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Articles by Yan Guo
All-In-One Integration of Inherently Flame-Retardant, UV-Resistant, and Antibacterial Polymer by a Biguanide Unit
1 Introduction As an indispensable material in modern life, polymer materials are facing a strong demand to shift from meeting basic usage requirements to providing multiple safety protections. Most polymer materials, such as polyesters, polyolefins, and epoxy resins, are highly flammable due to their organic C─C and C─H skeletons [1-3].
Necrotizing enterocolitis in very preterm infants: an epidemiological study in Jiangsu, China
Abstract Background: Epidemiological data focusing on clinical practices for necrotizing enterocolitis (NEC) in China remains scarce. To characterize the incidence, clinical management, and outcomes of NEC among very preterm infants (VPIs) in China. Methods: This study included all VPIs (gestational age <32 weeks) admitted to seven hospitals in Jiangsu, China between 2019 and 2021. Infants who died or were discharged within 72 h were excluded. NEC was defined as Bell's stage ≥ II.
Androgen receptor condensates drive gastric cancer through SWI/SNF-mediated chromatin remodeling and create a therapeutic vulnerability
Abstract Gastric cancer (GC) remains a leading cause of cancer mortality, with epidemiological patterns indicative of androgen signaling involvement. We establish androgen receptor (AR) as a pivotal oncogenic factor in GC and provide preclinical validation for its therapeutic targeting. AR expression was significantly elevated in GC tissues and correlated with adverse prognosis across ten independent cohorts (n = 1740).
β3GnT2-mediated N-glycosylation of EGFR and LDLR drives glioblastoma progression and can be targeted by AST-1306
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by a poor prognosis and limited therapeutic options. In this study, we identify β3GnT2 (β-1,3-N-acetylglucosaminyltransferase 2) as a critical driver of GBM progression and a potential therapeutic target. β3GnT2 is significantly upregulated in GBM tissues, and its high expression correlates with unfavorable patient survival.
MetaCAT enables reconstruction of high-quality microbial genomes and their association with host traits from metagenomic data
Abstract Recovering high-quality microbial genomes from metagenomic sequencing data is essential for accurate profiling and understanding microbial variation. However, existing clustering methods often suffer from limited accuracy and scalability. Here we present MetaCAT (Metagenome Clustering and Association Tool), a framework that combines recovery of microbial genomes from metagenomic data and analysis of their associations with host traits.
Conjugation-Controlled Ion Response in One-Dimensional Covalent Organic Frameworks for Seawater Photocatalysis
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description anie74483-sup-0001-SuppMat.docx38.8 MB Supporting File: anie74483-sup-0001-SuppMat.docx.
Semicircular-ring- and rectangular-cavity-assisted refractive index sensor based on Fano resonance and its application in temperature sensing
In this work, a high sensitivity refractive index sensor utilizing metal-insulator-metal (MIM) waveguide coupled with two pairs of semicircular rings and rectangular resonators is proposed. Fano resonance and optical sensing characteristics are investigated by using COMSOL Multiphysics and analyzed based on multi-mode interference coupled mode theory (MICMT). The effects of geometric parameters on the Fano resonance peaks and sensor performance are investigated in detail.
A New Approach to Visualize Peripheral Vestibular Disorders Using Pseudo-Color Perceptual Enhancement
You are already at the latest version Objective: Vestibular disorders are rarely diagnosed through imaging examinations intuitively. We try to explore a new approach to visualize peripheral vestibular disorders using pseudo-color perceptual enhancement. Methods : A total of 53 patients with unilateral abnormal caloric test results and 23 patients with normal results, treated at outpatient clinics between March 2025 and March 2026, were selected for analysis.
Chromosome-level genome assembly and annotation of the Diptychus maculatus
Abstract Diptychus maculatus is a state second-class protected fish species with significant ecological value, primarily distributed in Xinjiang, China. This study reports a high-quality chromosome-level genome assembly of D. maculatus, offering an essential resource for investigating its adaption to extreme environments. The assembly was achieved by integrating PacBio long-read sequencing, Hi-C chromatin interaction data, and transcriptomic evidence.
