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Articles by JIng Lu
An open-access CT-based 3D anatomical dataset of extant sharks (Selachii) across all major lineages
Abstract Sharks exhibit extraordinary morphological diversity across a wide range of ecological niches, yet large-scale, high-resolution digital datasets of their internal anatomy remain limited. Here we present an open-access 3D shark anatomical repository derived from published X-ray computed tomography (CT) data, featuring manually segmented and systematically annotated models of the chondrocranium, visceral arches, axial skeleton, musculature, and viscera in standard STL format.
Energy-efficient scheduling of unrelated parallel machines under time-of-use electricity pricing with release dates
Abstract Time-of-use (TOU) electricity pricing is widely applied in industrial energy management, motivating manufacturers to adjust production schedules to time-varying tariffs. This study investigates an energy-efficient scheduling problem in an unrelated parallel-machine setting with job release dates under TOU pricing, aiming to minimise total electricity cost within a bounded planning horizon.
Polymeric alpha-1 antitrypsin perturbs Paneth cell proteostasis and exacerbates intestinal inflammation
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Abstract Alpha-1 antitrypsin (AAT) is a serine protease inhibitor that protects tissue from neutrophil elastase and other proteases, particularly in the lung. Mutations in SERPINA1, including the Z mutation, lead to AAT deficiency (AATD), characterized by reduced circulating AAT and increased risk of pulmonary emphysema, liver cirrhosis, and hepatocellular carcinoma.
By Francesco Annunziata, JIng Lu, Claudia D’Agostino, Bruno Maria Custode, Gaetano Raiola, Rossella De Cegli, Eugenio Del Prete, Elena Polishchuk, Debora Compare, Gerardo Nardone, Francesco Neri, Nunzia Pastore, Irene Relvini, Giovanna Federico, Valentina Schiano, Veronica Maffia, Barbara De Marino, Carmen Ambrosio
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Nature
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Polysaccharides as emerging functional food components for mood regulation: advances, mechanisms, and future perspectives
Abstract Polysaccharides, widely distributed in plants, fungi, algae, and bacteria, have garnered increasing attention as promising natural agents for mood regulation due to their diverse chemical structures, bioactivities, and safety profiles. Mood disorders, including depression and anxiety, remain major global health challenges with limited treatment options, prompting interest in polysaccharide-based dietary interventions.
KCNH6 Controls Hepatic Lipid Metabolism by Regulating Mitochondrial Function Associated With IKKβ/NF-κB Activation
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All data generated or analyzed during this study are included in this published article (and its supporting information files). Peer Review The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/dom.71362.
Unveiling non-Hermitian band structures with non-Bloch supercells
Abstract Real-valued band structures underpin the analysis of periodic Hermitian systems and are well established experimentally. By contrast, non-Hermitian systems feature complex band structures, in which energy and momentum acquire imaginary parts, enabling phenomena that defy conventional Bloch theory. Mapping these complex bands—relating complex momentum to complex energy—and identifying their associated eigenstates is essential yet remains challenging.
Unicentric Castleman disease of plasma cell type in the adrenal region: a case report and literature review
Abstract Background: Castleman disease (CD) comprises a heterogeneous group of lymphoproliferative disorders. Unicentric CD (UCD) involving the adrenal region is uncommon and poses diagnostic challenges because it can resemble adrenal neoplasms. Case presentation: A 37-year-old female presented with a 10-year history of intermittent hyperhidrosis and facial flushing, and a one-month history of right chest and abdominal pain.
Decoding vascular calcification-neutrophil signature in pathogenesis of chronic IgA nephropathy: evidence from artificial intelligence-driven multi-omics and in vitro validation
Abstract Background: Dysregulation of neutrophil and consistent vascular calcification(VC) contributes to the pathogenesis and progression of chronic IgA nephropathy(C-IgAN). However, its integrated mechanism in IgAN has not yet been elucidated.
A pilot single-cell RNA sequencing study of endothelial activation signatures in large benign prostatic hyperplasia
Abstract Benign prostatic hyperplasia (BPH) is common in aging men, but the endothelial compartment in enlarged prostates remains poorly defined. In this hypothesis-generating pilot study, we generated a single-cell RNA-seq dataset from six surgically obtained BPH specimens (three Large BPH and three Small BPH) and analyzed 56,912 cells; public datasets GSE290213 and GSE242249 were used for external context.
