Matthew Rees,
Founder, Food and Health Facts (former White House speechwriter), now
highlighting America's toxic food culture and how it undermines human health
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Articles by Matthew Rees
EXCLUSIVE: University and Union Release Joint Statement Following Negotiations
The University and Dundee University and College Union (DUCU) have released a joint statement following discussions as part of the ongoing dispute resolution process. In an email sent to all staff, it is stated: “These discussions have resulted in the development of a draft proposal intended to address the issues at the heart of the current dispute while supporting a period of stability and recovery for the University community.
The growth of CrossFit—a fitness company built around high-intensity, low-tech workouts—owed a great deal to its army of followers. In 1995 Greg Glassman was 38 years old and muddling along as a personal trainer in the laid-back beach town of Santa Cruz, Calif. He owned neither a home nor a car, and he and his young son were between residences. They were living temporarily with a friend, her boyfriend and her children.
PLK4 inhibition-mediated centrosome amplification drives anti-tumor activity across euploid solid tumors
Abstract PLK4 is a master regulator of centriole biogenesis. Knockdown or complete inhibition of PLK4 results in centrosome depletion. Recently, it was demonstrated that normal cells can tolerate centriole depletion by utilizing acentriolar condensates of pericentriolar material to function as microtubule organizing centers during mitosis.
A genetic platform to deconvolve efficacy and toxicity reveals the on-target effects of CDK11 inhibition in vivo
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Abstract The cyclin-dependent kinase CDK11 is an understudied kinase that has been the subject of conflicting reports regarding its function in cancer. Here, we combine genetic and pharmacological approaches to demonstrate that CDK11 is a critical regulator of cancer cell survival that is required for RNA splicing and the expression of homologous recombination genes.
By Linda Julian, Lisa Crozier, Devon A. Lukow, Aditi Swamy, Sanat Mishra, Ryan Hagenson, Erin L. Sausville, Amy J. S. McGeoch, Sarah Thompson, Brianna E. Mendelson, Lu Qiao, Anand Vasudevan, Kuan-Ting Lin, Sonam Bhatia, Thierry Bertomeu, Andrew Chatr-aryamontri, Li Zhang, Matthew Rees, Melissa Ronan, Jennifer Roth, Timothy Nottoli, Suxia Bai, Jayalakshmi Lakshmipathi, Viswanathan Muthusamy, Jonathan G. Van Vranken, Gregory Gauthier-Coles, Steven Gygi, Joan Smith, Kendall Anderson, Sanjana Shah, Ranjit Bindra, Martin Akerman, David Spector Verified, Basil J. Greber, Adrian R. Krainer, Jason M. Sheltzer, Peter Sennhenn, Claudio Chuaqui
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Nature
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A design approach for bitopic kinase inhibitors
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Abstract Traditional kinase inhibitors face a trade-off between potency and selectivity because their affinity depends on limited molecular interactions in a single highly conserved binding site. Bitopic inhibitors overcome this limitation by engaging multiple sites on the same target1.
By Jack Stevenson, Kevin Lou, Joshua Reynolds, Ian R. Outhwaite, Kenneth Huang, Ivan Sokirniy, Amir Z. Munir, Celine Wang, Haider Inam, Sydney M. Figueroa, Matthew Rees, Melissa Ronan, Yan Zeng, Veronica Steri, Jennifer Roth, Neil Shah Verified, Ignacia Echeverria, Ziyang Zhang, Javid Moslehi, Markus A. Seeliger, Justin Pritchard Verified, Kevan Shokat, Sky Y. J. Peterson, Emma L. Gebauer, Ariel Leyte-Vidal, Anastasiia Grynyova, Fernando Salangsang
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Nature
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Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response
Abstract Triple-negative breast cancer (TNBC) has poor outcomes and few effective treatments, partly because of epigenetic heterogeneity. We show that the heterochromatin mark H4K20me3 is more variable than H3K9me3 across normal and malignant breast tissues, and that H4K20me3-enriched regions are linked to more open chromatin and active transcription.
