Yichen Li
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Articles by Yichen Li
Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data
Abstract Despite prolific genomic data from individuals with Alzheimer’s disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of European ancestry and 7 for African ancestry. This included epoxide hydrolase 2 (EPHX2), for which we identified a protective missense variant (p.Arg287Gln).
Association among first-aid literacy, training and life meaning: a KAP study of first-year undergraduates at a comprehensive university in China
Abstract Background: First-aid education has been widely implemented in universities, with first-aid literacy serving as key evaluation indicators. Meaning in life (MIL) positively influences health awareness and prosocial behavior; however, its relationship with first-aid literacy remains insufficiently explored.
Computer Science > Machine Learning
Accurate prediction of unsteady separated flows is challenging because the aerodynamic loads depend on nonlinear separation and vortex-shedding dynamics. Although high-fidelity CFD resolves these mechanisms, its cost limits repeated use in design and control. Standard field-level surrogate training, however, does not distinguish the flow regions that contribute most strongly to the aerodynamic loads.
Rising vapor pressure deficit and fuel availability exacerbate the dispersion of intra-annual burned area
Abstract Continuing climate warming is creating more favorable burning conditions both within and outside the core fire seasons, such as drier vegetation, increased fuel load, and more frequent lightning. These changes are expected to reshape wildfire regimes, with profound implications for wildfire management practices and the terrestrial carbon cycle.
Advances in the Intestinal Toxicity of Microcystin-LR
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing is not applicable to this article, as no datasets were generated or analyzed during the current study. References , , and . 2019. “The Role of the Gut Microbiota in Colorectal Cancer Causation.” International Journal of Molecular Sciences 20, no. 21: 5295. https://doi.org/10.3390/ijms20215295. , , , , and . 2004.
Ultrastretchable Electrochromic Hydrogel and Asymmetric Electrodes for Novel Flexible and Stretchable Passive-Matrix and Active-Matrix Dynamic Information Displays
1 Introduction Wearable flexible electronics have witnessed rapid advancement in recent years across multiple applications including sensing [1-3], health monitoring [4-6], and human-machine interface (HMI) [7-10]. Flexible sensors, touch panels, and other input devices have been developed for HMI [11-14], which translate human physiological or motion signals into computable data, enabling the interpretation of human actions.
Synthetic Biology of Sclareol: From the Plant Biosynthetic Pathway to Engineered Microbial and Photosynthetic Chassis
BTS1 geranylgeranyl pyrophosphate synthase DMAPP dimethylallyl pyrophosphate ERG20F96C farnesyl pyrophosphate synthase variant ERG9 squalene synthase FPP farnesyl diphosphate GGPP geranylgeranyl diphosphate GGPPS geranylgeranyl diphosphate synthase GPP geranyl diphosphate HMGR hydroxymethylglutaryl-CoA reductase IPP isopentenyl pyrophosphate LDPP labda-13-en-8-ol diphosphate SsLPPS Salvia sclarea labda-13-en-8-ol diphosphate synthase SsSS Salvia sclarea sclareol synthase tHMG1 truncated...
Oligonucleotide–siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease partly caused by gain-of-function mutations in superoxide dismutase 1 (SOD1). Here we developed RAG-17, an siRNA-targeting SOD1, using an accessory oligonucleotide conjugate platform for enhanced central nervous system (CNS) delivery.
Multiphysics Coupled Response of Stress and Seepage in Coal Under Borehole Disturbance and Optimization of Borehole Parameters
1 Introduction In coal seams with high gas content and pressure, coal and gas outbursts, gas explosions, and other gas-related hazards are prone to occur during mining. Yuan emphasized that coordinated coal and gas exploitation is an important strategy for gas-hazard prevention and control in deep coal mining [1]. Guo et al. analyzed gas accidents in Chinese coal mines and showed that gas-related accidents remain a major threat to mine safety [2]. Guo, Wang, et al.
