Ken Chen
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Articles by Ken Chen
Computer Science > Computation and Language
Latent communication requires both an effective continuous reasoning process and an interface through which an external model can leverage its intermediate computation. We present J-Comm, a framework comprising two core components. First, a training-free Geometric Agreement for Latent Reasoning (GEAR) reweights token candidates over existing model embeddings, which monotonically optimizes geometric consensus among candidate tokens in embedding space at each step.
Astrophysics > High Energy Astrophysical Phenomena
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Modernizing Protection: How AI in Cybersecurity Is Redefining Security Protocols for Modern Enterprises
Learn how AI is revolutionizing security measures for enterprises, ensuring robust protection and adapting to the challenges of the modern digital world.
How security teams can prepare for faster AI-enabled attacks
Organisations should combine timely telemetry, controlled automation, human oversight, and adaptable reasoning models while limiting operational risk Security teams are under growing pressure to detect, investigate, and contain attacks faster as automation improves on both sides of the conflict.
A pilot translational study of neoadjuvant fulvestrant plus abemaciclib in women with advanced low-grade serous carcinoma
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Abstract Low-grade serous carcinoma of the ovary (LGSOC) is relatively resistant to chemotherapy. Given its biological parallels to hormone receptor-positive breast cancer, including responsiveness to anti-estrogen therapies, we conducted a pilot phase II study to assess clinical benefit of neoadjuvant fulvestrant and abemaciclib in women with advanced, unresectable LGSOC (NCT03531645). Imaging assessments were performed every 8 weeks until resectable.
By Lauren Cobb, Yibo Dai, Max Ayala, Nejla Ozirmak Lermi, Sharia Hernandez, Joseph Davis Verified, SangHoon Lee, Richard Hajek, Joseph Celestino, Jinsong Liu, Linghua Wang, Cara Haymaker, Ken Chen, Mei Jiang, Wei Lu, Minghao Dang, Sara Hagen Hull, David Vining, Bryan M. Fellman, Ying Yuan, Anil K Sood, Shannon N. Westin, Jolyn S. Taylor, Aaron Shafer, Nicole Fleming, Karen H. Lu, David M. Gershenson, Amir A Jazaeri, Barrett Craig Lawson, Beatriz Sanchez-Espiridion, Michael Bevers
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Nature
Verified
Supplier Evaluation Using Multivariate Process Capability with Preserved Batch Heterogeneity
1 Introduction Driven by increasing process complexity and cost pressures, manufacturers commonly outsource the production of raw materials and semifinished parts to suppliers. To ensure that products meet specifications, manufacturers must evaluate and compare among competing suppliers on the basis of quality performance.
Free Doctor Hussam Abu Safiya
card-default flavor-online-only type-online-only term-online-only format-pullquote tax-online-only featured- Measuring “mistranslation,” assonance that won’t quit, plus two upcoming live (!) events Online Only Deeply I Groaned card-event flavor-online-only type-online-only term-events format-pullquote tax-online-only featured- Miss Translation Mixer Bela Shayevich in Brooklyn card-event flavor-online-only type-online-only term-events format-pullquote tax-online-only featured- Issue 53 Reading...
Comparison of the long-term impact of laparoscopy and open surgery on the prognosis of patients with locally advanced gastric cancer
Abstract Currently, the choice of surgical procedure for patients with locally advanced gastric cancer remains controversial. This study aimed to investigate the difference in prognosis between laparoscopy and open surgery in patients with locally advanced gastric cancer and explored the potential patients suitable for laparoscopy. Gastric cancer patients who underwent surgical treatment at Zhejiang Cancer Hospital from 2008 to 2019 were included in this study.
Agent-based modeling of cellular dynamics in adoptive cell therapy
Abstract Adoptive cell therapies (ACT) leverage tumor-immune interactions to cure cancer. Despite promising phase I/II clinical trials of chimeric-antigen-receptor natural killer (CAR-NK) cell therapies, molecular mechanisms and cellular properties required to achieve clinical benefits in broad cancer spectra remain underexplored. While in vitro and in vivo experiments are essential, they are expensive, laborious, and limited to targeted investigations.
