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Articles by Xiaofeng Wang
DGKE acts as a negative regulator of podocyte migration and injury in glomerular diseases
Abstract Podocyte injury is a major determinant of glomerular diseases. Although considerable advances have been made in the understanding of the mechanisms that trigger podocyte injury, effective cell-specific therapies remain clinically unavailable. In particular, recent studies have revealed that podocyte adhesion dysfunction and aberrant migration are pivotal events in the pathogenesis of podocyte loss and injury.
Computer Science > Cryptography and Security
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Global knowledge structure and thematic evolution in inflammation-associated gastric cancer epigenetics: a multidatabase science-mapping study with nested latent Dirichlet allocation and independent NMF validation
Abstract Background: Inflammation-associated epigenetic regulation links microbial exposure and chronic mucosal injury to gastric carcinogenesis, immune remodeling, molecular heterogeneity, and treatment resistance. Previous science-mapping studies have commonly relied on a single bibliographic database, which may introduce platform-specific coverage bias.
Association of B-Type Natriuretic Peptide With Intrinsic Capacity Trajectories Among Chinese Older Adults
Disclosure The funding sources had no role in the study design; data collection, analysis, or interpretation; participant recruitment; or the preparation, review, or approval of the manuscript. Conflicts of Interest We acknowledge all participants involved in the present study, and the authors declare no conflicts of interest.
Atlas of genetic architecture and exploratory temporal interaction networks of plasma protein-based organ and system aging
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Abstract Organ-level investigations provide insights into inter-individual heterogeneity in health and disease, yet aging across organs and systems remains incompletely understood.
By Fan Pu, Xueqing Jia, Xiaoxi Hu, Youheng Wu, Yanjie Zhao, Jiening Yu, Shuming Wang, Shuhui Wu, Shenghan Wang, Yishan Wang, Zhiyong Zhao, Dan Wu, Nan Liu, Junfang Chen, Xiaofeng Wang, Juulia Jylhävä, Chiara Herzog, Alan Cohen, Huaidong Du, Derrick Bennett, Robin G Walters, Canqing Yu, Jun Lv, Zhengming Chen, Li Jin, Dianjianyi Sun, Zixin Hu, Zuyun Liu, Ciyun Zhao, Duoduo Fu, Dianqing Chen
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Nature
Verified
Validation and Reliability Assessment of the Japanese Version of the Salzburg Stress Eating Scale in an Adult Population
Maintaining a healthy lifestyle encompasses managing various daily routines, including dietary habits. Disruptions in eating behavior have the potential to precipitate lifestyle-related diseases depending on their nature. Pannicke et al. (2021) identified food craving, stress, and emotions as prominent factors influencing eating behavior.
White matter hyperintensity burden and post-stroke cognitive impairment: a systematic review and meta-analysis of clinically comparable estimates
Abstract Introduction: White matter hyperintensity (WMH) burden is a common marker of cerebral small vessel disease and may identify stroke survivors with reduced cognitive reserve. Published estimates, however, use different imaging thresholds, cognitive definitions, follow-up periods, and effect measures. Methods: We searched PubMed/MEDLINE, Embase, Web of Science Core Collection, and the Cochrane Library from database inception through 13 August 2026.
Factors associated with cancer-related fatigue in breast cancer patients: a systematic review and meta-analysis
Abstract Background: Cancer-related fatigue (CRF) remains one of the most common and persistent complications among breast cancer survivors, profoundly impairing their psychosocial well-being. Although various predictors have been proposed, existing evidence yields inconsistent findings.
High-Order Conservative Crank–Nicolson Difference Scheme for the Hirota–Satsuma Coupled KdV Equation
Conflicts of Interest The author declares no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1 and , “Soliton Solutions of a Coupled Korteweg–de Vries Equation,” Physics Letters 85A (1981): 8–9.
FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap
Abstract Ultra-high dose rate radiotherapy (FLASH-RT) has emerged as a promising technology in recent years. Unlike conventional radiotherapy (CONV-RT), FLASH-RT delivers radiation at an ultra-high dose rate over a very short duration. This approach not only greatly shortens the treatment time, but also exhibits the “FLASH effect”, which significantly spares healthy tissues while maintaining antitumor efficacy comparable to that of CONV-RT.