AI Capex: Transforming the face of bond markets
We are witnessing one of the largest waves of investment spending in recent decades, with technology companies raising hundreds of billions through debt markets to finance AI infrastructure. As a result, AI is not simply reshaping the economy; it is changing the composition, pricing and opportunities within global bond markets.
How India influenced the US rebellion against the British 250 years ago
July 4 marks the 250th anniversary of the day America’s colonists issued a declaration stating their desire to be free of British rule. The anniversary is an occasion to revisit two questions that are fundamental to US history: what motivated the American colonies to turn against their overlords across the Atlantic? And how did an outmanned colonial military defeat a superior British fighting force? An unlikely country – India – factors into both answers.
‘In Defense of Sunlight’ Review: A Star Is Scorned
The media is saturated with dire findings about the risks of sun exposure. Lost in the noise are the undeniable health benefits of catching rays. As long as humans have roamed the earth, they have reaped the benefits of sun exposure. In recent decades, however, there has been a greater tendency for people to cloister inside. This is mainly due to technology and workplace requirements, but it is also a response to jeremiads about the sun’s harmful rays.
Credito sotto pressione: come le strategie di copertura fanno la differenza
CONTRIBUTO a cura di Matthew Rees, head of Global Bond Strategies - Unconstrained, Tom Farrington, Investment Specialist, e Grace Cheng, Lead Fixed Income Investment Specialist, Asia. Contenuto sponsorizzato da L&G. Questo è un articolo riservato agli utenti FundsPeople. Se sei già registrato, accedi tramite il pulsante Login. Se non hai ancora un account, ti invitiamo a registrarti per scoprire tutti i contenuti che FundsPeople ha da offrire.
Expanding the human proteome with microproteins and peptideins
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Abstract A major scientific drive is to characterize the protein-coding genome, which is a primary basis for studying human health. But the fundamental question remains of what has been missed in previous analyses. Over the past decade, the translation of non-canonical open reading frames (ncORFs) has been observed across human cell types and disease states1,2,3, with major implications for biomedical science.
By Eric Deutsch, Leron W. Kok, Jonathan Mudge, Cristian Valls, Irwin Jungreis, Jorge Ruiz-Orera, Zhi Sun, Ulrike Kusebauch, Ivo Fierro-Monti, Jennifer G. Abelin, M. Mar Albà, Julie L Aspden, Sreejan Bandyopadhyay, Kaushik Banerjee, Pavel V. Baranov, Ariel A. Bazzini, Francis Bourassa, Elspeth A. Bruford, Lorenzo Calviello, Steven Carr, Anne-Ruxandra Carvunis, Sonia Chothani, Jim Clauwaert, Kellie Dean, Pouya Faridi, Adam Frankish, Amy Goodale, Thomas Green, Norbert Hubner, Nicholas T. Ingolia, Manolis Kellis, Michele Magrane, Maria Martin Verified, María Martín Verified, Thomas Martinez, Gerben Menschaert, Uwe Ohler, Sandra Orchard, Alisa Potter, Owen Rackham, Matthew Rees, David Root, Jennifer Roth, Xavier Roucou, Fernando J. Sialana, Sarah A. Slavoff, Michał Świrski, Jack Tierney, Félix-Antoine Trifiro, Eivind Valen, Valeriia Vasylieva, Aaron Wacholder, Shengbo Wang, Li Wang, Jonathan S. Weissman, Wei Wu, Zhi Xie, Jyoti Choudhary, Michal Bassani-Sternberg, Juan Antonio Vizcaino, Nicola Ternette, Marie A. Brunet, Robert L. Moritz, John R. Prensner, Sebastiaan van Heesch
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Nature
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Management of hematological toxicities after BCMA-directed CAR-T cell therapy
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Abstract The CAR-HEMATOTOX (CAR-HT) score can assess hematotoxicity risk, but its utility in guiding supportive care remains underexplored. We analyzed 224 multiple myeloma patients treated with BCMA-directed CAR-T therapy (2016–2024), stratified by CAR-HT score (low <2 vs high ≥2).
