Marco Colonna
St. Louis
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Articles by Marco Colonna
Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human
Keywords perivascular macrophages microglia cMAF arteries immune-vascular axis cerebrospinal fluid cerebral blood flow IGF1 APOE4 Alzheimer's disease Introduction Brain macrophages are implicated in maintaining CNS homeostasis and immune defense.
Somatic mutations reveal the ontogeny of microglia in human aging
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Abstract Microglia are the resident macrophages of the central nervous system1. In mice, microglia seed the brain during embryogenesis and can be maintained throughout life with minimal input from adult hematopoiesis2-4. The origins of human microglia are less clear, but recent evidence suggests that marrow-derived cells contribute to the human microglial pool in certain individuals5-9.
By Julia A. Belk, Yaowen Zhang, Emily Reilly, Quanming Shi, Daniel Liu, Nicole L. Womack-Gambrel, Maarten van der Linde, Lisa Ma, Debasmita Paul, Alejandro Enciso, Raja Kalluru, Jacob Weiss, Rui Li, Anna Eastman, Chunfang Zhu, Arnav Chakravarthy, Syed A. Bukhari, Dipabarna Bhattacharya, Suyash Raj, Daniel Richard, Simone Brioschi, Matthew R. Chrostek, Daniel Nachun, Christopher M. Arends, Jayakrishnan Gopakumar, Isak W. Tengesdal, Ademar Bynum, Shaneice Mitchell, Katalin Sandor, Wenxi Zhang, Badri Vardarajan, Inma Cobos, Donald Born, Robert West, Anne Brunet, Marco Colonna, Krishna L. Bharani, Hannes Vogel, Thomas J. Montine, Caitlin Latimer, Irving L. Weissman, Magdalena Matusiak, Jody E. Hooper, C. Dirk Keene, Howard Chang, Siddhartha Jaiswal
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Nature
Verified
Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children
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Abstract Environmental enteric dysfunction (EED), a small intestinal disorder prevalent in undernourished children with stunted growth and their undernourished mothers, is associated with gut mucosal barrier disruption and decreased absorptive capacity. Here we provide preclinical evidence that intergenerational transmission of a perturbed small intestinal microbiota contributes to pathogenesis.
By Kali M. Pruss, Clara Kao, Alexandra Byrne, Robert Chen, Blanda Di Luccia, Reyan Coskun, Mackenzie Lemieux, Daniel Webber, Matthew C. Hibberd, Yi Wang, Haoxin Liu, Dmitry A. Rodionov, Andrei L Osterman, Marco Colonna, Christian Maueröder, Kodi S. Ravichandran, Michael J. Barratt, Tahmeed Ahmed, Jeffrey Gordon, Laura Karvelyte, Keshav Nepal
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Nature
Verified
Bone-derived Osterix+ osteolineage cells are a source of tumor-promoting myofibroblastic cancer-associated fibroblasts in breast cancer
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Abstract Cancer-associated fibroblasts (CAFs) are major regulators of breast cancer (BC) progression and therapeutic resistance, yet the extent to which CAF heterogeneity is dictated by distinct cellular origins remains unresolved. Here, we identify bone-derived Osterix+ (Osx) osteolineage cells as a source of CAFs in BC. Using BC models in female mice and biopsies from women with BC, we show that bone-resident Osx+ cells are recruited to primary tumors.
By Giulia Furesi, Carisa Zeng, Jennifer Zarrer, Deborah Veis, Jiayu Ye, Darya Khantakova, Alina Ulezko Antonova, Anupama Melam, Marco Colonna, Eric Hesse, Hanna Taipaleenmäki, Gregory D. Longmore, Sheila Stewart, Maxim N. Artyomov, Roberta Faccio, Emily M. Eul, Vasilios A. Morikis, Taylor Malachowski
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Nature
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Innate lymphoid cells in rheumatoid arthritis as mediators of pathology and resolution
Abstract Innate lymphoid cells (ILCs) are emerging as critical modulators of inflammation in rheumatoid arthritis, contributing to both disease pathology and resolution. Group 3 ILCs (ILC3s) mirror TH17 cells in their production of IL-17A and IL-22, promoting fibroblast activation, neutrophil recruitment and synovial inflammatory cascades. By contrast, group 2 ILCs (ILC2s) engage reparative and immunoregulatory pathways via secretion of IL-9, IL-13 and IL-10.
Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer
Results To investigate the diversity of pDCs in the human immune system, we conducted 3′ scRNA-seq on cells from blood samples (n = 8) and lymphoid organs (n = 15) with high pDC prevalence (Figures 1A, S1A, and S1B). These organs included the thymus (n = 8), ptLNs (n = 4), and tonsils (n = 3) (Figure 1A). Most of the samples originated from children (21 out of 23), with a male-to-female sample ratio of 12:11 (Figures S1C and S1D).
Author Correction: Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt
Correction to: Nature Immunology https://doi.org/10.1038/s41590-025-02240-5, published online 13 August 2025. In the version of this article initially published, there was a presentation error in the Fig. 8b RORγt gMFI and T-bet gMFI graphs where the top significance bars (p = 0.5313, 0.2617) did not straddle the second through fourth columns, as is now amended in the HTML and PDF versions of the article. About this article Bhattarai, B., Antonova, A.U., Fachi, J.L. et al.
Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells
Abstract IL-22, a signature cytokine for type 3 lymphoid cells, including T helper 17/22 (Th17/22) and type 3 innate lymphoid cells (ILC3), mediates epithelial homeostasis and protective pathogen responses in barrier tissues. Upon dysregulation, IL-22 can drive chronic inflammatory diseases, yet little is known about transcriptional elements modulating its expression. Here, we identify two enhancers, E22-1 and E22-2, with distinct capacities for regulating Il22 expression in type 3 lymphoid cells.
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties
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Keywords microglia monocyte monocyte-derived macrophages skull-bone marrow macrophage ontogeny Introduction Microglia, the major immune cell type situated in the central nervous system (CNS) parenchyma, account for 5%–20% of total glial cells in the CNS.1,2 During CNS development, microglia play important roles in various processes such as neurogenesis, synaptic pruning, and the establishment and rewiring of neural circuits.3,4,5,6,7 Fate-mapping studies demonstrated that microglia originate...
By Siling Du, Feiya Ou, Antoine Drieu, Eric Xu, Yumeng Cheng, Steffen E. Storck, Tornike Mamuladze, Jay J Cao, Nora Abduljawad, Bishan Bhattarai, Justin Rustenhoven, Niall Mortimer, Simone Brioschi, Khai Nguyen, Patrick Rodrigues, Igor G. Smirnov, Daniel Gibson, J. Michael White, Wandy Beatty, David G. DeNardo, Qingyun Li, Michael Meers, Claudia Han, Na Sun, Florent Ginhoux, Marina Cella, Marco Colonna, Jonathan Kipnis
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Cell Press
Verified
Immunity in Alzheimer’s disease: From mechanisms to therapies
Keywords Alzheimer’s disease microglia T cell β-amyloid tau neuroimmunology human mouse Get full text access Log in, subscribe or purchase for full access. References 1. Chen, X. ∙ Holtzman, D.M. Emerging roles of innate and adaptive immunity in Alzheimer’s disease Immunity. 2022; 55:2236-2254 2. Castellani, G. ∙ Croese, T. ∙ Peralta Ramos, J.M. ... Transforming the understanding of brain immunity Science. 2023; 380, eabo7649 3. Schwartz, M. ∙ Abellanas, M.A. ∙ Tsitsou-Kampeli, A. ...