Prognostic model for acute pancreatitis patients with acute respiratory failure
Abstract Acute respiratory failure (ARF) is a frequent complication in patients with acute pancreatitis (AP) and is associated with adverse clinical outcomes. This study aimed to develop a prognostic model for predicting mortality in AP patients complicated by ARF. Data from AP patients diagnosed with ARF were extracted from the Medical Information Mart for Intensive Care-III (MIMIC-III) database.
Stoichiometry-driven electronic heterogeneity in covalent organic frameworks for coupled H 2 O 2 photoproduction and chemoselective fragrance upgrading
Abstract Coupling H2O2 photoproduction with value-added organic transformations avoids the sluggish kinetics of water oxidation, yet integrating both processes within one photocatalyst remains challenging. Here, we report stoichiometry-driven electronic heterogeneity in covalent organic frameworks (COFs) as a strategy for simultaneous H2O2 photoproduction and chemoselective fragrance upgrading.
Dynamic mean arterial pressure trajectories and sepsis-associated acute kidney injury in ICU patients: a retrospective cohort study
Abstract Mean arterial pressure (MAP) is a cornerstone of hemodynamic monitoring in sepsis. However, its potential for identifying distinct patient subphenotypes through dynamic early-phase trends remains unexplored. This study aimed to identify MAP trajectory-based subphenotypes in ICU-diagnosed sepsis and evaluate their association with late-onset SA-AKI.
Transposable elements and homotypic niches drive immune dynamics and resistance in melanoma epigenetic-based immunotherapy
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Melanoma plasticity drives immune evasion and therapy resistance through dynamic cell-state transitions beyond genetic alterations. Although epigenetic remodeling is central to this process, its impact under therapeutic pressure remains unclear.
By Xin Yang, Jiaming Cao, Holly V. Moeller, Erika Ciervo, Francesco Ceccarelli, Piera Grisolia, Alessia Covre, Zein Mersini Besharat, Antonio De Falco, Francesca Caruso, Luigi Laezza, Luigi Ferraro, Gloria Martin, Daniel Bilbao, Sion Williams, Benjamin B. Currall, Maria Fortunata Lofiego, Elisabetta Ferretti, Yan Guo, Sean Holden, Ines Simeone, Roberta Mortarini, Andrea Anichini, Michele Maio, Tommaso Sani
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Science Magazine
Verified
Biosynthesis of a nanoscale Vibrio cholerae conjugate vaccine elicits potent immunity through size and receptor effects
Abstract Cholera, caused by Vibrio cholerae, remains a significant global health threat, with the O1 serotype being the predominant cause of recent global outbreaks. Although conjugate vaccines against V. cholerae have been developed via chemical methods, the feasibility of applying novel biosynthetic approaches remains uncertain due to the special structure of its O-polysaccharide, which should be recognized by oligosaccharyltransferases.
Direct RNA sequencing-based multi-omics profiling reveals transcriptional and post-transcriptional remodeling in mice with diet-induced atherosclerosis
Abstract Introduction: Atherosclerosis is a vascular disease whose pathogenesis involves complex transcriptional and post-transcriptional regulation. Conventional bulk RNA-seq captures gene-level expression but does not fully resolve isoform diversity and RNA regulatory features. Methods: Male apolipoprotein E-deficient mice were fed normal chow (NC) or a Western diet (AS) for 16 weeks to establish diet-induced atherosclerosis.
