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Articles by Lu Xia
Models Containing the Braden Scale Predict Activities of Daily Living Improvement in Post-Stroke Hemiplegia: A Single Center Retrospective Cohort Study
1 Introduction Stroke ranks as the third leading cause of mortality, responsible for 7.3 million deaths, and a primary contributor to long-term disability, following ischemic heart disease and COVID-19. In 2021, it was the fourth leading cause of disability-adjusted life-years (DALYs), affecting 160.5 million individuals globally.
Genomic landscape of rare variants in a Chinese autism cohort and discovery of novel risk genes
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Abstract Autism spectrum disorder (ASD) is a genetically complex neurodevelopmental condition with a high heritability. However, genomic studies of ASD have been underrepresented in East Asian populations, and the molecular yield in ASD cohorts remains modest. Here, we present a whole-genome sequencing analysis of 3109 samples across 1033 Chinese ASD families.
By Senwei Tan, Yongqing Lyu, Xiaoyue Sun, Ruolan Guo, Xiaolei Zhang, Zhuo Song, Kewen Chen, Yi Zheng, Canhui Jiang, Cai Qin, Ting Bai, Juan Li, Zhigao Long, Qian Pan, Jieqiong Tan, Ningxia Zhao, Yu Zhang, Yidong Shen, Jianjun Ou, Yonghua Cui, Chanjuan Hao, Xiangbin Jia, Lu Xia, Jinchen Li, Zhengmao Hu, Wei Li, Hui Guo, Kun Xia, Chenzhang Li, Guizhi Tang
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Nature
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Haplotype-resolved methylomes reveal parent-of-origin DNA methylation imbalance in autism spectrum disorder Original
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Epigenetic dysregulation plays an essential role in autism spectrum disorder (ASD), but the parent-of-origin effects (POEs) of DNA methylation remain unknown.
By Kateryna Murlanova, xinfeng Zhang, Dmitri A. Kalashnikov, Lu Xia, Hailiang Guo, Ruiting Liu, Xue Ren, Shaohuai Han, Xu Ying Huang, Ying Peng, Yan Zhu, Yuanfeng Huang, Zhaowei Jiang, Tengfei Zhu, Tengfei Luo, Zhikun Wang, Xun Zhou, Xiaobo Li, Yanping Zhu, Ting Bai, Qi Tian, Zhiqing Hu, Miaojin Zhou, Qian Jiang, Yidong Shen
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Science Magazine
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SnRNA-seq reveals seizure-induced remodelling of excitatory and inhibitory neuron populations
Abstract Epilepsy is one of the most common chronic neurological disorders. This study aimed to identify hippocampal neuronal subpopulations with the most prominent transcriptional alterations during the latent period following status epilepticus, thereby elucidating early molecular mechanisms of epileptogenesis in a pilocarpine-induced model.
Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is driven by unresolved inflammation, yet precise mechanisms linking immune metabolism to disease progression remain elusive. Here, we identified myeloid-expressed Mas, a G protein-coupled receptor, as a critical metabolic checkpoint in MASLD. Mas expression is elevated in hepatic myeloid cells from patients and diet-induced mouse models.
From Therapeutic Dilemma to Precision Modulation: Harnessing Biomaterials to Target the Dual Face of TGF-β in Osteoarthritis
Back to Journals » Journal of Inflammation Research » Volume 19 Review Musculoskeletal Inflammation Authors Peng P , Xia L, Shang X Received 9 May 2026 Accepted for publication 21 July 2026 Published 6 August 2026 Volume 2026:19 618988 DOI https://doi.org/10.2147/JIR.S618988 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Dr Ujjwol Risal Peng Peng, Lu Xia, Xiaobin Shang Department of Orthopedics, Renmin Hospital of...