RORγt+ dendritic cells are a distinct lymphoid-derived lineage
Editor’s summary A recently identified class of antigen-presenting cells expressing the transcription factor RORγt has emerged as key regulators of tolerance to gut microbiota and dietary antigens. Using lineage tracing approaches, Rodrigues et al. found that RORγt+ dendritic cells (DCs) develop from bone marrow lymphoid progenitors in adult mice.
Get **** done. I hate what Trello has become
I hate productivity tools. Not in a cute, ironic way. I mean I genuinely hate how they look, how they feel, and what they've turned into. They're bloated. They're ugly. And they're built for reporting, not for work. Before Atlassian bought Trello, it wasn't pretty - but it was reduced. It did one thing. And it didn't pretend to be enterprise-ready. Since then, everything seems optimized for big organizations that confuse visibility with progress. More workflows. More dashboards. More pricing tiers.
SquareCorners v1.1
just relased 1.1 of this tweak is a simple active .exe process running in background to disable the rounded corners in Windows 11 (also some helpfull tutorials in README for novices) https://github.com/70V07/SquareCorners REW Migrated from process polling to WinEventHook for near-zero CPU usage FIX Resolved the white border artifact (aliasing) by forcing DWMWA_BORDER_COLOR to a neutral dark value ADD AssemblyInfo metadata to the executable maybe can be helpfull for someone… the process...
Publisher Correction: Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience
Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-025-02158-z, published online 21 January 2026. In the version of the article initially published, scaling of some of the y axes in Fig. 5h was incorrect. The figure has now been amended in the HTML and PDF versions of the article, as shown below in Fig. 1. Fig. 1 Original and corrected Fig. 5h. About this article Du, S., Nguyen, K.M., Ulezko Antonova, A. et al.
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
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Keywords CAR T cells cancer immunotherapy IL-12 FOLR2 TREM2 tumor-associated macrophages ovarian cancer lung cancer anti-macrophage therapy Get full text access Log in, subscribe or purchase for full access. References 1. June, C.H. ∙ Sadelain, M. Chimeric Antigen Receptor Therapy N. Engl. J. Med. 2018; 379:64-73 2. Sterner, R.C. ∙ Sterner, R.M. CAR-T cell therapy: current limitations and potential strategies Blood Cancer J. 2021; 11:69 3. Ruella, M. ∙ Korell, F. ∙ Porazzi, P. ...
By Jaime Mateus-Tique, Bhavya Singh, Alfonso R. Sánchez-Paulete, Chiara Falcomatà, Matthew Lin, Gvantsa Pantsulaia, Alexander Tepper, Trung Nguyen, Trung Nguyễn, Angelo Amabile, Gurkan Mollaoglu, Luisanna Pia, Jessica Le Bérichel, Marco Colonna, Joshua Brody, Miriam Merad, Brian Brown, Ashwitha Lakshmi, Rhea Iyer, Divya Chhamalwan, Hunter Potak, Alessia Baccarini
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Cell Press
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Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience
Abstract The choroid plexus forms a key barrier and signaling interface between the brain and peripheral circulation, yet its immune landscape remains incompletely understood. Using single-cell transcriptomics combined with lineage and spatial tracing methods, we identified three biologically distinct populations of choroid plexus macrophages, defined by differential expression of CD163, MHCII or CD9.
Author Correction: Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy - Nature Cancer
Correction to: Nature Cancer https://doi.org/10.1038/s43018-025-01070-6, published online 4 December 2025. In the version of the article initially published, the surname of Peter Grzesik appeared incorrectly (as Grezsik) and has now been amended in the HTML and PDF versions of the article. About this article Giovannoni, F., Strathdee, C.A., Faust Akl, C. et al. Author Correction: Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.
Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy - Nature Cancer
Abstract Glioblastoma (GBM) is an aggressive, immunotherapy-resistant brain tumor. Here, we engineered an oncolytic virus platform based on herpes simplex virus 1 for GBM viroimmunotherapy. We mutated the highly cytopathic MacIntyre strain to increase spread and oncolytic activity, limit genetic drift, prevent neuron infection and enable PET tracing. We incorporated microRNA target cassettes to attenuate replication in healthy brain cells.
Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signature | Nature Communications
Abstract Traumatic brain injury (TBI) is an environmental risk factor for dementia and long-term neurological deficits, posing a significant public health challenge. TBI-induced neuroinflammation involves both brain-resident microglia and peripheral monocyte-derived macrophages (MDMs). Previous research has shown that MDMs contribute to the development of long-term memory deficits, yet their long-term behavior following brain infiltration remains unclear.
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells
Keywords TCF-1 Blimp1 T cell memory effector differentiation T cell exhaustion Introduction CD8+ T cells eradicate intracellular pathogens and tumors through cytotoxic functions. Upon antigen recognition, naive CD8+ T cells clonally expand and differentiate to a cytotoxic phenotype.
Rethinking TREM2 as a target for Alzheimer’s disease after the INVOKE-2 trial failure - Nature Medicine
When Alector announced in late 2024 that its phase 2 trial of AL002, a monoclonal antibody that targets TREM2, had failed to slow cognitive decline in Alzheimer’s disease (AD), it reignited debate over the viability of microglial targets in AD. Years of compelling genetic and preclinical research had positioned the microglial receptor TREM2 as a central player in AD pathology.
A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses
Keywords pneumonia central amygdala GABAergic neuron pulmonary sympathetic nerve norepinephrine macrophage β2-adrenergic receptor inflammation Introduction Respiratory infections pose a persistent threat to all species.1,2 As seen in conditions such as COVID-19 pandemic, pathogen invasion, and the ensuing cytokine storm, can result in severe disease and even mortality.3 Beyond direct activation of pulmonary immune cells by pathogens, mounting evidence indicates that during pneumonia,...
Psychedelics reduce fear by targeting immune cells that modulate brain cells
NEWS AND VIEWS 23 April 2025 Immune cells boost stress-linked fear responses by communicating with brain cells. One way that psychedelics lessen such fear is by modulating this interaction. Fear and stress have vital roles by helping animals to respond adaptively to threats. However, these evolved stress responses can lead to clinical problems such as chronic stress, depression and anxiety.
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression - Nature Immunology
Abstract Transforming growth factor beta (TGFβ) and activin A suppress natural killer (NK) cell function and proliferation, limiting the efficacy of adoptive NK cell therapies. Inspired by the partial resistance to TGFβ of NK cells with SMAD4 haploinsufficiency, we used CRISPR–Cas9 for knockout of SMAD4 in human NK cells.
Meningeal lymphatics-microglia axis regulates synaptic physiology
Keywords meningeal lymphatics E/I balance synapse microglia IL-6 aging VEGF-C VEGFR3 meningeas neuroimmunology Introduction Meningeal lymphatic vessels, located in the dura mater of the meninges, drain cerebrospinal fluid (CSF) together with its content of central nervous system (CNS)-derived waste primarily into deep cervical lymph nodes (dCLNs).1,2,3,4,5,6,7 Since the discovery of meningeal lymphatic vessels, accumulating evidence from mouse models and humans has linked their dysfunction to...
Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis
Get full text access Log in, subscribe or purchase for full access. References 1. Fischer, G.M. ∙ Jalali, A. ∙ Kircher, D.A. ... Molecular profiling reveals unique immune and metabolic features of melanoma brain metastases Cancer Discov. 2019; 9:628-645 2. Qiao, S. ∙ Qian, Y. ∙ Xu, G. ... Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging J. Neuroinflammation. 2019; 16, 4 3. Klemm, F. ∙ Möckl, A.
Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts
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Keywords macrophages transplantation heart TREM-1/3 CCR2 Research topic(s) CP: Immunology Introduction Cardiac transplantation remains the ultimate treatment for patients with end-stage heart disease.1 Myocardial ischemia-reperfusion injury (IRI) is a form of sterile inflammation that is of major clinical significance as it adversely impacts both short- and long-term outcomes.