SCGAN-MultiJNet-Based Data Synthesis Algorithm for Multi-Modal MRI Brain Tumor Images
You are already at the latest version Multi-modal MRI leverages complementary information from sequences including Flair, T1ce, T1 and T2, and has become a core technical support for accurate brain tumor segmentation. Nevertheless, clinical practice frequently suffers from insufficient data volume and modality missingness, which severely limit the performance of deep learning-based segmentation models.
Gut microbiota associates with frailty in older women
Abstract Frailty is a multifactorial geriatric condition linked to increased mortality and adverse health outcomes and is associated with gut microbiome features that differ from those observed in healthy ageing. We analyze gut metagenomic profiles in relation to estimated frailty severity and frailty-related clinical outcomes assessed with an internally developed and validated Frailty Mortality Index (FMI) in the SUPERB cohort, comprising 2,081 Swedish women aged 75–80 years.
An Exploratory Study of Slow Tourist Experience Formation
The formation of slow tourist experience remains underexplored despite its great significant theoretical and practical implications. Through thematic analysis of semi-structured interview and blog texts, this study proposes a research framework – centered on slow tourists and integrating specific settings and tourists’ interactive actions – to explore how slow tourist experiences are formed within particular experiencescapes.
Analysis of an AI-powered system for vaccination screening, monitoring, and management in adults aged 50 and above
Abstract Introduction: Currently, there is insufficient research on screening contraindications and post-vaccination monitoring for older adults prior to vaccination. Methods: This study pioneers the integration of artificial intelligence technology, developing a mobile-based medical system (Medduo) that leverages AI for the screening and monitoring of vaccinations in Older adults with chronic diseases. The system was piloted at five vaccination centers.
Spatial-Bioenergetic-Immune Axis in Type 2 Diabetes Mellitus-Associated Sarcopenia: A Review from Pathogenesis to Targeted Reconstruction
Back to Journals » Journal of Inflammation Research » Volume 19 Review Diabetes and Inflammation Authors Wu L , Ye H, Wang X, Ding Q, Zhang W Received 27 May 2026 Accepted for publication 7 August 2026 Published 26 August 2026 Volume 2026:19 627857 DOI https://doi.org/10.2147/JIR.S627857 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Bucci Lingfeng Wu,1 Hong Ye,2 Xiaofeng Wang,3 Qinggang Ding,4 Wenlong Zhang4...
Computer Science > Cryptography and Security
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Hierarchical materials from fused silk
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Abstract Silk is an extraordinary natural material whose unique chemistry and hierarchical organization enable performance beyond that of many synthetic counterparts. However, its poor processability arising from the molecular folding patterns of fibroin makes fabricating shapes other than fibres conceptually challenging. Here we report a simple and rapid thermomechanical process to fuse silk fibres into solid materials of arbitrary shapes.
By Qichen Zhou, Xiangyan Yu, Chongyang Zeng, Sarah Stadlmayr, Sang Lee, Wenqi Wang, Yushu Wang, John Kim, Jens Najorka, Xiaofeng Wang, Christine Radtke, Wei Shen Tan, Han Zhang, Dimitrios G. Papageorgiou, DAVID KAPLAN, Nicholas A. Kotov, Chunmei Li, Emiliano Bilotti, Bumchul Park, Brooke Longo, Glenn Leung, Silvestre Pinho
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Nature
Verified
Retraction Note: LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer
Retraction Note to: Cancer Gene Therapy https://doi.org/10.1038/s41417-017-0003-0, published online 12 December 2017 The authors have retracted this article following concerns raised on PubPeer and by the journal regarding the reliability of Figure 3D. The authors have re-examined the work and confirmed that the presented image in Figure 3D could not be verified due to the inability to access original source files.