Complex mechanisms of topoisomerase II poisons revealed by whole-genome analysis
Abstract Topoisomerase II (TOP2) represents a vital enzyme which functions by introducing transient DNA breaks to resolve topological issues in DNA and regulate gene expression. The potentially toxic nature of these DNA breaks made the drugs that stabilize them, TOP2 poisons, into highly successful anticancer agents, and research tools. However, despite decades-long widespread usage of these drugs, not much is known about differences in the genome-wide profiles of DNA breaks caused by them.
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation
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Abstract Approximately 70% of clear cell renal cell carcinoma (ccRCC) patients harbor von Hippel‒Lindau (VHL) deficiency, which drives pseudohypoxia and metabolic reprogramming. Here, we report a histone H4 lysine 12 lactylation (H4K12la)-fueled phosphoglycerate kinase 1 (PGK1)-lactate positive feedback loop that sustains glycolytic flux in VHL-deficient ccRCC and is pharmacologically disruptable by glucocorticoids.
By Kenan Zhang, Lin He, Yizhou Wang, Sen Qin, Chunyu Yu, Zedan Zhang, Yawei Xu, Xiaolin Chen, Yanhua Liu, Xiaoya Liu, Sudun Guan, Lu Xia, Feiya Suo, Fei Pei, Juan Du, Yiran Su, Yanze Li, Yu Chen Wu, Xuehong Zhou, Jingcheng Zhou, Lin Cai, XinJing Tang, Zheng Zhang, Yongfeng Shang, Qing Zhang, Luyang Sun, Enrun Zheng
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Nature
Verified
From gaps to progress: five-year global advances in the diagnosis of pediatric tuberculosis
Abstract Background: Pediatric tuberculosis (TB) remains a major global health challenge, characterized by age-specific difficulties especially in diagnosis compared to adults. This review summarizes key advances in pediatric TB diagnostics over the past five years. Methods: Literature was retrieved from PubMed/MEDLINE, Embase, Web of Science, Scopus, the Cochrane Library, and Google Scholar.
Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models
Keywords maternal immune activation MIA SETDB1 ERV RNA-DNA hybrids reverse transcriptase inhibitors RTIs C4b microglial synaptic pruning ASD Get full text access Log in, subscribe or purchase for full access. References 1. Zeidan, J. ∙ Fombonne, E. ∙ Scorah, J. ... Global prevalence of autism: A systematic review update Autism Res. 2022; 15:778-790 2. Baxter, A.J. ∙ Brugha, T.S. ∙ Erskine, H.E. ... The epidemiology and global burden of autism spectrum disorders Psychol. Med. 2015; 45:601-613 3.
Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer
1 Introduction Cancer cachexia is a complex metabolic syndrome characterized by loss of muscle mass with or without loss of fat mass, not reversed by nutritional supplementation, and leading to progressive functional impairment [1]. The host response to tumour burden can increase production of cytokines, decrease anabolic tone, and centrally suppress appetite, leading to hypermetabolism, weight loss, and reduced quality of life [2].
Maternal Immune Activation and Neurodevelopmental Disorders: Integrating Molecular, Cellular and Systems Mechanisms
Abstract Neurodevelopmental Disorders (NDDs) represent chronic cerebral dysfunctions arising from gene-environment interactions, encompassing conditions such Autism Spectrum Disorders (ASD) and attention-deficit/hyperactivity disorders (ADHD).
Application of Mixed Reality Technology in Medical Student Education: A Scoping Review
Abstract Objective To provide an overview of the current state of mixed reality (MR) technology’s application in medical education and to review a research scope of the area. Methods According to the Joanna Briggs Institute’s scope-based review procedures, searches were conducted in the following databases: PubMed, Embase, Web of Science Core Collection, Cochrane Library, CNKI, WanFang Database, and VIP Database.
Facile Tri‐Metallic Catalyst Fabrication Using the Dynamic Hydrogen Bubble Template method
1 Introduction Electrocatalysts play a fundamental role in enhancing the efficiency of several reactions relevant to the energy transition (such as water electrolysis, fuel cells, CO2 conversion to value-added products). By reducing activation energy and increasing reaction rates electrocatalysts enable more sustainable and scalable energy technologies.