Deciphering the Formulation-Dependent Neurotoxicity of Irinotecan: An Integrated Pharmacovigilance and Mechanistic Study
1 Introduction Irinotecan, a topoisomerase I inhibitor, is a cornerstone of chemotherapy regimens for metastatic colorectal, gastric, and pancreatic cancers [1]. Despite its efficacy, treatment is often limited by adverse effects, with neurotoxicity emerging as a clinically significant concern [2]. Notably, clinical reports and trials suggest a disparity in neurotoxicity profiles between the conventional formulation (C-Irinotecan) and its liposomal counterpart (L-Irinotecan) [3, 4].
Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy
Abstract Schizophrenia (SCZ) and bipolar disorder (BD) share cognitive impairments and autophagy disruptions, with haploinsufficiency of AKAP11 (A-kinase anchoring protein 11) emerging as a major genetic risk factor for both disorders, though its functional role remains poorly understood.
Next-generation strategies for anterior cruciate ligament repair: constructing biointelligent ligament grafts integrating biomimetic design, immune modulation, and sensory feedback
Abstract Anterior cruciate ligament (ACL) reconstruction conventionally prioritizes immediate mechanical stability; however, it does not fully prevent long-term post-traumatic osteoarthritis, residual neuromuscular deficits, or incomplete biological integration.
DIA-based serum proteomics of the complement–coagulation cascade identifies candidate biomarkers for myasthenia gravis
Abstract Objective: This study aims to analyze serum protein changes in patients with myasthenia gravis (MG) via proteomics to identify and validate potential biomarkers. Methods: Serum samples were collected from 10 MG patients and 10 healthy controls. The data-independent acquisition (DIA) quantitative proteomics technique was used to measure serum protein levels and identify differentially expressed proteins.
Correction to “Pharmacokinetics, Biodistribution, Immunogenicity, and Model-Informed-Based PK/PD Model of a Next-Generation Advanced Novel Gene Therapy for Hemophilia” Click to copy article link Article link copied!
Molecular Pharmaceutics Cite this: Mol. Pharmaceutics 2026, XXXX, XXX Click to copy citationCitation copied! . This publication is available under these Terms of Use. Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
PLOS Neglected Tropical Diseases
Loading metrics Open Access Peer-reviewed Research Article Citation: Lou Z, Lu J, Liang S, Zhao W, Huang L, Wang H, et al. (2026) Ecological signature on the epidemiological dynamics of severe fever with thrombocytopenia syndrome. PLoS Negl Trop Dis 20(6): e0014408. https://doi.org/10.1371/journal.pntd.0014408 Editor: Bo Zhang, Hainan University, CHINA Received: May 15, 2025; Accepted: May 24, 2026; Published: June 8, 2026 Copyright: © 2026 Lou et al.
A Modified Needle Technique for Enlarging a Small Capsulorhexis Under the Main Incision
Back to Journals » Clinical Ophthalmology » Volume 20 Authors Liu X , Lu J, Pan A, Ye L, Xie H, Yu F, Gong X Received 20 May 2026 Accepted for publication 12 September 2026 Published 30 September 2026 Volume 2026:20 621546 DOI https://doi.org/10.2147/OPTH.S621546 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Bharat Gurnani Supplementary video of “Modified Needle Technique for Enlarging a Small Capsulorhexis”...
Microencapsulation of cholic acid via complex coacervation enhances sustained release and antibacterial activity against Escherichia coli
Abstract This study aimed to develop a microencapsulated cholic acid (CA) preparation to improve the stability, sustained-release performance, and antibacterial activity of CA for potential use in antibiotic-free animal production. CA microcapsules were prepared by complex coacervation using gelatin and gum arabic as wall materials, and the formulation was optimized by single-factor and orthogonal experimental designs.
Differential detectability of pericyte and blood–brain barrier readouts across the Alzheimer’s disease clinical continuum: a systematic review and meta-analysis
Abstract Background: In Alzheimer’s disease (AD), neurovascular unit and blood–brain barrier (BBB) abnormalities are assessed using biologically distinct readouts, often across separate cohorts, complicating interpretation across clinical stages and biomarker domains.