Cerebrospinal Fluid Pharmacokinetics of Tigecycline in Lumbar and Ventricular Compartments After Lumbar Intrathecal Administration: A Three-Patient Case Series
Back to Journals » Infection and Drug Resistance » Volume 19 Authors Duan M , Wang R, Li Y, Zhao P Received 14 June 2026 Accepted for publication 14 September 2026 Published 23 September 2026 Volume 2026:19 631435 DOI https://doi.org/10.2147/IDR.S631435 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Sandip Patil Menglian Duan,1,2,* Rong Wang,1,* Yichen Li,1,3,* Penglai Zhao1,2 1Department of...
Ultralow chromium doping enables all-PbSe thermoelectric cooling
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Editor’s summary Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Chromium doping of the semiconductor lead selenide (PbSe) leads to symmetric Seebeck coefficients and thermal expansion of n- and p-type materials that enables a practical thermoelectric cooling device.
By Takuji Usui, Andrew Newman, Akshaye A. Bhambore, Shibo Liu, Yu Tian, Yi Wen, Shulin Bai, Bingchao Qin, Haonan Shi, Lizhong Su, Xiaokun Feng, Rong Liu, Dezheng Gao, Yang Jin, Yixuan Hu, Tian Gao, Dongrui Liu, Yichen Li, Yumo Zhu, Shaowei Han, Linlong Xing, Sining Wang, Xiang Gao, Yongjin Chen, Yongxin Qin
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Science Magazine
Verified
Computer Science > Information Retrieval
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
High-entropy 1D halide perovskite piezoelectrics found by megalibrary synthesis and rapid nonlinear optical screening
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Piezoelectric molecular crystals offer excellent compositional and structural tunability and sustainable processability. However, their discovery is slow, primarily due to the serial synthesis and screening processes used.
Entropy-Stabilized Diamondoid AgCdInSe 3 with Ultralow Thermal Conductivity and High Carrier Mobility for Thermoelectrics Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Recently, diamondoid thermoelectric materials have attracted widespread attention owing to their unique transport properties and high lattice compatibility, which provide a promising platform for simultaneously tuning electron and phonon transport through compositional modulation.
Relationship between digital health literacy and self-assessment of health among older adults in Xuzhou City: based on the mediating effect of health self-management
Abstract Background: With the global rise in aging populations and the proliferation of digital technologies, digital health literacy has emerged as a critical determinant of older adults’ ability to access health information and enhance their health outcomes. This study investigates the complex interplay and mechanisms linking digital health literacy, health self-management, and self-assessed physical health among older adults in Xuzhou, China.
[2602.12486] Human-Like Coarse Object Representations in Vision Models
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Circular RNA circNUP214 serves as a microRNA-31 sponge to promote the progression of myasthenia gravis through NFAT5
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Abstract Myasthenia gravis (MG) is an autoimmune disease driven by autoantibodies targeting the neuromuscular junction, leading to muscle weakness. Although emerging evidence implicates circular RNAs (circRNAs) in MG, their specific regulatory mechanisms remain largely unknown. In particular, the role of circNUP214 in MG has not been characterized. CircNUP214 expression in PBMCs and CD4+ T cells from MG patients and healthy controls was determined by qRT-PCR.
By Fanfan Xu, Xiaotong Kong, Shanshan Peng, Lifang Li, Wenqi Tian, Yichen Li, Ying Li, Jingyan Niu, Nan Zhang Verified, Huixue Zhang, Lihua Wang, Hanlu Cai
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Frontiers
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
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Main text (Cell 186, 786–802.e1–e15; February 16, 2023) In our original published article, we performed western blots and imaging of induced motor neurons (iMNs) to elucidate the mechanism through which PIKFYVE inhibition causes secretion and clearance of aggregation-prone proteins such as phosphorylated TDP-43 (pTDP-43). Since publication, we have become aware of 3 errors in figure legends or images that we are now correcting.
