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Patrick Dougherty

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Articles

Gender-Specific Behavior Reductions in Spontaneous Locomotive and Rearing in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy: A Pilot Study

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By Serena Kim, Kevin Cao, Patrick Dougherty
| Dove Medical Press
Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of various chemotherapy agents, characterized by distal symmetric sensory loss, neuropathic pain, and functional impairment in a predominantly stocking-and-glove distribution.1,2 Prevalence of CIPN among patients receiving neurotoxic chemotherapy ranges from 19% to over 85%.
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Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature

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By Erez N. Baruch, Frederico O. Gleber-Netto, Priyadharsini Nagarajan, michael davies, Sonali Jindal, Sreyashi Basu, Ali Ahmadi, Derrick L. Tao, Nadim J. Ajami, Andrew Futreal, Kunal Rai, Sharia Hernandez, Jing L. Wang, Stephanie S. Watowich, George A. Calin, Mona M Yuan, Naijiang Liu, William L Hwang, Paola D. Vermeer, Nisha J. D’Silva, Yuri L. Bunimovich, Jared K. Burks, Javier Gomez, Javier Gómez, Patrick Dougherty, Kenneth Y. Tsai, Padmanee Sharma, Jennifer Wargo, Jeffrey Myers, Sebastien Talbot, Neil Gross
| Nature Verified
Abstract Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types1, yet its mechanism remains unclear. Here we provide clinical and mechanistic insights into the role of PNI and cancer-induced nerve injury (CINI) in resistance to anti-PD-1 therapy. Our study demonstrates that PNI and CINI of tumour-associated nerves are associated with poor response to anti-PD-1 therapy among patients with cutaneous squamous cell carcinoma, melanoma and gastric cancer.
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Ransomware Is Getting Smarter. Are We?

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By Patrick Dougherty
| Medium
By Patrick Dougherty Founder, Cyber Integrity Solutions | Cybersecurity Strategist | U.S. Marine Veteran Press enter or click to view image in full size The average ransomware payment in Q2 2025 hit $1.13 million. That’s more than double the previous quarter. (ITPro) This isn’t just a bigger number. It’s a warning shot. Ransomware has entered a new era. The business model has shifted: Data exfiltration now occurs in 74% of attacks (ITPro).
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