Rethinking Household Asset Allocation Under Capital Constraints
Posted In: Drivers of Value, Investment Topics, Performance Measurement & Evaluation, Private Wealth Management The 60/40 equity–bond portfolio remains a widely used benchmark for long-term asset allocation, despite ongoing debate about its optimality (Pham et al., 2025). For many households, however, the challenge lies not in the framework itself but in the amount of capital required to implement it.
Critical quantum metrology robust against dissipation and nonadiabaticity
Abstract Critical systems near quantum phase transitions were predicted to be useful for improvement of metrological precision, thanks to their ultrasensitive response to tiny variations of the control Hamiltonian. However, realizing criticality enhanced quantum metrology is experimentally challenging, mainly owing to decoherence and critical slowing down associated with the corresponding quantum state preparation.
Aging drives a program of DNA methylation decay in plant organs
Editor’s summary DNA methylation typically represses the expression of transposable elements. Studying this process in a short-lived plant, Dai et al. found that epigenetic silencing of transposable elements declined as organs aged. However, this epigenetic aging did not occur in the self-renewing stem cell pools of shoot apical meristems, thereby resetting the aging clock in newly formed organs.
AI-powered Immune Cell Knowledge Graph (ICKG) with granular immune contexts enables immune program interpretation
Abstract The widespread application of single-cell and spatial omics to models and patient samples has transformed immune cell profiling across physiological conditions. However, knowledge of immune cell states, functions, and gene regulation remains fragmented across publications, limiting our ability to synthesize insights and derive mechanistic understanding from the literature.
The actionable transcriptome: a framework for incorporating RNA sequencing into precision oncology - Nature Reviews Clinical Oncology
Abstract Comprehensive, multiplexed RNA sequencing (RNA-seq) is increasingly being incorporated into molecular tumour-profiling assays owing to overall cost-effectiveness related to enhanced detection of clinically actionable biomarkers. RNA-seq assays are now quite robust, with turnaround times of a few weeks and reasonable costs that support integration into routine clinical workflows.
Soluble immune factor profiles in blood and CSF associated with LRRK2 mutations and Parkinson’s disease - npj Parkinson's Disease
Abstract Mutations in LRRK2, a leading genetic cause of Parkinson’s disease (PD), are linked to immune dysregulation, but the immune profiles in the periphery and central nervous system (CNS) remain incompletely defined. This study utilized a large cohort of serum samples (n = 651) and matched CSF samples (n = 129) from LRRK2 mutation carriers and non-carriers, with and without PD, to assess immune regulators using Luminex immunoassay.
Building Harvey’s iManage Integration
Harvey now integrates directly with iManage, enabling teams to pull documents into Harvey, work with them, and push as artifacts back to iManage seamlessly. No exports or duplicates; just a secure, bidirectional flow that removes friction from legal workflows. We codeveloped solutions and worked closely with both customer teams and iManage to ensure the integration met Harvey’s bar for enterprise readiness and governance.
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets - Nature Cell Biology
Abstract Spatial domain detection methods often focus on high-variance structures, such as tumour-adjacent regions with sharp gene expression changes, while missing low-variance structures with subtle gene expression shifts, like those between adjacent normal and early adenoma regions. Here, to address this, we introduce ‘compare and contrast spatial transcriptomics’ (CoCo-ST), a graph contrastive feature representation framework.
Serene and Delirious | Ken Chen
At first I did not know how to watch the fresh and giggling, gasp-of-delight-inducing, omnivorous, often deliberately pointless, even trolling and irritating movies of Miguel Gomes, who has been lauded as one of contemporary cinema’s most original political filmmakers. What confounded me wasn’t that his works were particularly dull or unentertaining—it’s that they were often both dull and entertaining.