By Shu-Ting Hung, Gabriel R. Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Sarah Beth Perry, Jonathan Chang, Alexander Couto, Jesse D. Lai, Yichen Li, Eric A. Hendricks, Berislav V. Zlokovic, Dion Dickman, J. Parker, Daniela C. Zarnescu, Fen-Biao Gao, Justin Ichida, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Duhaime, Claudia Maios, Joscany Perez, Samuel V. Alworth
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Cell Press
Verified
Construction of the Dictamnine Framework via an Alkynylation/Cyclization Cascade Enabled by Quinolinone-Fused Cyclic Diaryliodonium Salts
Organic Letters Cite this: Org. Lett. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Construction of the Dictamnine Framework via an Alkynylation/Cyclization Cascade Enabled by Quinolinone-Fused Cyclic Diaryliodonium Salts
Cite Jump to ExpandCollapse LetterDecember 31, 2025 Construction of the Dictamnine Framework via an Alkynylation/Cyclization Cascade Enabled by Quinolinone-Fused Cyclic Diaryliodonium Salts Click to copy article linkArticle link copied! Kaitao Huang Kaitao Huang Department of Nuclear Medicine, First School of Clinical Medicine, First Affiliated Hospital of Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou 510080, China School of Pharmacy, Guangdong...
[2512.14157] Incentivizing Tool-augmented Thinking with Images for Medical Image Analysis
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Temporal network analysis of comorbidities among people with HIV in South Carolina
INTRODUCTION With advancements in antiretroviral therapy (ART), life expectancy among people with HIV has increased significantly [1], with over half of people with HIV in the United States aged 50 years and older [2]. With increasing longevity, people with HIV face a growing burden of comorbidities [3, 4], leading to a shift from managing HIV itself to addressing the rising comorbidity challenge [5].
Superior Energy‐Storage Performance in Sandwich‐Structured AgNbO3‐Based Ceramics
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma71345-sup-0001-SuppMat.docx1.1 MB Supporting Information References 1, , , , , , , , , , , Nature 2015, 523, 576. 2, , , , , , , , , , , , , , , , , , Nat. Mater. 2022, 21, 1074. 3, , , , , , , , , , , , , , , Science 2019, 365, 578. 4, , , , , Adv. Mater. 2017, 29, 1701824. 5, , , , , , , , Energy Storage Mater. 2021, 34, 417. 6, , , , , , , , , , , Nat. Commun. 2020, 11, 4824.
BisBINOL-Based Fluorescent Probes: Effect of Alkane Linkers and Chemo- and Enantioselective Recognition of Arginine
1. Introduction Click to copy section linkSection link copied! Development of chemoselective as well as enantioselective fluorescent probes for amino acids has received significant attention in recent years because of the importance of amino acids in both nature and organic synthesis and also the advantages of the fluorescence-based detection such as easily available instrument, high sensitivity and potential for online and remote sensing.
Reversible Metal Electrodeposition Enabled by Composites of PEDOT:PSS/MXene for Durable Smart Windows with Broadband Electromagnetic Wave Modulation
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll70713-sup-0001-SuppMat.docx4.7 MB Supporting Information References 1, , , , Chem. Rev. 2022, 122, 14679. 2, , , , , Mater. Sci. Eng. R Rep. 2020, 140, 100524. 3, , , , , , , , , , Nano Energy 2020, 78, 105199. 4, , , Chem. Soc. Rev. 2020, 49, 8687. 5, , Adv. Funct. Mater. 2024, 35, 2407439. 6, , , Small 2025, 21, 2410283. 7, , , , , , , Nano-Micro Lett. 2023, 15, 240. 8, , , , , , J. Mater. Sci. Technol.
Realizing High ZTave in N‐Type Diamondoid AgInSe2 Thermoelectrics via Lone‐Pair Electrons and Isomorphous Alloy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202506188-sup-0001-SuppMat.docx9.8 MB Supporting Information References 1, , , , , , , et al., J. Phys.: Mater. 2023, 6, 042501. 2, , , Acta Metall. Sin-Engl. 2025, 38, 707. 3, , , , , , , , , Energy Environ. Sci. 2024, 17, 2588. 4, , , Science 2024, 386, adp2444. 5, , , , , , Science 2025, 387, 845. 6, , , , Science 2024, 384, 757. 7, , , , , , , , , , , , , , , , , , , , Science 2025, 387, 202.
