Xia Shen
Hangzhou
PI @ Statistical Medical Genetics Lab, School of Medicine, Westlake University
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Articles by Xia Shen
Reflex-Mediated Bradycardia and Asystole During Skull Base and Parapharyngeal Surgery: A Three-Case Series Highlighting Anatomical Predictability
1 Introduction Bradycardia, sinus arrest, and asystole during skull base, parapharyngeal, or pericarotid surgery are uncommon but potentially life-threatening. Such events are often managed as sudden intraoperative crises. However, in operations involving the jugular foramen, cranial nerve rootlets, carotid sheath, and parapharyngeal space, abrupt cardioinhibition may reflect activation of anatomically plausible neurogenic reflex pathways rather than random hemodynamic instability.
Proteogenomics in human populations
Abstract In human population studies, proteogenomics integrates genomic and proteomic data to uncover how genetic variation shapes protein expression and function. A central focus of proteogenomics is the identification of protein quantitative trait loci (pQTL), which link genetic variants to protein abundance and offer critical insights into the molecular basis of disease.
Electrical Breakdown of Heterogeneous Rock Under High-Voltage Electric Pulse: Multiphysics Modeling Framework and Plasma Channel Development Characteristics
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1, , , , and , “Evaluation of the Cross-Scale Mechanical Behavior and Fracability of Deep Shales: How Innovations Benefit the Exploitation of Deep Resources,” Advances in Geo-Energy Research 17, no. 2 (2025): 91–94.
Origin and Enrichment Conditions of Shallow Shale Gas in the Qing 1 Member, Southeastern Uplift, Songliao Basin
, , , , , and , “Origin and Enrichment Conditions of Shallow Shale Gas in the Qing 1 Member, Southeastern Uplift, Songliao Basin.” Journal of Petroleum Geology (2026): . https://doi.org/10.1111/jpg.70089 Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Postoperative kinesiophobia in elderly patients with femoral neck fractures: a prospective study of psychological and social determinants
ORIGINAL RESEARCH article Volume 16 - 2025 | https://doi.org/10.3389/fpsyg.2025.1622585 Highlights • This study provides the first comprehensive analysis of multiple influencing factors of postoperative kinesiophobia in elderly patients with femoral neck fractures. • This study finds that a low education level is a significant risk factor for kinesiophobia. • This study reveals that social support and psychological resilience are negatively correlated with kinesiophobia.
Comprehensive single-cell analysis reveals mast cells’ roles in cancer immunity - Oncogene
Abstract Mast cells, traditionally known for their roles in allergic reactions and pathogen defense, have been revealed to possess significant functional diversity within the tumor microenvironment (TME). Through single-cell RNA sequencing analysis across 15 solid tumors (385 samples from 264 patients), 10 distinct mast cell states characterized by unique gene expression patterns and functional attributes were identified.
Preoperative anxiety in vestibular schwannoma surgery: prevalence, risk factors, and a retrospective cohort of 404 patients
Abstract Background Vestibular schwannoma (VS) is a benign, slow-growing tumor arising from schwann cells of the vestibulocochlear nerve. Despite its non-malignant pathology, its location in the cerebellopontine angle and lies close to the brainstem, leading to both neurological deficits and emotional strain. Microsurgical resection remains a primary treatment option, for large or symptomatic tumors. However, surgery and general anesthesia can also heighten patients’ emotional distress.
Reply To: Re-Evaluating Local Genetic Correlation Analysis in the HDL Framework
This version is not peer-reviewed. Yuying Li,Yudi Pawitan,Xia Shen * Yuying Li,Yudi Pawitan,Xia Shen * This version is not peer-reviewed. The LAVA method has been proposed for detecting local genetic correlations between traits. We show, using theoretical analysis and simulations, that LAVA’s “fixed-effects” model does not estimate genetic correlation in the statistical genetics sense, but instead detects the presence of regional genetic effects.
High Power Factor Bridgeless Critical Conduction Mode Buck-Flyback PFC Converter
References 1, , , , and , “Single Phase Power Factor Correction: A Survey,” IEEE Transactions on Power Electronics 18, no. 3 (2003): 749–755. 2, , , , , and , “A Review of Single-Phase Improved Power Quality AC-DC Converters,” IEEE Transactions on Industrial Electronics 50, no. 5 (2003): 962–981. 3, “ Current Quality and Performance Tradeoffs Under Active Power Factor Correction,” in 2004 IEEE Workshop on Computers in Power Electronics, 2004.
The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project - Nature Genetics
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Abstract Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype–Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and environmental contexts.
