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Articles by Jonathan Mitchell
TM184C is a GPCR-like regulator of intercellular exchange and autophagy
Abstract Sequence similarity underlies most protein annotation, yet many functions remain hidden beyond detectable homology1,2,3. By mining millions of AlphaFold2 models4,5, we identify two human families of ‘superdark’ seven-transmembrane proteins—TM184 and PRRT—with structural homology to G-protein-coupled receptors (GPCRs). These proteins exhibit hallmark GPCR activities, including β-arrestin recruitment and GPCR kinase (GRK)-dependent phosphorylation.
GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells
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Abstract Sex differences in immune responses impact cancer outcomes and treatment response, including in glioblastoma (GBM). However, host factors underlying distinct immune-cancer interactions are poorly understood. Here we identify γ-aminobutyric acid (GABA) as a female-specific driver of GBM-promoting immune response.
By Asmita Pathak, Palavalasa Sravya, Bruno Colon, Yadi Zhou, Brandon Leon, Jonathan Mitchell, Beatriz Mateo-Victoriano, Andrew Scott, Harrison Wong, Li Zhang, Juyeun Lee, Kristen E. Kay, Efe Karaca, Diana H. Chin, Haleh Amirian, Irem Karaman, Katelyn Sellick, Danielle Dean, Daniel Cortes, Jashodeep Datta, Scott M. Welford, Maria Franco, Kiran Kurmi, Ashish Shah, Feixiong Cheng, Justin D Lathia, Priyamvada Rai, David B. Lombard, Costas A. Lyssiotis, Dionysios C. Watson, Michele Ceccarelli, Daniel Wahl, Defne Bayik, Erika Ciervo, Oriana Y. Teran Pumar, Durga Prasad Gannamedi, Preyasha Shrestha
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Nature
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Author Correction: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes
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Correction to: Nature https://doi.org/10.1038/s41586-025-10087-x Published online 4 February 2026 In the version of the article initially published, Dimitrios Vitsios (Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK) was missing from the list of AstraZeneca Genomics Initiative members and has now been added to the HTML and PDF versions of the article.
By Xueqing Zou, Fengyuan Hu, Haiyi Lou, Oliver S. Burren, Xiaoyin Li, Karyn Megy, Eleanor Wheeler, Qiang Wu, Santosh S. Atanur, Marcin Karpinski, Douglas P. Loesch, Zammy Fairhurst-Hunter, Sri V. V. Deevi, Erin Oerton, Sean Wen, Xiao Lei Jiang, Cecilia Salvoro, Jonathan Mitchell, Abhishek Nag, Ben Hollis, Amanda O’Neill, Jen Harrow, Stewart MacArthur, Sebastian Wasilewski, Sean O’Dell, Lifeng Tian, Katherine Smith, Guillermo del Angel, Margarete A. Fabre, Ryan S. Dhindsa, Quanli Wang, Slavé Petrovski
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Nature
Verified
Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes - Nature
Abstract Copy number variants (CNVs) are key drivers of human diversity and disease risk1. Here we evaluate the role of CNVs across a broad range of human phenotypes and diseases by analysing CNVs from 470,727 UK Biobank whole-genome sequences and conducting a variant- and gene-level phenome-wide association study (PheWAS) with 2,941 plasma protein abundance measurements, 13,336 binary clinical phenotypes and 1,911 quantitative traits.
Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis - Nature Genetics
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Abstract The mechanisms through which mutations in splicing factor genes drive clonal hematopoiesis (CH) and myeloid malignancies, and their close association with advanced age, remain poorly understood. Here we show that telomere maintenance plays an important role in this phenomenon.
By William Dunn, Jake Tobin, Yash Pershad, Nicholas Williams, Daniel Leongamornlert, Rachael Wilson, Malgorzata Gozdecka, Josep F. Nomdedéu, Edoardo Fiorillo, Valeria Orrù, Irina Mohorianu, Alan Warren, Francesco Cucca, Eoin F. McKinney, E. Baxter, Moritz Gerstung, Jonathan Mitchell, Daniel H. Wiseman, Alexander Bick, Margarete A. Fabre, Pedro M. Quirós, Jyoti Nangalia
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Nature
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The Most Promising Global Money Transfer Providers Right Now
The present and future of cross-border payments have clearly shifted from reliance on traditional bank wires to modern fintech solutions, which generally meet the market demand for fast, affordable, and transparent international money transfer services. The Migration Policy Institute (MPI), in a 2024 study, “Leaving No One Behind,” emphasizes how fintechs have gone beyond meeting these demands to also become the champions of global financial inclusion.
