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Articles by Yu Cheng
Physiologically based pharmacokinetic modelling and dose optimization of tedizolid in paediatric patients
CONFLICT OF INTEREST STATEMENT Xueyong Li, Yu Cheng, Rongqi Lin, Jingping Shao, Luqi Lou, Tian Lin, Xuemei Wu and Hongqing Qiu have no conflicts of interest that are directly relevant to the content of this study. DATA AVAILABILITY STATEMENT All datasets analysed in the present study are included in the article/Supporting Information. Supporting Information Filename Description bcp70845-sup-0001-Supplementary_Material.docxWord 2007 document , 26.3 KB Table S1.
Targeting mitochondrial EGFR by CTAB in triple-negative breast cancer
Abstract EGFR is an oncogenic factor highly expressed in multiple tumor types. While previous research has primarily focused on plasma membrane-localized EGFR, the role of its mitochondrial localization (mitoEGFR) in breast cancer remains poorly understood. This study reveals that EGFR is enriched in mitochondria in triple-negative breast cancer (TNBC), with high mitoEGFR expression closely associated with aggressive phenotypes.
Cabbage-Inspired Graphene Aerogel Microspheres as Efficient Micro-Reactors for High-Yield Production of Short Carbon Nanotubes Toward Li + Battery
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll75860-sup-0001-SuppMat.docx1.6 MB Supporting File: smll75860-sup-0001-SuppMat.docx. References 1, , , , , and , “Graphite: The New Critical Mineral,” Nature Reviews Materials 11 (2026): 65–78, https://doi.org/10.1038/s41578-025-00848-5.
Deepfake Detection Beyond Benchmark Accuracy: Generalization, Robustness, and Reproducibility
Submitted: 14 September 2026 Posted: 16 September 2026 You are already at the latest version Deepfake detection has become a central problem in computer vision and multimedia security as generative systems make synthetic images, video, and audio increasingly accessible. This systematic literature review presents a large-scale, per-paper full-text analysis of 1,410 papers published from January 2018 through the January 2026 cutoff.
Impact of body mass index on perioperative outcomes and short-term recovery profiles of single-incision laparoscopic appendectomy: a propensity score-matched analysis
Abstract Objective: This study aimed to evaluate the association between stratified body mass index (BMI) and the intraoperative outcomes and short-term postoperative recovery profiles of patients undergoing single-incision laparoscopic appendectomy (SILA), utilizing a propensity score-matched (PSM) analysis to minimize baseline selection bias and confounding clinical factors.
LGR5-positive fibroblasts orchestrate skin mechanoadaptation through JAK1 modulation
Abstract Mechanical adaptation is a fundamental yet poorly understood process in stromal tissue biology. Here, we identify a population of LGR5+ mechanically induced regulatory fibroblasts (LGR5+ MIRFs) in mouse and human dermis, whose induction requires a YAP/AP-1-dependent transcriptional program. LGR5+ MIRFs channel mechanical input toward adaptive tissue remodeling by coordinating extracellular matrix reorganization while restraining inflammation.
An eccentric massive protobinary assembled via a core-merger parabolic encounter
Abstract Most massive stars form in binary systems, which profoundly influence their subsequent evolution. However, how such systems form remains poorly understood, with several competing scenarios proposed, including disk fragmentation, core fragmentation and capture.
TGW1a locus simultaneously shortens growth duration and boosts grain yield in rice
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Modern cropping systems with multiple crops grown per year demand shorter growing periods per crop. However, these condensed crop durations often lead to lower yield. Using rice accessions with contrasting flowering time and grain yield, Li et al.
Structure, Stability, Spectroscopy and Chemical Bonding Analyses on the Novel X 6 (X = N, P, As, Sb, Bi) Molecules
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the of this article. Supporting Information Filename Description jcc70479-sup-0001-Supinfo.docxWord 2007 document , 5.5 MB Figure S1: Geometrical structures of selected low-lying isomers of N6 molecule searched by using the TGMin (v3.0) package interfaced with the xTB (v6.7.1) package.
ZCCHC10 as a novel prognostic biomarker associated with immune infiltration in breast cancer
Abstract CCHC zinc finger protein 10 (ZCCHC10) has been implicated in the progression of multiple malignancies, but its prognostic value and role in immune infiltration in breast cancer remain unclear. In this study, we systematically analyzed ZCCHC10 expression using public databases and validated the findings by immunohistochemistry. Associations with clinicopathological features and patient prognosis were assessed, and a prognostic nomogram was constructed.