Computer Science > Cryptography and Security
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Data-driven sustainability assessment of global water management using an Entropy–TOPSIS approach
Abstract Introduction: Increasing freshwater stress, climatic variability, and population-driven water demand have intensified the need for robust and data-driven frameworks for sustainable water management. This study evaluates global water management performance by integrating an objective multi criteria decision making approach with a comprehensive open access water consumption dataset.
Computer Science > Artificial Intelligence
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
The Impact of Integration Between Innovation Chain, Industrial Chain, and Talent Chain on Urban Carbon Productivity: Evidence from China
This open access article is published under a , which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
A prospective multicenter trial of deep learning auto-segmentation for organs at risk in thoracic radiotherapy
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Abstract Widespread clinical implementation of rapidly evolving auto-segmentation tools remains constrained by a scarcity of high-quality prospective evidence. Here we show the results of a prospective, multicenter, observational trial (NCT05787522) evaluating the clinical performance of a deep learning model (iCurveE) for artificial intelligence (AI)-assisted delineation of organs at risk (OARs) in thoracic and breast cancer radiotherapy.
By Gengmin Niu, Yong Guan, Yifan Zhang, Yongchun Song, Songfeng Li, Tao Liu, Sheng Huang, Jingru Chen, Xiaofeng Wang, Wencheng Zhang, Junjie Chen, Jing Huang, Kunyu Yang, Jianzhong Cao, Hongqin Yuan, Xiaofeng Pei, Dongmei Wu, Yang Nan, Yao Lu, Lujun Zhao, Zhiyong Yuan, Maobin Meng, Yeman Liu, Yintao Fu, Donghe Zhao, Shuanshuan Guo, Ziye Yan
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Nature
Verified
Μπορούν οι μύκητες να ελέγξουν τον καιρό; Νέα έρευνα ανοίγει τον δρόμο
Οι μύκητες ενδέχεται να κρύβουν ένα ελάχιστα γνωστό «κλειδί» για τον σχηματισμό πάγου στα σύννεφα. Μπορούν οι μύκητες να επηρεάσουν τον καιρό; Μπορεί να ακούγεται απίθανο, αλλά μια νέα έρευνα υποδηλώνει ότι ίσως και να ισχύει. Μια διεθνής ομάδα ερευνητών, συμπεριλαμβανομένων των επιστημόνων του Virginia Tech, Xiaofeng Wang και Boris A. Vinatzer, εντόπισε πρωτεΐνες μυκήτων που μπορούν να πυροδοτήσουν τον σχηματισμό πάγου σε σχετικά υψηλές υπό του μηδενός θερμοκρασίες.
Reliability analysis and optimal maintenance decision for a repairable system with multiple failure modes
Equipment failures in large-scale manufacturing systems are triggered by diverse stresses or factors. If failures of all types are jumbled together without clear analysis and classification, technicians misjudge strategies, incurring unnecessary costs. Therefore, systematically categorizing failures and prescribing corresponding maintenance actions are critical for optimal maintenance decision-making.
Influence of cracks on the response characteristics of explosive columns under drop-weight impact
To investigate the influence of cracks on the response characteristics of explosive columns under drop-weight impact, a finite element simulation model of a drop-weight impacting an RDX-based aluminized explosive column was established. Columns without cracks, with a close fit, with 1 mm cracks, and with 1.5 mm cracks were prepared, and drop-weight impact loading experiments were conducted.
A bionic robotic trunk with tensegrity-enabled elephant-comparable stiffness variability for assisted daily living - Nature Communications
Abstract Elephant trunks can rapidly vary their stiffness over a broad range, seamlessly switching between soft states for dexterous operation and rigid states for load-bearing tasks. Despite extensive efforts to mimic this stiffness variability using various approaches, such as jamming structures and phase-change materials, existing bionic robots are limited to narrow tunable stiffness ranges and/or slow switching frequencies.
Policy-Guided Model Predictive Path Integral for Safe Manipulator Trajectory Planning with Constrained Discounted Reinforcement Learning
Submitted: 27 February 2026 You are already at the latest version Aiming at the problems of difficult hard constraint enforcement, weak environmental generalization ability in the safe trajectory planning of manipulators in complex environments, a Policy-Guided Model Predictive Path Integral (PG-MPPI) planning framework is proposed.