Crypto and Fintech Executives Urge Trump to Block Bank Data Fees
Discover top fintech news and events! Subscribe to FinTech Weekly's newsletter Read by executives at JP Morgan, Coinbase, Blackrock, Klarna and more More than 80 executives from crypto and fintech firms are pressing President Donald Trump to prevent U.S. banks from charging customers and third parties for access to bank account data. The group argued that the fees would restrict consumer choice, damage their businesses, and weaken America’s position in the global digital economy.
Agentic AI Explained: The Next Chapter for Banks and Fintechs
Jonathan Mitchell is Financial Industry Lead at Founder Shield. Discover top fintech news and events! Subscribe to FinTech Weekly's newsletter Read by executives at JP Morgan, Coinbase, Blackrock, Klarna and more The conversation around artificial intelligence is rapidly evolving. We're moving beyond simple chatbots that answer questions and generative models that create content on command.
Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease
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Sample-level quality control To perform genetic association tests, we defined cohorts of people with PD (cases) and people without any neurological disorder (controls) from four datasets (Table S1).19,48,50,53,54 Samples retained for analysis were determined by per-dataset quality control (QC) protocols described below.
By Thomas P. Spargo, Chloe F Sands, Isabella R Juan, Jonathan Mitchell, Vida Ravanmehr, Jessica Butts, Ruth B. De-Paula, Youngdoo Kim, Fengyuan Hu, Quanli Wang, Dimitrios M. Vitsios, Manik Garg, Lawrence Middleton, Michal Tyrlik, Mirko Messa, Guillermo del Angel, Daniel G. Calame, Laurie A. Robak, Ben Hollis, Huda Zoghbi, Joshua M. Shulman, Slavé Petrovski, Ismael Al-Ramahi, Ioanna Tachmazidou, Ryan S. Dhindsa, Hiba Saade, Vishnu A. Cuddapah
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Cell Reports
Verified
Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases - Nature Communications
Abstract To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls from five cohorts with germline whole exome or genome sequencing data, and one cohort with imputed array data.
TINNiK: Inference of the Tree of Blobs of a Species Network Under the Coalescent
Abstract The tree of blobs of a species network shows only the tree-like aspects of relationships of taxa on a network, omitting information on network substructures where hybridization or other types of lateral transfer of genetic information occur. By isolating such regions of a network, inference of the tree of blobs can serve as a starting point for a more detailed investigation, or indicate the limit of what may be inferrable without additional assumptions.
Clinical application of tumour-in-normal contamination assessment from whole genome sequencing
Abstract The unexpected contamination of normal samples with tumour cells reduces variant detection sensitivity, compromising downstream analyses in canonical tumour-normal analyses. Leveraging whole-genome sequencing data available at Genomics England, we develop a tool for normal sample contamination assessment, which we validate in silico and against minimal residual disease testing.
RELAXING SELECTIVE PRESSURES ON DEVELOPMENTALLY COMPLEX INTEGUMENTARY STRUCTURES: FEATHER VANE SYMMETRY EVOLVES IN ADDITION TO BODY MASS AND WING LENGTH AFTER FLIGHT LOSS IN RECENT BIRDS
Abstract Feathers are complex integumentary structures with high diversity across species and within plumage and have varied functions (e.g., thermoregulation, flight). Flight is lost in many crown lineages, and frequently occurs in island founding or semiaquatic context. Different extant lineages lost flight across at least three orders of magnitude of time (~79.58 Ma-15 Ka).
Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice
Impact of a diet high in LA on the gut metabolome To determine whether the gut metabolome is affected by the SO diet and whether the gut microbiota plays a role, we applied the metabolomic analysis in Figure 6 to the IECs isolated from Conv and GF mice fed either Viv chow or the SO+f diet. We chose a shorter time on the diet (8 weeks) to identify compounds that might cause barrier dysfunction without the confounding factor of obesity seen at later time points.
Comparison of SARS-CoV-2 Antibody Response After 2-Dose mRNA-1273 vs BNT162b2 Vaccines in Incrementally Immunosuppressed Patients
Comparison of SARS-CoV-2 Antibody Response After 2-Dose mRNA-1273 vs BNT162b2 Vaccines in Incrementally Immunosuppressed Patients | Allergy and Clinical Immunology | JAMA Network Open | JAMA Network [Skip to Navigation] Table 1. Demographic Characteristics and Immunosuppressive Regimens of Patients With Rheumatic and Musculoskeletal Diseases and Solid Organ Transplant Recipients Stratified by Vaccine Platforma Table 2.