Observation of the Single- and Double-Well Hydrogen Bonding in HSO 4 − • HX and H 2 SO 4 • X − (X = F, Cl, Br, I, At)
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the of this article. Supporting Information Filename Description qua70272-sup-0001-supinfo.docxWord 2007 document , 2.8 MB Figure S1: The geometric structures of HSO4− • H+ • X− (X = F, Cl, Br, I, At) complexes optimized at DFT B3LYP–D4/def2–TZVP level with dispersion corrections. The selected bond length is shown in Angstrom.
Turritopsis nutricula -Inspired Engineered Biomimetic Skin Promoting Aged Wound Repair via DAZAP1 Phase Separation-Related Mitochondrial Metabolism Reprogramming
1 Introduction Chronic wounds, including diabetic foot ulcers, venous leg ulcers, and pressure injuries, represent a devastating and escalating global health crisis [1-3]. Affecting millions worldwide, their prevalence is exacerbated by the global aging pandemic and rising rates of diabetes and obesity, imposing staggering morbidity, mortality, and socioeconomic costs estimated in the hundreds of billions annually [4-6].
DTX3 promotes anti-tumor immunity by inducing PD-L1 ubiquitination and is suppressed by p65/miR-222 in bladder cancer
Abstract The limited efficacy of programmed death ligand-1 (PD-L1)/programmed death 1 (PD-1) immunotherapy remains a major challenge in bladder cancer (BC). Here, we identified Deltex E3 ubiquitin ligase 3 (DTX3) as a negative regulator of PD-L1 expression through whole-exome sequencing (WES) and functional screening. DTX3 overexpression inhibited CD3⁺CD8⁺ T cell apoptosis via the PD-1/PD-L1 axis, increased IFN-γ secretion, and enhanced the anti-tumor effect of anti-PD-1 monoclonal antibody (mAb).
Iron/Manganese Oxide-Bound Nitrogen Suppresses Microbial Mediated Nitrate Reduction in Soil
1 Introduction The soil nitrogen cycle is a central driving force of productivity in farmland ecosystems, and its cycling efficiency directly affects both crop nitrogen use efficiency and environmental sustainability (Hartmann and Six 2023; Li et al. 2025). This process is predominantly mediated by microorganisms and is strongly regulated by the composition and concentration of different nitrogen forms in the soil (Kuypers et al. 2018; Tang et al. 2026).
比利時 QUUT - 金字塔模型組
比利時 QUUT - 金字塔模型組 材質：PP、產地：中國、適用年齡：3歲 尺寸: 22,5 x 22,5 x 9 cm、重量: ± 300 gr 到海邊孩子都會想蓋座美美的沙堡，但沒有工具輔助，孩子要堆疊沙堡其實很費力，QUUT 為此研發的金紫塔模型，只要填充沙子就能輕鬆蓋出一座堅固又漂亮的沙堡！給孩子滿滿的成就感。 蓋好的沙堡用點小巧思，加個軌道，放上一顆球，就有百變玩法！
ClareV: a contrastive learning framework for context-aware TRBV representations in TCR repertoires
Abstract Background: V gene segments of the T cell receptor (TCR) β chain (TRBV) are crucial for antigen recognition, yet previous studies have treated them as fixed categories and neglected repertoire-specific immune dynamics that inform functional diversity. Methods: We introduce ClareV, a contrastive learning framework that partitions T cell receptor repertoires into V gene-specific groups to extract data-driven embeddings capturing these dynamics.
Assessment of pelvic floor muscle training video information quality and associated factors on Douyin and Bilibili: a cross-sectional study
Abstract This study evaluated the information quality of pelvic floor muscle training (PFMT) videos on Douyin (the Chinese version of TikTok) and Bilibili and examined factors associated with higher-quality content. A cross-sectional analysis was conducted on 200 PFMT videos (100 per platform). Dissemination and engagement metrics were collected.
Mechanisms Influencing Pro-Environmental Behavior Among Outdoor Hikers an Integrated TPB–PMT Framework
You are already at the latest version The rapid expansion of outdoor hiking activities has increased pressure on natural ecosystems, and environmentally irresponsible behaviors by hikers have become an important source of environmental degradation. However, limited attention has been paid to the mechanisms driving pro-environmental behavior among outdoor hiking participants.
Design of UHMWPE Short Fiber‐Reinforced and Fabric‐Laminated Polyurethane Composites via a Synergistic Reinforcement Strategy
Record-Breaking Bridge Longer Than World's Tallest Building Just Opened
A view of the Danjiang Bridge under construction over the Tamsui River in January. Taiwan has officially opened the world’s longest asymmetric, single-mast bridge-the Danjiang Bridge, a landmark infrastructure project spanning the mouth of the Tamsui River in Taipei, the Taiwanese capital.