By Yuriko Terada, Wenjun Li, Junedh Amrute, Charles Liu, Andrew Koenig, Hannah P. Luehmann, Gyu Seong Heo, Alexander N Wein, Yongjian Liu, Jon Ritter, Sumanth D. Prabhu, Rubén Nava, Andrew Gelman, Marina Cella, Marco Colonna, Kory J. Lavine, Daniel Kreisel, Amit I. Bery, Venkatrao Nunna, Christian Corbin Frye, Macee C. Owen
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Cell Reports
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TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity - Nature Communications
Abstract Lung macrophages play a pivotal role in pulmonary fibrosis, with monocyte-derived alveolar macrophages driving disease progression. However, the mechanisms regulating their pro-fibrotic behavior and survival remain unclear, and effective therapeutic strategies are lacking.
Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection
Keywords diet fibers short-chain fatty acids gut microbiota MHC-II intestinal epithelial cells Clostridioides difficile group 3 innate lymphoid cells interleukin-22 intraepithelial lymphocytes Introduction Clostridioides difficile is an opportunistic enteric pathogen and the leading cause of hospital-acquired gastrointestinal infections.1 Normally, its colonization is prevented by the gut's microbial community. However, C.
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
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Abstract Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease.
By Michael T. Heneka, Dietmar Rudolf Thal, Delphine Boche, Frederic Brosseron, Charlotte Teunissen, Paul Edison, Alfredo M. Ramirez, Alfredo Ramírez, Jean-Charles Lambert, Jose Vicente Sanchez-Mut, André Fischer, Sergio Castro-Gomez, Luca Kleineidam, Michael Wagner, Marco Prinz, Guy Brown, Gary E. Landreth, Miguel Moutinho, Jaime Grutzendler, Diego Gomez-Nicola, Roisin McManus, Róisín M. McManus, Katrin I. Andreasson, Christina Ising, Shane A. Liddelow, Alexei Verkhratsky, Malú G Tansey, Ludwig Aigner, Guillaume Dorothée, Klaus-Armin Nave, Gabriela Constantin, ALBERTO PASCUAL, Gabor C. Petzold, Jonathan Kipnis, Marco Colonna, Jochen Walter, Andrea J. Tenner, M. Kerry O’Banion, Magdalena Sastre, Kiran Bhaskar, Soyon Hong, Richard M. Ransohoff, David Morgan, Renzo Mancuso, Agustin Ruiz Laza, Alon Monsonego
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Nature
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Amplification of autoimmune organ damage by NKp46-activated ILC1 - Nature
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Abstract In systemic lupus erythematosus (SLE) loss of immune tolerance, autoantibody production and immune complex deposition are required but not sufficient for organ damage1. How inflammatory signals are initiated and amplified in the setting of autoimmunity remains elusive. Here, we set out to dissect layers and hierarchies of autoimmune kidney inflammation in order to identify tissue-specific cellular hubs that amplify auto-inflammatory responses.
By Tom Aschman, Irene Mattiola, Giannino Patone, Eric Lindberg, Oliver Hölsken, Gerhard Krönke, Arthur Mortha, Reinhard E. Voll, Alexander Clarke, Anja E. Hauser, Marco Colonna, Andreas Schlitzer, Christoph Schneider, Efstathios G. Stamatiades, Mir-Farzin Mashreghi, Stipan Jonjic, Norbert Hubner, Andreas Diefenbach, Masatoshi Kanda, Anna Taranko, Karolin W. Hublitz
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Nature
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Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis - Nature
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Abstract Platelet homeostasis is essential for vascular integrity and immune defence1,2. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to constantly replenish the pool of MKs by their progenitor cells (megakaryopoiesis) remains unclear3,4. Here we use intravital imaging to track the cellular dynamics of megakaryopoiesis over days.