Remembering Maxine Lewis: ‘The biggest champion’ for SLO’s underprivileged
Maxine Lewis was involved with helping those in need through Grassroots and Grassroots II in San Luis Obispo until her death in 1988. She is seen here Aug. 27, 1981. Ken Chen Telegram-Tribune file Maxine Lewis dedicated her life to helping the underprivileged in San Luis Obispo beginning in the early 1960s. She was a force of nature who was at her best distributing a meal, clothing or shelter at the level of need.
Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency
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Cloning of viral constructs We obtained the pMSCV-U6sgRNA(BbsI)-PGKpuro2ABFP73 from Sarah Teichmann (Addgene plasmid # 102796) and modified it to express a specific sgRNA using standard molecular cloning techniques.
By Alexander Biederstädt, Rafet Basar, Jeong-Min Park, Nadima Uprety, Rejeena Shrestha, Francia Silva, Merve Dede, John Watts, Sunil P Acharya, Donghai Xiong, Bin Liu, May Daher, Hind Rafei, Pinaki P. Banerjee, Ping Li, Sanjida Islam, Huihui Fan, Mayra Shanley, Jingling Jin, Bijender Kumar, Paul Lin, Silvia Tiberti, Xin Jiang, Patrick Zhang, Seema Rawal, Enli Liu, Luis Muniz-Feliciano, Elizabeth J. Shpall, Natalie Fowlkes, Ken Chen, Katayoun Rezvani, Vernikka Woods, Inci Biederstädt, Gary M. Deyter
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Cell Press
Verified
Simulations show dwarf galaxies and their gas environments evolve together
Throughout cosmic evolution, although dwarf galaxies are individually small, they are numerous and serve as the fundamental building blocks shaping the large-scale structure of today's universe. These small galaxies are also the ancestors of our own Milky Way. Dwarf galaxies are not only the "raw materials" for constructing massive galaxies but may also harbor secrets about the formation of the earliest stars and black holes in the universe.
Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics
Abstract Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease characterized by cystic destruction and metastatic growth of smooth muscle-like cells. Despite advances in understanding its genetic basis, the cellular heterogeneity, regulatory mechanisms, and microenvironmental interactions driving LAM progression remain poorly defined.
KCBX is celebrating 50 years of public radio. See photos from station’s early years
KCBX-FM studios, Bearded Charlie Savoca trains “Big Band Show” members Bob Connolly, Al Davis and Jack Graham. This image is from Oct. 8, 1980. Ken Chen Uniquely is a Tribune series that covers the moments, landmarks and personalities that define what makes living in SLO County so special. Radio used to be more locally rooted. DJs, playlists and news were connected to the local community with their programming.
Synergetic integration of solar heating and radiative cooling for self-adaptive thermal regulation
Keywords: photothermal conversion radiative cooling temperature regulation thermal radiation spectrum modulation hydrogel thermal comfort Introduction In recent years, the demand for temperature regulation has significantly increased across various backgrounds, including building environments and personal thermal comfort.
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells - Nature
Abstract Chimeric antigen receptor (CAR) natural killer (NK) cell immunotherapy offers a promising approach against cancer1,2,3. However, the molecular mechanisms that regulate CAR-NK cell activity remain unclear. Here we identify the transcription factor cyclic AMP response element modulator (CREM) as a crucial regulator of NK cell function.
A visual–omics foundation model to bridge histopathology with spatial transcriptomics - Nature Methods
Abstract Artificial intelligence has revolutionized computational biology. Recent developments in omics technologies, including single-cell RNA sequencing and spatial transcriptomics, provide detailed genomic data alongside tissue histology. However, current computational models focus on either omics or image analysis, lacking their integration.
