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Articles by Mei Li
Mineralizer-Assisted Synthesis of Zircon Silicate-Based Glass-Ceramics for High CeO 2 Immobilization
1 Introduction The extensive use of fossil fuels currently intensifies environmental protection challenges. The international community is increasingly emphasizing clean and green energy sources. Thus, in the current era of green energy and environmental protection, nuclear energy finds wide applications in fields such as military, medical, biological, and agricultural sectors. Meanwhile, it has the advantages of being green and low-carbon, with high energy density economic benefits.
Safety and efficacy of human gingiva-derived mesenchymal stem cells in patients with type 1 diabetes: a double-blind, randomized, placebo-controlled, phase 1 trial
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Abstract Current therapies for type 1 diabetes mellitus (T1DM) rarely halt progressive β-cell function loss due to autoimmune attack. Human gingiva-derived mesenchymal stem cells (GMSCs) have been shown to have therapeutic effects on a variety of autoimmune diseases through their potent immunomodulatory capacity, but clinical evidence for these effects is lacking in patients with T1DM.
By Qi Tang, Li Zhou Verified, Liwen Fan, Wei Zhang, Xixiang Tang, Mei Li, Yanhua Zhu, Jia Yuan, Zheng Chen, Song Zheng, Yanming Chen, Donglan Zeng, Mengyin Cai
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Nature
Verified
3D-printed porous titanium versus PEEK interbody cages in lumbar fusion: biomechanical rationale, clinical evidence, and emerging indications
Abstract Lumbar interbody fusion is a cornerstone treatment for degenerative spinal conditions. PEEK cages offer an elastic modulus approximating cancellous bone and radiolucency, yet their bioinert surface can result in fibrous encapsulation rather than direct bone apposition.
Structural insights into assembly and environmental adaptation of photosystem I from a lichen green alga
Abstract Photosystem I (PSI) of terrestrial plants typically contains an antenna system smaller than that of aquatic algae, presumably an adaptation to terrestrial high-light conditions. Moreover, green plants face multiple other stresses including drought when colonizing terrestrial environments and have evolved effective protective mechanisms. However, how exactly PSI antenna size is reduced and the precise nature of these photoprotective strategies remain to be elucidated.
Associations between baby swimming and preschooler child intelligence quotient: a cohort study
Abstract Baby swimming is a widely practiced early childhood healthcare activity, but its long-term health outcomes remain unclear. This study aimed to investigate whether baby swimming participation during the first six months of life is associated with intellectual development at preschool age. Children from the Wuhan Healthy Baby Cohort who completed follow-up questionnaires at 1 and 6 months and intelligence quotient (IQ) assessments between March 2022 and November 2023 were recruited.
CFTR regulates lipid metabolism by relieving adipose inflammation in obesity
Abstract The downregulation of the cystic fibrosis transmembrane conductance regulator (CFTR) reduces lipogenesis and alters lipid metabolism. However, the role of CFTR in inflammation regulation in adipose tissue has been unknown. This study aims to explore the role of CFTR in adipose inflammation and lipid metabolism and the underlying mechanism using both in vivo and in vitro models.
Risk Factors for Anxiety or Depression in Patients With Stroke During the Acute and Recovery Phases: An Independent Cohort Study
Background: To identify the overall risk factors for any clinically significant anxiety or depressive anxiety or depression in patients with stroke in the acute and recovery phase cohorts, compare the differences in overall risk factors between two independent patient cohorts at different disease stages, so as to provide a reliable basis for early screening and staged intervention of post-stroke emotional anxiety or depression.
Middle meningeal artery embolization for chronic subdural hematoma: Interpreting divergent randomized evidence and guiding patient selection
Abstract Chronic subdural hematoma (cSDH) is among the most common neurosurgical conditions in adults, with incidence rising steadily in aging populations and with increasing antithrombotic drug use. Burr-hole drainage remains the standard treatment for symptomatic cSDH; however, postoperative recurrence rates range from 8 to 30%.