Clinical application of tumour in normal contamination assessment from whole genome sequencing
New Results Jonathan Mitchell, Jack Bartram, Susan Walker, Jane Chalker, Magdalena Zarowiecki, Salvatore Milite, Genomics England Research Consortium, Alona Sosinsky, View ORCID ProfileGiulio Caravagna doi: https://doi.org/10.1101/2022.03.09.483623 Abstract Bioinformatics pipelines designed for paired analysis of tumour and matched normal samples use germline variants detected from normal tissue samples to identify bona fide tumour somatic mutations.
Interpersonal Gut Microbiome Variation Drives Susceptibility and Resistance to Cholera Infection
Highlights • Interpersonal human gut microbiome variation confers variable infection resistance • Microbiome-dependent infection resistance can be restored through co-transplantation • Colonization resistance is mediated through the bile salt hydrolase enzyme activity • Bile salt hydrolase abundance in human microbiomes correlates to final infection Summary The gut microbiome is the resident microbial community of the gastrointestinal tract.
Interpersonal Gut Microbiome Variation Drives Susceptibility and Resistance to Cholera Infection
Highlights • Interpersonal human gut microbiome variation confers variable infection resistance • Microbiome-dependent infection resistance can be restored through co-transplantation • Colonization resistance is mediated through the bile salt hydrolase enzyme activity • Bile salt hydrolase abundance in human microbiomes correlates to final infection Summary The gut microbiome is the resident microbial community of the gastrointestinal tract.
A Christmas radio drama by Kurt Andersen.
Kurt Andersen’s version of a Christmas story doesn’t have your typical talking snowman or mistletoe. Instead, this holiday tale involves extraterrestrial surveillance and melting polar ice caps. "Human Intelligence" was produced for radio by Jonathan Mitchell, and stars Melanie Hoopes, John Ottavino and Ed Herbstman. The unabridged version was published in "Stories: All New Tales," an anthology edited by Neil Gaiman and Al Sarrantonio. (Originally aired December 24, 2010)
Targeting Sleep Duration and Timing for Prevention of Adolescent Obesity
[Skip to Content Landing] Editorial September 16, 2019 JAMA Pediatr. 2019;173(11):1018-1020. doi:10.1001/jamapediatrics.2019.3080 Full Text Adolescent obesity is highly prevalent,1 but there is mounting evidence that this public health problem can be partly addressed by targeting improvements in sleep patterns.
Benefit of haemostatic spray in variceal bleeding: early application of spray or early application of guidelines?
Benefit of haemostatic spray in variceal bleeding: early application of spray or early application of guidelines?
A radio drama of a Christmas story by Kurt Andersen.
Kurt Andersen’s version of a Christmas story doesn’t have your typical talking snowman or mistletoe. Instead, this holiday tale involves extraterrestrial surveillance and melting polar ice caps. "Human Intelligence" was produced for radio by Jonathan Mitchell, and stars Melanie Hoopes, John Ottavino and Ed Herbstman. The unabridged version was published in "Stories: All New Tales," an anthology edited by Neil Gaiman and Al Sarrantonio. (Originally aired December 24, 2010)
Benefit of haemostatic spray in variceal bleeding: early application of spray or early application of guidelines?
We read with considerable interest the recent report by Ibrahim et al 1 on the use of haemostatic powder in addition to standard of care management for oesophageal variceal bleeding.
Solvent inhibition in the liquid-phase catalytic oxidation of 1,4-butanediol: Understanding the catalyst behaviour from NMR relaxation time measurements - Catalysis Science & Technology (RSC Publishing)
Catalytic reaction studies and Nuclear Magnetic Resonance (NMR) relaxation time measurements have been compared to study the influence of competitive adsorption of reactant and solvent on catalytic conversion. The reaction chosen is the aerobic catalytic oxidation of 1,4-butanediol in methanol over different supported-metal catalysts.
Nlrp6 limits inflamation in mouse colon by regulating microbiota
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that involves chronic inflammation involving the colon. We have previously shown that NLRP6 protects against the development of chemically-induced colitis. Here, we demonstrate that NLRP6 is important for suppressing the development of spontaneous colitis in the IL-10−/− mice model of IBD.
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