Low‐Molecular‐Weight Angelica sinensis Polysaccharide Improves Neurological Function and Neuroplasticity Following Cerebral Ischemia-Reperfusion Injury - Lin - 2025 - Food Science & Nutrition - Wiley Online Library
1 Introduction Stroke remains the second leading cause of death worldwide and is the primary contributor to long-term disability, with ischemic stroke accounting for the majority of cases (approximately 87%) (Fan et al. 2023). Notably, the incidence of ischemic stroke has been on the rise, with 7,804,449 new cases reported in 2021 (Hou et al. 2024).
Pneumonia-specific plasma metabolite profiles among patients hospitalised with infection in Southeast Asia
Original Research Article | Respiratory Infections Pneumonia-specific plasma metabolite profiles among patients hospitalised with infection in Southeast Asia Article Figures & Tables Info & Metrics Introduction Community-acquired pneumonia (CAP) poses a significant global threat and remains understudied in regions of the world with the highest burden, including Southeast Asia [1, 2].
Asymmetrically tailored catalysts towards electrochemical energy conversion with non-precious materials
Asymmetrically tailored catalysts towards electrochemical energy conversion with non-precious materials Electrocatalytic technologies, such as water electrolysis and metal–air batteries, enable a path to sustainable energy storage and conversion into high-value chemicals. These systems rely on electrocatalysts to drive redox reactions that define key performance metrics such as activity and selectivity.
Cross Relaxation Controlled Ultralow Temperature Detection in High‐Level‐Doping Upconversion Thermometer
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description lpor202402222-sup-0001-SuppMat.docx54.9 MB Supporting Information References 1a) , J. Appl. Phys. 2020, 128, 040902; b) , , Nanoscale 2012, 4, 4301. 2a) , , , , , , , , , , , , Nat. Commun. 2022, 13, 1032; b) , , Angew. Chem., Int. Ed. 2011, 50, 5808; c) , , , , Chem. Rev. 2014, 114, 5161; d) , , , , , Acc. Chem. Res. 2020, 53, 2692; e) , , , , Light Sci. Appl.
Operando-informed precatalyst programming towards reliable high-current-density electrolysis - Nature Materials
Abstract Electrocatalysts support crucial industrial processes and emerging decarbonization technologies, but their design is hindered by structural and compositional changes during operation, especially at application-relevant current densities. Here we use operando X-ray spectroscopy and modelling to track, and eventually direct, the reconstruction of iron sulfides and oxides for the oxygen evolution reaction.
Metal–Phenolic Nanomedicines Targeting Fatty Acid Metabolic Reprogramming to Overcome Immunosuppression in Radiometabolic Cancer Therapy
Special Issue Published as part of ACS Applied Materials & Interfaces special issue “Innovations in Radiotherapeutic Materials for Personalized Oncology”. Introduction Click to copy section linkSection link copied! Radiation therapy (RT) is a cornerstone of clinical cancer treatment; however, its therapeutic potential is often constrained by radiation resistance.
Effects of Redox Condition on Bacteria-Mediated Hydrochemical Processes and Bacterial Community During Managed Aquifer Recharge
1. Introduction The sustainable management of groundwater resources is particularly critical, due to the fact that the world’s drinking water and irrigation demands highly rely on groundwater [,,,]. However, over-reliance on groundwater resources can lead to a series of environmental geological problems, posing a severe threat to the health and safety of human life [,,].
A metal-phenolic nanotuner induces cancer pyroptosis for sono-immunotherapy
A metal–phenolic nanotuner induces cancer pyroptosis for sono-immunotherapy† Although ultrasound therapy is efficacious and safe in clinical oncology, its capacity to elicit an anti-tumor immune response is constrained by ultrasound-induced apoptosis. Pyroptosis, which releases immunogenic damage-associated molecular patterns (DAMPs), can significantly enhance immune activation. It necessitates robust Gasdermin E (GSDME) expression in cancer cells for caspase-3-mediated pyroptosis.