By Lingzhao Fang, Jinyan Teng, Dailu Guan, Bingjie Li, Ying Yu, Jacqueline Smith, Konrad Rawlik, Ruidong Xiang, Amanda Chamberlain, Greger Larson, David E. MacHugh, Goutam Sahana, Zhihua Jiang, Guoqiang Yi, Yuwen Liu, Zhonglin Tang, Xiao Wang, Robert Young, Xia Shen, Charley Xia, Li Ma, John Cole, Cong-Jun Li, Benjamin Rosen, Nayan Bhowmik, Joan K. Lunney, Wansheng Liu, Xin Zhao, Eveline M. Ibeagha-Awemu, Yonglun Luo, Lin Lin, James E. Koltes, Christopher K. Tuggle, Elisabetta Giuffra, Marcel Amills, Alex Clop, Maria Ballester, Gwenola Tosser-Klopp, Ming Fang, Qishan Wang, Zhuocheng Hou, Fuping Zhao, Lin Jiang, Guiping Zhao, Zhengkui Zhou, Rong Zhou, Long Jin, Mingzhou Li, Delin Mo, Shuhong Zhao, Hui-Zeng Sun, Yu Jiang, Dongdong Wu, Kui Li, Ning Yang, Xiaoxiang Hu, Wen Huang, Jian Yang, Claudia Kasper, Xiang Zhou, Wei Li, Edward S. Buckler, Bing Ren, Michael C Schatz, Jingyi Li, Abraham A. Palmer, Laurent A. F. Frantz, Huaijun Zhou, Zhe Zhang, George Liu
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Nature
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An enhanced framework for local genetic correlation analysis - Nature Genetics
Abstract Genetic correlation is a key parameter in the joint genetic model of complex traits, but it is usually estimated on a global genomic scale. Understanding local genetic correlations provides more detailed insight into the shared genetic architecture of complex traits. However, a state-of-the-art tool for local genetic correlation analysis, LAVA, is prone to false inference.
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description jmv29945-sup-0001-JMV_24_22746_Supplementary_Figures_Highlighted.docx4.2 MB Supporting information. jmv29945-sup-0002-JMV_24_22746_Supplementary_Table_S1.docx16.9 KB Supporting information. jmv29945-sup-0003-JMV_24_22746_Supplementary_Table_S2.docx17.4 KB Supporting information. jmv29945-sup-0004-JMV_24_22746_Supplementary_Table_S3.docx21.7 KB Supporting information.
Cancer: Modeling glioblastoma
Glioblastoma is the most common type of brain cancer in adults. Patients initially have relatively non-specific symptoms such as headaches, nausea and cognitive changes. Their diagnostic journey usually involves undergoing magnetic resonance imaging (MRI) of the brain, as this approach is highly effective at distinguishing glioblastoma from other conditions with similar symptoms.
YAP/TAZ enhances P-body formation to promote tumorigenesis
eLife assessment This valuable study advances our understanding that YAP/TAZ, as well as their target genes, plays a prominent role in the formation of processing bodies (P-bodies). The evidence supporting the conclusions is convincing. The article could be improved through further analysis to elucidate the mechanistic link between P-body formation and oncogenesis. The work will be of broad interest to scientists working in the field of Hippo signaling and cancer biology.
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers - Nature Communications
Abstract Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head and neck, lung, ovary, pancreas, kidney, and malignant non-melanoma) using cis protein Mendelian randomisation and colocalization. We conduct additional analyses to identify adverse side-effects of altering risk proteins and map cancer risk proteins to drug targets.
On-Wire Design of Axial Periodic Halide Perovskite Superlattices for High-Performance Photodetection
Comparative Genomic Analysis of PEBP Genes in Cucurbits Explores the Interactors of Cucumber CsPEBPs Related to Flowering Time
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Causality-enriched epigenetic age uncouples damage and adaptation - Nature Aging
Abstract Machine learning models based on DNA methylation data can predict biological age but often lack causal insights. By harnessing large-scale genetic data through epigenome-wide Mendelian randomization, we identified CpG sites potentially causal for aging-related traits. Neither the existing epigenetic clocks nor age-related differential DNA methylation are enriched in these sites.
Metal Halide Perovskites: Promising Materials for Light-Emitting Diodes
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Metal Halide Perovskite: A Promising Materials for Light Emitting Diodes
Preprint Review Version 1 This version is not peer-reviewed Version 1 : Received: 24 December 2023 / Approved: 25 December 2023 / Online: 26 December 2023 (01:43:20 CET) Li, X.; Shen, X.; Lv, Q.; Guo, P.; Xiao, L. Metal Halide Perovskite: A Promising Materials for Light Emitting Diodes. Preprints 2023, 2023121844. https://doi.org/10.20944/preprints202312.1844.v1 Li, X.; Shen, X.; Lv, Q.; Guo, P.; Xiao, L. Metal Halide Perovskite: A Promising Materials for Light Emitting Diodes.