Fixed-dose inotuzumab ozogamicin (INO) combined with Vincristine and Prednisone (VP) regimen as induction therapy for newly diagnosed B-cell acute lymphocytic leukemia (B-ALL): a multi-center, open-label, single-arm, prospective clinical study
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Dear editors: Adult B-ALL exhibits significant heterogeneity and poor prognosis compared with the pediatric population. While the complete remission (CR) rate of traditional induction chemotherapy is 70%–90% for newly diagnosed patients [1], only 30–50% of patients attain long-term disease-free survival (DFS) exceeding 5-years [2]. For the Philadelphia chromosome-positive (ph+) patients, the addition of tyrosine kinase inhibitors (TKIs) significantly improved the CR rates [3].
By Lei Ju, Jilei Zhang, Yuyu Liu, Qiang Song, Lin Dong, Yan Guo, Xuemei Qin, Jie Jenny Zou Verified, Chenglu Yuan, Dexiao Kong, Kaifeng Wang, qiang li, Donglin Yang, Qingliang Teng, Erlie Jiang, Jun Peng, Guanchen Bai, Sifeng Gao
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Nature
Verified
A prehistoric East-Asian Yersinia pestis genome and a ~5.3 ka trans-Eurasian expansion of plague
Abstract Plague, caused by Yersinia pestis, has affected human societies for millennia, yet the timing, scale and biological shifts underlying its earliest spread remain unclear. Here, we screened 1,400 ancient human remains from eastern Eurasia (8,000-400 cal. BP) and recovered three prehistoric Y. pestis genomes, including one from East Asia. Integrating these data with 136 published ancient and modern Y.
Копирование сделок торгового сигнала JIC28126715 для MetaTrader 5
Торговый Сигнал JIC28126715 для MetaTrader 5: копирование сделок, мониторинг счета, автоматическое исполнение сигналов и социальный трейдинг
An interpretable machine learning model for predicting febrile seizures following enterovirus infection in children
Abstract Objective This study aims to develop an interpretable machine learning model for predicting the risk of FS in children with enterovirus (EV) infections and to implement it for clinical application. Methods This retrospective study included 446 hospitalized children with EV infection (144 FS, 302 non‑FS). LASSO regression and BORUTA algorithm selected 15 key predictors from 53 clinical variables.
Association between the dietary obesity-prevention score and risk of gestational diabetes mellitus: an exploratory subgroup analysis
Abstract Background: Gestational diabetes mellitus (GDM) presents significant risks to maternal and offspring health. Modifiable factors like dietary quality are important for prevention. The Dietary Obesity-Prevention Score (DOS) is a validated tool for assessing obesity-related dietary quality. Nevertheless, its association with GDM remain unclear. This study aimed to examine the relationship between DOS and GDM risk.
Cationic carbon nanotube modulates surface fields for general acidic CO 2 reduction with aqueous organic cations
Abstract The (bi)carbonate formation in neutral or alkaline media severely limits the carbon and energy efficiency of electrochemical CO2 reduction reaction (CO2RR). Alkali metal cations and polymer coatings employed to inhibit hydrogen evolution reaction (HER) during acidic CO2RR often exacerbate salt precipitation or increase cell resistivity. Here we report cationic carbon nanotubes (CCNTs) as universal additives enabling efficient CO2RR in strong acids.
Evaluation of Seismic Parameters for High-Strength Steel Frame-Tube Structure With Double-Channel Shear Link
Data Availability Statement Research data are not shared. References 1, , and , “Engineering Pioneer of Modern Architecture,” Structure and Infrastructure Engineering 9, no. 1 (1929-1982): 1–7. 2 ANSI/AISC 358–16. Prequalified Connections for Special and Intermediate Steel Moment Frames for Seismic Applications (American Institute of Steel Construction, 2016). 3 GB 50011–2010, Code for Seismic Design of Buildings (China Architecture & Building Press, 2010) [in Chinese].