The Impact of Age on Six-Minute Walk Distance, Functional Class, and Right Ventricular Function in Pulmonary Arterial Hypertension
Key words 6MWT functional class pulmonary arterial hypertension right ventricular function risk stratification six-minute walk test Get full text access Log in, subscribe or purchase for full access. References 1. Humbert, M. ∙ Kovacs, G. ∙ Hoeper, M.M. ... ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension Eur Respir J. 2022; 61(1) 2023 2. Tonelli, A.R. ∙ Arelli, V. ∙ Minai, O.A. ... Causes and circumstances of death in pulmonary arterial hypertension Am J Respir Crit Care Med.
RBP4 interferes with tongue squamous cell carcinoma progression by inhibiting the PI3K/AKT signaling pathway and promoting macrophage M1-type polarization | Scientific Reports
Abstract Tongue squamous cell carcinoma (TSCC) is a common type of oral mucosal epithelial malignancy that can severely affect patient quality of life. Therefore, novel therapeutic strategies for TSCC are needed. This study aimed to investigate the role and mechanism of action of retinol-binding protein 4 (RBP4) in TSCC progression and its effect on tumor-associated macrophages.
Bryostatin enhances CD20 CAR-T therapy efficacy against B-cell lymphoma by overcoming trogocytosis-mediated antigen loss
1 Introduction ALL is the second most common acute leukemia in adults, with over 6,500 new U.S. cases each year and approximately 75% of cases derived from B-cell precursors. Despite the use of intensive chemotherapy and allogeneic stem cell transplantation, long-term remission is achieved in only about 40% of patients (1), leaving a substantial portion with limited durable benefit. Consequently, the management of relapsed or refractory (R/R) B-ALL represents a significant unmet medical need.
Cone Beam CT with Integration Improves Diagnostic Yield of Bronchoscopic Peripheral Pulmonary Lesion Biopsies
Keywords 3D imaging cone beam CT imaging integration lung nodule peripheral pulmonary lesion robotic bronchoscopy Get full text access Log in, subscribe or purchase for full access. References 1. Siegel, R.L. ∙ Miller, K.D. ∙ Wagle, N.S. ... Cancer statistics, 2023 CA Cancer J Clin. 2023; 73:17-48 2. Gould, M.K. ∙ Tang, T. ∙ Liu, I.L. ... Recent Trends in the Identification of Incidental Pulmonary Nodules Am J Respir Crit Care Med. 2015; 192:1208-1214 3. Gould, M.K. ∙ Donington, J. ∙ Lynch, W.R. ...
Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity
Abstract Click to copy section linkSection link copied! Cavities at protein-protein interaction interfaces are considered “undruggable” because their shallow or large geometries hinder stable binding by small molecules. Overcoming this limitation is essential for developing new therapies. Cerium oxide nanoparticles (CeO2NPs) of a suitable size can occupy the 5 nm central cavity of the SARS-CoV-2 spike (S) trimer, thereby inhibiting infection.
Enhancing Study Design and Analysis of MR Imaging Markers Through Measurement Error Modeling
1 Introduction Imaging has a fundamental role in medical decision-making, supporting clinical workflow from disease diagnosis to treatment planning, and outcome monitoring [1, 2]. Imaging studies provide non-invasive, data-rich measurements that, when analyzed together with disease characteristics and outcomes, may uncover specific patterns to guide clinical care.
Trojan Horse Effect of Biologically Aged Microplastics-An Intracellular Carrier of LPS for Licensing Noncanonical Inflammasome Activation
Environmental Science & Technology Cite this: Environ. Sci. Technol. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Fabrication of low-tortuosity thick electrodes with low material loss by temporally shaped ultraviolet femtosecond laser - Nature Communications
Abstract Conventional battery electrodes exhibit high tortuosity, which severely impedes ion transport. This limitation restricts electrode thickness, decreases power density, and shortens battery lifetime. Fabricating through-holes can reduce tortuosity, but existing methods are generally complex with poor space utilization. Here, an array of high-density through-holes are fabricated by temporally shaped ultraviolet femtosecond laser.