Prevalence and transmission of pretreatment drug resistance and acquired drug resistance among people living with HIV-1 in Chongqing, China, 2014–2024
Abstract Objectives: To explore the epidemic trends of pretreatment drug resistance (PDR) and acquired drug resistance (ADR) among people living with HIV (PLWH) from 2014 to 2024 in Chongqing, China. Methods: Samples and clinical data of PLWH were collected from 2014 to 2024. The HIV-1 pol gene was amplified using One-step reverse transcription-polymerase chain reaction (RT-PCR) and nested PCR.
Association of the c-reactive protein-triglyceride glucose index with myocardial ischemia in patients with minimal to moderate coronary artery disease
Abstract Objective: This study sought to explore the relationship between the C-reactive protein-triglyceride-glucose index (CTI) and the incidence of myocardial ischemia in patients with minimal to moderate coronary artery disease (CAD). Methods: The research retrospectively included 707 patients who underwent coronary computed tomography angiography (CTA) and blood tests for triglycerides, glucose, and C-reactive protein (CRP).
Soil moisture shifts under warming are associated with divergent topsoil nitrogen responses in permafrost-affected ecosystems
Abstract Understanding how soil nitrogen (N) responds to climate warming is critical for predicting permafrost carbon–climate feedbacks, yet long-term N responses and their underlying mechanisms remain elusive. Here we show that divergent topsoil N responses to warming are associated with warming-induced shifts in soil moisture. Twelve-years of high-level warming increases topsoil N stocks in mesic alpine meadows but triggers substantial topsoil N losses in waterlogged swamp meadows.
Signal-induced recruitment and dispatchment in reconfigurable phase-separated protocell networks
Abstract The construction of protocell networks with self-regulated spatial dynamics and functions is an important challenge in the emerging field of colloidal systems chemistry.
Predictors of postoperative complications in elderly patients undergoing pulmonary lobectomy: a retrospective cohort study
Abstract Background: Elderly patients undergoing pulmonary lobectomy for lung cancer are at increased risk of postoperative morbidity. Identifying modifiable risk factors and establishing a practical risk stratification method are essential for improving perioperative management. Methods: This retrospective cohort study included 212 consecutive patients aged ≥65 years who underwent pulmonary lobectomy for non-small cell lung cancer from 2020 to 2024.
Act Environmentally When Peers Do So? The Effect of Friends' and Strangers' Resource Extraction on Preschool Children's Pro-Environmental Behavior
Conflicts of Interest The authors declare that there are no conflicts of interest. Data Availability Statement All data in this study are available upon request by contact with the corresponding author, in consideration of data protection, a formal data-sharing agreement is needed when the data are requested. Supporting Information Filename Description desc70267-supp-0001-SuppMat.docx17.3 KB Supporting Information: desc70267-supp-0001-SuppMat.docx References , and . 2009.
Electro- and Photocatalytic C─X Bond Coupling in Valorization of Waste Plastics/Biomass: Reaction Mechanism and Catalyst Engineering
Zongyang Ya and Yu Zheng contributed equally to this work. Conflicts of Interest The authors declare no competing interests. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. References 1, , , and , “A Unified View on Catalytic Conversion of Biomass and Waste Plastics,” Nature Reviews Chemistry 6, no. 9 (2022): 635–652, https://doi.org/10.1038/s41570-022-00411-8.
Epidemiological characteristics of varicella and factors associated with breakthrough varicella among children aged 0–14 years in Jiangsu Province, China
ABSTRACT Background This study aimed to explore the epidemiological characteristics of varicella and breakthrough varicella (BV), as well as factors associated with the BV proportion during 2021–2024. Research design and methods Data on varicella cases aged 0–14 years were extracted from the national surveillance system and linked to individual immunization records. Logistic and linear regression were adopted.
Experience of sexual recovery after percutaneous coronary intervention in young and middle-aged men: a qualitative study
Abstract Background: Sexual recovery is an important but often neglected component of cardiac rehabilitation after percutaneous coronary intervention (PCI). Young and middle-aged men may experience concerns about physical safety, sexual confidence, partner relationship, and cultural taboos. However, evidence on sexual recovery after PCI in the Chinese cultural context remains limited.
Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
Abstract Crimean–Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus and causes severe, often fatal, human infections. Lacking licensed vaccines or drugs, CCHFV is a World Health Organization priority pathogen requiring urgent development of medical countermeasures1,2. The CCHFV Large (L) protein functions as the viral RNA-dependent RNA polymerase CCHFV-L, representing a promising antiviral target, and is among the largest viral polymerases in the order Bunyavirales.