By Florian Gaertner, Hellen Ishikawa-Ankerhold, Anne Dueck, Valeria Fumagalli, Alejandro Navarro Verified, Louisa von Baumgarten, Tobias Straub, Vanessa Zheden, Saskia von Stillfried, Peter Boor, Marco Colonna, Christian Schulz, Thomas Bröcker, Barbara Walzog, Christoph Scheiermann, Claus Nerlov, Stefan Engelhardt, Robert Hauschild, Matteo Iannacone, Matthias Heinig, Jan Kranich, Sebastian Clauß
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Nature
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High-dimensional single-cell analysis of human natural killer cell heterogeneity - Nature Immunology
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Abstract Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used single-cell RNA sequencing (scRNA-seq) and cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) to dissect the heterogeneity of NK cells.
By Janine E. Melsen, Daniela Basurto-Lozada, Avinash Bhandoola, Yenan T. Bryceson, Roberta Castriconi, Frank Cichocki, Marco Colonna, Daniel Davis, Andreas Diefenbach, Muzlifah Haniffa, Lewis L. Lanier, Karl-Johan Malmberg, Jeffrey Miller, Lorenzo Moretta, Emilie Narni-Mancinelli, Chiara Romagnani, Dan Feng Sun, Lucas Rebuffet
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Nature
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Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation
CONFLICT OF INTEREST STATEMENT All authors declare no potential conflicts of interest with respect to publication of this review article. REFERENCES 1, . Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis. Nat Immunol. 2016; 17(7): 765-774. 2. Innate lymphoid cells: diversity, plasticity, and unique functions in immunity. Immunity. 2018; 48(6): 1104-1117. 3, , , , , . Tissue-specific features of innate lymphoid cells. Trends Immunol. 2020; 41(10): 902-917. 4, , .
TREM2 protects from atherosclerosis by limiting necrotic core formation - Nature Cardiovascular Research
Abstract Atherosclerosis is a chronic disease of the vascular wall driven by lipid accumulation and inflammation in the intimal layer of arteries, and its main complications—myocardial infarction and stroke—are the leading cause of mortality worldwide1,2. Recent studies have identified triggering receptor expressed on myeloid cells 2 (TREM2), a lipid-sensing receptor regulating myeloid cell functions3, to be highly expressed in macrophage foam cells in experimental and human atherosclerosis4.
Reviewing the Clostridioides difficile Mouse Model: Insights into Infection Mechanisms
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma
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ArticleVolume 187, Issue 1p149-165.e23Open Archive 1Department of Systems Immunology, Weizmann Institute of Science, 7610001 Rehovot, Israel 2Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland 3Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA 4Department of Stem Cell Transplantation and Cellular Therapy, the University of Texas MD Anderson Cancer Center,...
By Daniel Kirschenbaum, Ken Xie, Florian Ingelfinger, Yonatan Katzenelenbogen, Kathleen Abadie, Thomas Look, Fadi Sheban, Truong San Phan, Baoguo Li, Pascale Zwicky, Ido Yofe, Eyal David, Kfir Mazuz, Jinchao Hou, Yun Chen, Hila Shaim, Mayra Shanley, Soeren Becker, Jiawen Qian, Marco Colonna, Florent Ginhoux, Katayoun Rezvani, Fabian J. Theis, Nir Yosef, Tobias Weiss, Assaf Weiner, Ido Amit
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Cell Press
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A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells | Proceedings of the National Academy of Sciences
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells Alina Ulezko Antonova, Silvia Lonardi, Matilde Monti, +21 , Francesco Missale, Changxu Fan, Matthew L. Coates, Mattia Bugatti, Natalia Jaeger, Patrick Fernandes Rodrigues, Simone Brioschi, Tihana Trsan, José L. Fachi, Khai M. Nguyen, Ryan M. Nunley, Daniele Moratto, Stefania Zini, Lingjia Kong, Jacques Deguine https://orcid.org/0000-0001-9218-3040, Mark E.