Computer Science > Cryptography and Security
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Suppressing M2 Macrophage Polarization by Glycine Combined with β-Elemene via the IL-6/JAK2/STAT3 Signaling Pathway to Inhibit Triple-Negative Breast Cancer Progression
Back to Journals » Breast Cancer: Targets and Therapy » Volume 18 Authors Li H, Cheng Y, Meng Y, Nan L, Huang S, Ling X, Lin X, Xie S Received 22 May 2026 Accepted for publication 14 July 2026 Published 22 July 2026 Volume 2026:18 626034 DOI https://doi.org/10.2147/BCTT.S626034 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Pranela Rameshwar Huan Li,1,* Yu Cheng,1,* Yanyun Meng,2 Liang Nan,1 Sicheng...
The dominance of turbulence over magnetism in the formation of massive star cluster seeds
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Abstract High-mass stars form in protoclusters, where gravo-magnetic processes elongate collapsing clouds and clumps preferentially perpendicular to magnetic (B) fields. Yet it remains unclear whether gravo-magnetic processes still govern the formation of 0.01-pc-scale condensations in massive star-forming protoclusters, which are crucial for understanding the stellar initial mass function and multiplicity.
By Junhao Liu, Patricio Sanhueza, Piyali Saha, Kaho Morii, Josep Miquel Girart, Qizhou Zhang, Fumitaka Nakamura, Paulo C. Cortés, Valeska Valdivia, Benoît Commerçon, Patrick Koch, Kate Pattle, Xing Lu, Janik Karoly, Manuel Fernández-López, Ian Stephens, Huei-Ru Vivien Chen, Chi-Yan Law, Keping Qiu, Shanghuo Li, Henrik Beuther, Eun Jung Chung, Jia-Wei Wang, Fernando A. Olguin, Yu Cheng, Jihye Hwang, Sandhyarani Panigrahy, Chakali Eswaraiah, Qiuyi Luo, Spandan Choudhury, Ji-Hyun Kang, Wenyu Jiao, Luis A Zapata, A-Ran Lyo
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Nature
Verified
Magnetic medical microrobots with memory-capable genetic circuits
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Autonomous microrobots can reach hard-to-access regions in the human body for minimally invasive therapy. However, their microscale size limits the integration of on-board memory, making their operation dependent on external controls.
By Xuhong Yang, David Anthony Verified, Dazhi Wang, Haotian Chen, Yujun Chen, Yingying Wang, Peng Ning, Yingze Li, Yuantai Sun, Xueyan Wei, Rui Gao, Xing Fan, Feng Tao, Zihan Guo, Weicheng Gu, Zhenguang Li, Xinjian Fan, Zhen Yin, Yu Cheng
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Science Magazine
Verified
Clinical experience with eravacycline-based combination therapy for carbapenem-resistant Acinetobacter baumannii pneumonia: a prospective observational case series
Abstract Objective: This study was conducted to investigate the clinical response, safety, and pharmacokinetic (PK) profile of eravacycline-based combination therapies in patients with pulmonary infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB). Methods: A prospective observational case series was conducted on patients with CRAB pneumonia treated at Fujian Medical University Union Hospital between February 2024 and August 2025.
Taiwan's Lai arrives in Eswatini, defying China-backed blockade
Taiwan's President Lai Ching-te attends an exclusive interview with AFP at the Presidential Office Building in Taipei on Feb. 10, 2026. (Yu Chen Cheng/AFP/Getty Images/TNS) Taiwan's President Lai Ching-te arrived at Eswatini on Saturday after an earlier trip was derailed by several China-friendly African countries closing their airspace to his aircraft.
Taiwanese President Lai Ching-te, pictured in February, said 'unexpected external forces' had forced the suspension of his previously planned trip to Eswatini
Taiwanese President Lai Ching-te on Saturday announced his arrival in Eswatini -- Taipei's only diplomatic ally in Africa -- after an earlier trip was cancelled when several countries revoked overflight permits.
Taiwanese President Lai Ching-te, pictured in February, said 'unexpected external forces' had forced the suspension of his previously planned trip to Eswatini
The United States slammed China's "intimidation campaign" on Wednesday after several African countries were reportedly pressured by Beijing to derail an official trip by Taiwan's President Lai Ching-te by revoking overflight permits.
GMHEA: A New Software for the Multi-Variable Optimization of High-Entropy Alloy by the Improved Genetic Algorithm and Effective Medium Theory
Y.-Y.Zhang, Y.Cheng, and S.-W.Zhang, “GMHEA: A New Software for the Multi-Variable Optimization of High-Entropy Alloy by the Improved Genetic Algorithm and Effective Medium Theory,” Journal of Computational Chemistry47, no. 11 (2026): e70385, https://doi.org/10.1002/jcc.70385. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the of this article.
Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
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Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
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Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
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Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
To view our latest edition click the image on the left. To view our latest Special Section click the image on the left. Articles Images Videos Commented Sorry, there are no recent results for popular videos. Right Now 59° Clear Humidity: 88% Feels Like: 58° Heat Index: 59° Wind: 6 mph Wind Chill: 58° UV Index: 6 High Sunrise: 06:08:30 AM Sunset: 07:52:18 PM Dew Point: 55° Visibility: 10 mi Today Partly cloudy this morning, then becoming cloudy during the afternoon. High 81F. Winds S at 15 to 25 mph.
Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
Taiwan's President Lai Ching-te was forced to postpone his trip to Eswatini -- the island's only diplomatic ally in Africa -- after "Seychelles, Mauritius and Madagascar unexpectedly and without prior notice revoked the charter's overflight permits"
President Lai Ching-te was due to visit Eswatini from April 22 to 26
Taiwanese President Lai Ching-te has postponed an official trip to Eswatini, the democratic island's only diplomatic ally in Africa, after several countries revoked overflight permits following "intense pressure" from China, a senior aide said Tuesday.
President Lai Ching-te was due to visit Eswatini from April 22 to 26
The Daily Our flagship newsletter. Get our front page stories each morning as well as the latest updates each afternoon during the week + more in-depth weekend editions on Saturdays & Sundays. News Alerts Get the latest need-to-know information delivered to your inbox as it happens. Health Matters-North Mississippi Health Services Get a free dose of heath care news and wellness tips delivered to your inbox each Tuesday morning. Powered by North Mississippi Health Services.
President Lai Ching-te was due to visit Eswatini from April 22 to 26
Taiwanese President Lai Ching-te has postponed an official trip to Eswatini, the democratic island's only diplomatic ally in Africa, after several countries revoked overflight permits following "intense pressure" from China, a senior aide said Tuesday.
President Lai Ching-te was due to visit Eswatini from April 22 to 26
To view our latest edition click the image on the left. To view our latest Special Section click the image on the left. Articles Images Videos Commented Sorry, there are no recent results for popular videos. Right Now 74° Sunny Humidity: 44% Feels Like: 74° Heat Index: 74° Wind: 12 mph Wind Chill: 74° UV Index: 7 High Sunrise: 06:11:32 AM Sunset: 07:50:02 PM Dew Point: 50° Visibility: 10 mi Today Partly cloudy. High 78F. Winds WSW at 10 to 20 mph. Tonight Clear to partly cloudy. Low 51F.
How green marathons are associated with pro-sustainable behavior: the chain-mediating roles of environmental empathy and self-sustainable identity
Abstract The global rise of green marathons has sparked interest in their potential to be associated with pro-sustainable behaviors. However, the mechanisms underlying this process are not well understood.
Computer Science > Computer Vision and Pattern Recognition
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Design of natural frequency solution method based on the lateral disturbance modeling of slurry discharge pipelines in slurry shield machines
Abstract This study applies classical fluid-structure interaction (FSI) principles to analyze the lateral deflection and natural frequency of slurry discharge pipelines in slurry shield machines.
Computer Science > Computer Vision and Pattern Recognition
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Case Report: Strangulated transverse colon inguinal hernia complicated by cecal perforation in a patient with sclerosing mesenteritis
Abstract Background: Transverse colon herniation into the inguinal canal is exceptionally rare. The transverse colon, being entirely intraperitoneal and suspended by the transverse mesocolon, is anatomically resistant to inferior displacement. Few cases of transverse colon herniation into inguinal or femoral hernias are documented, most occurring in the presence of giant hernia defects, malignancy, or concurrent omental herniation.
Computer Science > Artificial Intelligence
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
LightningCreeper / MIA like 4
Memory Intelligence Agent (MIA) is a memory framework designed for deep research agents (DRAs). It transforms agents from "passive record-keepers" into "active strategists" using a sophisticated Manager-Planner-Executor architecture.
PSMD11 stabilizes PGM3 by antagonizing Parkin to promote bladder cancer progression through energy metabolism reprogramming
Abstract Bladder cancer (BCa), a highly prevalent and aggressive tumor of the urinary system, typically exhibits poor clinical outcomes, particularly in advanced stages where therapeutic efficacy remains inadequate. A key characteristic of tumorigenesis, metabolic reprogramming, contributes substantially to cancer cell proliferation and metastatic progression.
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