Association of a CCB-Related Pharmacogenomics-Guided Strategy with Blood Pressure Outcomes and Short-Term Safety in Chinese Patients with Hypertension: A Secondary Exploratory Analysis of Two Randomized Cohorts
Introduction Hypertension remains a leading cause of cardiovascular morbidity and mortality globally, serving as a major modifiable risk factor for adverse outcomes such as stroke, coronary heart disease, heart failure, and chronic kidney disease,1 and imposes a heavy economic and medical burden on society.2 Its pathogenesis is multifactorial, involving genetic predisposition, aging, dyslipidemia, obesity, impaired glucose tolerance, psychological stress, and unhealthy lifestyle factors.3...
A TcdB-Targeting Antivirulence Compound Preserves Gut Homeostasis and Ameliorates Clostridioides difficile Infection Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Clostridioides difficile (C. difficile) is a leading cause of antibiotic-associated diarrhea and colitis, with hypervirulent or resistant strains and high recurrence, limiting current therapies. Antivirulence therapy presents a promising alternative by neutralizing toxins without damaging the gut microbiota or promoting resistance.
Numerical Simulation and Composition Prediction of Steel Grade Transition for Five-Strand Billet in the Full Continuous Casting Process
, , , , , Numerical Simulation and Composition Prediction of Steel Grade Transition for Five-Strand Billet in the Full Continuous Casting Process, steel research international2026, 0, e70572. https://doi.org/10.1002/srin.70572 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Research data are not shared.
Копирование сделок торгового сигнала JX07726625 для MetaTrader 5
Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 22 Прибыльных трейдов: 10 (45.45%) Убыточных трейдов: 12 (54.55%) Лучший трейд: 866.86 USD Худший трейд: -3 532.28 USD Общая прибыль: 1 683.12 USD (10 780 pips) Общий убыток: -6 653.76 USD (17 706 pips) Макс. серия выигрышей: 4 (324.38 USD) Макс. прибыль в серии: 866.86 USD (1) Коэффициент Шарпа: -0.27 Торговая активность: n/a Макс.
Author Correction: Complete defluorination of PFASs via photocatalytic reduction in water
Correction to: Nature Communications https://doi.org/10.1038/s41467-026-69933-9, published online 23 February 2026 In the version of this article initially published, there was an error in the first paragraph of the Results and Discussion section, where in the sentence now reading “Upon visible light irradiation, TAPP undergoes primary electron excitation from the highest occupied crystal orbital (HOCO) to the lowest unoccupied crystal orbital (LUCO)”, “occupied” appeared originally as...
Association of the hsCRP- triglyceride-glucose index (CTI) with early infarct growth rate in acute ischemic stroke due to large artery occlusion
Abstract Background: Rapid infarct growth in acute ischemic stroke (AIS) due to large artery occlusion (LAO) is associated with poor clinical outcomes despite successful recanalization. The hypersensitive C-reactive protein (hsCRP)-triglyceride-glucose (TyG) index (CTI), a novel biomarker integrating insulin resistance and systemic inflammation, may reflect a meta-inflammatory state that exacerbates ischemic injury. However, its relationship with early infarct growth rate (IGR) remains unexplored.
Копирование сделок торгового сигнала JX27926615 для MetaTrader 5
Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 3 Прибыльных трейдов: 1 (33.33%) Убыточных трейдов: 2 (66.67%) Лучший трейд: 14.22 USD Худший трейд: -7.28 USD Общая прибыль: 14.22 USD (1 093 pips) Общий убыток: -10.11 USD (2 870 pips) Макс. серия выигрышей: 1 (14.22 USD) Макс. прибыль в серии: 14.22 USD (1) Коэффициент Шарпа: 0.15 Торговая активность: n/a Макс.
TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma
1 Introduction Thyroid cancer (TC) is a prevalent endocrine malignancy, with rising global incidence, especially among females [1]. TC generally has a favorable outlook, with a five-year survival rate over 98% [2]. However, anaplastic thyroid cancer (ATC) is notably aggressive, lacking effective treatments and showing a one-year survival rate below 20% [3].