Refaat Alareer’s “If I Must Die”: The Death of the Author, the Afterlife of the Tale
Introduction Since its prehistoric inception around the campfire, humankind has utilized storytelling to express and rationalize their visceral hopes and fears. ‘Rationalize’ could be variably glossed in elementary terms such as ‘tame’ and ‘explain away’ as well as in more complex ones as identified by Friedman: “domesticate […] socialize […] validate” (1982: 65). The most overarching expression that is conventionally herded under “hopes” in literature is love. Of fears, it is death.
Label-Aware Distance Mitigates Temporal and Spatial Variability for Clustering and Visualization of Single-Cell Gene Expression Data
Abstract Clustering and visualization are essential parts of single-cell gene expression data analysis. The Euclidean distance used in most distance-based methods is not optimal. The batch effect, i.e., the variability among samples gathered from different times, tissues, and patients, introduces large between-group distance and obscures the true identities of cells.
A Deep Convolution Method for Hypertension Detection from Ballistocardiogram Signals with Heat-Map-Guided Data Augmentation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A statistical approach for systematic identification of transition cells from scRNA-seq data
Keywords cell transitions gene regulatory network dynamic systems cell differentiation cell development carcinogenesis single-cell RNA sequencing differential equations gene expression correlation statistical analysis Research topic(s) CP: systems biology CP: developmental biology Introduction In the complexity of life, change is not just inevitable, it is essential.
"Spatially Resolved Transcriptomics of High-Grade Serous Ovarian Carcin" by Elaine Stur, Sara Corvigno et al.
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Predicting the next supernova explosion: New simulations reveal the physics of supernova shock breakout
Stars with masses between 10 and 30 times that of the sun, in their final evolutionary stages, form an iron core that ultimately collapses into a neutron star. This collapse releases a tremendous amount of gravitational potential energy through neutrinos, triggering a shockwave that destroys the entire star. The shock wave propagates supersonically within the star and plays a crucial role in the supernova formation process.
Aging drives a program of DNA methylation decay in plant organs
Abstract How organisms age is a question with broad implications for human health. In mammals, DNA methylation is a biomarker for biological age, which may predict age more accurately than date of birth. However, limitations in mammalian models make it difficult to identify mechanisms underpinning age-related DNA methylation changes.
Temporal recording of mammalian development and precancer - Nature
Abstract Temporal ordering of cellular events offers fundamental insights into biological phenomena. Although this is traditionally achieved through continuous direct observations1,2, an alternative solution leverages irreversible genetic changes, such as naturally occurring mutations, to create indelible marks that enables retrospective temporal ordering3,4,5.
Detecting Potential Mediators of the Effect of Education on Stroke: A Two-Step, Two-Sample Mendelian Randomization Study
The authors have declared no competing interest. The present study is a Mendelian Randomization study, thus we did not have a clinical trial ID. No external funding was received. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
A Deep Learning Method for Human Sleeping Pose Estimation with Millimeter Wave Radar
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Aviation Photo #7646517: Airbus A320-251N - Hainan Airlines
Distinct Views: 11 Photo Added: August 22, 2024 Photo Copyright © Wang Wenxuan. All rights reserved. Airliners.net is not affiliated with any entity mentioned or pictured herein. All trademarks are the property of their respective owners.
Phase II study of talazoparib in advanced cancers with BRCA1/2, DNA repair, and PTEN alterations - npj Precision Oncology
Abstract Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto one of four cohorts based on molecular alterations: (1) somatic BRCA1/2, (2) other homologous recombination repair pathway, (3) PTEN and (4) germline BRCA1/2.
Multifunctional Wearable Electronic Based on Fabric Modified by PPy/NiCoAl‐LDH for Energy Storage, Electromagnetic Interference Shielding, and Photothermal Conversion
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202402510-sup-0001-SuppMat.docx24.8 MB Supporting Information References 1, , , Acc. Chem. Res. 2021, 54, 4051. 2, , , , Adv. Sci. 2022, 9, 2203856. 3, , , , J. Cleaner Prod. 2019, 208, 1524. 4, , , , , , Nat Rev Earth Environ 2020, 1, 189. 5, , , , , , , , Adv. Funct. Mater. 2023, 33, 2307301. 6, , , , , , J. Mater. Sci. Technol. 2022, 97, 190. 7, , , , , ACS Appl. Mater. Interfaces 2023, 15, 3395.