Bone Shape Feature Differences in Single and Recurrent Patellar Dislocations via Statistical Shape Modeling
1 Introduction Patellar dislocation is a traumatic injury caused by direct impact to or severe twisting of a knee that may cause significant functional impairment to a young, active patient population. The incidence of acute patellar dislocation in the highly active young population of age 10–17 has been estimated to be 4 times more than in the general population [1]. Roughly over 60% of these dislocations occur during active exercise or sports [1].
Ni-Induced Low-Valence Tungsten Oxide for Highly Selective and Stable Glycerol Electro-Oxidation to Formic Acid
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll74650-sup-0001-SuppMat.docx2.4 MB Supporting File: smll74650-sup-0001-SuppMat.docx.
Selective Photocatalytic CO 2 Reduction via Enhanced CO 2 Adsorption and Activation Over Co-Salen Functionalized Zr-MOF Catalyst
Mei Li, Cha Li, and Yawen Shi contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description anie73581-sup-0001-SuppMat.docx10.2 MB Supporting File: anie73581-sup-0001-SuppMat.docx.
Change point testing for two phase Wiener process with nonlinear drift
Abstract With the advancement and development of science and technology, critical equipment in the aerospace and electronics fields has gradually evolved toward multifunctionality, long life, and high reliability.
Safety extending beyond the cabin: A social semiotic study of the multimodal engagement strategies in Chinese preflight safety videos
Flight safety remains a top priority in the aviation industry, with preflight safety videos (PSVs) playing a critical role in preparing passengers for potential emergencies. In recent years, airlines worldwide have increasingly incorporated multimodal resources into PSV design. However, limited research has examined how these resources are configured to engage passengers and enhance safety communication.
Development of human resources in malaria microscopy during and after the malaria elimination phase in China
Abstract Under the context of sustained low malaria incidence in China, maintaining an adequate number of qualified microscopists remains a critical component to ensure and sustain the success of malaria elimination. Therefore, this paper presents the efforts made, achievements attained, and future prospects regarding the development of human resources in malaria microscopy during and after the malaria elimination phase in China.
The translation landscape of ovarian clear cell carcinoma indicates that RBM4 plays a pro-oncogenic role in tumor progression
Abstract Ovarian clear cell carcinoma (OCCC) is a highly aggressive gynecological malignancy characterized by distinct clinicopathological features and resistance to chemotherapy. Despite advances in multi-omics characterization, the translational regulatory landscape of OCCC remains unexplored. Here, we performed ribosome profiling to systematically investigate translation control mechanisms in OCCC.
Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders
Abstract Stimulator of Interferon Genes (STING) is a pivotal adaptor protein in the innate immune pathway, and its aberrant activation is closely associated with the pathogenesis of autoimmune diseases. Although it has emerged as an attractive therapeutic target for inflammatory disorders, current STING inhibitors still face challenges including off-target toxicity and limited understanding of binding mechanism.
Fusion-specific co-mutational architecture and treatment-response associations in pediatric core-binding factor acute myeloid leukemia: a multicenter exome-profiled cohort
Abstract Introduction: Core-binding factor acute myeloid leukemia (CBF-AML) is defined by one of two founding fusions, but cooperating lesions may differ between fusion subtypes. We characterized the broader diagnostic co-mutational architecture of pediatric CBF-AML and examined its relationship with post-induction measurable residual disease (MRD) and outcome.
Exploring subclinical median nerve biomechanical changes in elderly rheumatoid arthritis patients with nerve ultrasound and shear wave elastography: a cross-sectional study
Abstract In elderly patients with rheumatoid arthritis (RA), subclinical median nerve (MN) involvement often goes undetected. This study aimed to evaluate whether combining nerve-ultrasound with shear wave elastography (SWE) could identify early MN alterations. A cross-sectional study enrolled 81 RA patients (≥ 60 years) without clinical symptoms of MN neuropathy, divided into late-onset RA (LORA) and young-onset RA (YORA), and 51 controls.