Genome-resolved and culture-based atlas of the feline gut microbiome enables host-adapted probiotic development
Abstract Domestic cats (Felis catus) depend on their gut microbiome for metabolism, immunity, and pathogen defense, yet its genomic characterization remains limited. We combined large-scale metagenomics and culturomics to define the feline gut microbiome and identify indigenous probiotic candidates. Analysis of 412 feline fecal metagenomes produced 2852 strain-resolved metagenome-assembled genomes (MAGs) grouped into 514 species-level genome bins, including 106 putative novel taxa.
Modified YOLO for tape-sealing defects in outer packaging of cigarette carton
Abstract Defective sealing of outer packaging can result in squeezed, deformed, or fallen-off products, inevitably leading to losses for businesses or individuals. Thus, detecting tape-sealing defects in external packaging is crucial in industrial manufacturing. Systems for detecting surface defects based on visual perception are popular in industrial quality inspection. Nevertheless, traditional surface defect detection methods demonstrate limited precision and slow performance.
Clinical Spectrum, independent risk factors, and treatment outcomes of pediatric arrhythmias: a multicenter retrospective analysis in Xinjiang
Abstract Background: Pediatric arrhythmias are heterogeneous and differ from adult disease in presentation and management; evidence from geographically vast, resource-variable regions of northwestern China remains limited, particularly in settings where access to pediatric electrophysiology services and prolonged rhythm monitoring is uneven.
Parametric Study on the Hysteretic Behavior of High-Strength Steel Frame-Tube Structures With Splice-Plate Bolted Shear Links
1 Introduction Seismically resilient structures reduce personal injury and property loss during earthquakes, enabling buildings to quickly restore functionality afterward. Structures with replaceable shear-link components represent a type of resilient system [1]. Among various energy-dissipation components, shear links dissipate seismic energy through shear deformation. First proposed in eccentrically braced structures, shear links are high-performance energy-dissipation components [2].
Analysis of the clinical features of chest pain in adolescents and children in the Shihezi area of Xinjiang
Abstract Objective: To investigate the causes and clinical characteristics of chest pain in adolescents aged 8-17 years in the Shihezi area of Xinjiang, and to provide reference for clinical diagnosis and treatment. Methods: A retrospective analysis was conducted on 243 children aged 8-17 years who presented with non-traumatic chest pain at the Pediatric Emergency and Outpatient Department of the First Affiliated Hospital of Shihezi University from January 2023 to December 2024.
Solar-driven peroxyacid group activation enables＞ 500 h stable hydroxyl-radical defluorination of industrial perfluorophenol wastewater
Abstract Fluoroarenes persist in aquatic environments because aromatic delocalization and aqueous speciation suppress selective C-F bond cleavage, limiting both reductive activation and direct hole oxidation. Hydroxyl radicals (·OH) can mineralize these contaminants, yet near-neutral·OH generation typically relies on added oxidants or Fenton chemistry, creating chemical demand and secondary residues.
QUBO-enhanced SARIMA scenario generation for day-ahead market bidding of hybrid energy storage aggregators
Abstract Day-ahead joint bidding exposes a hybrid energy storage aggregator (HESA) to uncertainty in the locational marginal price, regulation market clearing capacity price, and regulation market performance clearing price. Conventional seasonal autoregressive integrated moving average (SARIMA) modeling calibrates forecast residuals separately for each price and hour, without using their co-movement within complete historical days.
Steering Charge Transfer in Isostructural kgd Covalent Organic Frameworks via π-Bridge Modulation for Overall H 2 O 2 Photoproduction
Y.Guo, Z.-S.Xu, P.Yang, and J.-Y.Yue, “Steering Charge Transfer in Isostructural kgd Covalent Organic Frameworks via π-Bridge Modulation for Overall H2O2 Photoproduction.” Advanced Functional Materials (2026): e75996. https://doi.org/10.1002/adfm.75996 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Photocatalytic Defluorination of Perfluorooctanoic Acid by Twisted Linear Polymer Radicals Click to copy article link Article link copied!
