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Dadi Jiang

As seen in: Nature, Frontiers, Cell Press, Texas Medical Center
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Articles by Dadi Jiang

A transferable gut microbiota–bile acid pathway programs nanomedicine pharmacokinetics and therapeutic response

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By Mengyu Chang, Yifan Wang Verified, JongHoon Ha, Zoey R. Neale, Nadim J. Ajami, Laurence P Diggs, Ansel P. Nalin, Yifan Ma, Shiyan Dong, Abderrahman Day, Seong Dong Jeong, Annette Wu, Benjamin R. Schrank, Jared Edwards, Tianyu Wang, Xiaotian Wang, Yen-Tzu Chang, Chaoyang Tang, Anthony Lim, Michelle Torres, Weiye Deng, Sangeeta Goswami, Dadi Jiang, Albert C. Koong, Padmanee Sharma, Jennifer Wargo, Wen Jiang, Betty Kim, Yasmine M. Hoballah, Timothy Peitsch, Maurice J. Dufilho IV
| Nature Verified
Abstract The clinical efficacy of nanomedicines is often limited by hepatic sequestration, yet the endogenous programs determining this clearance state remain incompletely understood. Here we identify the gut microbiota as a regulator of nanomedicine biodistribution through bile-acid-associated programming of Kupffer cell phagocytic state.
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Microdosimetric characterization of proton relative biological effectiveness in pancreatic ductal adenocarcinoma cell lines

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By Tianyu Wang, Yuting Li, Lawrence Bronk, Paige Taylor Verified, Tara N Fujimoto, Dadi Jiang, Albert C. Koong, Fada Guan, Sabrina N. Campelo
| Frontiers
Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is among the most radioresistant malignancies. Proton therapy assumes a uniform relative biological effectiveness (RBE) of 1.1 regardless of radiation quality. We characterized proton RBE as a function of dose-mean lineal energy (ȳD) in PDAC cell lines. Methods: Proton RBE was assessed in Panc-1 and COLO 357 FG cells using a high-throughput 96-well irradiation platform with an 81.4 MeV spot-scanning proton beam.
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Spatial multi-omics landscape of colorectal cancer macro- and micrometastases

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By Yang Liu, Akshaya Jadhav, Yuwen Pan, Jianlong Liao, Isha Khanduri, Yunhe Liu, Riham Katkhuda, Wei Lu, Kyung Serk Cho, Zhimin Tong, Tieling Zhou, Kangyu Lin, Baohua Sun, Mei Jiang, Sharia Hernandez, Patrick Brennan, Guangsheng Pei, Kai Yu, Yibo Dai, Tian Ren Chu, Fuduan Peng, Saxon Rodriguez, Ling Xia, Youming Guo, Alicia Mejia, Sean Barnes, Ou Shi, Shreeya Indulkar, Alaa Mohamed, Natalie Fowlkes, Timothy Newhook, Yun Shin Chun, Van Morris, David G. Menter, Dadi Jiang, John Paul Shen, Ryan Sun, Jean-Nicolas Vauthey, Ruoyan Li, Humam Kadara, Luisa M. Solis Soto, Scott Kopetz, Linghua Wang, Dipen M. Maru
| Cell Press Verified
Introduction While early detection through screening has significantly reduced the incidence of localized colorectal cancer (CRC),1 limited understanding of the biological mechanisms driving colorectal metastasis remains a major barrier to improving long-term survival.
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Exploiting metabolic cell death for cancer therapy - Nature Reviews Cancer

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By Dadi Jiang, Albert C. Koong
| Nature Verified
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Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer

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By Alice Soragni, Erik S. Knudsen, Thomas N. O’Connor, Cristina E. Tognon, Jeffrey W. Tyner, Beatrice Gini, Donghwa Kim, Trever G. Bivona, Xingxing Zang, Agnieszka K. Witkiewicz, David Goodrich, Dadi Jiang, Seth T Gammon, Christopher D. Willey, Paul Boutros, Vlad C. Sandulache, Abdullah Osman, Jeffrey Myers, Kamiya Mehla, Pankaj K. Singh, Keith Chan, Hongbo Gao, Himangi G. Marathe
| Nature Verified
Abstract Development of acquired therapeutic resistance limits the efficacy of cancer treatments and accounts for therapeutic failure in most patients. How resistance arises, varies across cancer types and differs depending on therapeutic modalities is incompletely understood. Novel strategies that address and overcome the various and complex resistance mechanisms necessitate a deep understanding of the underlying dynamics.
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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

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By Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack Roth, Nicholas E Navin, Albert C. Koong, Mingjian James You, Steven Lin, Boyi Gan
| Cell Press Verified
Results The involvement of cuproptosis in RT remains unclear. We observed a dose-dependent increase in intracellular copper levels following RT in cancer cells (Figure 1A), suggesting a potential link between RT and cuproptosis. The inductively coupled plasma mass spectrometry (ICP-MS) analysis further confirmed that RT induced an increase in copper concentrations in cancer cells (Figure 1B).
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"IRE1α Determines Ferroptosis Sensitivity Through Regulation of Glutath" by Dadi Jiang, Youming Guo et al.

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By Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang
| Texas Medical Center
Abstract Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer and normal cells depleted of IRE1α gain resistance to ferroptosis, while enhanced IRE1α expression promotes sensitivity to ferroptosis.
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IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis - Nature Communications

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By Dadi Jiang, Liang Wang, Yuelong Yan, Rakesh Bam, Hyemin Lee, Boyi Gan
| Nature Verified
Abstract Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer and normal cells depleted of IRE1α gain resistance to ferroptosis, while enhanced IRE1α expression promotes sensitivity to ferroptosis.
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Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells - Nature Biomedical Engineering

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By Kristin Huntoon, Yifan Wang Verified, Yifei Lu, Thomas D. Gallup, Shiyan Dong, Benjamin R. Schrank, Abin Antony, Liang Wang, Wen Jiang, Dadi Jiang
| Nature Verified
Abstract Intracellular DNA sensors regulate innate immunity and can provide a bridge to adaptive immunogenicity. However, the activation of the sensors in antigen-presenting cells (APCs) by natural agonists such as double-stranded DNAs or cyclic nucleotides is impeded by poor intracellular delivery, serum stability, enzymatic degradation and rapid systemic clearance.
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