Love, Quest, Adventure: The Storytelling Behind Xi Jinping’s Speeches and China’s Grand Strategy
This article is republished from The Conversation under a Creative Commons license. Read the original article. By Mei Li, University of Sydney For many in the West, China still feels hard to fully understand. Public debate and media coverage too often focus on the “China threat”. Critics highlight the flaws of China’s political system and limits on freedom, yet China has still managed to rise as a major power that can now compete with the United States.
Love, quest, adventure: the storytelling behind Xi Jinping’s speeches and China’s grand strategy
For many in the West, China still feels hard to fully understand. Public debate and media coverage too often focus on the “China threat”. Critics highlight the flaws of China’s political system and limits on freedom, yet China has still managed to rise as a major power that can now compete with the United States. One reason for this gap in understanding is that the media often interprets China through a Western-centric perspective.
Love, quest, adventure: the storytelling behind Xi Jinping’s speeches and China’s grand strategy Original
For many in the West, China still feels hard to fully understand. Public debate and media coverage too often focus on the “China threat”. Critics highlight the flaws of China’s political system and limits on freedom, yet China has still managed to rise as a major power that can now compete with the United States. One reason for this gap in understanding is that the media often interprets China through a Western-centric perspective.
Trim47 protects against hypoxic–ischaemic brain injury in neonatal rats by reducing brain microvascular endothelial inflammation and BBB disruption by interacting with ZO1
Abstract Hypoxic–ischaemic (HI) brain damage is the main contributor to neonatal brain damage and neurodevelopmental impairments. The E3 ubiquitin ligase tripartite motif 47 (Trim47) plays pivotal roles in regulating inflammation, autophagy, and apoptosis in the pathological processes of various diseases. However, the role of Trim47 in neonatal HI brain injury remains unknown.
Differential inhibition of Morbillivirus and Henipavirus polymerases by ERDRP-0519 and structure-guided inhibitor optimization
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Keywords Nipah virus measles virus peste des petits ruminants virus RNA-dependent RNA polymerase non-nucleoside inhibitor structure-guided drug design Get full text access Log in, subscribe or purchase for full access. References 1. Duprex, W.P. ∙ Dutch, R.E. Paramyxoviruses: Pathogenesis, Vaccines, Antivirals, and Prototypes for Pandemic Preparedness J. Infect. Dis. 2023; 228:S390-S397 2. Libbey, J.E. ∙ Fujinami, R.S. Morbillivirus: A highly adaptable viral genus Heliyon. 2023; 9, e18095 3.
By Lu Xue, Jiacheng Gui, Shenghua Gao, Xiaoxiao Gao, Jielin Tang, Mingxia Zhang, Zimu Li, Heyu Zhao, Longyu Wang, Mei Li, Lijun Rong, Richard K. Plemper, Xinwen Chen, Jun He, Peng Zhan, Xiaoli Xiong, Tiancai Chang, Hainei Pan, Binqian Zou, Rongjuan Pei, Tiancai Chang, Hainei Pan, Binqian Zou, Rongjuan Pei
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Cell Press
Verified
Nutrition information-seeking behavior among patients recovering at home after esophageal cancer surgery: a qualitative study
Abstract Objective: Patients after esophageal cancer surgery often have unmet nutritional information needs during home rehabilitation. However, research on how these patients acquire, understand, and apply nutritional information in real-life contexts remains limited.
Decoding the CAF–TAM axis: multi-omics dissection and therapeutic targeting of stromal–immune crosstalk in the tumor microenvironment
Abstract Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are pivotal stromal and immune components of the tumor microenvironment (TME) that orchestrate immune evasion, metabolic reprogramming, and therapeutic resistance. Regions enriched in CAFs are frequently accompanied by dense TAM infiltration, underscoring their close structural and functional interdependence.
PRDX1 promotes clear cell renal cell carcinoma progression by modulating EGFR-dependent AKT pathway activation
Abstract Background: Renal cell carcinoma (RCC) is a highly heterogeneous malignant tumor, characterized by a globally increasing incidence and mortality rate. Although surgical resection serves as the standard treatment for localized RCC, recurrence and metastasis remain major clinical challenges. Based on patient sample analysis and signaling pathway investigation, the present study identifies peroxiredoxin 1 (PRDX1) as a potential therapeutic target for RCC.