Habitat Radiomics Based on Diffusion-weighted MRI for Predicting PARP Inhibitor Resistance in Advanced High-grade Serous Ovarian Cancer
Abbreviations AUC (Area under the curve) BIC (Bayesian information criteria) CA125 (Carbohydrate antigen 125) ctDNA (Circulating tumor DNA) DCA (Decision curve analysis) DWI (Diffusion-weighted imaging) FIGO (Federation of Gynecology and Obstetrics) HE4 (Human epididymis protein 4) HGSOC (High-grade serous ovarian cancer) IQR (Interquartile range) IRB (Institutional Review Board) LDH (Lactate dehydrogenase) MRI (Magnetic resonance imaging) NLR (Neutrophil-to-lymphocyte ratio) NPV (Negative...
A Synergistic Hydrogel-Microalgae Platform for Dual-Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease
1 Introduction Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory disorders [1]. Individuals with IBD frequently suffer from depression, anxiety, and cognitive impairments [2-4], which can significantly compromise their quality of life, complicate clinical management [5], and potentially exacerbate the frequency of disease activity [6].
Stage- and compartment-specific remodeling of autophagy and selective mitophagy in glaucoma: from aqueous outflow dysfunction to retinal ganglion cell neurodegeneration
Abstract Background: Glaucoma is a leading cause of irreversible blindness and is increasingly understood as a chronic neurodegenerative disorder rather than a disease explained solely by elevated intraocular pressure (IOP). Although IOP lowering remains the cornerstone of treatment, many patients continue to progress despite apparently adequate pressure control, indicating that additional mechanisms shape retinal ganglion cell (RGC) vulnerability and disease course.
S2SWCLIP: semantic-optimized prompts with spatial-wavelet synergy for zero-shot anomaly detection
Abstract Zero-shot anomaly detection is crucial for privacy-sensitive scenarios with limited target data. However, prominent methods based on visual-language models suffer from semantic overlap due to simplistic generic prompts, while the reductive design of visual representations fails to capture crucial local details and global structures, leading to alignment deviation between text and visual embeddings.
New fossil reveals the weird 'tooth cushions' of an apex predator from 425 million years ago
Life reconstruction of the biggest Silurian vertebrate Megamastax amblyodus.. Credit: Image by NICE PaleoVislab, IVPP Roughly 425 million years ago, in the warm seas over what is now southern China, there lived a meter-long bony fish with jaws full of clusters of spiky teeth.
New fossil reveals the weird ‘tooth cushions’ of an apex predator from 425 million years ago
Roughly 425 million years ago, in the warm seas over what is now southern China, there lived a metre-long bony fish with jaws full of clusters of spiky teeth. Long extinct, this predatory fish (Megamastax amblyodus) was an ancient forerunner of all animals with a skeleton and a backbone alive today – including you and me – and was the world’s oldest known vertebrate apex predator that lived at the top of the food chain in its environment.
The oldest articulated bony fish from the early Silurian period
Abstract Osteichthyans, comprising sarcopterygians and actinopterygians, dominate modern vertebrate biodiversity1,2,3, yet their pre-Devonian fossil record remains scarce and fragmentary4,5. The oldest articulated sarcopterygian6 and stem osteichthyan7 date to the late Silurian, whereas undisputed actinopterygian fossils in articulation appear only in the Middle Devonian8.
Largest Silurian fish illuminates the origin of osteichthyan characters
Abstract Osteichthyans (bony fishes and tetrapods) encompass 98% of modern vertebrate species. However, our understanding of the sequence of character evolution among stem osteichthyans has been substantially limited by the fragmentary nature of known stem osteichthyan fossils1,2,3,4. Here we investigate newly discovered articulated head and trunk material of Megamastax amblyodus5, which yields previously unseen morphological details of a Silurian stem osteichthyan.
Export Market, Digital Empowerment and Female Skill Demand: Evidence From Online Recruitment Data
1 Introduction Since the reform and opening up of China, the implementation of the export-oriented trade strategy has driven the sustained and rapid growth of China's economy and trade. While boosting economic growth, export trade also has profound impacts on the supply and demand situation and structural changes in the labour market (Jadhav and Arora 2023). Enterprises are the primary units of product production and the direct targets of the impact of international trade on the labour market.
Spin States of Fe‐N4 Sites Regulates PMS Activation Pathways for Ultrafast Sulfamethoxazole Degradation
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Relevant data that support the conclusions of this study are accessible from the corresponding author upon reasonable request. Supporting Information Filename Description smll72400-sup-0001-SuppMat.docx7.6 MB Supporting File: smll72400-sup-0001-SuppMat.docx.