Photoinduced Twisting of the BT–Fl–Py Linear Polymer The bithiophene–fluorene–pyridine (BT–Fl–Py), along with control polymers bithiophene–fluorene (BT–Fl) and fluorene homopolymer (Fl), were synthesized via the Suzuki cross-coupling polymerization reaction ( Figure 1 a, Schemes S1–S3 ). Their chemical structures were characterized by solid-state 13 C nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectroscopy.
Photocatalytic Defluorination of Perfluorooctanoic Acid by Twisted Linear Polymer Radicals Click to copy article link Article link copied!
Introduction Click to copy section linkSection link copied! Per- and polyfluoroalkyl substances (PFAS) represent a class of synthetic compounds that have been extensively utilized as surfactants and surface treatment agents since the 1940s.
Diagnostic performance of wearable acoustic–electrocardiographic indices for screening secundum atrial septal defect in children
Abstract Objective: To evaluate the diagnostic performance of acoustic–electrocardiographic indices derived from a wearable phonocardiogram–electrocardiogram (ECG) sensor for screening secundum atrial septal defect (ASD) in children. Methods: In this cross-sectional study, 50 children (4–12 years) with secundum ASD and 50 age- and sex-matched healthy controls were enrolled.
Копирование сделок торгового сигнала H для MetaTrader 4
Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 146 Прибыльных трейдов: 107 (73.28%) Убыточных трейдов: 39 (26.71%) Лучший трейд: 680.50 USD Худший трейд: -317.80 USD Общая прибыль: 9 605.70 USD (89 265 pips) Общий убыток: -6 763.00 USD (67 614 pips) Макс. серия выигрышей: 22 (2 328.20 USD) Макс. прибыль в серии: 2 328.20 USD (22) Коэффициент Шарпа: 0.14 Торговая активность: 100.00% Макс.
EP61 DISTINCT HLA-DR+ TUMOR CELLS SHAPE THE IMMUNE MICROENVIRONMENT AND CD8+ T-CELL EXHAUSTION IN HBV- ASSOCIATED HEPATOCELLULAR CARCINOMA
Also available on ScienceDirect
Also available on ScienceDirect
Копирование сделок торгового сигнала JY12026422 для MetaTrader 5
Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Прирост Баланс Средства Просадка
Копирование сделок торгового сигнала JX63626422 для MetaTrader 5
Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 297 Прибыльных трейдов: 187 (62.96%) Убыточных трейдов: 110 (37.04%) Лучший трейд: 36.74 USD Худший трейд: -163.61 USD Общая прибыль: 429.20 USD (188 135 pips) Общий убыток: -545.23 USD (162 292 pips) Макс. серия выигрышей: 12 (13.62 USD) Макс. прибыль в серии: 38.73 USD (3) Коэффициент Шарпа: -0.01 Торговая активность: n/a Макс.
LSTM-GRU hybrid model for multi-layer microclimate prediction in solar greenhouse
Abstract Precise microclimate control across vertical canopy layers is critical for optimizing crop production in horticulture solar greenhouses, yet existing prediction models fail to capture the complex spatiotemporal heterogeneity of temperature and humidity distributions.
A TIEGCM-based inversion model for ionosphere-thermosphere parameters driven by three-dimensional electron density
Abstract A challenge in Earth and space sciences is the capability to continuously monitor the key parameters of space systems that frequently experience complex, multiscale dynamics. The ionosphere-thermosphere (I-T) system is a region where the direct measurement of essential quantities such as electric fields, neutral winds, and temperatures remain largely inaccessible.
Atroposelective organocatalytic nucleophilic aromatic substitution for C–O bond construction
Abstract The development of catalytic asymmetric strategies for directly constructing axially chiral diaryl ethers presents a substantial challenge owing to the inherent flexibility of the C–O bond and sterically congested substitution patterns that typically suppress both reactivity and enantioselectivity. Here we report an organocatalytic C–O bond-forming reaction that enables the facile synthesis of these chiral scaffolds.
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