Pharmacodynamic Evaluation of Phage Therapy in Ameliorating ETEC-Induced Diarrhea in Mice Models
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First Principles Study of Bismuth Vacancy Formation in (111)-Strained BiFeO3
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dysregulated immunologic landscape of early host response in melioidosis
ResearchImmunologyInfectious disease Open Access | 10.1172/jci.insight.179106 JCI Insight. https://doi.org/10.1172/jci.insight.179106. Copyright © 2024, Rongkard et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Novel hypoxia-induced HIF-1αactivation in asthma pathogenesis - Respiratory Research
Purchase 45 healthy female BALB/c mice, aged 4–6 weeks and weighing 18–22 g, from the Shanghai Laboratory Animal Research Center. House each mouse separately in an SPF-grade animal laboratory. The laboratory humidity is 60-65%, the temperature is 25 ± 2℃, and free access to food and water is provided under alternating 12-hour light and dark conditions. The experiment starts one week after adapting to the feeding regimen, and the mice’s health status is observed before the experiment.
Critical roles of soil composition and pollutant properties on the degradation of PPCPs during ferrous/persulfate processes
Pharmaceuticals and personal care products (PPCPs) such as triclosan (TCS), triclocarban (TCC), and naproxen (NPS) are widely used as antimicrobial agents and nonsteroidal anti-inflammatory drugs worldwide [1]. These organic compounds are usually difficult to remove during conventional wastewater treatment processes, such as coagulation, sedimentation, flocculation, and active sludge treatment [2].
Materials challenges on the path to gigatonne CO2 electrolysis - Nature Reviews Materials
Abstract CO2 electroreduction (CO2E) is one promising strategy towards decarbonization, offering a path to produce widely used chemicals such as fuels or manufacturing feedstocks using renewable energy and waste CO2 (as opposed to fossil fuels). CO2E performance at the laboratory scale is advancing quickly, including ongoing scale-up and industrialization efforts.
The Critical Analysis of Membranes Towards Sustainable and Efficient Vanadium Redox Flow Batteries
Vanadium redox flow batteries (VRFB) are a promising technology for large-scale storage of electrical energy, combining safety, high capacity, ease of scalability, and prolonged durability; features which have triggered their early commercial implementation. Furthering the deployment of VRFB technologies requires addressing challenges associated to a pivotal component: the membrane.
Single-site iron-anchored amyloid hydrogels as catalytic platforms for alcohol detoxification - Nature Nanotechnology
Abstract Constructing effective antidotes to reduce global health impacts induced by alcohol prevalence is a challenging topic. Despite the positive effects observed with intravenous applications of natural enzyme complexes, their insufficient activities and complicated usage often result in the accumulation of toxic acetaldehyde, which raises important clinical concerns, highlighting the pressing need for stable oral strategies.
Common occurrence of hotspots of single strand DNA breaks at transcriptional start sites - BMC Genomics
We previously reported that nucleotide-level hotspots of DNA damage can be defined in at least two ways as illustrated in the Fig. 1A: (1) in the same sample based on detection by multiple reads (sample-level hotspots) and (2) in different samples but with one or more reads (sample-shared hotspots) [10].
Relationship between Natural Fracture and Structural Style and its Implication for Tight Gas Enrichment: A Case Study of Deep Ahe Formation in the Dibei-Tuzi Area, Kuqa Depression - XIA - 2024 - Acta Geologica Sinica - English Edition - Wiley Online Libra
References , 2020. Understanding the relationship between large-scale fold structures and small-scale fracture patterns: A case study from the Oman Mountains. Geosciences, 10: 490. , , , , and , 2010. Stress and strain patterns, kinematics and deformation mechanisms in a basement-cored anticline: Sheep Mountain Anticline, Wyoming. Tectonics, 29: TC1005. , 1951. The Dynamics of Faulting and Dyke Formation with Applications to Britain ( 2nd ed.). Edinburgh: Oliver and Boyd, 206. , , and , 2015.