By Joselle M. Cook, Supriya Gupta, Nadine Abdallah, Matthew Rees, Christopher Graham, Radhika Bansal, Rahma M. Warsame, David Dingli, Wilson I Gonsalves, Taxiarchis Kourelis, Morie A Gertz, Suzanne R Hayman, Nelson W. Y. Leung, Prashant Kapoor, Lisa Hwa, Amie Fonder, Miriam Hobbs, Leif Bergsagel, Udit Yadav, Erin Wiedmeier-Nutor, Saurabh Chhabra, Rafael Fonseca, Sikander Ailawadhi, Ricardo D. Parrondo, Shaji Kumar Verified, Yi Lin, Kristina Helms
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Nature
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The Safety and Efficacy of Commercial BCMA-Directed CAR T-Cell Therapy in Systemic AL Amyloidosis With Concurrent Myeloma
Dear Editor, Light-chain (AL) amyloidosis is a rare and life-threatening plasma cell dyscrasia characterized by the production of immunoglobulin free light chains (FLCs) that misfold and deposit in vital organs, leading to organ failure [1]. The mainstay of treatment is the suppression of amyloidogenic FLC production using anti-plasma cell therapy. Achieving a rapid and deep hematologic response is essential for improving organ function and reducing early-mortality [2].
‘Hotwired' review: In praise of sweat
Matthew Rees “We are, hands down, the sweatiest animal on the planet,” writes Bill Gifford in “Hotwired.” His splendid book is devoted to a topic—the health benefits derived from exposure to high temperatures—that could be tedious in the wrong hands. Mr. Gifford, though, has exceptional skills as a reporter and storyteller, and he deploys them here to deliver a perspective that may change the way readers think about the otherwise unpleasant condition of feeling damp on a warm day.
‘Hotwired’ Review: In Praise of Sweat
Adaptations allowed early humans to thrive in sunbaked climates. Even now health benefits can be associated with a sweaty sauna session. “We are, hands down, the sweatiest animal on the planet,” writes Bill Gifford in “Hotwired.” His splendid book is devoted to a topic—the health benefits derived from exposure to high temperatures—that could be tedious in the wrong hands.
Improving Fellow Continuity Clinic With Multiple Subspecialties: A Quality Improvement Initiative
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description pbc70070-sup-0001-FigureS1.tif530 KB Supporting Figure 1: Potential interventions graded by potential impact and required effort. Red, adopted interventions; white, interventions considered but not yet implemented; gray, interventions abandoned.
Emmy-Nominated ‘Destination Oak Tree Road’ Chronicles Indian-American Legacy in New Jersey
A thoroughfare linking the New Jersey towns of Edison and Iselin is the subject of “Destination Oak Tree Road.” The inspiring documentary focuses on one of the most important centers of Indian-American commerce and culture in the United States. Nominated for two New York Emmy Awards, it was directed and narrated by Rohit Vyas, a veteran Indian-American journalist, who also served as co-writer and executive producer.
From Iselin to India: What we learned about tariffs, trade and trust
[[{„value”:” Iselin, New Jersey It’s Diwali season — a five-day period when Hindus around the world commemorate the triumph of light over darkness on the Indian subcontinent centuries ago. But the colorful Diwali celebrations held annually in Indian-American communities throughout the United States are more muted this year compared to the past. The reason? Prices on everything from saris to spices have skyrocketed since August 27.
From Iselin to India: What we learned about tariffs, trade and trust
Iselin, New Jersey It’s Diwali season — a five-day period when Hindus around the world commemorate the triumph of light over darkness on the Indian subcontinent centuries ago. But the colorful Diwali celebrations held annually in Indian-American communities throughout the United States are more muted this year compared to the past. The reason? Prices on everything from saris to spices have skyrocketed since August 27. That was the day President Trump imposed 50% tariffs on goods imported from India.
From Iselin to India: What we learned about tariffs, trade and trust
Iselin, New Jersey It’s Diwali season — a five-day period when Hindus around the world commemorate the triumph of light over darkness on the Indian subcontinent centuries ago. But the colorful Diwali celebrations held annually in Indian-American communities throughout the United States are more muted this year compared to the past. The reason? Prices on everything from saris to spices have skyrocketed since August 27. That was the day President Trump imposed 50% tariffs on goods imported from India.