Biportal endoscopic laminectomy vs. open-door laminoplasty for 2–3 levels of cervical myelopathy: a prospective observational cohort study
Abstract Background: Unilateral biportal endoscopy (UBE) is increasingly used in cervical spine surgery, but comparative data against open-door laminoplasty (OD-L) for cervical myelopathy (CM) remain limited. This prospective observational study compared biportal endoscopic laminectomy (BE-L) with OD-L for multilevel CM, focusing on neurological recovery, perioperative burden, and sagittal alignment. Methods: From November 2022 to May 2024, 128 patients with 2–3 level CM were enrolled.
A qualitative study on the self-management experience and needs of postmenopausal patients with metabolic dysfunction-associated steatotic liver disease from the perspective of active health
Abstract Background: Metabolic dysfunction-associated steatotic liver disease is a prevalent chronic liver disease globally. Postmenopausal women may face a higher risk of developing this disease due to the metabolic changes related to menopausal transition. Although lifestyle adjustments remain the core of the care process, sustained self-management often remains highly challenging.
Digitaria genome analyses indicate introgression may drive local adaptation and herbicide resistance - Nature Communications
Abstract Crabgrasses (Digitaria spp.) rank among the most invasive upland weeds globally, exhibiting remarkable ecological plasticity. To uncover the genomic basis underlying their weediness and environmental adaptability, we generate a telomere-to-telomere (T2T) reference genome of Digitaria sanguinalis, along with its diploid progenitor D. radicosa and tetraploid progenitor D. milanjiana. In addition, we re-sequence 579 accessions collected from fields of 24 grain-producing provinces in China.
Knockdown of KLK13 has a protective effect against ovalbumin-induced asthma in mice
Ayuda Buscar en la ayuda Buscar en la ayuda Knockdown of KLK13 has a protective effect against ovalbumin-induced asthma in mice Siyu Wu [1] ; Chengcheng Yang [2] ; Lu Chen [1] ; Mei Li [3] ; Shuo Wang [1] [1] Department of Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. [2] Department of Pneumology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Mitochondrial Dysfunction in Inflammatory Skin Diseases: Mechanisms, Biomarkers, and Emerging Therapeutic Strategies
Mitochondrial dysfunction critically underpins the pathogenesis of inflammatory skin diseases such as psoriasis, vitiligo, atopic dermatitis, and impaired wound healing. This comprehensive review synthesizes recent evidence to elucidate mechanisms, including compromised bioenergetics, excessive reactive oxygen species (ROS), mitochondrial DNA (mtDNA) damage, and aberrant mitochondrial dynamics.
Electrochemical Nickel-Catalyzed Selective Defluorination for the Synthesis of α-Fluoroarylacetic Acid Derivatives
Cite Jump to ExpandCollapse LetterDecember 12, 2025 Electrochemical Nickel-Catalyzed Selective Defluorination for the Synthesis of α-Fluoroarylacetic Acid Derivatives Click to copy article linkArticle link copied! Mei Li Mei Li State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China Pengwei Hu Pengwei Hu State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology...
Azacitidine as maintenance therapy in pediatric de novo acute myeloid leukemia
1Department of Paeditric Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China 2Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, China Background: Relapse remains a major challenge in pediatric acute myeloid leukemia (AML), particularly in patients ineligible for hematopoietic stem cell...
Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy
Keywords pancreatic cancer obesity pseudouridine CSTA mast cell Get full text access Log in, subscribe or purchase for full access. References 1. Klein, A.P. Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors Nat. Rev. Gastroenterol. Hepatol. 2021; 18:493-502 2. Michaud, D.S. ∙ Giovannucci, E. ∙ Willett, W.C. ... Physical activity, obesity, height, and the risk of pancreatic cancer JAMA. 2001; 286:921-929 3. Tao, W. ∙ Lagergren, J.
Protocell Survival Networks in Spatially Modulated Chemical Gradients
Cite Jump to ExpandCollapse ArticleNovember 25, 2025 Protocell Survival Networks in Spatially Modulated Chemical Gradients Click to copy article linkArticle link copied! Shuqi Wu Shuqi Wu Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China Innovation Center for Smart Medical Technologies & Devices, Binjiang...
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