Complementary probes for the electrochemical interface - Nature Reviews Chemistry
Abstract The functions of electrochemical energy conversion and storage devices rely on the dynamic junction between a solid and a fluid: the electrochemical interface (EI). Many experimental techniques have been developed to probe the EI, but they provide only a partial picture. Building a full mechanistic understanding requires combining multiple probes, either successively or simultaneously. However, such combinations lead to important technical and theoretical challenges.
Myeloid‐Mas Signaling Modulates Pathogenic Crosstalk among MYC+CD63+ Endothelial Cells, MMP12+ Macrophages, and Monocytes in Acetaminophen‐Induced Liver Injury
1 Introduction Acetaminophen (APAP), a common antipyretic and analgesic, is the leading cause of drug-induced liver injury (DILI) resulting from abuse or accidental overdose, necessitating heightened vigilance during the coronavirus disease 2019 pandemic.[1] APAP-induced liver injury (AILI) is also the primary cause of acute liver failure (ALF).[2] Given its limited therapeutic alternatives, it is imperative to delve into the fundamental mechanisms underlying the progression of advanced...
Research Trends and Hotspots for the Data Mining in Nursing
Rui Zhang,1,2,* Yingying Ge,3,* Lu Xia,4 Yun Cheng5 1Department of Nursing, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 2Department of Nursing, Fudan University, Shanghai, 200433, People’s Republic of China; 3Yijiangmen Community Health Service Center, Nanjing, 210009, People’s Republic of China; 4Day Surgery Unit, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 5School of Medicine, The...
Facile and Green Synthesis of Well‐Defined Nanocrystal Oxygen Evolution Catalysts by Rational Crystallization Regulation
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202308594-sup-0001-SuppMat.pdf1.3 MB Supporting Information References 1, , , , , , Energy Environ. Sci. 2015, 8, 1404. 2, , , , , , , J. Am. Chem. Soc. 2018, 140, 7748. 3, , , Chem. Rev. 2016, 116, 14120. 4, , , , , , J. Am. Chem. Soc. 2015, 137, 4347. 5, , , , , , , , , , , , , Angew. Chemie. 2019, 131, 15919. 6, , , , , , , , Chem. Sci. 2018, 9, 2762. 7, , , , , Adv. Mater. Interfaces 2019, 6, 1900788.
Preoperative Physical Dysfunction in Lung Cancer Patients
Back to Journals » Journal of Multidisciplinary Healthcare » Volume 17 Authors Zhang R , Yang Z, Shen X, Xia L, Cheng Y Received 19 December 2023 Accepted for publication 9 April 2024 Published 23 April 2024 Volume 2024:17 Pages 1743—1754 DOI https://doi.org/10.2147/JMDH.S455669 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Scott Fraser Rui Zhang,1,2 Zhengyao Yang,3 Xiaoyong Shen,3 Lu Xia,4 Yun Cheng5 1Department...
Montmorillonite-Sodium Alginate Oral Colon-Targeting Microcapsule Design for WGX-50 Encapsulation and Controlled Release in Gastro-Intestinal Tract
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
ReCLIP: Refine contrastive language image pre-training with source free domain adaptation
Large-scale pre-trained vision-language models (VLM) such as CLIP have demonstrated noteworthy zero-shot classification capability, achieving 76.3% top-1 accuracy on ImageNet without seeing any examples. However, while applying CLIP to a downstream target domain, the presence of visual and text domain gaps and cross-modality misalignment can greatly impact the model performance.
