Has data issue: false hasContentIssue false Review products Tine Buffel, Patty Doran and Sophie Yarker (eds), Reimagining Age-Friendly Communities: Urban Ageing and Spatial Justice Policy Press, Bristol, 2024, 266pp, pbk £23.25, ISBN 13: 9781447368557 Published online by Cambridge University Press: 13 October 2025 Abstract Information Type Reviews Information Ageing & Society , Volume 46 ,...
Preoperative Beta and Gamma EEG Spectral Power as Independent Predictors of Acute Postoperative Pain in Spinal Surgery: A Prospective Observational Cohort Study
Back to Journals » Journal of Pain Research » Volume 19 Original Research Acute Pain and Perioperative Care Authors Wu H, Zhou M, Liu S, Qi Y , Zhou F, Wang L, Fan C Received 14 January 2026 Accepted for publication 24 April 2026 Published 30 April 2026 Volume 2026:19 593873 DOI https://doi.org/10.2147/JPR.S593873 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Jinlei Li Hui Wu,1– 4,* Meiyan Zhou,2,*...
Why Manual Traders Fail Prop Firm Challenges (And How I Fixed It with Code)
Hi fellow traders, If you are a manual trader like me, you probably know the pain of taking a Prop Firm Challenge (FTMO, Funding Pips, etc.). We have the strategy. We know the direction. But we still fail. Why? After analyzing hundreds of my own trades, I realized the problem wasn't my "Strategy" (SMC). The problem was my "Execution" and "Psychology". Here are the 3 biggest enemies of a manual trader, and how I built a tool called Aurora SMC Sniper to defeat them. 1. The "Math" Problem: Speed vs.
GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain
eLife Assessment This important study investigates nerve-injury-induced allodynia by studying the role of a subpopulation of excitatory dorsal horn CCK+ neurons that express the estrogen receptor GPR30 and potentially modulate nociceptive sensitivity via direct inputs from primary somatosensory cortex.
Survival Analysis Under the Aalen's Additive Hazards Model With Covariate Measurement Error: Application to Causal Mediation Analysis
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The ACTG175 data can be obtained from the R package “speff2trial”. Supporting Information Filename Description sim70346-sup-0001-SupplementaryMaterial.pdfPDF document, 515.2 KB Data S1. Supporting Information. References 1, “Regression Models and Life Tables (With Discussion),” Journal of the Royal Statistical Society, Series B: Statistical Methodology 34 (1972): 187–220.
Clinical Effectiveness of Acupoint Moxibustion Therapy in Patients with Post-Haemorrhoidectomy Urinary Retention
Ayuda Buscar en la ayuda Buscar en la ayuda Clinical Effectiveness of Acupoint Moxibustion Therapy in Patients with Post-Haemorrhoidectomy Urinary Retention Longzhen Wang [1] ; Guodong Zhang [1] ; Mingjing Xu [1] ; Hui Wu [1] ; Yuxue Fu [2] ; Fei Yang [3] ; Lu Xu [4] [1] General Surgery and Anorectal Department, Nanjing Pukou People’s Hospital, Liangjiang Hospital, Southeast University, 211899 Nanjing, Jiangsu, China [2] Interventional Operating Room, Nanjing Pukou People’s Hospital,...
Heavy Metal Pollution to Shallow Groundwater Aquifer Caused by CO2 Leakage During Geological Carbon Storage (GCS)
1 Introduction Rising carbon emissions since the industrial era have been a major contributor to global warming, leading to numerous destructive impacts on the earth, such as climate change, increasingly frequent extreme weather events, and sea level rise, among others (Davis et al., 2010; Rolnick et al., 2022; Yoro & Daramola, 2020).
Simulate the natural four-season fermentation system for high-salt diluted-state soy sauce brewing: Application in flavor promotion regulation
Loading metrics Open Access Peer-reviewed Research Article Citation: Wu C, Wu H, Yu X, Jia T, He T, Hong Q, et al. (2025) Simulate the natural four-season fermentation system for high-salt diluted-state soy sauce brewing: Application in flavor promotion regulation. PLoS One 20(10): e0334707.
Comparative study of muscle content assessed by different anthropometric indicators in the diagnosis of GLIM malnutrition in elderly patients with intermediate and advanced malignant tumors - RETRACTION | British Journal of Nutrition | Cambridge Core
The Editor-in-Chief of the British Journal of Nutrition has retracted this article. Following publication, the journal was informed that this article had been published previously in Chinese by different authors (DOI: 10.16151/j.1007-810x.2023.05.007). Furthermore, the journal has been made aware of authorship concerns.
Adaptive exponential weighted composite sliding mode-based direct yaw moment control for four-wheel independently actuated autonomous vehicles
Loading metrics Open Access Peer-reviewed Research Article Citation: Tao Z, Wu M, Qu M, Wu H, Sun B, Xie D, et al. (2025) Adaptive exponential weighted composite sliding mode-based direct yaw moment control for four-wheel independently actuated autonomous vehicles. PLoS One 20(8): e0330474.
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