Smart Wound Management System Capable of On‐Chip Machine Learning and Closed‐Loop Therapeutic Feedback
Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adfm72951-sup-0001-SuppMat.docx6.9 MB Supporting Information adfm72951-sup-0002-MovieS1.mp412.7 MB Supplemental Movie 1 References 1, , , Adv. Funct. Mater. 2022, 32, 2111022. 2, , , JAMA, J. Am. Med. Assoc. 2018, 320, 1481. 3, Adv.
Case Series of Bacteremia Associated with Probiotic Use in Children after Cardiac Surgery, China
Depoorter L, Vandenplas Y. Probiotics in pediatrics. A review and practical guide. Nutrients. 2021;13:2176. DOIPubMedGoogle Scholar Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H, van der Schoor SRD, et al.; Multispecies Probiotic in AAD Study Group. Multispecies probiotic for the prevention of antibiotic-associated diarrhea in children: a randomized clinical trial. JAMA Pediatr. 2022;176:860–6.
[2512.11125] Design and Experimental Validation of Closed-Form CBF-Based Safe Control for Stewart Platform Under Multiple Constraints
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Study on the physical properties, anti-aging properties, and rheological characteristics of graphene oxide/rubber powder composite modified asphalt
ORIGINAL RESEARCH article Volume 12 - 2025 | https://doi.org/10.3389/fmats.2025.1758696 This article is part of the Research TopicFunctional Materials for Sustainable Pavement Engineering: Multi-scale Design and Environmental IntegrationView all 8 articles 1 Introduction Approximately 1.4 billion tires are used annually due to the fast growth of the global automotive industry and the ongoing rise in the number of cars in use, which results in an increasing amount of waste rubber tires (Li et...
Dual‐Pathway Modulated Biomimetic Conductive Hydrogel Conduit Enables Spatiotemporal Co‐Delivery of Engineered C3‐Exosomes and TT‐10 to Potentiate Optic Nerve Regeneration
Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adfm73186-sup-0001-SuppMat.docx40 MB Supporting Information References 1, , , Science 2017, 356, 1031. 2, , , , , , , , , , , , Cell Death Dis. 2023, 14, 570. 3, , , , , , , , , , , , , , , , , , Sci. Adv. 2024, 10, ado0866.
Electromyography Signal Classification With Artificial Intelligence for Detection of Neuromuscular Disorders Using a Large Clinically‐Acquired Database
Conflicts of Interest Authors M.T., S.H., X.W., and J.A.M. have received support from the Cleveland Clinic Office of Research Development, Lerner Research Institute-Artificial Intelligence in Medicine (AIM) Internal Funding Program Grant. The remaining author (A.S.) declares no conflicts of interest. Data Availability Statement Research data are not shared.
Impact of a multifaceted prevention strategy on invasive fungal infect
Back to Journals » Infection and Drug Resistance » Volume 19 Authors Wang X, Li S, Huo D , Chen Q, Wang W, Zhang Q, Gao Y, Yan T, Wang X Received 25 November 2025 Accepted for publication 20 February 2026 Published 27 February 2026 Volume 2026:19 Pages 1—9 DOI https://doi.org/10.2147/IDR.S575009 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
IndirectAD: Practical Data Poisoning Attacks against Recommender Systems for Item Promotion
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Surfaced‐based detection of focal cortical dysplasia using magnetic resonance fingerprinting and machine learning
We developed a two-stage ML framework for FCD detection using surface-based processing of 3D MRF, including 44 FCD patients and 70 healthy controls. T1w + MRF + FLAIR yielded 71.4% sensitivity, 4.7 FPs/patient, and 1.1 FPs/control. The classification effectively reduced FPs in patients and controls. Sensitivity was higher in type II and seizure-free patients; detection probabilities were greater for TP than FP clusters.
VLA-R1: Enhancing Reasoning in Vision-Language-Action Models
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
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