Association of prognostic nutritional index with mortalities in American adult cancer survivors: A cohort study based on NHANES, 1999-2018
1 INTRODUCTION Cancer is a widespread and serious global health issue, representing one of the common causes of mortality and posing significant challenges to patients' quality of survival and prognosis. Predictions indicate that the United States could witness a staggering surge in newly diagnosed cancer cases by the year 2030, potentially reaching an alarming 22.1 million cases (Miller et al., 2019).
Hydrodynamic and dissolved oxygen-biochemical oxygen demand transport characteristics at the river confluence in China's largest alluvial plain-A modeling study - Shen - JAWRA Journal of the American Water Resources Association - Wiley Online Library
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES , , and . 2010. “Influence of River Discharge Patterns on the Hydrodynamics and Potential Contaminant Dispersion in the Douro Estuary (Portugal).” Water Research 44(10): 3133–46. 1987. “Closure to Separation Zone at Open-Channel Junctions.” Journal of Hydraulic Engineering 113: 545–48.
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss - BMC Genomics
In summary, this is the first study to present the m6A transcriptome-wide map about the mouse hippocampus following HL. The results provide novel insights into the dynamics of m6A modifications after HL, with indication that the FTO might play a critical role. Those findings expand our understanding of the role about m6A modifications and the underlying mechanisms contributing to cognitive impairment following HL from an epigenetic perspective.
Frailty, illness perception in lung cancer patients
Back to Journals » Patient Preference and Adherence » Volume 17 Authors Gu X , Shen X , Chu JH , Fang TT , Jiang L Received 7 September 2023 Accepted for publication 20 October 2023 Published 2 November 2023 Volume 2023:17 Pages 2773—2787 DOI https://doi.org/10.2147/PPA.S435944 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Jongwha Chang Xue Gu,1 Xia Shen,1 Jiang-Hui Chu,2 Ting-Ting Fang,2 Lei Jiang3 1Wuxi School...
YAP/TAZ enhance P-body formation to promote tumorigenesis
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Bibliometric Analysis of Research Topics on Blood-Brain Barrier Breakdown and Cognitive Function over the Last Two Decades (2000-2021)
Introduction Under normal physiological conditions, the human brain requires 20% of the cardiac output and consumes 20% of the body’s oxygen and glucose (Iadecola, 2013). Since the brain stores little energy, it obtains energy through its blood supply, which must pass through the blood–brain barrier (BBB; Iadecola, 2017). The BBB is an important structure that maintains the homeostasis of the brain’s internal environment and protects the physiological functions of the central nervous system.
Dietary protein intake affects the association between urinary iodine and clinically relevant depression: Evidence from NHANES 2007-2018
4 DISCUSSION The present study evaluated a representative sample of American adults, and we found a positive association between UIC and the risk of CRD, even though adjusted for potentially important confounders. We also found that in the fully adjusted model, the ORs for CRD in participants with low UIC compared to the normal UIC group were 0.73 (95% CI: 0.533, 0.995) in the high protein intake group.
Association between dietary niacin intake and cognitive function in the elderly: Evidence from NHANES 2011-2014
Diagnosis of cognitive impairment assessment Four tests were used to assess cognitive function (CDC. National Health and Nutrition Examination Survey 2011–2012 Data Documentation) in participants aged 60 years or older: including the Delayed Recall Test (DRT), the Immediate Recall Test (IRT), the Animal Mobility Test (AFT), and the Digit Symbol Substitution Test (DSST).
A Novel Variable On-Time Control Scheme for Boundary Conduction Mode SEPIC PFC Converter
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Dexmedetomidine Improved Sleep Quality in the ICU
Back to Journals » Drug Design, Development and Therapy » Volume 17 Authors Huang J , Qin M , Lu W, Shen X Received 20 March 2023 Accepted for publication 30 May 2023 Published 2 June 2023 Volume 2023:17 Pages 1631—1640 DOI https://doi.org/10.2147/DDDT.S413321 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Georgios D Panos Jingjing Huang,1,2,* Minju Qin,3,* Weisha Lu,3 Xia Shen3 1ENT Institute and...
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease - Nature Communications
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Study cohorts Fourteen studies (32 ancestry-specific sub-studies) and 23 studies (40 ancestry-sub-studies) contributed GWAS summary statistics for spQRSTa and fQRSTa meta-analyses, respectively. These included members of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium60 (Supplementary Data 1). This study was approved by all participating cohorts. Ethics and consent was obtained at a study level.