From Iselin to India: What we learned about tariffs, trade and trust
India: White van swept away in torrential rain, onlookers panic as streets turn into flooded rivers Guwahati, India - October 16, 2025 A scooty rider, distracted while holding a mobile phone in one hand, lost control and toppled onto the road in front of an oncoming car. The vehicle swerved just in time, narrowly preventing a serious accident. The incident took place in the Ahmedabad district, in western India’s Gujarat, on October 16.
Incertidumbre: la nueva certeza
TRIBUNA de Matthew Rees, head of Global Bond Strategies, L&G. Comentario patrocinado por L&G. Este es un artículo exclusivo para los usuarios registrados de FundsPeople. Si ya estás registrado, accede desde el botón Login. Si aún no tienes cuenta, te invitamos a registrarte y disfrutar de todo el universo que ofrece FundsPeople.
EBV+ polymorphic B-cell lymphoproliferative disorder, NOS: a single-center study of a newly recognized pathologic entity - Blood Cancer Journal
‘Food Intelligence’ Review: The Caloric Conundrum
Unhealthy foods have proliferated in U.S. grocery stores. To what extent does the food environment explain high obesity rates? The intersection of food and health is receiving unprecedented attention in the United States. Health and Human Services Secretary Robert F. Kennedy Jr. is pushing a Make America Healthy Again agenda. Millions of Americans are using weight-loss drugs such as Ozempic and Wegovy.
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer - Nature Genetics
Abstract Prostate cancer is driven by oncogenic transcription factor enhanceosomes comprising chromatin and epigenetic regulators. The lysine acetyltransferases p300 and CREB-binding protein (CBP) are key cofactors that activate enhancers through histone acetylation. Here we identify p300/CBP-mediated multisite histone H2B N-terminal acetylation (H2BNTac) as a defining feature of oncogenic enhanceosomes in androgen receptor (AR)-positive prostate cancer.
Multi‐Institutional Study of ALK‐Positive Large B‐Cell Lymphoma: Outcomes in the Era of ALK Inhibitors and Biologically Informed Therapies
Conflicts of Interest S.Y.: Consulting: Bristol Myers Squibb, Kite Pharma; Advisory board: Bristol Myers Squibb, Kite Pharma, Abbvie, Genmab.
Highly specific intracellular ubiquitination of a small molecule - Nature Chemical Biology
Abstract Ubiquitin is a small, highly conserved protein that acts as a posttranslational modification in eukaryotes. Ubiquitination of proteins frequently serves as a degradation signal, marking them for disposal by the proteasome.
Incidental vs. symptomatic diagnosis of follicular lymphoma: implications of earlier detection - Blood Cancer Journal
Abstract Follicular lymphoma (FL) is usually diagnosed at an advanced stage when the patient presents with a palpable lymph node or symptoms such as pain and fatigue. However, due to advances in imaging techniques used for many diseases and cancer screening, incidental diagnosis of FL is expected to rise.
Cómo las estrategias sin restricciones pueden ayudar a navegar entornos volátiles
TRIBUNA de Matthew Rees, head of Global Bond Strategies, y Tom Farrington, Fixed Income Investment specialist, L&G. Comentario patrocinado por L&G. Este es un artículo exclusivo para los usuarios registrados de FundsPeople. Si ya estás registrado, accede desde el botón Login. Si aún no tienes cuenta, te invitamos a registrarte y disfrutar de todo el universo que ofrece FundsPeople.
KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage - Nature Genetics
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Abstract Basal breast cancer is a subtype with a poor prognosis in need of more effective therapeutic approaches. Here we describe a unique role for the KDM4C histone lysine demethylase in KDM4C-amplified basal breast cancers, where KDM4C inhibition reshapes chromatin and transcriptomic landscapes without substantial alterations of its canonical substrates, trimethylated histone H3 lysine 9 (H3K9me3) and lysine 36 (H3K36me3).