Single‐Atom Catalysts Unlock Advanced Oxidation Pathways for Sustainable Precious Metal Recovery
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Protonation‐Triggered Structural Transformations in 4‐Hydroxypyridinium Halides for Solar‐Blind UV Functional Crystals
Conflict of Interests The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description anie71014-sup-0001-SuppMat.pdf20.8 MB Supporting Information anie71014-sup-0002-Data.zip1 MB Supporting Information References 1, , , , , , , , , Nat. Photonics. 2023, 17, 694.
Anti‐Inflammatory and Antidiabetic Metabolites From Mitragyna diversifolia: In Vitro, Phytochemical, and Computational Studies
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in Appendix of this article. Supporting Information Filename Description cbdd70234-sup-0001-AppendixS1.docxWord 2007 document , 3.8 MB Table S1: Top ten targets information of PPI network in inflammation. Table S2: Top ten targets information of PPI network in diabetes. Table S3: Binding energy of compounds 8–10 and core targets (kcal/mol).
A new fossil fish sheds light on the rapid evolution of early lungfishes
Get full text access Log in, subscribe or purchase for full access. References 1. Chang, M.M. ∙ Yu, X.B. Structure and phylogenetic significance of Diabolichthys speratus gen. et sp. nov., a new dipnoan-like form from the Lower Devonian of eastern Yunnan, China Proc. Linn. Soc. N.S.W. 1984; 107:171-184 2. Reisz, R.R. ∙ Smith, M.M. Lungfish dental pattern conserved for 360 Myr Nature. 2001; 411, 548 3. Rosen, D.E. ∙ Forey, P.L. ∙ Gardiner, B.G. ... Lungfishes, tetrapods, paleontology, and plesiomorphy Bull.
Exploring the Influence of Response Time Allocation on Item Revisiting: Implications for Test‐Taking Strategies in Cognitive Diagnostic Assessments
Conflict of Interest Statement Each author signed a form for disclosure of potential conflicts of interest. No authors reported any financial or other conflicts of interest in relation to the work described. The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Data Availability Statement The data set was derived from the following resources available in the public domain: http://www.oecd.org/pisa.
Response to letter regarding iTr35 cells a novel immunoregulatory subset involved in bone loss in rheumatoid arthritis and clinical implications
We sincerely thank Li, Lv, and colleagues for their insightful letter and generous acknowledgment of the clinical and translational significance of our research on iTr35 cells in rheumatoid arthritis (RA)-associated bone loss [Citation1,Citation2]. We appreciate the opportunity to respond and outline how their suggestions are being integrated into our ongoing and future research. 1.
Spatiotemporal Crosstalk Between Oocyte and the Microenvironment Governs Preovulatory Follicle Aging
1 Introduction Reproductive aging is the progressive decline in fertility with age (Dong et al. 2023). It comprises a branch of reproductive sciences that has diverse implications for human health, livestock farming, conservation of endangered species and pest control. In mammals, aging is associated with a decrease in ovarian reserve and oocyte quality. The ovarian reserve is defined as the fixed number of primordial follicles an animal is born with, which decreases with age (Gleicher et al.
Spearmint planting in combination with its leaf amendment spurred dissipation of polycyclic aromatic hydrocarbons in soil
Abstract Oil-bearing aromatic plants are superior to traditional crops and grasses in phytoremediation due to their high stress tolerance and ornamental value. Here, spearmint (Mentha crispa), a model aromatic plant species, with or without spearmint leaf amendment, was used in a pot experiment to evaluate the phytoremediation effects on a PAHs-contaminated soil.
Latent profiles and associated factors of medication literacy in older adult patients with chronic diseases
1Department of Geriatrics, Deyang People's Hospital, Deyang, China 2Department of Nursing, Sichuan Nursing Vocational College, Chengdu, China 3Department of Nephrology, Deyang People's Hospital, Deyang, China Background: With the global burden of chronic diseases and the acceleration of population aging, medication literacy is crucial for self-management among older adult patients.
Effects of weekly unilateral application of 1% atropine on reducing anisometropia in Chinese children with low myopia
Ayuda Buscar en la ayuda Buscar en la ayuda Effects of weekly unilateral application of 1% atropine on reducing anisometropia in Chinese children with low myopia Jing Lu [1] ; Wen Long [1] ; Bingru Zheng [1] ; Ziqi Liang [1] ; Fei Hou [1] ; Dongmei Cui [1] [1] Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, 18 Zetian Road, Futian District, Shenzhen, 518040, China Localización: Journal of Optometry: peer-reviewed Journal of the Spanish General Council of...