Numerical Investigation of Hydrodynamic Responses of a Moored Liquefied Natural Gas Ship under Multimodal Waves
3. Results and Discussion This section presents the findings derived from the analysis of the eight distinct cases under examination. Note that when assessing the degrees of freedom (DOFs) encompassing surge, heave, pitch, roll, and yaw, the statistical data pertaining to their respective motions is computed as the cumulative sum of the maximum absolute values observed on both sides. This methodology is implemented by employing an “up-cross-zero” approach to the data.
Assessment of Eutrophication Characteristics and Evaluation of the First-Generation Eutrophication Model in the Nearshore Waters of Shantou City
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1, 1, 2, 3,* and 1,* 1 Haikou Marine Geological Survey Center, China Geological Survey, Haikou 570100, China 2 College of Computer Science and Software Engineering, Shenzhen University, Shenzhen 518060, China 3 Hainan Zhongchang Construction Engineering Co., Ltd., Haikou 570100, China * Authors to whom correspondence should be addressed.
Alkali-stable polybenzimidazole anion exchange membranes tethered with N,N-dimethylpiperidinium cations for dilute aqueous KOH fed water electrolyzers
Alkali-stable polybenzimidazole anion exchange membranes tethered with N,N-dimethylpiperidinium cations for dilute aqueous KOH fed water electrolyzers Polybenzimidazole (PBI) is currently considered as a membrane material for alkaline water electrolyzers (AWEs), and has to be fed with highly concentrated aqueous KOH electrolytes in order to ensure sufficient electrolyte uptake and conductivity. However, the harsh operating conditions significantly limit the lifetime of PBI membranes.
Grain Size Characteristics of Surface Sediments and Their Migration Trends in the Nearshore Waters of East Guangdong
Open AccessArticle by Hongbing Wang 1, Yuxi Wu 2, Xiaoming Wan 1, Lu Xia 3,* and Si Wang 4,* 1 Haikou Marine Geological Survey Center, China Geological Survey, Haikou 570100, China 2 College of Marine Science and Technology, China University of Geosciences, Wuhan 430074, China 3 Hainan Zhongchang Construction Engineering Co., Ltd., Haikou 570100, China 4 College of Computer Science and Software Engineering, Shenzhen University, Shenzhen 518060, China * Authors to whom correspondence should be...
Statistical Inference for Cox Proportional Hazards Models with a Diverging Number of Covariates
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Effects of Polyacrylamide, Biochar, and Palm Fiber on Soil Erosion at the Early Stage of Vegetation Concrete Slope Construction
Abstract : The goal of this research is to investigate strategies to increase the erosion resistance of the slope surface during the early stages of vegetation concrete construction, as well as to offer a scientific foundation for improving vegetation concrete formulation.
Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a
Open AccessArticle by Zhijing Wang 1,†, Yaru Zhu 2,†, Lu Xia 1, Jing Li 1,*, Meiyi Song 1,* and Changqing Yang 1,* 1 Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China 2 Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China * Authors to whom correspondence should be addressed. † These authors contributed equally to this work.
CameraPose: Weakly-supervised monocular 3D human pose estimation by leveraging in-the-wild 2D annotations
To improve the generalization of 3D human pose estimators, many existing deep learning based models focus on adding different augmentations to training poses. However, data augmentation techniques are limited to the ”seen” pose combinations and hard to infer poses with rare ”unseen” joint positions.
Study on the expression and function of chordin‐like 1 in oral squamous cell carcinoma
ORIGINAL ARTICLE Abstract Objective The aim of this study was to investigate the role and related mechanism of chordin-like 1 (CHRDL1) in oral squamous cell carcinoma (OSCC). Methods The expressions of CHRDL1 were analyzed in both mRNA and protein levels by bioinformatics analysis, immunohistochemistry, and fluorescence in situ hybridization in OSCC. Survival analysis was used to determine the relationship between CHRDL1 and prognosis.
Surface Chlorophyll-A Fronts in the Yellow and Bohai Seas Based on Satellite Data
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