By Zheqi Li, Xintao Qiu, Marco Seehawer, Maeve McFadden Verified, Eva Papachristou, Natalie Kingston, Jun Nishida, Kendell Clement, Daniel Temko, Muhammad B. Ekram, Rong Li, Matthew Rees, Melissa Ronan, Jennifer Roth, Anton Simeonov, Stephen C. Kales, Ajit Jadhav, Franziska Michor, Alex Meissner, Justin M. Balko, Jason Carroll, Malvina Papanastasiou, Henry Long
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Nature
Verified
A physician uses advanced sports-science technology to train athletes—and revels in giving guidance that defies standard practice. Today’s professional basketball players are capable of athletic feats that would have been unthinkable a few decades ago. Think Stephen Curry’s extraordinary shooting range or Nikola Jokić’s sheer mastery of the game. But there’s one way in which NBA players are regressing compared to their predecessors: They’re getting injured more often.
After Decades of Distrust, Will Indians Fly Air India?
In the three-plus years since the Tata Group acquired Air India, the airline has announced a variety of improvements, from ordering hundreds of new planes to unveiling a new logo. But after decades of poor performance, it’s going to take time to persuade Indians and the Indian diaspora to travel on the country’s flagship carrier – as I learned in connection with a recent trip to India. Air India has a storied – if checkered – history.
Designing an Estate Gate where Elegance and Function Align
An estate gate is more than an entry—it’s a statement. A custom-designed gate doesn’t just boost curb appeal; it adds tangible lifestyle and property benefits. Think increased privacy, perimeter security, safety for children and pets, aesthetic cohesion and controlled access to your property. Whether you’re a homeowner, real estate professional, or contractor, here’s what you need to know when considering a custom gate system.
100 days of president Trump: What is the outlook for fixed income?
The one constant we expected from the new US administration was volatility, driven by uncertainties over trade, fiscal, and immigration policies. But we have still been surprised by the level of volatility across global markets in the first 100 days. Fixed income markets have shared concerns with their equity counterparts over the potential end of US exceptionalism. US government and corporate debt have underperformed other developed markets significantly in the year to date.
Author Correction: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer - Nature
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Correction to: Nature https://doi.org/10.1038/s41586-024-07379-z Published online 8 April 2024 In the version of the article initially published, in the Data availability section, the GEO accession number was incorrect and has now been amended to GSE252002 in the HTML and PDF version of the article.
By Alvaro Curiel-Garcia, Margo I Orlen, Clint A. Stalnecker, Julien Dilly, Marie C. Hasselluhn, Stephanie Chang, Cynthia Clendenin, Rina Sor, William Vostrejs, Amber M. Amparo, Matthew Rees, Melissa Ronan, Jennifer Roth, Laura Herring, Brian Wolpin, Kenneth Y. Tsai, David Wildes, Scott Lowe, Andrew J. Aguirre, Robert H Vonderheide, Ben Z. Stanger, Channing J. Der
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Nature
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Characteristics and outcomes of incidentally diagnosed diffuse large B‐cell lymphoma and implications for cancer screening
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL) subtype in the world and most cases present with stages III/IV disease.1-3 These patients usually palpate a mass, develop pain, or have abnormal blood tests at the time of a routine exam leading to imaging, biopsy, and the diagnosis.
Five Best: Books on Swimming
By P.H. Mullen (2001) 1. Swimming typically attracts some of the highest television ratings of the Olympics, but most of the sport’s standouts train in nearly total anonymity.
Clinical features associated with poor response and early relapse following BCMA-directed therapies in multiple myeloma - Blood Cancer Journal
Abstract Three classes of BCMA-directed therapy (BDT) exist: antibody drug-conjugates (ADCs), CAR-T, and T-cell engagers (TCEs), each with distinct strengths and weaknesses. To aid clinicians in selecting between BDTs, we reviewed myeloma patients treated at Mayo Clinic with commercial or investigational BDT between 2018-2023.