Data quality and uncertainty issues in flood prediction: a systematic review
ABSTRACT The twenty-first century has witnessed an increase in the frequency and severity of flood events, amplifying the consequences of data quality and uncertainty in flood prediction. This study conducts a systematic literature review to critically examine the challenges associated with the quality and uncertainty of diverse data types related to flood prediction, evaluate existing mitigation strategies, and identify future research directions.
Construction of a Yeast Protein-Chitooligosaccharide W/O/W Emulsion System for Carrying and Stabilization of Betacyanins
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A Systematic Survey on Federated Sequential Recommendation
You are already at the latest version Sequential recommendation is an advanced recommendation technique that utilizes the sequence of user behaviors to generate personalized suggestions by modeling the temporal dependencies and patterns in user preferences. However, it requires a server to centrally collect users' data, which poses a threat to the data privacy of different users.
Potential Dependent Degradation of Spinel LiMn2O4 (LMO) and Related Structures Assessed via Manganese- and Oxygen-Sensitive Scanning Electrochemical Microscopy
Potential Dependent Degradation of Spinel LiMn2O4 (LMO) and Related Structures Assessed via Manganese- and Oxygen-Sensitive Scanning Electrochemical Microscopy Manganese dissolution has been a long-standing problem that limits the widespread application of Mn-based Li-ion battery (LIB) cathodes, despite their low cost and potential use in Li-rich cathodes.
[2503.04557] Learning Generalizable Language-Conditioned Cloth Manipulation from Long Demonstrations
Tailoring the Structural Evolution of Multi‐Electron Redox Conversions via Strong Selenium-Carbon Interaction for Robust Aqueous Copper‐Ion Batteries
1 Introduction Aqueous metal-ion batteries attract extensive research interest because of their excellent safety, design flexibilities, low costs, and environmental friendliness.[1] Among the various energy storage devices based on multivalent aqueous metal ions, metal-sulfur (M-S) battery systems involve multi-electron phase-conversion redox reactions with high theoretical capacities.
GaN‐Based Vertical‐Cavity‐Surface Emitting Lasers with Polarization‐Induced Interface Charges and Bulk Charges to Manage the Carrier Injection
Conflict of Interest The authors declare no conflict of interest. References 1 , , , , , , , , , Prog. Quantum Electron. 2018, 57, 1. 2 , , , , , in Proc. 55th Electronic Components and Technology Conf., Vol. 1 and 2, IEEE, Lake Buena Vista, FL, June 2005, p. 1353. 3 , , , IEEE Photonics Technol. Lett. 2020, 32, 1277. 4 , , , , , , , , , , , , Biomed. Opt. Express 2013, 4, 4799. 5 , , , , , AIP Adv. 2023, 13, 015105. 6 , , , J. Appl. Phys. 2010, 108, 043110. 7 , , , , , , , , , , IEEE Trans. Nanotechnol.
Better Knowledge Enhancement for Privacy‐Preserving Cross‐Project Defect Prediction
References 1, , and , “Predicting the Location and Number of Faults in Large Software Systems,” IEEE Transactions on Software Engineering 31, no. 4 (2005): 340–355, https://doi.org/10.1109/TSE.2005.49. 2, , , and , “Benchmarking Classification Models for Software Defect Prediction: A Proposed Framework and Novel Findings,” IEEE Transactions on Software Engineering 34, no. 4 (2008): 485–496, https://doi.org/10.1109/TSE.2008.35.
Quadruple-band synglisis enables high thermoelectric efficiency in earth-abundant tin sulfide crystals
Reactions of Unsymmetric Chiral Dialdehydes with Lysine: Regio‐ and Enantioselective Macrocyclization and Fluorescent Sensing
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Comparison of the Effects of NaOH and Deep Eutectic Solvent Catalyzed Tobacco Stock Lignin Isolation: Chemical Structure and Thermal Characteristics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
SARS-CoV-2 Assembly: Gaining Infectivity and Beyond
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Lactoferrin-Based Heteroprotein Systems, From Their Formation Mechanism, Properties, To Applications
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