Construction and evaluation of a risk prediction model for postoperative deep vein thrombosis in gynecological patients
INTRODUCTION Venous thromboembolism (VTE) is a common vascular disease comprising deep vein thrombosis (DVT) and pulmonary embolism (PE).1-3 DVT refers to the abnormal coagulation of blood within the deep veins, leading to partial or complete blockage of the vein lumen, causing venous stasis.4-6 Without timely treatment, dislodged thrombi can travel to the lungs through the bloodstream, resulting in pulmonary embolism, which can be fatal or non-fatal.7 Patients with gynecological diseases are...
The dynamics of the focusing NLH with a potential beyond the mass-energy threshold
In this paper, we study the dynamics of the focusing nonlinear Hartree equation with a Kato potential under some assumptions on the potential. We prove the blow up versus global existence dichotomy for solutions beyond the threshold, based on the method from Duyckaerts–Roudenko in [6]. Our result extends the work of [13], which studied the blow up and scattering theory for solutions ofbelow that threshold.
Addressing Mechanistic and Translational Challenges
在这里添加一些文本 RIS (ProCite, Reference Manager) BibTeX Therapeutic Promise of Exosomal CD73 for Diabetic Bone Disorders: Addressing Mechanistic and Translational Challenges Aging and disease ›› 2025, Vol. 17 ›› Issue (5) : 2273-2274.
Nitration of Tyrosine Residue Y10 of Aβ1‐42 Ameliorates Aβ1‐42‐Induced Neurotoxicity and Memory Impairment In Vitro and In Vivo
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jnc70218-sup-0001-DataS1.pdfPDF document, 623.4 KB Data S1: jnc70218-sup-0001-DataS1.pdf. References , , , and . 2009. “Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins.” Journal of Proteome Research 8, no. 7: 3222–3238. , and . 2015.
Multifunctional Responsive Gas‐Releasing Metal Organic Framework Nanoplatform for Tumor Therapy Application
Conflict of Interest The authors declare no conflict of interest. References 1, , , , ACS Nano 2019, 13, 10887. 2, , , , , , , , Chem. Eng. J. 2023, 469, 143969. 3, , Nat. Rev. Drug Discovery 2010, 9, 728. 4, Nat. Rev. Drug Discovery 2007, 6, 917. 5, , , , Int. J. Oncol 1992, 1, 147. 6, Nat. Rev. Drug Discovery 2016, 15, 185. 7, , , , , , Adv. Funct. Mater. 2023, 33, 2303254. 8, , , , , Chem. Soc. Rev. 2020, 49, 2378. 9, , , , , Dalton Trans. 2020, 49, 11045. 10, , , , , , Nano Today 2022, 42, 101381. 11, , , , , RSC Adv.
A Study on the Identification of Geohazards in Henan Province Based on the Basic Deformation Products of LuTan-1
This version is not peer-reviewed. Jing Lu,Xinming Tang *,Tao Li,Lei Wei,Lingfei Guo,Xiang Zhang,Xuefei Zhang Jing Lu,Xinming Tang *,Tao Li,Lei Wei,Lingfei Guo,Xiang Zhang,Xuefei Zhang This version is not peer-reviewed. Henan Province, characterized by hills and mountains in its western, northern and southern region, is a high-risk area for geohazards in China.
A ray localized vacuolar sucrose transport is required for wood formation in Populus tomentosa
CONFLICT OF INTEREST The authors have not declared a conflict of interest. Supporting Information Filename Description tpj70347-sup-0001-FigureS1.docxWord 2007 document , 11.9 MB Figure S1. Selection of candidate SWTs genes which potentially participate in radical transport in wood. (A) Heatmap of PtrSWTs transcript levels in the phloem, cambium, and developing wood, based on previous studies (Mahboubi & Niittyla, 2018; Sundell et al., 2017).
Association Between Irisin Level and Cognitive Function: A Systematic Review and Meta‐Analysis
1 Introduction Cognitive impairment can lead to abnormalities in various aspects such as memory, language, calculation, emotion, attention, orientation, and executive function, thereby having a negative impact on patients’ daily lives and social participation. In severe cases, it can be diagnosed as dementia, accompanied by behavior problems and personality changes.
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