‘Frostbite’ Review: The Art of Keeping Cool
Step into an American grocery store and you’re likely to find avocados from Mexico, meat from New Zealand and rice from India. Food is one of the world’s most globalized industries: Two-thirds of fruits and vegetables are consumed outside the borders within which they are grown. Frostbite: How Refrigeration Changed Our Food, Our Planet, and Ourselves Penguin Press 400 pages We may earn a commission when you buy products through the links on our site.
Navigating High-Risk and Ultrahigh-Risk Multiple Myeloma: Challenges and Emerging Strategies
Research ExplorerPublicationsNavigating High-Risk and Ultrahigh-Risk Multiple Myeloma: Ch... Abstract Bibliographical data
Population density and ranging behaviour of a generalist carnivore varies with human population
1 INTRODUCTION Mammalian predators have adapted to urban and peri-urban environments across the world, resulting in positive and negative interactions with people (Bateman & Fleming, 2012). To exploit the different types of resources available to them, individual animals utilising urban areas may exhibit behaviours distinct to their less urbanised counterparts (Klump et al., 2022).
‘Magic Pill’ Review: Ozempic and Hunger for Less
It’s hard not to notice: More than a few celebrities—and millions of regular citizens—are managing to lose weight without taxing their willpower. The reason is Ozempic and other weight-loss drugs, which suppress appetite and make the ordeal of forswearing calories seem needless. Doctors who specialize in hip and knee replacement are getting nervous, as are the sales teams at food companies. Ozempic jokes have been delivered by hosts at the Academy Awards and the Grammys.
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition - Nature Communications
Abstract Chemical discovery efforts commonly target individual protein domains. Many proteins, including the EP300/CBP histone acetyltransferases (HATs), contain several targetable domains. EP300/CBP are critical gene-regulatory targets in cancer, with existing high potency inhibitors of either the catalytic HAT domain or protein-binding bromodomain (BRD).
High‐risk multiple myeloma: Redefining genetic, clinical, and functional high‐risk disease in the era of molecular medicine and immunotherapy
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES 1, , , et al. Real-world results of autologous stem cell transplantation in newly diagnosed patients with multiple myeloma: a multi-institutional report from the Canadian Myeloma Research Group (CMRG) database. Blood. 2022; 140(Suppl 1): 289-291. 2, , , et al. Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients. Leukemia. 2014; 28(5): 1122-1128.
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy - Nature
Abstract RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 611. Small molecule inhibitors of the KRAS(G12C) oncoprotein have demonstrated clinical efficacy in patients with multiple cancer types and have led to regulatory approvals for the treatment of non-small cell lung cancer2,3.
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer - Nature
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Abstract Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human cancer patients whose tumors are driven by RAS mutations1,2. RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants (RAS(ON) multi-selective)3.
By Alvaro Curiel-Garcia, Margo I Orlen, Clint A. Stalnecker, Julien Dilly, Marie C. Hasselluhn, Stephanie Chang, Cynthia Clendenin, Rina Sor, William Vostrejs, Matthew Rees, Melissa Ronan, Jennifer Roth, Laura Herring, Brian Wolpin, David Wildes, Scott Lowe, Andrew J. Aguirre, Robert H Vonderheide, Ben Z. Stanger, Channing J. Der, Amber M. Amparo, Kenneth Y. Tsai
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Nature
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Intensive temporal and spatial sampling of polychaete biodiversity reveals significant implications for impact assessment and marine park design
1 INTRODUCTION Sediment inhabiting invertebrates are a substantial component of the marine biodiversity (Gray, 2002; Snelgrove et al., 1997) and provide numerous ecosystem functions (Belley & Snelgrove, 2016; Elena et al., 2006; Snelgrove et al., 2000).
Baiting foxes can make feral cats even more 'brazen,' study of 1.5 million forest photos shows
Foxes and cats kill about 2.6 billion mammals, birds and reptiles across Australia, every year. To save native species from extinction, we need to protect them from these introduced predators. But land managers tend to focus on foxes, which are easier to control. Unfortunately this may have unintended consequences. We wanted to find out how feral cats respond to fox control.
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