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer - Nature Immunology
Abstract Natural killer (NK) cells are commonly reduced in human tumors, enabling many to evade surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found that, in human lung cancer, the presence of NK cells inversely correlated with that of monocyte-derived macrophages (mo-macs).
Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome - Nature Microbiology
Ethics statement All animal experimentation was conducted according to the National Institutes of Health guidelines for the housing and care of laboratory animals. All experiments were performed in accordance with institutional regulations after review and approval by the Animal Studies Committee at Washington University School of Medicine in St Louis, Missouri.
AMN Reviews: Giulia Cianca - Nuda Pelle [New Ethic Society]
This austerely beautiful cycle of songs and recitations for voice, bass clarinet, and percussion was co-composed by vocalist Giulia Cianca and bass clarinetist Marco Colonna, who are joined by percussionist Lorenzo D’Erasmo. The melodic motifs, which have a modal flavor, are elegantly simple and set out with a classically sharp clarity that allows for elaboration and dramatic, dynamic flights when the emotional force of the music calls for it.
The biology of TREM receptors - Nature Reviews Immunology
Abstract Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.
Adaptive differentiation promotes intestinal villus recovery
Highlights • Epithelial dynamics in human enteropathy captured in an acute gastroenteritis model • Villus injury triggers TA cells to differentiate and acquire a fetal-like state • Adaptive epithelial differentiation restores barrier integrity • Proper adaptive differentiation is required for rebuilding damaged villi Summary Loss of differentiated cells to tissue damage is a hallmark of many diseases.
Turning enemies into allies-reprogramming tumor-associated macrophages for cancer therapy
Summary Checkpoint blockade therapies that target inhibitory receptors on T cells have revolutionized clinical oncology. Antibodies targeting CTLA-4 or the PD-1/PD-1 ligand (PD-L1) axis are now successfully used alone or in combination with chemotherapy for numerous tumor types. Despite the clinical success of checkpoint blockade therapies, tumors exploit multiple mechanisms to escape or subvert the anti-tumor T cell response.
Fifty Shades of Microglia
In a recent study, Masuda and colleagues ( Nature 2019;566:388–392) used single-cell RNA-sequencing (scRNA-seq) to profile microglia across different anatomical compartments, developmental stages, and types of brain pathology in mice. Moreover, the authors performed a novel transcriptomic characterization of microglia from multiple sclerosis patients and identified phenotypically conserved microglial subsets between species.
The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis
Highlights • Perturbation of the intestinal microbiome results in enhanced alphavirus infection • An altered microbiome diminishes type I IFN responses in monocytes and pDCs • Recolonization with a single Clostridium symbiont restores antiviral immunity • Secondary bile acids restore pDC and IFN responses to restrict CHIKV dissemination Summary Chikungunya virus (CHIKV), an emerging alphavirus, has infected millions of people.
Interferon responses in viral pneumonias
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak quickly developed into a pandemic in March 2020. To date, no vaccines or antiviral medications are available, and given the urgency, many clinical trials have started screening existing antiviral drugs for efficacy against SARS-CoV-2 infection.
Interferon responses in viral pneumonias
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak quickly developed into a pandemic in March 2020. To date, no vaccines or antiviral medications are available, and given the urgency, many clinical trials have started screening existing antiviral drugs for efficacy against SARS-CoV-2 infection.
Keeping time in group 3 innate lymphoid cells
Abstract Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s.
Brain Parenchymal and Extraparenchymal Macrophages in Development, Homeostasis, and Disease
Simone Brioschi, Yingyue Zhou and Marco Colonna J Immunol January 15, 2020, 204 (2) 294-305; DOI: https://doi.org/10.4049/jimmunol.1900821 Abstract Microglia are parenchymal macrophages of the CNS; as professional phagocytes they are important for maintenance of the brain’s physiology. These cells are generated through primitive hematopoiesis in the yolk sac and migrate into the brain rudiment after establishment of embryonic circulation.
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