The Enigma of Frantz Fanon
Can we count on you? In the coming election, the fate of our democracy and fundamental civil rights are on the ballot. The conservative architects of Project 2025 are scheming to institutionalize Donald Trump’s authoritarian vision across all levels of government if he should win. We’ve already seen events that fill us with both dread and cautious optimism—throughout it all, The Nation has been a bulwark against misinformation and an advocate for bold, principled perspectives.
Topological phase transitions and thermal Hall effect in a noncollinear spin texture
The noncollinear spin textures provide promising avenues to stabilize exotic magnetic phases and excitations. They have attracted vast attention in the past decades due to their nontrivial band topology.
mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis
Abstract Lymphangioleiomyomatosis (LAM) is a rare disease which causes lung cysts and respiratory failure. TSC2 deficient LAM cells with dysregulated mTOR signalling form nodules with fibroblasts causing lung injury. We examined if mTOR dysregulation could induce senescence and impair responses to lung injury. Senescence markers p21 and p16 were increased in LAM lungs and co-localised with alveolar type 2 cells.
Somehow
Find and share the perfect poems. For Norman You visit me in a dream after passing, after I’ve been awaiting you for weeks, because Chinese belief teaches us our loved ones will appear when we’re asleep. It’s real when I enter the hotel restaurant in the middle of nowhere town I live in, as the Midwest architecture transforms into Kowloon at evening time. We eat bird’s nest soup, and I remember the time my father ordered me this four-hundred- year-old delicacy at Hong Kong airport.
Interpretable Spatial Gradient Analysis for Spatial Transcriptomics Data
Abstract Cellular anatomy and signaling vary across niches, which can induce gradated gene expressions in subpopulations of cells. Such spatial transcriptomic gradient (STG) makes a significant source of intra-tumor heterogeneity and can influence tumor invasion, progression, and response to treatment.
A Mother's Relentless Quest to Find her Missing Son
The mother’s quest began on August 24, 2000. Her name was Yu Lai Wai-ling, a housewife who lived in a public-housing estate with her husband, a civil servant, and her son, an autistic teenager. Outside the walls of their small flat, a typhoon breached Hong Kong and calmed into a storm. The unsettling weather disturbed her son, so her husband suggested a diversion: lunch.
Case of the Month from the Peter MacCallum Cancer Centre, Melbourne, Australia: an operative approach to large renal angiomyolipoma associated with lymphangioleiomyomatosis
AML angiomyolipoma LAM lymphangioleiomyomatosis TSC tuberosclerosis complex Case Summary A 25-year-old woman was referred to our quaternary cancer centre with a 30-cm left-sided angiomyolipoma (AML), complicated by a bleed into the lesion. CT of the chest revealed small lesions consistent with lymphangioleiomyomatosis. eGFR and haemoglobin on admission was 90 (normal >90 ml/min/1.73 m2) and 98 (normal 115-165 g/L), respectively.
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial - Nature Medicine
Abstract There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) cells expressing anti-CD19 chimeric antigen receptor and interleukin-15 (CAR19/IL-15) in 37 patients with CD19+ B cell malignancies. The primary objectives were safety and efficacy, defined as day 30 overall response (OR).
Choosing the Perfect Camera: 5 Best Cameras for Photography Beginners
Embarking on a photographic journey is an exhilarating experience, and choosing the right camera is a crucial first step for any budding photographer. In the vast realm of options, finding a balance between features, usability, and budget is essential. In this comprehensive guide, we’ll delve into some of the best cameras for photography beginners in 2023, spotlighting the Sony Alpha a6400, Canon EOS Rebel T8i (EOS 850D), Nikon D5600, Fujifilm X-T200, and Panasonic Lumix G85 (G80).
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