By William Young, Jan-Walter Benjamins, Aaron Isaacs, Andrew Harper, Julia Ramirez, Sophie Garnier, Maria Pina Concas, Luisa Foco, Jonas L. Isaksen, Raymond Noordam, Negin Soroush, Stella Trompet, Alvaro Alonso, Álvaro Alonso Verified, Jennifer Brody, Archie Campbell, Adolfo Correa, Dawood Darbar, Jean-Francois Deleuze, Christina Ellervik, Christian Fuchsberger, Anuj Goel, Xiuqing Guo, Torben Frøstrup Hansen, Susan R. Heckbert, Allan Linneberg, Peter W. Macfarlane, Alanna C. Morrison, Pau Navarro, David Porteous, Peter P. Pramstaller, Lorenz Risch, Xia Shen, Gianfranco Sinagra, Elsayed Z. Soliman, Andrew Tinker, Helen R Warren, Eric A. Whitsel, Kerri L. Wiggins, Christy L. Avery, Giorgia Girotto, Niels Grarup, Caroline Hayward, J.Wouter Jukema, Morten Salling Olesen, Bruce M. Psaty, Cristian Pattaro, Niek Verweij, Michele Orini, Philippe Charron, Hugh Watkins, Charles Kooperberg, Henry Lin, James WIlson, James Wilson, Jørgen K. Kanters, Borbala Mifsud, Larisa G. Tereshchenko
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Nature
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The YAP/TEAD4 complex promotes tumor lymphangiogenesis by transcriptionally upregulating CCBE1 in colorectal cancer.
To further investigate the regulatory mechanism of tumor lymphangiogenesis by the YAP/TEAD4 complex in CRC, we performed RNA-seq analysis of TEAD4 knockdown HCT116 cells ( Supplementary Table 1 , GSE176062). Although a recent study showed a decreased mRNA level of Vegfc in Yap/Taz KO intestinal stromal cells ( 22 Hong S.P. Yang M.J. Cho H. Park I. Bae H. Choe K. Suh S.H. Adams R.H. Alitalo K. Lim D.
Quantitative Evaluation Method for Construction Disturbance and Ecological Restoration of Waterway Engineering and Its Application
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Clinical Significance of MYD88 non‐L265P Mutations in Diffuse Large B‐Cell Lymphoma
Abstract Diffuse large B-cell lymphoma (DLBCL) is a group of heterogeneous tumors with different molecular traits and clinical features. MYD88 is an oncogene that activates the nuclear factor κB pathway in DLBCL. MYD88 L265P mutation frequently occurs in DLBCL with poor prognosis, while the clinical significance of non-L265P mutations needs to be clarified. Next-generation sequencing was performed on a cohort of 356 patients with DLBCL to investigate the impact of MYD88 mutation.
Whole-genome sequencing reveals host factors underlying critical COVID-19 - Nature
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Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms.
By Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Susan Walker, Tomas Malinauskas, Yang Wu, Xia Shen, Katherine Elliott, Bo Wang, Lucija Klaric, Nick Parkinson, Alistair Nichol, Malcolm G Semple, Julian Knight, Christine Patch, Aris Baras, Goncalo Abecasis, Daniel Rader, Marylyn D. Ritchie, Manu Shankar-Hari, Charlotte Summers, Danny F McAuley, Hugh Montgomery, Paul Elliott, Albert Tenesa, Lee Murphy, Kathy Rowan, Chris P. Ponting, Veronique Vitart, James WIlson, James Wilson, Jian Yang, Andrew Bretherick, Loukas Moutsianas, Andy Law, J. Kenneth Baillie, Shahla Salehi, Greg Elgar, Charles Hinds, GenOmicc investigators, Sara Clohisey Hendry
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Nature
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Serum metabolomics identifies dysregulated pathways and potential metabolic biomarkers for hyperuricemia and gout
FULL LENGTH Xia Shen, School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031 China CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, 200031 China University of Chinese Academy of Sciences, CAS, Beijing, 100049 China Equal contribution Search for more papers by this author Can Wang, Shandong Provincial Key Laboratory of Metabolic Diseases and Qingdao Key Laboratory of...
High-definition likelihood inference of genetic correlations across human complex traits
Abstract Genetic correlation is a central parameter for understanding shared genetic architecture between complex traits. By using summary statistics from genome-wide association studies (GWAS), linkage disequilibrium score regression (LDSC) was developed for unbiased estimation of genetic correlations. Although easy to use, LDSC only partially utilizes LD information.
Profiling surface proteins on individual exosomes using a proximity barcoding assay
Abstract Exosomes have been implicated in numerous biological processes, and they may serve as important disease markers. Surface proteins on exosomes carry information about their tissues of origin. Because of the heterogeneity of exosomes it is desirable to investigate them individually, but this has so far remained impractical.
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G
We start with discussion of the methodological implications, and continue to discuss biological aspects of our findings. Our analyses are of methodological interest over and above the new biological insight they have provided.The fact that we discover and replicate a number of new loci using a multivariate approach is consistent with results previously demonstrated by Inouye et al.13 for metabolomics, and, although to a lesser extent, by Stephens10 for classical lipids.
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